992 resultados para 658.51


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In this introductory paper we summarize the history and achievements of the Potrok Aike maar lake Sediment Archive Drilling prOject (PASADO), an interdisciplinary project embedded in the International Continental Scientific Drilling Program (ICDP). The stringent multiproxy approach adopted in this research combined with radiocarbon and luminescence dating provided the opportunity to synthesize a large body of hydrologically relevant data from Laguna Potrok Aike (southern Patagonia, Argentina). At this site, lake level was high from 51 ka until the early Holocene when the Southern Hemisphere Westerlies (SHW) were located further to the north. At 9.3 ka cal. BP the SHW moved southward and over the latitude of the study area (52 degrees S) causing a pronounced negative water balance with a lake level decrease of more than 50 m. Two millennia later, the SHW diminished in intensity and lake level rose to a subsequent maximum during the Little Ice Age. Since the 20th century, a strengthening of the SHW increased the evaporative stress resulting in a more negative water balance. A comparison of our data with other hydrological fluctuations at a regional scale in south-eastern Patagonia, provides new insights and also calls for better chronologies and high-resolution records of climate variability.

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Vorbesitzer: Eljāqīm Carmoly

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Vorbesitzer: Bartholomaeusstift Frankfurt am Main

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OBJECTIVES The aim of the Cavalier trial was to evaluate the safety and performance of the Perceval sutureless aortic valve in patients undergoing aortic valve replacement (AVR). We report the 30-day clinical and haemodynamic outcomes from the largest study cohort with a sutureless valve. METHODS From February 2010 to September 2013, 658 consecutive patients (mean age 77.8 years; 64.4% females; mean logistic EuroSCORE 10.2%) underwent AVR in 25 European Centres. Isolated AVRs were performed in 451 (68.5%) patients with a less invasive approach in 219 (33.3%) cases. Of the total, 40.0% were octogenarians. Congenital bicuspid aortic valve was considered an exclusion criterion. RESULTS Implantation was successful in 628 patients (95.4%). In isolated AVR through sternotomy, the mean cross-clamp time and the cardiopulmonary bypass (CPB) time were 32.6 and 53.7 min, and with the less invasive approach 38.8 and 64.5 min, respectively. The 30-day overall and valve-related mortality rates were 3.7 and 0.5%, respectively. Valve explants, stroke and endocarditis occurred in 0.6, 2.1 and in 0.1% of cases, respectively. Preoperative mean and peak pressure gradients decreased from 44.8 and 73.24 mmHg to 10.24 and 19.27 mmHg at discharge, respectively. The mean effective orifice area improved from 0.72 to 1.46 cm(2). CONCLUSIONS The current 30-day results show that the Perceval valve is safe (favourable haemodynamic effect and low complication rate), and can be implanted with a fast and reproducible technique after a short learning period. Short cross-clamp and CPB times were achieved in both isolated and combined procedures. The Perceval valve represents a promising alternative to biological AVR, especially with a less invasive approach and in older patients.

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Vorbesitzer: Johann Friedrich Faust von Aschaffenburg; Wilhelm Fitzer; Matthaeus Merian; Johann Maximilian zum Jungen;

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Vorbesitzer: Georg von Breidenbach; Dominikanerkloster Frankfurt am Main

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u.a.: Streitigkeiten über die geplante Vermögensaufteilung; Mutter-Sohn-Konflikt;

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83 Briefe und Beilagen zwischen Arthur Hübscher und Max Horkheimer, 1963-1973; 15 Briefe und Beilagen zwischen Bundesminister a. D. Ewald Bucher und Max Horkheimer, 1966-1971; 1 Brief und Beilage von Dr. Christoph Meyer an Max Horkheimer, 1969; 6 Briefe zwischen Dr. Johann Joeden und Max Horkheimer, 1966; 5 Briefe zwischen dem Oberregierungsrat Gustav Adolf Hünniger und Max Horkheimer, 1951-1953; 2 Briefe und eine Empfehlung und ein Gutachten von Edith Hünniger an Max Horkheimer, 1952-1953;