Biodistribution of anti-CEA F(ab')2 fragments after intra-arterial and intravenous injection in patients with liver metastases due to colorectal carcinoma.

The biodistribution of simultaneous intra-arterial and intravenous injections of a radiolabelled anti-CEA MAb F(ab')2 fragment was studied in three patients with liver metastases from colorectal cancer. Identical MAb fragments, labelled with either 125I or 131I, were injected over a period of 30 min into the hepatic artery and into a peripheral vein. After 1 or 2 days, biodistribution was measured in the surgically removed metastases, normal tissue samples and blood. By tissue radioactivity counting, tumour uptake in the range 6.3-9.1% of injected dose per gram was found. Superimposable metastasis-to-blood and metastasis-to-normal liver ratios were obtained for both iodine isotopes in all three patients. The results indicate that the intra-arterial injection of MAb F(ab')2 fragments gives no measurable advantage over more convenient injections into a peripheral vein.

Dermatofibrosarcoma presenting as a nodule in the breast of a 75-year-old woman: a case report.

ABSTRACT: INTRODUCTION: Dermatofibrosarcoma protuberans is a rare neoplasm of soft tissues and its location in the breast is extremely uncommon. Confusion is possible with other primary breast lesions. CASE PRESENTATION: A 75-year-old Caucasian woman presented with a mass in her left breast 21 years after being diagnosed with invasive ductal carcinoma of the right breast, treated by a right mastectomy and axillary dissection followed by radiotherapy and breast reconstruction. Mammography revealed a dish-shaped skin nodule formation in the upper outer quadrant of her left breast. Echography confirmed the presence of a lesion measuring 1.4 x 0.8 cm. Based on imaging, the diagnosis was a probable angiosarcoma. Due to the presence of a pacemaker for cardiac arrhythmia and full anticoagulation therapy for a pulmonary embolism, magnetic resonance imaging and a biopsy were not done. We proceeded directly to a quadrantectomy and the final diagnosis revealed a dermatofibrosarcoma protuberans, 1. 8 cm in its greatest microscopic dimension, located 0.1 cm from the upper surgical margin. To ensure the wide resection margins required for this type of neoplasm, a re-excision was performed. CONCLUSION: A dermatofibrosarcoma protuberans of the breast is an uncommon discovery. The aim of this case report is to highlight the importance of the surgical procedure in cases of the discovery of dermatofibrosarcoma protuberans. Re-excision may be necessary to ensure adequate resection margins.

Risques rénaux des compléments alimentaires: une cause ignorée [Renal risks of dietary complements: a forgotten cause].

The use of dietary complements like vitamins, minerals, trace elements, proteins, aminoacids and plant-derived agents is prevalent in the general population, in order to promote health and treat diseases. Dietary complements are considered as safe natural products and are easily available without prescription. However, these can lead to severe renal toxicity, especially in cases of unknown pre-existing chronic kidney disease (CKD). In particular, Chinese herbs including aristolochic acid, high doses of vitamine C, creatine and protein complements may lead to acute and chronic renal failure, sometimes irreversible. Dietary complement toxicity should be suspected in any case of unexplained renal impairement. In the case of pre-existing CKD, the use of potentially nephrotoxic dietary complements should be screened for.

Identification of quantitative trait loci for resistance against soybean sudden death syndrome caused by Fusarium tucumaniae

The objective of this work was to identify genomic regions that underlie resistance to Fusarium tucumaniae sp. nov., the causing agent of sudden death syndrome (SDS) in soybean in South America, using a population with a genetic background different from that previously reported for Fusarium virguliforme sp. nov. (F. solani f. sp. glycines), also responsible for SDS in soybean. Although major genes and quantitative trait loci (QTL) for SDS resistance have been identified, little is known about the same disease caused by Fusarium tucumaniae sp. nov., in South America. To identify genetic factors related to resistance to F. tucumaniae and DNA markers associated with them, a QTL analysis was performed using recombinant inbred lines. The map locations of the four loci, here identified, differed from those SDS resistance QTL previously described. It was screened a residual heterozygous line (RHL), which was heterozygous around the most effective QTL, RSDS1, and homozygous for the other genomic regions. The genetic effect of RSDS1 was confirmed using near-isogenic lines (NIL) derived from the RHL. The line which was homozygous for the Misuzudaizu genotype showed resistance levels comparable with that of the line homozygous for the Moshidou Gong 503 genotype.

Aprender a ser docente en un mundo en cambio. Simposio internacional

[spa] Este texto recoge el conjunto de contribuciones presentadas al simposio internacional Aprender a ser docente en un mundo en cambio, que tuvo lugar en Barcelona el 21 y 22 de noviembre de 2013, un acto organizado por los grupos de investigación consolidados Esbrina - Subjetividades y entornos de aprendizaje contemporáneos (2009SGR 503) de la Universidad de Barcelona y ELKARRIKERTUZ (IT-563-13) de la Universidad del País Vasco.El simposio nos dio la oportunidad de debatir con la comunidad educativa el sentido de ser docente en el mundo actual y nos permitió presentar y debatir los resultados del proyecto de investigación coordinado La construcción de la identidad docente del profesorado educación infantil y primaria en la formación inicial y los primeros años de trabajo (Identidoc) (Ministerio de Economía y Competitividad. EDU2010-20852-C02-01/EDU2010-20852-C02-02), e intercambiar con otros colegas conocimientos y reflexiones en torno a estos temas.[cat]Aquest text recull el conjunt de contribucions presentades al simposi internacional Aprender a ser docente en un mundo en cambio, que va tenir lloc a Barcelona el 21 i 22 de novembre de 2013, un acte organitzat pels grups de recerca consolidats ESBRINA - Subjectivitats i entorns educatius contemporanis (2009SGR 503) de la Universitat de Barcelona i ELKARRIKERTUZ (IT-563-13) de la Universitat del País Basc.El simposi ens va donar l'oportunitat de debatre amb la comunitat educativa el sentit de ser docent en el món actual i ens va permetre presentar i debatre els resultats del projecte de recerca coordinat La construcción de la identidad docente del profesorado educación infantil y primaria en la formación inicial y los primeros años de trabajo (Identidoc) (Ministeri d'Economia i Competitivitat. EDU2010-20852-C02-01/EDU2010-20852-C02-02), i intercanviar amb altres col·legues coneixements i reflexions al voltant d'aquests temes.

Aprender a ser docente en un mundo en cambio. Simposio internacional

[spa] Este texto recoge el conjunto de contribuciones presentadas al simposio internacional Aprender a ser docente en un mundo en cambio, que tuvo lugar en Barcelona el 21 y 22 de noviembre de 2013, un acto organizado por los grupos de investigación consolidados Esbrina - Subjetividades y entornos de aprendizaje contemporáneos (2009SGR 503) de la Universidad de Barcelona y ELKARRIKERTUZ (IT-563-13) de la Universidad del País Vasco.El simposio nos dio la oportunidad de debatir con la comunidad educativa el sentido de ser docente en el mundo actual y nos permitió presentar y debatir los resultados del proyecto de investigación coordinado La construcción de la identidad docente del profesorado educación infantil y primaria en la formación inicial y los primeros años de trabajo (Identidoc) (Ministerio de Economía y Competitividad. EDU2010-20852-C02-01/EDU2010-20852-C02-02), e intercambiar con otros colegas conocimientos y reflexiones en torno a estos temas.[cat]Aquest text recull el conjunt de contribucions presentades al simposi internacional Aprender a ser docente en un mundo en cambio, que va tenir lloc a Barcelona el 21 i 22 de novembre de 2013, un acte organitzat pels grups de recerca consolidats ESBRINA - Subjectivitats i entorns educatius contemporanis (2009SGR 503) de la Universitat de Barcelona i ELKARRIKERTUZ (IT-563-13) de la Universitat del País Basc.El simposi ens va donar l'oportunitat de debatre amb la comunitat educativa el sentit de ser docent en el món actual i ens va permetre presentar i debatre els resultats del projecte de recerca coordinat La construcción de la identidad docente del profesorado educación infantil y primaria en la formación inicial y los primeros años de trabajo (Identidoc) (Ministeri d'Economia i Competitivitat. EDU2010-20852-C02-01/EDU2010-20852-C02-02), i intercanviar amb altres col·legues coneixements i reflexions al voltant d'aquests temes.

Aprender a ser docente en un mundo en cambio. Simposio internacional

[spa] Este texto recoge el conjunto de contribuciones presentadas al simposio internacional Aprender a ser docente en un mundo en cambio, que tuvo lugar en Barcelona el 21 y 22 de noviembre de 2013, un acto organizado por los grupos de investigación consolidados Esbrina - Subjetividades y entornos de aprendizaje contemporáneos (2009SGR 503) de la Universidad de Barcelona y ELKARRIKERTUZ (IT-563-13) de la Universidad del País Vasco.El simposio nos dio la oportunidad de debatir con la comunidad educativa el sentido de ser docente en el mundo actual y nos permitió presentar y debatir los resultados del proyecto de investigación coordinado La construcción de la identidad docente del profesorado educación infantil y primaria en la formación inicial y los primeros años de trabajo (Identidoc) (Ministerio de Economía y Competitividad. EDU2010-20852-C02-01/EDU2010-20852-C02-02), e intercambiar con otros colegas conocimientos y reflexiones en torno a estos temas.[cat]Aquest text recull el conjunt de contribucions presentades al simposi internacional Aprender a ser docente en un mundo en cambio, que va tenir lloc a Barcelona el 21 i 22 de novembre de 2013, un acte organitzat pels grups de recerca consolidats ESBRINA - Subjectivitats i entorns educatius contemporanis (2009SGR 503) de la Universitat de Barcelona i ELKARRIKERTUZ (IT-563-13) de la Universitat del País Basc.El simposi ens va donar l'oportunitat de debatre amb la comunitat educativa el sentit de ser docent en el món actual i ens va permetre presentar i debatre els resultats del projecte de recerca coordinat La construcción de la identidad docente del profesorado educación infantil y primaria en la formación inicial y los primeros años de trabajo (Identidoc) (Ministeri d'Economia i Competitivitat. EDU2010-20852-C02-01/EDU2010-20852-C02-02), i intercanviar amb altres col·legues coneixements i reflexions al voltant d'aquests temes.

Association between the PNPLA3 (rs738409 C>G) variant and hepatocellular carcinoma: Evidence from a meta-analysis of individual participant data.

The incidence of hepatocellular carcinoma (HCC) is increasing in Western countries. Although several clinical factors have been identified, many individuals never develop HCC, suggesting a genetic susceptibility. However, to date, only a few single-nucleotide polymorphisms have been reproducibly shown to be linked to HCC onset. A variant (rs738409 C>G, encoding for p.I148M) in the PNPLA3 gene is associated with liver damage in chronic liver diseases. Interestingly, several studies have reported that the minor rs738409[G] allele is more represented in HCC cases in chronic hepatitis C (CHC) and alcoholic liver disease (ALD). However, a significant association with HCC related to CHC has not been consistently observed, and the strength of the association between rs738409 and HCC remains unclear. We performed a meta-analysis of individual participant data including 2,503 European patients with cirrhosis to assess the association between rs738409 and HCC, particularly in ALD and CHC. We found that rs738409 was strongly associated with overall HCC (odds ratio [OR] per G allele, additive model=1.77; 95% confidence interval [CI]: 1.42-2.19; P=2.78 × 10(-7) ). This association was more pronounced in ALD (OR=2.20; 95% CI: 1.80-2.67; P=4.71 × 10(-15) ) than in CHC patients (OR=1.55; 95% CI: 1.03-2.34; P=3.52 × 10(-2) ). After adjustment for age, sex, and body mass index, the variant remained strongly associated with HCC. Conclusion: Overall, these results suggest that rs738409 exerts a marked influence on hepatocarcinogenesis in patients with cirrhosis of European descent and provide a strong argument for performing further mechanistic studies to better understand the role of PNPLA3 in HCC development.

Reduction in the use of diagnostic tests in infants with risk factors for early-onset neonatal sepsis does not delay antibiotic treatment.

Despite a low positive predictive value, diagnostic tests such as complete blood count (CBC) and C-reactive protein (CRP) are commonly used to evaluate whether infants with risk factors for early-onset neonatal sepsis (EOS) should be treated with antibiotics. We investigated the impact of implementing a protocol aiming at reducing the number of diagnostic tests in infants with risk factors for EOS in order to compare the diagnostic performance of repeated clinical examination with CBC and CRP measurement. The primary outcome was the time between birth and the first dose of antibiotics in infants treated for suspected EOS. Among the 11,503 infants born at ≥35 weeks during the study period, 222 were treated with antibiotics for suspected EOS. The proportion of infants receiving antibiotics for suspected EOS was 2.1% and 1.7% before and after the change of protocol (p = 0.09). Reduction of diagnostic tests was associated with earlier antibiotic treatment in infants treated for suspected EOS (hazard ratio 1.58; 95% confidence interval [CI] 1.20-2.07; p <0.001), and in infants with neonatal infection (hazard ratio 2.20; 95% CI 1.19-4.06; p = 0.01). There was no difference in the duration of hospital stay nor in the proportion of infants requiring respiratory or cardiovascular support before and after the change of protocol. Reduction of diagnostic tests such as CBC and CRP does not delay initiation of antibiotic treatment in infants with suspected EOS. The importance of clinical examination in infants with risk factors for EOS should be emphasised.

05017-006 Lake Storm Lake Watershed Final Report

This project will include the construction of four separate drainage and retention facilities to handle urban runoff that currently flows directly into Lake Storm Lake. These facilities will filter storm water from approximately 503 acres of urban land including two large industrial users Tyson Fresh Meats and Sara Lee Turkey Processing as well as other commercial and residential sections that currently go directly to the lake without filtration. Specifically the project involves the construction of a two cell dry bottomed detention pond system, construction of two rain gardens/bio retention areas, construction of rain gardens along storm water intakes on Highway 7, and construction of a porous rock detention area. The completed project will provide for cleaner water outleting to the fake in an area that has the largest potential for pollutants to enter the lake. This project is being done in conjunction with other watershed improvements including two additional rain gardens already in place and a multi-year dredging effort of Lake Storm Lake that will be starting its fifth year in 2006. Improvements in the rural water shed are also taking place with the help of a watershed coordinator. Some of these projects include buffer strips and filter slips along the waterways in the watershed.

Assessment of growth and yield performance of rubber tree clones of the IAC 500 series

The objective of this work was to evaluate the performance of 15 clones of the IAC 500 series of Hevea brasiliensis, developed at Instituto Agronômico (IAC), over a 12-year period, in the northwest region of São Paulo State, Brazil. The 15 new clones evaluated are primary clones obtained from selected ortets within half-sib progenies. The clone RRIM 600, of Malaysian origin, was used as the control. Dry rubber yield performance over a four-year period, mean girth at the tenth year, girth increment before and during tapping, thermal properties of the natural rubber produced and other characters of the laticiferous system were evaluated. Forty percent of the clones were superior in comparison to the control for yield. Clone IAC 500 recorded the highest yield (66.81 g per tree per tapping) over four years of tapping, followed by IAC 502 (62.37 g per tree per tapping), whereas the control recorded 48.71 g per tree per tapping. All selected clones were vigorous in growth. The natural rubber from this IAC clones showed thermal stability up to 300ºC. No differences were observed in the thermal behavior of rubber among the IAC series and the RRIM 600 clones. The clones IAC 500, IAC 501, IAC 502, IAC 503 and IAC 506 are the more promising for small-scale plantations, due to growth and yield potential.