994 resultados para 90-592


Relevância:

20.00% 20.00%

Publicador:

Resumo:

This sample contains clasts that range from small to large. A few fractured grains can be seen. The grain shape ranges from angular to rounded. Rotation structures can be seen throughout the sample along with some edge-to-edge grain crushing.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Dark brown sediment with clasts ranging from small to large in size. The clast shape ranges from angular to sub-rounded. Many of the larger clasts are fractured. Grain crushing is abundant throughout the sample. A few lineations can also be seen throughout the sample.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Brown sediment with clasts ranging from small to medium in size. Clast shape ranges from angular to sub-rounded. Rotation structures are abundant in this sample. Edge-to-edge grain crushing, comet structures, and lineations can also be seen in this sample.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

The By-Law summary states it is "a by-law relating generally to the transaction of the business and affairs of Barnes Wines, Limited". The sub headings of the bill are as follows: Head Office, Corporate Seal, Meetings of Shareholders, Directors, Officers, Notices, Interpretation.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Tesis (Maestría en Ciencias con Orientación en Química Analítica Ambiental) UANL, 2010.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Diabetes mellitus is a heterogeneous metabolic disorder characterized by hyperglycemia with disturbances in carbohydrate, protein and lipid metabolism resulting from defects in insulin secretion, insulin action or both. Currently there are 387 million people with diabetes worldwide and is expected to affect 592 million people by 2035. Insulin resistance in peripheral tissues and pancreatic beta cell dysfunction are the major challenges in the pathophysiology of diabetes. Diabetic secondary complications (like liver cirrhosis, retinopathy, microvascular and macrovascular complications) arise from persistent hyperglycemia and dyslipidemia can be disabling or even life threatening. Current medications are effective for control and management of hyperglycemia but undesirable effects, inefficiency against secondary complications and high cost are still serious issues in the present prognosis of this disorder. Hence the search for more effective and safer therapeutic agents of natural origin has been found to be highly demanding and attract attention in the present drug discovery research. The data available from Ayurveda on various medicinal plants for treatment of diabetes can efficiently yield potential new lead as antidiabetic agents. For wider acceptability and popularity of herbal remedies available in Ayurveda scientific validation by the elucidation of mechanism of action is very much essential. Modern biological techniques are available now to elucidate the biochemical basis of the effectiveness of these medicinal plants. Keeping this idea the research programme under this thesis has been planned to evaluate the molecular mechanism responsible for the antidiabetic property of Symplocos cochinchinensis, the main ingredient of Nishakathakadi Kashayam, a wellknown Ayurvedic antidiabetic preparation. A general introduction of diabetes, its pathophysiology, secondary complications and current treatment options, innovative solutions based on phytomedicine etc has been described in Chapter 1. The effect of Symplocos cochinchinensis (SC), on various in vitro biochemical targets relevant to diabetes is depicted in Chapter 2 including the preparation of plant extract. Since diabetes is a multifactorial disease, ethanolic extract of the bark of SC (SCE) and its fractions (hexane, dichloromethane, ethyl acetate and 90 % ethanol) were evaluated by in vitro methods against multiple targets such as control of postprandial hyperglycemia, insulin resistance, oxidative stress, pancreatic beta cell proliferation, inhibition of protein glycation, protein tyrosine phosphatase-1B (PTP-1B) and dipeptidyl peptidase-IV (DPPxxi IV). Among the extracts, SCE exhibited comparatively better activity like alpha glucosidase inhibition, insulin dependent glucose uptake (3 fold increase) in L6 myotubes, pancreatic beta cell regeneration in RIN-m5F and reduced triglyceride accumulation in 3T3-L1 cells, protection from hyperglycemia induced generation of reactive oxygen species in HepG2 cells with moderate antiglycation and PTP-1B inhibition. Chemical characterization by HPLC revealed the superiority of SCE over other extracts due to presence of bioactives (beta-sitosterol, phloretin 2’glucoside, oleanolic acid) in addition to minerals like magnesium, calcium, potassium, sodium, zinc and manganese. So SCE has been subjected to oral sucrose tolerance test (OGTT) to evaluate its antihyperglycemic property in mild diabetic and diabetic animal models. SCE showed significant antihyperglycemic activity in in vivo diabetic models. Chapter 3 highlights the beneficial effects of hydroethanol extract of Symplocos cochinchinensis (SCE) against hyperglycemia associated secondary complications in streptozotocin (60 mg/kg body weight) induced diabetic rat model. Proper sanction had been obtained for all the animal experiments from CSIR-CDRI institutional animal ethics committee. The experimental groups consist of normal control (NC), N + SCE 500 mg/kg bwd, diabetic control (DC), D + metformin 100 mg/kg bwd, D + SCE 250 and D + SCE 500. SCEs and metformin were administered daily for 21 days and sacrificed on day 22. Oral glucose tolerance test, plasma insulin, % HbA1c, urea, creatinine, aspartate aminotransferase (AST), alanine aminotransferase (ALT), albumin, total protein etc. were analysed. Aldose reductase (AR) activity in the eye lens was also checked. On day 21, DC rats showed significantly abnormal glucose response, HOMA-IR, % HbA1c, decreased activity of antioxidant enzymes and GSH, elevated AR activity, hepatic and renal oxidative stress markers compared to NC. DC rats also exhibited increased level of plasma urea and creatinine. Treatment with SCE protected from the deleterious alterations of biochemical parameters in a dose dependent manner including histopathological alterations in pancreas. SCE 500 exhibited significant glucose lowering effect and decreased HOMA-IR, % HbA1c, lens AR activity, and hepatic, renal oxidative stress and function markers compared to DC group. Considerable amount of liver and muscle glycogen was replenished by SCE treatment in diabetic animals. Although metformin showed better effect, the activity of SCE was very much comparable with this drug. xxii The possible molecular mechanism behind the protective property of S. cochinchinensis against the insulin resistance in peripheral tissue as well as dyslipidemia in in vivo high fructose saturated fat diet model is described in Chapter 4. Initially animal were fed a high fructose saturated fat (HFS) diet for a period of 8 weeks to develop insulin resistance and dyslipidemia. The normal diet control (ND), ND + SCE 500 mg/kg bwd, high fructose saturated fat diet control (HFS), HFS + metformin 100 mg/kg bwd, HFS + SCE 250 and HFS + SCE 500 were the experimental groups. SCEs and metformin were administered daily for the next 3 weeks and sacrificed at the end of 11th week. At the end of week 11, HFS rats showed significantly abnormal glucose and insulin tolerance, HOMA-IR, % HbA1c, adiponectin, lipid profile, liver glycolytic and gluconeogenic enzyme activities, liver and muscle triglyceride accumulation compared to ND. HFS rats also exhibited increased level of plasma inflammatory cytokines, upregulated mRNA level of gluconeogenic and lipogenic genes in liver. HFS exhibited the increased expression of GLUT-2 in liver and decreased expression of GLUT-4 in muscle and adipose. SCE treatment also preserved the architecture of pancreas, liver, and kidney tissues. Treatment with SCE reversed the alterations of biochemical parameters, improved insulin sensitivity by modifying gene expression in liver, muscle and adipose tissues. Overall results suggest that SC mediates the antidiabetic activity mainly via alpha glucosidase inhibition, improved insulin sensitivity, with antiglycation and antioxidant activities.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Absolute Kr 4s-electron photoionization cross sections as a function of the exciting-photon energy between 30 and 90 eV were measured by photon-induced fluorescence spectroscopy (PIFS). The measurements were compared with available experimental data and theoretical calculations.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

The influence of the occupation of the single particle levels on the impact parameter dependent K - K charge transfer occuring in collisions of 90 keV Ne{^9+} on Ne was studied using coupled channel calculations. The energy eigenvalues and matrixelements for the single particle levels were taken from ab initio self consistent MO-LCAO-DIRAC-FOCK-SLATER calculations with occupation numbers corresponding to the single particle amplitudes given by the coupled channel calculations.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

This study was conducted to evaluate the effects of feeding molasses or maize grain with agro-processing by-products on yield and quality of meat from Tanzania shorthorn zebu (TSZ) cattle. Forty five steers aged 2.5 to 3.0 years with 200 +/- 5.4 kg body weight were allocated into five dietary treatments namely hominy feed with molasses (HFMO), rice polishing with molasses (RPMO), hominy feed with maize meal (HFMM), rice polishing with maize meal (RPMM) and maize meal with molasses (MMMO). Ad libitum amount of each dietary treatment and hay were offered to nine steers for 90 days. Cooking loss (CL) and Warner Bratzler shear force (WBSF) values were determined on M. longissimus thoracis et lumborum aged for 3, 6, 9 and 12 days. Steers fed on HFMO diet had higher (P < 0.05) nutrient intake (86.39 MJ/d energy; 867 g/d CP), weight gain (919 g/d) and half carcass weight (75.8 kg) than those fed other diets. Meat of steers from all diets was tender with average WBSF values of 47.9 N cm^(−2). The CL (22.0 +/- 0.61%) and WBSF (53.4 +/- 0.70 N cm^(−2)) were highest in meat aged for 3 days followed by 6, 9 and 12 days. WBSF values for meat aged for 9 and 12 days from steers fed HFMO and RPMM diets were similar and lower than those on other dietary treatments x aging periods. Overall, molasses and hominy feed can be used to replace maize meal in feedlot finishing diets to spare its use in animal feeds.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Conocer la valoraci??n que los estudiantes de COU y tercero de FP hacen de la orientaci??n profesional y ocupacional recibida en su trayectoria acad??mica, as?? como de los diferentes momentos y agentes de informaci??n implicados en la misma, para aportar datos objetivos que permitan la planificaci??n de tareas de orientaci??n profesional en los centros de Ense??anzas Medias y posibilitar la detecci??n de las necesidades existentes desde la perspectiva de los alumnos. Estudiantes de los ??ltimos cursos de Ense??anzas Medias en 1989-90 de centros p??blicos de Asturias. Las muestras de los dos colectivos (COU y tercero de FP II) son estad??sticamente representativas de la poblaci??n de or??gen. Caracter??sticas de los alumnos (personales y acad??micas); opiniones sobre la orientaci??n profesional (agentes de informaci??n, sistema educativo, informaci??n actividad profesional, consideraci??n de la orientaci??n); procesos de toma de decisiones (momentos en la decisi??n, plan de actuaci??n a corto plazo, opini??n-dependencias de decisi??n, criterios toma de decisi??n). Cuestionario elaborado por los autores cuyos fundamentos eran comunes tanto para los alumnos de COU como para los de FP, con algunas preguntas espec??ficas para cada colectivo. Las caracter??sticas personales de los alumnos de COU y de los de tercero de FP II son diferentes. Las caracter??sticas acad??micas no permiten hacer comparaciones por presentar peculiaridades propias y distintivas. En la valoraci??n de la orientaci??n e informaci??n profesional, s??lo juzgan satisfactoria su propia actuaci??n de b??squeda de informaci??n y los que por su profesi??n, profesores, deber??an ser agentes de informaci??n profesional reciben las puntuaciones m??s bajas entre los alumnos de COU, en FP se valoran m??s, lo que puede ser debido a la relaci??n existente entre profesores de FP y el mundo laboral. Visto esto, no es de extra??ar que la valoraci??n global de la orientaci??n se mueva entre los m??rgenes de ninguna y/o escasa para la mayor??a de los estudiantes. El planteamiento del futuro profesional se produce durante los ??ltimos a??os de los ciclos educativos, aunque los de COU muestran un elevado porcentaje de indecisi??n y prima tercero de BUP como fundamental en los de tercero de FP II el grado de indecisi??n es muy reducido y el curso importante es octavo de EGB. Los criterios utilizados en la toma de decisiones son muy similares para los dos grupos y son: gusto personal, capacitaci??n personal, mercado laboral, dinero a lograr y servicio que pueden prestar. El hecho de trabajar con dos muestras independientes de estudiantes asturianos de COU y tercero de FP II les permite, sostienen los autores, tener una idea clara sobre cuales son sus opiniones y valoraciones respecto a la orientaci??n profesional y vocacional recibida a lo largo de la trayectoria escolar.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Desarrollar una actitud investigadora en los futuros docentes. Situar a la teoría como instrumento al servicio del análisis de las realidades educativas. Un curso del CAP con dos grupos de 25 alumnos cada uno. Un tutor de prácticas para cada seis alumnos. Los alumnos asisten durante dos o tres días a la semana -diez horas aproximadamente- a los centros de prácticas y otros días acuden a las clases de los módulos teóricos y de investigación en el aula una hora cada módulo. Los pasos son: participación intensiva en la práctica. Registro de lo que ocurre en la situación. Reflexión analítica de lo registrado. UUE de Novak y Gowin, 1988. También elaboran algunos materiales. Tabla Aristotélica de invención. Soporte mural para la UUE. Grabación en vídeo de las secciones de puesta en común. Utilizan documentos bibliográficos. Revisión y análisis de los diferentes acontecimientos que han tenido lugar en el módulo de investigación en el aula que se estructuran en torno a secuencias. Dificultades para utilizar de forma comprensiva y constructiva la información teórica. En pocos trabajos se han llegado a formular hipótesis sobre los cambios que se pueden efectuar en una práctica educativa. Falta de experiencia y capacidad técnica para llegar a ser, según algún grupo, más objetivos y rigurosos. Resultados desiguales en los trabajos en equipo. Se puede afirmar que ha sido valioso el módulo porque: ha proporcionado a los alumnos herramientas y estrategias para el proceso de enseñanza-aprendizaje. Ha iniciado una vía de interrelación entre la teoría y la práctica. Ha permitido a los alumnos de prácticas elaborar su propio conocimiento a partir de sus experiencias.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Resumen tomado de la publicaci??n. Resumen tambi??n en ingl??s