Granular cell tumor presenting as a tongue nodule: Two case reports

Introduction. Granular cell tumor is an uncommon neoplasm that can occur in any part of the body, including the orofacial region. The tumor is usually benign, but there are reports of cases in which the tumor shows a locally aggressive behavior, malignancy, and distant metastases. The most widely accepted hypothesis is that granular cell tumor arises from the altered metabolism of Schwann cells. The tumor is typically asymptomatic and appears as a nodule that does not exceed 3 cm. Case presentation. In case 1, a 26-year-old Caucasian man was seen at the Oral Medicine out-patient clinic of the São José dos Campos Dental School, Universidade Estadual Paulista, with a 'small blister on the tongue', which he had noted approximately three years ago. The nodule was located on the dorsum of the tongue, measured about 1.5 cm in diameter, and was not tender to palpation. Treatment consisted of an excisional biopsy performed on the basis of the diagnostic hypothesis of granular cell tumor, which was confirmed by microscopic analysis. In case 2, a 31-year-old Caucasian woman attended the out-patient clinic of the São José dos Campos Dental School, Universidade Estadual Paulista, with a five-year history of a 'painful lump on the tongue'. Intra-oral examination revealed the presence of a nodular lesion measuring approximately 0.8 cm in diameter, which was located deep in the submucosa of the right lateral margin of the tongue. Treatment consisted of an excisional biopsy performed on the basis of the differential diagnosis of neurofibroma and granular cell tumor. Microscopic analysis defined the final diagnosis of granular cell tumor. Conclusions: Granular cell tumor is an uncommon tumor that must be carefully diagnosed and treated correctly. © 2012 Sena Costa et al; licensee BioMed Central Ltd.

Visceral mast cell tumor and mastocythemia in a dog

Mast cell tumor manifests as a localized proliferation of mast cells in the skin, or less frequently as a systemic disorder, which may be accompanied by the presence of neoplastic mast cells in the peripheral blood (mastocythemia). In some cases, the neoplastic circulating mast cells originate in the bone marrow, designated as mast cell leukemia, rarely observed in dogs, or the cells may arise from visceral mast cell tumors, characterizing systemic mastocytosis. The aim of this report was to describe a case of a six-year-old female German shepherd dog presenting with history of anorexia, hematemesis and diarrhea. The blood work revealed intense mastocythemia (43%), with degranulated mast cells, and anisocytosis. At necropsy, white nodular lesions in the thymic region and an infiltrative mass in mesenteric and abdominal lymph nodes were observed. Those lymph nodes were enlarged and off-white. Histopathological examination revealed neoplastic mast cells in the liver, spleen, lymph nodes, kidneys, lungs, gastric and enteric mucosae, and adrenal glands. The clinical, hematological and histopathological findings were compatible with mastocythemia, associated with a moderately differentiated visceral mast cell tumor.

Computer techniques towards the automatic characterization of graphite particles in metallographic images of industrial materials

The automatic characterization of particles in metallographic images has been paramount, mainly because of the importance of quantifying such microstructures in order to assess the mechanical properties of materials common used in industry. This automated characterization may avoid problems related with fatigue and possible measurement errors. In this paper, computer techniques are used and assessed towards the accomplishment of this crucial industrial goal in an efficient and robust manner. Hence, the use of the most actively pursued machine learning classification techniques. In particularity, Support Vector Machine, Bayesian and Optimum-Path Forest based classifiers, and also the Otsu's method, which is commonly used in computer imaging to binarize automatically simply images and used here to demonstrated the need for more complex methods, are evaluated in the characterization of graphite particles in metallographic images. The statistical based analysis performed confirmed that these computer techniques are efficient solutions to accomplish the aimed characterization. Additionally, the Optimum-Path Forest based classifier demonstrated an overall superior performance, both in terms of accuracy and speed. © 2012 Elsevier Ltd. All rights reserved.

Tratamento cirúrgico intrabucal das fraturas de ângulo mandibular com uma miniplaca de titânio: estudo clínico e radiográfico

Pós-graduação em Odontologia - FOA

Determinação das lesões orais e das estruturas anatônicas ósseas odontológias mandibulares e maxilares utilizando a tomografia computadorizada em gato-do-mato-pequeno (Leopardus tigrinus) e gato-mourisco (Puma yagouaroundi)

Pós-graduação em Medicina Veterinária - FMVZ

Análise biomecânica do movimento mastigatório antes e após o ajuste da oclusão dentária em equino

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Estudo radiográfico retrospectivo de lesões ósseas mandibulares em cães

Pós-graduação em Cirurgia Veterinária - FCAV

Avaliação dos padrões histopatológicos da pele e imunomarcação de células CD3+ e CD79a+ em cães infectados naturalmente por Leishmania spp

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Lesão de células gigantes periférica da cavidade bucal: avaliação da agressividade das lesões por meio dos estudos clínico-radiográfico retrospectivo, histopatológico, histoquímico e imunohistoquímico

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Estudo radiográfico digital e densitométrico em mandíbulas de suínos, submetidas a osteotomia com brocas de alta e baixa rotação, com refrigeração líquida

Pós-graduação em Odontologia - FOA

Osteotomia com brocas de alta e baixa rotação, com e sem refrigeração líquida: estudo histopatológico duplo cego em suínos

Pós-graduação em Odontologia - FOA

Estudo clínico, imaginológico, histopatológico e imunohistoquímico de ameloblastomas submetidos à descompressão

Pós-graduação em Odontologia - FOA

Análise do perfil de susceptibilidade antimicrobiana de microrganismos isolados de processos infecciosos bucais

Pós-graduação em Odontologia - FOA

Estudo de imagem por tomografia espiral em suínos submetidos a enxerto ósseo mandibular autógeno e homógeno

Pós-graduação em Odontologia - FOA

Estudo da precisão da análise de tomografias espirais de mandíbulas humanas secas realizadas pelo tomógrafo X-Mind Tome

Pós-graduação em Odontologia - FOA