South-west elevation, Prasser House, Buderim

As seem from the street.

North-west elevation, Carpenter Hall house, Wilston, Brisbane

House in foreground, with view to city beyond.

North-West elevation, Smeeton Residence, Buderim

Street (North-West) elevation.

South-west elevation, Addison House, Brisbane

View of south-west elevation through house to rear deck.

North-west elevation, Sunshine Coast University Library, Maroochydore

North-west elevation as seen from library forecourt.

North-west elevation and entrance court, Sunshine Coast University Library, Maroochydore

View of entrance court under construction, with north-west elevation behind.

Colonnade to south-west elevation, Sunshine Coast University Library, Maroochydore

View from south-east as seen from exterior.

North-west elevation, Sunshine Coast University Library, Maroochydore

Library and Building K as seen from outer ring road.

Vertical sunshades to south-west elevation, Sunshine Coast University Library, Maroochydore

View of vertical sunshade to south-west elevation with glazing behind.

North-west elevation, Sunshine Coast University Library, Maroochydore

North-west elevation as seen from Building K.

Vaccine-induced Th1-type responses are dominant over Th2-type responses in the short term whereas pre-existing Th2 responses are dominant in the longer term

The effect of adjuvant on induction of human papillomavirus type 16 E7 protein-specific cytotoxic T lymphocytes (CTL) and immunoglobulin G (IgG)(2a) antibody was studied in C57BL/6 J mice immunized with various adjuvants and E7 protein. Quil-A adjuvant, but not complete Freund's adjuvant (CFA) or Algammulin, induced a T-helper 1 (Th1)-type response to E7, which was characterized by CTL activity against a tumour cell line transfected with E7 protein and by E7-specific IgG(2a). All tested adjuvants elicited comparable levels of E7-specific IgG(1). The longest duration and greatest magnitude of CTL response was seen following two immunizations with the highest dose of E7 and Quil-A. Simultaneous immunization with a Th1 and a T helper 2 (Th2)-promoting adjuvant gave a Th1-type response. However, E7 and Quil-A were unable to induce a Th1-type response (as measured by the inability to generate anti-E7 IgG(2a) antibody) in animals with a pre-existing Th2-type response to E7. These results suggest that saponin adjuvants may be suitable for immunotherapy in humans where a Th1-type response is sought, provided that there is no pre existing Th2-type response to the antigen.