Pääministeri Mauno Koivisto 7/1 1970

Kirje 7.1.1970

Valtiopäivät 1970 (avajaispuhe)

Puhe

Doktor Johannes Virolainen 8.7.1970

Kirje

Rouva Armi Ratia 28/10 1970

Kirje 28.10.1970

Maanviljelijä Kalle Keränen 15/6 1970

Kirje 15.6.1970

Assistentti Seppo Laakso 1/6 1970

Kirje 1.6.1970

Tumor necrosis factor-α activates estrogen signaling pathways in endometrial epithelial cells via estrogen receptor α.

The pro-inflammatory cytokine TNF-α and the female hormone estrogen have been implicated in the pathophysiology of two common gynecological diseases, endometriosis and endometrial adenocarcinoma. Here we describe a novel capacity of TNF-α to activate ER signaling in endometrial epithelial cells. TNF-α induced luciferase expression in the absence and presence of estradiol and also augmented expression of the estrogen-regulated genes c-fos, GREB1, and progesterone receptor. Furthermore, TNF-α mediated ER transcriptional activity is dependent on the Extracellular Regulated Kinase (ERK) 1/2 pathway. Co-treatment with a pure ER antagonist resulted in an inhibition of this TNF-α-induced ERE luciferase activity and gene expression, demonstrating that this cytokine signals through ERs. Additional investigations confirmed that TNF-α acts specifically via ERα. Taken together, these data provide a rationale for the potential use of inhibitors of TNF-α and estrogen production/activity in combination for the treatment of endometrial pathologies.

Ylipuutarhuri Pekka Huuskonen 19/11 1970

Kirje 19.11.1970

Valtioneuvos K.-A.Fagerholm 8/6 1970

Kirje 8.6.1970

Statsminister Mauno Koivisto 7. 1. 1970

Kirje