874 resultados para Barrier to trade


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National Highway Traffic Safety Administration, Washington, D.C.

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National Highway Traffic Safety Administration, Washington, D.C.

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National Highway Traffic Safety Administration, Washington, D.C.

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National Highway Traffic Safety Administration, Washington, D.C.

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National Highway Traffic Safety Administration, Washington, D.C.

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Vol. 1 prepared by Andrew L. Stoler.

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The two reports reprinted in this volume were framed by the Earl of Liverpool, President of the Committee on Trade and Foreign Plantations. cf. Introd. p.xiii.

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Water marketing, or mechanisms to acquire and redistribute water such as temporary water transfers, can represent a valuable response to drought for irrigation districts. The Department of Ecology, the US Bureau of Reclamation, and a workgroup composed of members from various entities collaborated to develop the Yakima River Basin Integrated Water Resource Management Plan (Integrated Plan) to better manage water resources and address ecosystem issues in the Yakima River Basin. The Integrated Plan addresses water marketing but it does not provide specifics on how barriers to inter‐district water transfers will be eliminated. This study asks irrigation district managers in the Yakima River basin about the factors they consider when deciding whether to engage in a temporary inter‐district water transfer or not. Results show that institutional barriers are the most common barrier to inter‐district water transfers. This topic requires further research on fallowing and irrigation district behavior in relation to the other water supply efforts outlined in the Integrated Plan. Finally, the water market in the Yakima basin can benefit from education and outreach to senior water rights holders, shortening the time frame to process expedited transfers, and documentation from irrigation districts reporting denial reasons for temporary inter‐district water transfers.

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The BZLF1 antigen of Epstein-Barr virus includes three overlapping sequences of different lengths that conform to the binding motif of human leukocyte antigen (HLA) B*3501. These 9-mer ((56)LPOGQLTAy(64)), 11-mer ((54)EPLPQGQLTAy(64)), and 13-mer ((52)LPEPLPQGQLTAY(64)) peptides all bound well to B*3501; however, the CTL response in individuals expressing this HILA allele was directed strongly and exclusively towards the 11-mer peptide. In contrast, EBV-exposed donors expressing HLA B*3503 showed no significant CTL response to these peptides because the single amino acid difference between B*3501 and B*3503 within the F pocket inhibited HLA binding by these peptides. The extraordinarily long 13-mer peptide was the target for the CTL response in individuals expressing B*3508, which differs from B*3501 at a single position within the D pocket (B*3501, 156 Leucine; B*3508, 156 Arginine). This minor difference was shown to enhance binding of the 13-mer peptide, presumably through a stabilizing interaction between the negatively charged glutamate at position 3 of the peptide and the positively charged arginine at HLA position 156. The 13-mer epitope defined in this study represents the longest class I-binding viral epitope identified to date as a minimal determinant. Furthermore, the potency of the response indicates that peptides of this length do not present a major structural barrier to CTL recognition.