994 resultados para 71-514
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Der Pergamenteinband enthält innenliegend einen Heiratsvertrag datiert vom 28.11.1571
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Vorbesitzer: Bartholomaeusstift Frankfurt am Main
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Vorbesitzer: Bartholomaeusstift Frankfurt am Main
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Welsch (Projektbearbeiter): Aufruf von 14 Urwählern des Berliner 71. Bezirks, nur solche Wahlmänner zu wählen, die den Staatsstreich des 9. November 1848 (Verlegung der Nationalversammlung nach Brandenburg) wieder rückgängig machen und eine Verfassung schaffen, welche im Unterschied zu der vom 5. Dezember 1848 kein Gnadengeschenk darstellt
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BACKGROUND The purpose of this clinical study was to assess the prevalence of acidic oral mucosal lesions and periodontal conditions in patients suffering from erosive esophageal reflux disease (ERD) compared with non erosive esophageal reflux disease (NERD) patients, both treated with long term proton pump inhibitors (PPI). METHODS Seventy-one patients with diagnosed GERD were studied: i.e. 29 ERD and 42 NERD patients. Thorough visual examination of the oral mucosa and a periodontal evaluation was performed. The primary outcome was defined as a statistically significant difference, between the two groups, in the presence of acidic lesions of the oral mucosa and specific periodontal parameters. RESULTS This study failed to demonstrate statistically significant differences between ERD and NERD patients with respect to the prevalence of oral mucosal lesions. However, significantly more ERD patients suffered from severe periodontitis (CAL ≥ 5 mm) as compared to NERD patients. Accordingly, it may be assumed that PPI-use had no adverse effects on the prevalence of acidic oral mucosal lesions and on periodontal destruction. CONCLUSIONS Within the limitations of this study it may be concluded that ERD and NERD patients need separate evaluation with respect to periodontal destruction. Moreover, long term PPI medication had no adverse clinical impact on acidic oral mucosal lesions and periodontal destruction. Further studies are necessary to elucidate the role of reflux in the periodontal destruction of ERD individuals.
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A missense variant (c.1637C>T, T546M) in ABCC11 encoding the MRP8 (multidrug resistance protein 8), a transporter of 5-fluorodeoxyuridine monophosphate, has been associated with an increased risk of 5-fluorouracil-related severe leukopenia. To validate this association, we investigated the impact of the ABCC11 variants c.1637C>T, c.538G>A and c.395+1087C>T on the risk of early-onset fluoropyrimidine-related toxicity in 514 cancer patients. The ABCC11 variant c.1637C>T was strongly associated with severe leukopenia in patients carrying risk variants in DPYD, encoding the key fluoropyrimidine-metabolizing enzyme dihydropyrimidine dehydrogenase (odds ratio (OR): 71.0; 95% confidence interval (CI): 2.5-2004.8; Pc.1637C>T*DPYD=0.013). In contrast, in patients without DPYD risk variants, no association with leukopenia (OR: 0.95; 95% CI: 0.34-2.6) or overall fluoropyrimidine-related toxicity (OR: 1.02; 95% CI: 0.5-2.1) was observed. Our study thus suggests that c.1637C>T affects fluoropyrimidine toxicity to leukocytes particularly in patients with high drug exposure, for example, because of reduced fluoropyrimidine catabolism.
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Eugen Wolbe
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Eugen Wolbe
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Vorbesitzer: Dominikanerkloster Frankfurt am Main
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u.a.: Carolin Médon; Carolin Marquet;
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58 Briefe zwischen dem Professor Ludwig von Friedeburg (Kultusminister) und Max Horkheimer, 1953-1973; Gutachten über die Habilitationsschrift von Friedeburg 1959 (Blatt 53-66); Antrittsvorlesung von Friedeburg: "Universität und Öffentlichkeit" 1967 (Blatt 159-173); Sonderdrucke und Fragebogen;
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u.a.: Buchhändler; Religion; Rezension in der Zeitschrift "Litterarische Blätter"; Goethes Faust; Brockhaus-Verlag; William Shakspeare; Arbeit an der 2. Auflage "Die beiden Grundprobleme der Ethik";
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u.a.: Besuch in Frankfurt im Mai 1858; geplante 3. Auflage der "Welt als Wille und Vorstellung" vom Verlag Brockhaus; geplanter kritischer Aufsatz gegen Abhandlung von Georg Carl Rudolph Seydel; Kommentar Schopenhauers zu Goethes Faust; Arbeit an der Übersetzung; Reise nach Paris; Veröffentlichungen von Carl Georg Bähr und Charles Dollfus zur Philosophie Schopenhauers in der Zeitschrift Revue Germanique; Artikel "Aus und über Schopenhauer" von Louis Büchner; Rezension von Franz Brendel; Preisschrift Karl Georg Bährs; David Asher; A. Mailard; Jules Lunteschütz, Charles Dolfus. Louis Büchner; Franz Brendel;
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u.a.: Berlin; Leipzig; Brockhaus; Parerga; Artikel von Francesco de Sanctis: "Schopenhauer e Leopardi" in der in Turin herausgegebenen Rivista Contemporanea; Übersetzung von Ernst Otto Timotheus Lindner; Schopenhauer-Portrait von Jules Lunteschütz; Angilbert Göbel; Kunstverein; Rezension von Georg Carl Rudolph Seydel; Veröffentlichung von David Asher beim Verlag Brockhaus; Johann Wolfgang von Goethe;