Acreage Living, October-November, 2004

Acreage Living newsletter for those persons living on or interested in acreage living.

Acreage Living, December 2004-January 2005

Newsletter for those who reside on acreages

Association with coregulators is the major determinant governing peroxisome proliferator-activated receptor mobility in living cells.

The nucleus is an extremely dynamic compartment, and protein mobility represents a key factor in transcriptional regulation. We showed in a previous study that the diffusion of peroxisome proliferator-activated receptors (PPARs), a family of nuclear receptors regulating major cellular and metabolic functions, is modulated by ligand binding. In this study, we combine fluorescence correlation spectroscopy, dual color fluorescence cross-correlation microscopy, and fluorescence resonance energy transfer to dissect the molecular mechanisms controlling PPAR mobility and transcriptional activity in living cells. First, we bring new evidence that in vivo a high percentage of PPARs and retinoid X receptors is associated even in the absence of ligand. Second, we demonstrate that coregulator recruitment (and not DNA binding) plays a crucial role in receptor mobility, suggesting that transcriptional complexes are formed prior to promoter binding. In addition, association with coactivators in the absence of a ligand in living cells, both through the N-terminal AB domain and the AF-2 function of the ligand binding domain, provides a molecular basis to explain PPAR constitutive activity.

Acreage Living, December 1999, Vol 5, no.9

Acreage Living newsletter for those persons living on or interested in acreage living.

Acreage Living, March 2000, Vol 6, no.3

Acreage Living newsletter for those persons living on or interested in acreage living.

Acreage Living, May 2000, Vol.6, no.5

Monthly newsletter for people in Iowa that live on Acreages, produced by Iowa State University Copperative Extension.

Acreage Living, January 2000, Vol.6, no.1

Monthly newsletter for people in Iowa that live on Acreages, produced by Iowa State University Copperative Extension.

Acreage Living, February 2000, Vol.6, no.2

Monthly newsletter for people in Iowa that live on Acreages, produced by Iowa State University Copperative Extension.

Acreage Living, April 2000, Vol.6, no.4

Monthly newsletter for people in Iowa that live on Acreages, produced by Iowa State University Copperative Extension.

Acreage Living, June 2000, Vol.6, no.6

Monthly newsletter for people in Iowa that live on Acreages, produced by Iowa State University Copperative Extension.

Acreage Living, April 2002, Vol.8, no.4

Monthly newsletter for people in Iowa that live on Acreages, produced by Iowa State University Copperative Extension.

Acreage Living, July 2000, Vol.6, no.5

Monthly newsletter for people in Iowa that live on Acreages, produced by Iowa State University Copperative Extension.

Acreage Living, August 2000, Vol.6, no.8

Monthly newsletter for people in Iowa that live on Acreages, produced by Iowa State University Copperative Extension.

Acreage Living, September 2000, Vol.6, no.9

Monthly newsletter for people in Iowa that live on Acreages, produced by Iowa State University Copperative Extension.