Preliminary mineralogy and ore petrology of the intermediate-sulfidation pallancata deposit, Ayacucho, Peru

Se investiga la compleja mineralogía del Yacimiento de Pallancata (6º productor de plata del mundo) y se establecen las condiciones de formación (P.T) basadas en la petrología de las menas comparada con los datos de mineralogía experimental y en la petrografía y microtermometría de inclusiones fluídas en la ganga silicatada, resultando un depósito típicamente caracterizado como epitermal de sulfuración intermedia.ABSTRACT:Pallancata is a world-class intermediate-sulfidation epithermal deposit, hosted by upper Miocene volcanics of the south-central Peruvian Andes in a sinuous N70ºW, ∼75º SW strike-slip structure, with wide (up to 35 m) pull-apart dilation zones related to bends of the vein strike. The structural evolution of the vein from earlier brecciation to later open space infill resembles the Shila Paula district (Chauvet et al. 2006). Fluid inclusion petrography and microthermometry show that ore deposition is related to protracted boiling of very diluted, mainly meteoric fluids, starting at 250–260 ºC, under ∼300 m hydrostatic head. The mineralogical-petrological study reveals a complex sequence of mineralization (eight stages) and mineral reactions consistent with Ag2S enrichment or Sb2S3 depletion, or both, during cooling over the temperature range 250–200 ºC: pyrite, sphalerite, galena, miargyrite, pyrargyrite-proustite, chalcopyrite, polybasite-pearceite, argentite (now acanthite), and Au–Ag alloy (“electrum”). This Ag2S enrichment and Sb2S3depletion during cooling may be explained by decay of a Ag-rich galena precursor at deeper levels (Pb2S2–AgSbS2 solid solution), which rapidly becomes unstable with decreasing temperature, producing residual (stoichiometric) PbS and more mobile Ag and Sb sulfide phases, which migrated upward and laterally away from the thermal core of the system. The core is still undisclosed by mining works, but the available geochemical evidence (logAg/log Pb ratios decreasing at depth) is consistent with this interpretation, implying a deeper potential resource. Data from sulfide geothermometry, based on mineral equilibria, document the thermal evolution of the system below 200 ºC (stephanite, uytenbogaardtite, jalpaite, stromeyerite, mckinstryite, among others). The end of the most productive stages (3, 4, and 5) is marked by the precipitation of stephanite at temperatures below 197 ± 5 ºC, but precipitation of residual silver continues through the waning stages of the hydrothermal system down to <93.3 ºC (stromeyerite) or in a supergene redistribution (stage 8, acanthite II).

Desarrollo de un sistema automático de detección de disgrafías en niños de 4 a 5 años

La escritura es una actividad psicomotora muy importante en el desarrollo infantil. Tanto es así que su correcto aprendizaje condicionará el futuro de una persona, pues estará presente en todo tipo de situaciones cotidianas. La disgrafía es el término utilizado para referirse a los problemas relacionados con la escritura, y se manifiesta cuando la escritura de un determinado sujeto es ilegible o lenta como resultado de un aprendizaje fallido de los procesos motores de la escritura. Estos problemas intentan resolverse durante el desarrollo infantil mediante diferentes pruebas que miden las capacidades visomotoras de los niños basándose en criterios de forma (número y posición correcta de trazos). Sin embargo, a lo largo de los años estos criterios han demostrado no ser totalmente precisos en la detección prematura de posibles casos de disgrafía. Por ello, en este proyecto se ha desarrollado una aplicación que ayuda a ampliar la fiabilidad de los test actuales, utilizando un criterio cinemático. Esta aplicación, desarrollada para una tableta Android, muestra al niño una serie de figuras que él debe copiar en la tableta haciendo uso de un lápiz óptico. Los trazos registrados por la aplicación son analizados para valorar aspectos como la fluidez, continuidad y regularidad, ampliando así la fiabilidad de los test actuales, lo que permite desechar falsos positivos y detectar irregularidades que antes no podían ser detectadas. La aplicación desarrollada ha sido validada con un total de ocho niños de cuatro años y siete meses de media de edad, confirmando que cumple con las expectativas planteadas. ABSTRACT. Writing is a very important psychomotor activity in child development because it will be present in all kinds of everyday situations; therefore its proper learning will determine the future of the individual. Dysgraphia is the term used to refer to the problems related to writing, and it takes place when a particular person’s writing is unreadable or slow-moving as a result of a failed learning of writing motor processes. These problems are usually detected by different tests that measure children’s visual motor abilities based on shape criteria (correct number and position of strikes). However, over the years these criteria haven’t proved to be completely accurate in the early detection of possible cases of dysgraphia. Therefore, in this project is presented an application that extends the reliability of current test, using a kinematic approach. This application, developed for an Android tablet, displays a series of figures that the child must copy to the tablet by using a stylus. Strokes recorded by the application are then analyzed to assess aspects such as fluidity, continuity and regularity, expanding the reliability of the current test, discarding false positives created by the conventional criteria and detecting irregularities that previously could not be detected. The developed application has been validated with a total of eight children about four years and seven months in average age, confirming that the application fulfills the initial expectations.

5-HT2A and 5-HT2C receptors as hypothalamic targets of developmental programming in male rats

Funding The research reported in this publication was supported by the Biotechnology and Biological Sciences Research Council (E007821/1 to M.S.M-G, R.L.C and E00797X/1; BB/K001418 /1 to L.K.H), the British Heart Foundation (FS/09/029/27902 to S.E.O.), the UK Medical Research Council Metabolic Diseases Unit (MC_UU_12012/4 to S.E.O and MC_UU_12012/1 to G.S.H.Y), the Wellcome Trust (WT081713 and WT098012 to L.K.H), the European Union (FP7-HEALTH-266408 Full4Health to G.S.H.Y) and the Helmholtz Alliance ICEMED to G.S.H.Y.

Étude du rôle des régions variables 4 et 5 dans les changements de conformation de la gp120 du VIH-1

Le VIH infecte les cellules par fusion de sa membrane avec la membrane de la cellule cible. Cette fusion est effectuée par les glycoprotéines de l'enveloppe (Env) qui sont synthétisées en tant que précurseur, gp160, qui est ensuite clivé en gp120 et gp41. La protéine gp41 est la partie transmembranaire du complexe de l'enveloppe et l’ancre à la particule virale alors que la gp120 assure la liaison au récepteur cellulaire CD4 et corécepteur CCR5 ou CXCR4. Ces interactions successives induisent des changements de conformation d’Env qui alimentent le processus d'entrée du virus conduisant finalement à l'insertion du peptide de fusion de la gp41 dans la membrane de la cellule cible. La sous-unité extérieure gp120 contient cinq régions variables (V1 à V5), dont trois (V1, V2 et V3) étant capables d’empêcher l’adoption spontanée de la conformation liée à CD4. Cependant, le rôle de régions variables V4 et V5 vis-à-vis de ces changements de conformation reste inconnu. Pour étudier leur effet, des mutants de l'isolat primaire de clade B YU2, comprenant une délétion de la V5 ou une mutation au niveau de tous les sites potentiels de N-glycosylation de la V4 (PNGS), ont été générés. L'effet des mutations sur la conformation des glycoprotéines d'enveloppe a été analysé par immunoprécipitation et résonance de plasmon de surface avec des anticorps dont la liaison dépend de la conformation adopté par la gp120. Ni le retrait des PNGS de la V4 ni la délétion de V5 n’a affecté les changements conformationnels d’Env tels que mesurés par ces techniques, ce qui suggère que les régions variables V1, V2 et V3 sont les principaux acteurs dans la prévention de l’adoption de la conformation lié de CD4 d’Env.

Changes in the vegetation and trade winds in equatorial Northwest Africa 140,000-70,000 yr B.P., as deduced from two marine pollen records

The deep-sea cores M 16415-2 and M 16416-2 at about 9°N off Sierra Leone were analysed palynologically for the time interval 140,000-70,000 yr B.P. Results were presented in absolute (pollen concentration and pollen influx) and relative diagrams (pollen percentage). In a previous study it was evidenced that in northwest Africa pollen is mainly transported to the Atlantic by wind, so that the efficiency of aeolian pollen transport (pollen flux) could be used to evaluate changes in the intensity of the northeast trade winds. The glacial episodes (represented by the oxygen isotope stages 6 and 4) are characterized by strong northeast trade winds, whereas the last interglacial (stage 5) is characterized by weak trade winds. The pollen influx diagram shows that the intensity of the trade winds increased slightly during the relatively cool intervals of stage 5 (viz. 5.4 and 5.2). Tropical forest had maximally expanded around 124,000 yr B.P. (stage 5.5), around 98,000 yr B.P. (transition of stage 5.3 to 5.2), and around 70,000 yr B.P. (first part of stage 4): an increasing delay of the response of tropical forest to global intervals with maximum temperature is apparent during the last interglacial. As tropical forests need continuous humidity, the record of tropical forest monitors changes in climatic humidity south of the Sahara. During the last interglacial, the southern boundary of the Sahara shifted only little: expansions and contractions of the tropical forest area are correlated with contra-oscillations of the grass-dominated savanna zone. Great latitudinal shifts of the desert savanna boundary, on the contrary, occurred during the penultimate glacial interglacial transition (around 128,000 yr B.P.) to the north, and during the last interglacial-glacial transition (around 65,000 yr B.P.) to the south.

Alkenones and sea surface reconstruction of sediments from, the Arabian Sea

Deep-sea sediments of two cores from the western (TY93-929/P) and the southeastern (MD900963) Arabian Sea were used to study the variations of the Indian monsoon during previous climatic cycles. Core TY93-929/P was located between the SW monsoon driven upwelling centres off Somalia and Oman, which are characterized by large seasonal sea surface temperature (SST) and particle flux changes. By contrast, core MD900963, was situated near the Maldives platform, an equatorial ocean site with a rather small SST seasonality (less than 2°C). For both cores we have reconstructed SST variations by means of the unsaturation ratio of C37 alkenones, which is compared with the delta18O records established on planktonic foraminifera. In general, the SST records follow the delta18O variations, with an SST maximum during oxygen isotope stage 5.5 (the Last Interglacial at about 120-130 kyr) and a broad SST minimum during isotope stage 4 and 3.3 (approximately 40-50 kyr). The SST difference between the Holocene and the Last Glacial Maximum (LGM) is of the order of 2°C. In both cores the SSTs during isotope stage 6 are distinctly higher by 1-2°C than the cold SST minima during the last glacial cycle (LGM and stage 3). To reconstruct qualitatively the past productivity variations for the two cores, we used the concentrations and fluxes of alkenones and organic carbon, together with a productivity index based on coccolith species (Florisphaera profunda relative abundance). Within each core, there is a general agreement between the different palaeoproductivity proxies. In the southeastern Arabian Sea (core MD900963), glacial stages correspond to relatively high productivity, whereas warm interstadials coincide with low productivity. All time series of productivity proxies are dominated by a cyclicity of about 21-23 kyr, which corresponds to the insolation precessional cycle. A hypothesis could be that the NE monsoon winds were stronger during the glacial stages, which induced deepening of the surface mixed layer and injection of nutrients to the euphotic zone. By contrast, the records are more complicated in the upwelling region of the western Arabian Sea (core TY93-929/P). This is partly due to large changes in the sedimentation rates, which were higher during specific periods (isotope stages 6, 5.4, 5.2, 3 and 2). Unlike core MD900963, no simple relationship emerges from the comparison between the delta18O stratigraphy and productivity records. The greater complexity observed for core TY93-929/P could be the result of the superimposition of different patterns of productivity fluctuations for the two monsoon seasons, the SW monsoon being enhanced during interglacial periods, whereas the NE monsoon was increased during glacial intervals. A similar line of reasoning also could help explain the SST records by the superimposition of variations of three components: global atmospheric temperature, and SW and NE monsoon dynamics.

Multidisciplinary accident investigation summaries. Volume 4. No. 5.

Mode of access: Internet.

Katalog einer Autographen-Sammlung bestehend aus wertvollen Musik-Manuskripten und Musiker-Briefen aus den Nachlässen von Julius Stockhausen und Wilhelm Taubert und des Musikverlegers Maurice Schlesinger aus Paris (1798-1871) sowie aus Autographen von Dichtern, Schriftstellern, Schauspielern, Bildenden Künstlern, Fürsten, Staatsmännern, Kriegsleuten und Reformatoren. Versteigerung am 4. und 5. November 1907 durch den vereideten und öffentlich angestellten Versteigerer Werner Haehnel.

Cover title.

Le Quercy en 1889 : compte rendu des travaux de l'Assemblée provinciale représentative du Quercy tenue à Cahors les 3, 4 et 5 juin 1889.

Mode of access: Internet.

Memoria histórica de la inundacion de la Ribera de Valencia en los dias 4 y 5 de Noviembre de 1864 /

Mode of access: Internet.

The Spoiled child, a farce. With prefatory remarks ... Faithfully marked with the stage business, and stage directions, as it is performed at the Theatres Royal.

Ascribed variously to Mrs. Jordan, Richard Ford and Isaac Bickerstaffe. Cf. Dict. nat. biog; Baker; Oxberry's new English drama, v. 15 [no. 4] p. ii.

Les crustacés, les arachnides et les insectes, distribués en familles naturelles, ouvrage formant les tomes 4 et 5 de m. le baron Cuvier su le Règne animal (deuxième édition),

Mode of access: Internet.

De la déchéance de la puissance paternelle comparée avec la destitution du droit de garde : lois du 24 juillet 1889, titre 1er, et du 19 avril 1898, articles 4 et 5 /

Th. : Droit : Toulouse : 1903.

Organizational, DS, GS, and depot maintenance manual : crane-shovel, basic unit, truck mounted, 20 ton, 3/4 cu. yd., gasoline engine, 6x6 (American Hoist and Derrick models) model 2360 (non-winterized) FSB 3810-989-0505, model W2360 (winterized) FSN 3810-989-0506.

"December 1974."