Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR

Sterol regulatory element-binding protein-1c (SREBP-1c) enhances transcription of genes encoding enzymes of unsaturated fatty acid biosynthesis in liver. SREBP-1c mRNA is known to increase when cells are treated with agonists of liver X receptor (LXR), a nuclear hormone receptor, and to decrease when cells are treated with unsaturated fatty acids, the end products of SREBP-1c action. Here we show that unsaturated fatty acids lower SREBP-1c mRNA levels in part by antagonizing the actions of LXR. In cultured rat hepatoma cells, arachidonic acid and other fatty acids competitively inhibited activation of the endogenous SREBP-1c gene by an LXR ligand. Arachidonate also blocked the activation of a synthetic LXR-dependent promoter in transfected human embryonic kidney-293 cells. In vitro, arachidonate and other unsaturated fatty acids competitively blocked activation of LXR, as reflected by a fluorescence polarization assay that measures ligand-dependent binding of LXR to a peptide derived from a coactivator. These data offer a potential mechanism that partially explains the long-known ability of dietary unsaturated fatty acids to decrease the synthesis and secretion of fatty acids and triglycerides in livers of humans and other animals.

Anandamide and diet: Inclusion of dietary arachidonate and docosahexaenoate leads to increased brain levels of the corresponding N-acylethanolamines in piglets

Endogenous ligands of cannabinoid receptors have been discovered recently and include some N-acylethanolamines (NAEs; e.g., N-arachidonoylethanolamine) and some 2-acylglycerols (e.g., sn-2-arachidonoylglycerol). Previously, we found these compounds to be active biologically when administered per os in large quantities to mice. In the present work, piglets were fed diets with and without 20:4n−6 and 22:6n−3 fatty acid precursors of NAEs, in levels similar to those found in porcine milk, during the first 18 days of life, and corresponding brain NAEs were assessed. In piglets fed diets containing 20:4n−6 and 22:6n−3, there were increases in several biologically active NAEs in brain homogenates—20:4n−6 NAE (4-fold), 20:5n−3 NAE (5-fold), and 22:5n−3 and 22:6n−3 NAE (9- to 10-fold). These results support a mechanism we propose for dietary long-chain polyunsaturated fatty acids influences on brain biochemistry with presumed functional sequelae. This paradigm will enable targeted investigations to determine whether and why specific populations such as infants, elderly, or persons suffering from certain clinical conditions may benefit from dietary long-chain polyunsaturated fatty acids.

Donrichardsia, a new genus of Amblystegiaceae (musci) / Howard Crum, Lewis E. Anderson.

n.s. no.1(1979)

Riflessioni critiche sulla lezione di Maria Leonor Xavier, “A questão do argumento anselmiano”

Estas reflexões críticas prezam o trabalho histórico-filosófico desenvolvido na lição da Xavier, sobre a questão do argumento de Anselmo. Todavia, algumas objecções podem ser levantadas a respeito do primeiro e do terceiro artigos. Quanto ao primeiro artigo, é contestável a interpretação da Xavier, no que concerne à relação entre existência real e existência pensada. Por outro lado, a sua perspectiva sobre a relação entre essência e existência em Anselmo pode ser aproximada do pensamento de Alvin Plantinga sobre os universais e as entidades abstractas. O segundo artigo não é criticado. Em contrapartida, o terceiro artigo é o mais contestado. A construção de um argumento a favor da existência de um mal insuperável não é autorizada pelo argumento de Anselmo. O mal não pode ser um maior insuperável; pode ser apenas um menor inultrapassável.

Putting Up a Big Front: Car Design and Size Affect Road-Crossing Behaviour

Previous research suggests that people tend to see faces in car fronts and that they attribute personality characteristics to car faces. In the present study we investigated whether car design influences pedestrian road-crossing behaviour. An immersive virtual reality environment with a zebra crossing scenario was used to determine a) whether the minimum accepted distance for crossing the street is larger for cars with a dominant appearance than for cars with a friendly appearance and b) whether the speed of dominant-looking cars is overestimated as compared to friendly-looking cars. Participants completed both tasks while either standing on the pavement or on the centre island. We found that people started to cross the road later in front of friendly-looking low-power cars compared to dominant-looking high-power cars, but only if the cars were relatively large in size. For small cars we found no effect of power. The speed of smaller cars was estimated to be higher compared to large cars (size-speed bias). Furthermore, there was an effect of starting position: From the centre island, participants entered the road significantly later (i. e. closer to the approaching car) and left the road later than when starting from the pavement. Similarly, the speed of the cars was estimated significantly lower when standing on the centre island compared to the pavement. To our knowledge, this is the first study to show that car fronts elicit responses on a behavioural level.

Observation of manganese nodules and crusts in the Blake Plateau area

In late June and July, 1967, the Deep Submergence Research Vehicle (DSRV) ALVIN, aboard its mother ship, LULU, proceeded from the spring base of operations, Nassau, to its home port of Woods Hole. During this trip, from July 2 to July 14, a series of five dives were made by ALVIN on the Blake Plateau off Georgia and South Carolina, and on the continental slope north of Cape Hatteras. One of the objectives of the dive was to investigate the manganese and phosphate deposits of the Blake Plateau.

Tom Harmon, UM Football, carrying ball vs Ohio State 1940

[blocking for Harmon L-R: Albert Wistert (11), Ed Frutig (87), Ralph Fritz (63), Bob Westfall (86), Robert Ingalls (66) OSU player is Thomas Kinkade (16)

1979 Men's Gymnastics Team

Back Row: asst. coach Bob Darden, Darrell Yee, Bruce Schuchard, John Rieckhoff, Jim Varilek, Doug Zahoun, coach Newt Loken

Front Row: co-captain Bob Creek, Chris Van Mierlo, Dorian Deaver, Gordon Higman, Alvin Berger, Ron Tickman, co-captain Nigel Rothwell

An evaluation of cotton dust control systems in the picking and garnetting areas of the Atlanta Federal Penitentiary /

Mode of access: Internet.

The U. S. Marines on Iwo Jima,

Mode of access: Internet.

Deutsche Ausgabe von Dr. Chase's drittem, letzten und vollständigem Recept-Buch und Haus-Arzt, oder, Praktische Lehren für das Volk : das Resultat langjähriger Beobachtungen des Verfassers, enthaltend die werthvollsten und neuesten Recepte in allen Zweigen der Medizin, und Gemeinnutziges für den Haushalt, einschliesslich einer Abhandlung über Frauen- und Kinder-Krankheiten ... /

Includes sections on dairying, beekeeping, gardening, and household hints; recipes in rhyme; some recipes include wine or liquor as an ingredient.

Everything about dogs /

Includes advertising matter.