PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores.

The PAT family of lipid droplet proteins includes 5 members in mammals: perilipin, adipose differentiation-related protein (ADRP), tail-interacting protein of 47 kDa (TIP47), S3-12, and OXPAT. Members of this family are also present in evolutionarily distant organisms, including insects, slime molds and fungi. All PAT proteins share sequence similarity and the ability to bind intracellular lipid droplets, either constitutively or in response to metabolic stimuli, such as increased lipid flux into or out of lipid droplets. Positioned at the lipid droplet surface, PAT proteins manage access of other proteins (lipases) to the lipid esters within the lipid droplet core and can interact with cellular machinery important for lipid droplet biogenesis. Genetic variations in the gene for the best-characterized of the mammalian PAT proteins, perilipin, have been associated with metabolic phenotypes, including type 2 diabetes mellitus and obesity. In this review, we discuss how the PAT proteins regulate cellular lipid metabolism both in mammals and in model organisms.

Judaeus christicida gravissime peccans et vapulans : sive perspicua & solida demonstratio, caedem & rejectionem Jesu Nazareni veram esse causam praesentis diuturni Judaeorum exilii, omnisque illorum miseriae originem ; cum app. dissertationis philologicae ejusdem argumenti

von Joh. Jac. Schudt

Judaeus christicida gravissime peccans et vapulans : sive perspicua et solida demonstratio, caedem & rejectionem Jesu Nazareni veram esse causam praesentis tam diuturni Judaeorim exilii, onmisque illiorum miseriae originem ; cum app. dissertationis philologicae ejusdem argumenti ; cui accedunt addiamenti loco, 2 orationes ...

von Joh. Jac. Schudt

Compendium historiae Judaicae, de origine, incrementis & rebus gestis Judaeorum, ad ductum Justini Histor. libr. XXXVI potissimum ex gentilium scriptoribus collectum ... : acc. app.

Joh. Jacobi Schudt

I cognomi degli Ebrei d'Italia : con un' app. su le famiglie nobile Ebree d'Italia

[von] Samuele Schaerf

An account of the recent persecution of the Jews at Damascus : with reflections thereon ; an app., cont. various documents connected with the subject

by David Salomons

Protestantisches Ethos als „Killer-App"? Die umstrittenen moralischen Ressourcen des Protestantismus und die Nachhaltigkeitsfrage

Der Artikel thematisiert und problematisiert die Beiträge protestantischer Theologie zu einer Ethik der Nachhaltigkeit.

Hepatic and intramyocellular glycogen stores in adults with type 1 diabetes and healthy controls.

Glycogen levels in liver and skeletal muscle assessed non-invasively using magnetic resonance spectroscopy after a 48-h pre-study period including a standardized diet and withdrawal from exercise did not differ between individuals with well-controlled Type 1 DM and matched healthy controls.

Network Store: Exploring Slicing in Future 5G Networks

In this paper, we present a revolutionary vision of 5G networks, in which SDN programs wireless network functions, and where Mobile Network Operators (MNO), Enterprises, and Over-The-Top (OTT) third parties are provided with NFV-ready Network Store. The proposed Network Store serves as a digital distribution platform of programmable Virtualized Network Functions (VNFs) that enable 5G application use-cases. Currently existing application stores, such as Apple's App Store for iOS applications, Google's Play Store for Android, or Ubuntu's Software Center, deliver applications to user specific software platforms. Our vision is to provide a digital marketplace, gathering 5G enabling Network Applications and Network Functions, written to run on top of commodity cloud infrastructures, connected to remote radio heads (RRH). The 5G Network Store will be the same to the cloud as the application store is currently to a software platform.

English Dialect App

Do you pronounce the /r/ in 'arm'? Do you call a shelf a 'sheuf'? And what on earth is a 'hoddy-doddy'? There is extensive variation in English dialects: this is why your answers to such questions will allow this app to localize your broader dialect region on a map of England. Did your home dialect change over time? Our algorithm is based on historical data from the Survey of English Dialects. If it guesses where you are from correctly, your home dialect has probably remained stable over the past decades. If the guess is far off, however, it is probably because of dialect change. - Can we localize your dialect based on your pronunciation of 26 words? - Record your dialect and listen to recordings of other users and to historical dialect recordings! - Choose a pronunciation variant, e.g. 'sheuf', and discover where in England it is used...or choose a place and explore its dialect!