[Défilé du 14 juillet 1919 sur les Champs-Elysées, les troupes américaines] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 54984

[Défilé du 14 juillet 1919, dépôt de gerbes au cénotaphe place de l'Etoile] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 54985

[Défilé du 14 juillet 1919 sur les Champs-Elysées, la cavalerie française] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 54986

[Défilé du 14 juillet 1919 à Paris, soldats français] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 54987

[Défilé du 14 juillet 1919 à Paris, soldats français] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 54987 bis

[Défilé du 14 juillet 1919 sur les Champs-Elysées, officier français à cheval] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 54988

[Défilé du 14 juillet 1919 sur les Champs-Elysées, officier français à cheval] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 54988 bis

[Défilé du 14 juillet 1919 sur les Champs-Elysées, soldats français] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 54989

[Défilé du 14 juillet 1919 sur les Champs-Elysées, soldats français] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 54989 bis

[Défilé du 14 juillet 1919 place de la Concorde, devant le jardin des Tuileries, maréchaux Joffre et Foch ?] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 54990

[Défilé du 14 juillet 1919 place de la Concorde, devant le jardin des Tuileries, maréchaux Joffre et Foch ?] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 54990 bis

[Défilé du 14 juillet 1919 sur les Champs-Elysées, soldats français] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 54991

Predictive value of the MGMT promoter methylation status in metastatic melanoma patients receiving first-line temozolomide plus bevacizumab in the trial SAKK 50/07.

The O6-methylguanine-DNA-methyltransferase (MGMT) promoter methylation status is a predictive parameter for the response of malignant gliomas to alkylating agents such as temozolomide. First clinical trials with temozolomide plus bevacizumab therapy in metastatic melanoma patients are ongoing, although the predictive value of the MGMT promoter methylation status in this setting remains unclear. We assessed MGMT promoter methylation in formalin-fixed, primary tumor tissue of metastatic melanoma patients treated with first-line temozolomide and bevacizumab from the trial SAKK 50/07 by methylation-specific polymerase chain reaction. In addition, the MGMT expression levels were also analyzed by MGMT immunohistochemistry. Eleven of 42 primary melanomas (26%) revealed a methylated MGMT promoter. Promoter methylation was significantly associated with response rates CR + PR versus SD + PD according to RECIST (response evaluation criteria in solid tumors) (p<0.05) with a trend to prolonged median progression-free survival (8.1 versus 3.4 months, p>0.05). Immunohistochemically different protein expression patterns with heterogeneous and homogeneous nuclear MGMT expression were identified. Negative MGMT expression levels were associated with overall disease stabilization CR + PR + SD versus PD (p=0.05). There was only a poor correlation between MGMT methylation and lack of MGMT expression. A significant proportion of melanomas have a methylated MGMT promoter. The MGMT promoter methylation status may be a promising predictive marker for temozolomide therapy in metastatic melanoma patients. Larger sample sizes may help to validate significant differences in survival type endpoints.

Potential Impacts of Climate Change on Ecosystem Services in Europe: the Case of Pest Control by Vertebrates. BioScience.

Global environmental changes threaten ecosystems and cause significant alterations to the supply of ecosystem services that are vital for human well-being. We provide an assessment of the potential impacts of climate change on European diversity of vertebrates and their associated pest control services. We modeled the distributions of the species that provide this service using ensembles of forecasts from bioclimatic envelope models and then used their results to generate maps of potential species richness among vertebrate providers of pest control services. We assessed how potential richness of pest control providers would change according to different climate and greenhouse emissions scenarios. We found that potential richness of pest control providers was likely to face substantial reductions, especially in southern European countries that had economies highly dependent on agricultural yields. In much of central and northern Europe, where countries had their economies less dependent on agriculture, climate change was likely to benefit pest control providers

Pretreatment and outcome correlates of sexual and physical trauma in an epidemiological cohort of first-episode psychosis patients.

OBJECTIVES: High prevalence of trauma has been reported in psychosis. While role of trauma as a risk factor for developing psychosis is still debated, its negative impact on outcome has been described. Few studies have explored this issue in first-episode psychosis (FEP) patients. We assessed rate of stressful events, as well as premorbid and outcome correlates of past sexual and/or physical abuse (SPA) in an epidemiological FEP patients cohort. METHODS: The Early Psychosis Prevention and Intervention Centre admitted 786 FEP patients between 1998 and 2000. Data were collected from patients' files using a standardized questionnaire. A total of 704 files were available, 43 excluded because of a nonpsychotic diagnosis at end point and 3 due to missing data regarding past stressful events; 658 patients were analyzed. RESULTS: A total of 83% patients had been exposed to at least one stressful event and 34% to SPA. SPA patients were more likely to have presented other psychiatric disorders before psychosis onset (posttraumatic stress disorder, substance use disorder), to have made suicide attempts in the past, and to have had poorer premorbid functional levels. Additionally, SPA patients had higher rate of comorbid diagnosis at program entry and were more likely to attempt suicide during treatment. CONCLUSIONS: SPA prevalence is high in FEP patients and must be explored by clinicians considering its durable impact on psychological balance and link with long-lasting suicidal risk. More research is warranted to better understand mechanisms involved between trauma and its potential consequences, as well as to develop psychological interventions adapted to this very sensitive and complex issue.