Correlation of regional cerebral blood flow and change of plasma sodium concentration during genesis and satiation of thirst

Positron emission tomography studies were conducted during genesis of moderate thirst by rapid i.v. infusion of hypertonic saline (0.51 M) and after satiation of thirst by drinking water. The correlation of regional cerebral blood flow with the change in the plasma Na concentration showed a significant group of cerebral activations in the anterior cingulate region and also a site in the middle temporal gyrus and in the periaqueductal gray. Strongest deactivations occurred in the parahippocampal and frontal gyri. The data are consistent with an important role of the anterior cingulate in the genesis of thirst.

Chromatin structure mapping in Saccharomyces cerevisiae in vivo with DNase I

Most methods for assessment of chromatin structure involve chemical or nuclease damage to DNA followed by analysis of distribution and susceptibility of cutting sites. The agents used generally do not permeate cells, making nuclear isolation mandatory. In vivo mapping strategies might allow detection of labile constituents and/or structures that are lost when chromatin is swollen in isolated nuclei at low ionic strengths. DNase I has been the most widely used enzyme to detect chromatin sites where DNA is active in transcription, replication or recombination. We have introduced the bovine DNase I gene into yeast under control of a galactose-responsive promoter. Expression of the nuclease leads to DNA degradation and cell death. Shorter exposure to the active enzyme allows mapping of chromatin structure in whole cells without isolation of nuclei. The validity and efficacy of the strategy are demonstrated by footprinting a labile repressor bound to its operator. Investigation of the inter-nucleosome linker regions in several types of repressed domains has revealed different degrees of protection in cells, relative to isolated nuclei.

The genesis of avian neural crest cells: a classic embryonic induction.

Neural crest cells arise from the ectoderm and are first recognizable as discrete cells in the chicken embryo when they emerge from the neural tube. Despite the classical view that neural crest precursors are a distinct population lying between epidermis and neuroepithelium, our results demonstrate that they are not a segregated population. Cell lineage analyses have demonstrated that individual precursor cells within the neural folds can give rise to epidermal, neural crest, and neural tube derivatives. Interactions between the neural plate and epidermis can generate neural crest cells, since juxtaposition of these tissues at early stages results in the formation of neural crest cells at the interface. Inductive interactions between the epidermis and neural plate can also result in "dorsalization" of the neural plate, as assayed by the expression of the Wnt transcripts characteristic of the dorsal neural tube. The competence of the neural plate changes with time, however, such that interaction of early neural plate with epidermis generates only neural crest cells, whereas interaction of slightly older neural plate with epidermis generates neural crest cells and Wnt-expressing cells. At cranial levels, neuroepithelial cells can regulate to generate neural crest cells when the endogenous neural folds are removed, probably via interaction of the remaining neural tube with the epidermis. Taken together, these experiments demonstrate that: (i) progenitor cells in the neural folds are multipotent, having the ability to form multiple ectodermal derivatives, including epidermal, neural crest, and neural tube cells; (ii) the neural crest is an induced population that arises by interactions between the neural plate and the epidermis; and (iii) the competence of the neural plate to respond to inductive interactions changes as a function of embryonic age.

An abridgment of what I extracted while an undergraduate at Harvard College, 1766-1769

The bound volume contains excerpts copied by Benjamin Wadsworth from books he read as a student at Harvard in the late 1760s. The volume includes almost no personal commentary on the readings. The excerpts are arranged by year of study for the academic years 1766-1769, beginning when Wadsworth was a sophomore. Each entry begins with a title indicating the book title and author for the passage, and there is an alphabetical index at the end of the volume. Wadsworth selected “extracts” from both religious and secular texts including several histories of England, American histories (with a focus on Puritans), the Bible, and in his senior year, “the Koran of Mohammed.” He also read several books on the art of speech and the art of preaching. There are few science texts included, though the final five-page entry is titled, “What I thought fit to note down from Mr. Winthrop’s experimental Lectures” and contains notes both on the content of Professor John Winthrop’s lectures as well as the types of experiments being performed in class. Wadsworth’s commonplace book offers a window on the state of higher education in the eighteenth century and offers a firsthand account of academic life at Harvard College.

Influence de la Bible sur les contes et mythes ivoiriens

Etant enfant, j'ai été bercée par des contes que mes grands-parents aimaient me relater. Ces magnifiques histoires sur le comment et le pourquoi certaines créatures existaient au monde. En grandissant, je suis entrée en contact avec la Bible et certaines de ses histoires ressemblaient beaucoup aux contes de mon enfance. J'ai donc décidé de faire certaines recherches et comprendre mieux certains aspects culturels liés. Da bambina, sono stata cullata da storie che i miei nonni adoravano raccontarmi. Questi bellissimi racconti sul come e sul perché esistevano certe creature al mondo. Diventata grande, sono entrata in contatto con la Bibbia e alcune delle sue storie somigliavano molto ai racconti della mia infanzia. Ho quindi deciso di fare delle ricerche per capire meglio alcuni aspetti culturali collegati.

The works of Matthew Arnold.

"This edition consists of seven hundred and seventy-five copies."

Homélies sur les nombres /

Translations of: Homiliae in Numeros.

Die Hauptpersonen des Richterbuches in Talmud und Midrasch. I. Simson.

Cover title.

Sbornik, sluzhashchīĭ dopolnenīem k Prostoĭ ri͡echi o mudrenykh veshchakh.

Mode of access: Internet.

Drevle-slavianskii Karpinskii apostol XIII [i.e. trinadtsatogo] vieka,

t.2., ch.1. Poslaniia Sviatago Apostola Pavla.

Morales sur Job /

Vol. 1 has also been published in a 2nd ed., 1975, and a 3rd ed., 1989.

Biblia sacra iuxta Latinam Vulgatam versionem ad codicum fidem, iussu Pii pp. XI,

v. 1. Genesis -- v. 2. Exodi et levitici -- v. 3. Numerorum et deuteronomii -- v. 4. Iosue, iudicum, ruth -- v. 5. Samuhelis -- v. 6. M̈alachim -- v.7. Verborum dierum -- v. 8. Ezrae, tobiae, iudith -- v. 9. Hester-- v. 9. Hester et iob -- v. 10. Psalmi -- v. 11. Proverbia, ecclesiastes, canticum, canticorum -- v. 12. Sapientia-Sirach -- v. 13. Isaiae -- v. 14. Hieremias -- v. 15 Hezechielis -- v. 16. Danihelis -- v. 17 Duodecim prophetarum.

Historia de la Compañía de Jesús en la asistencia de España,

"Titulos completos de obras que se citan incidentalmente": v.1, p. [xliii]-xlv.

The Targum of Onkelos to Genesis. A critical enquiry into the value of the text exhibited by Yemem Mss. compared with that of the European recension together with some specimen chapters of the Oriental text.

Mode of access: Internet.