Epstein-Barr virus-related post-transplant lymphoproliferative disorder in solid organ transplant recipients.

Epstein-Barr virus (EBV) contributes to the pathogenesis of post-transplant lymphoproliferative disease (PTLD) in more than 70% of cases. EBV DNAemia surveillance has been reported to assist in the prevention and treatment of PTLD in hematopoietic stem-cell transplantation (HSCT) recipients. Derived from experience in HSCT and taking into account that PCR-based EBV monitoring techniques are currently available in most solid organ transplant (SOT) centres, there is a great interest in EBV surveillance and prevention of PTLD in SOT recipients. In the present document we have tried to address from a practical perspective different important topics regarding the prevention and management of EBV-related PTLD in SOT. To this end, available information on SOT was analysed and combined with potentially useful data from HSCT and expert observations. The document is therefore structured according to different specific questions, each of them culminating in a consensus opinion of the panel of European experts, grading the answers according to internationally recognized levels of evidence. The addressed issues were grouped under the following topics. (i) Timing and epidemiological data of PTLD. Prophylaxis guided by clinical risk factors of early and late PTLD in SOT. (ii) Relationship of EBV DNAemia load monitoring and the development of PTLD in solid organ transplant recipients. (iii) Monitoring of EBV DNAemia after SOT. Which population should be monitored? What is the optimal timing of the monitoring? (iv) Management of SOT recipients with persistent and/or increasing EBV DNAemia.

Wayne-Ringgold-Decatur County Solid Waste Management Commission, June 30, 2001 & June 30, 2002

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Pocahontas County Solid Waste Commission, June 30, 2001 & June 30, 2002

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Jones County Solid Waste Management Commission, June 30, 2001 & June 30, 2002

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Hardin County Sanitary Solid Waste Disposal Commission, June 30, 2002

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Delaware County Solid Waste Disposal Commission, June 30, 2001 & June 30, 2002

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Crawford County Area Solid Waste Agency Commission, June 30, 2001 & June 30, 2002

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Butler County Solid Waste Commission, June 30, 2001 & June 30, 2002

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Jones County Solid Waste Management Commission, June 30, 2002 & June 30, 2003

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Hardin County Sanitary Solid Waste Disposal Commission, June 30, 2003

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Shelby County Area Solid Waste Agency, June 30, 2002 & June 30, 2003

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Butler County Solid Waste Commission, June 30, 2002 & June 30, 2003

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Updated international consensus guidelines on the management of cytomegalovirus in solid-organ transplantation.

Cytomegalovirus (CMV) continues to be one of the most common infections after solid-organ transplantation, resulting in significant morbidity, graft loss, and adverse outcomes. Management of CMV varies considerably among transplant centers but has been become more standardized by publication of consensus guidelines by the Infectious Diseases Section of The Transplantation Society. An international panel of experts was reconvened in October 2012 to revise and expand evidence and expert opinion-based consensus guidelines on CMV management, including diagnostics, immunology, prevention, treatment, drug resistance, and pediatric issues. The following report summarizes the recommendations.

Pocahontas County Solid Waste Commission, June 30, 2003

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