Semiparametric Normal Transformation Models for Spatially Correlated Survival Data

There is an emerging interest in modeling spatially correlated survival data in biomedical and epidemiological studies. In this paper, we propose a new class of semiparametric normal transformation models for right censored spatially correlated survival data. This class of models assumes that survival outcomes marginally follow a Cox proportional hazard model with unspecified baseline hazard, and their joint distribution is obtained by transforming survival outcomes to normal random variables, whose joint distribution is assumed to be multivariate normal with a spatial correlation structure. A key feature of the class of semiparametric normal transformation models is that it provides a rich class of spatial survival models where regression coefficients have population average interpretation and the spatial dependence of survival times is conveniently modeled using the transformed variables by flexible normal random fields. We study the relationship of the spatial correlation structure of the transformed normal variables and the dependence measures of the original survival times. Direct nonparametric maximum likelihood estimation in such models is practically prohibited due to the high dimensional intractable integration of the likelihood function and the infinite dimensional nuisance baseline hazard parameter. We hence develop a class of spatial semiparametric estimating equations, which conveniently estimate the population-level regression coefficients and the dependence parameters simultaneously. We study the asymptotic properties of the proposed estimators, and show that they are consistent and asymptotically normal. The proposed method is illustrated with an analysis of data from the East Boston Ashma Study and its performance is evaluated using simulations.

Method of Detecting System Function by Measuring Frequency Response

Real-time battery impedance spectrum is acquired using a one-time record. Fast Summation Transformation (FST) is a parallel method of acquiring a real-time battery impedance spectrum using a one-time record that enables battery diagnostics. An excitation current to a battery is a sum of equal amplitude sine waves of frequencies that are octave harmonics spread over a range of interest. A sample frequency is also octave and harmonically related to all frequencies in the sum. The time profile of this signal has a duration that is a few periods of the lowest frequency. The voltage response of the battery, average deleted, is the impedance of the battery in the time domain. Since the excitation frequencies are known and octave and harmonically related, a simple algorithm, FST, processes the time record by rectifying relative to the sine and cosine of each frequency. Another algorithm yields real and imaginary components for each frequency.

Regeneration and Transformation of Millets

Millets are versatile in tolerating to diverse climatic and soil conditions such as poor soil fertility and moisture deficit. Establishing optimum regeneration method for each millet type and ecotype is a pre-requisite prior to embarking on plant transformation as successes in plant transformation is largely dependent on the efficiency of regeneration. Various studies made to identify optimum regeneration and transformation methods as well as prospects of applying advanced techniques to these vital but under-studied crops of developing world are discussed.

Novel method to improve the signal-to-noise ratio in the far-field results obtained from planar near-field measurements

A method to reduce the noise power in far-field pattern without modifying the desired signal is proposed. Therefore, an important signal-to-noise ratio improvement may be achieved. The method is used when the antenna measurement is performed in planar near-field, where the recorded data are assumed to be corrupted with white Gaussian and space-stationary noise, because of the receiver additive noise. Back-propagating the measured field from the scan plane to the antenna under test (AUT) plane, the noise remains white Gaussian and space-stationary, whereas the desired field is theoretically concentrated in the aperture antenna. Thanks to this fact, a spatial filtering may be applied, cancelling the field which is located out of the AUT dimensions and which is only composed by noise. Next, a planar field to far-field transformation is carried out, achieving a great improvement compared to the pattern obtained directly from the measurement. To verify the effectiveness of the method, two examples will be presented using both simulated and measured near-field data.

Advances in the Simultaneous Multiple Surface optical design method for imaging and non-imaging applications

Classical imaging optics has been developed over centuries in many areas, such as its paraxial imaging theory and practical design methods like multi-parametric optimization techniques. Although these imaging optical design methods can provide elegant solutions to many traditional optical problems, there are more and more new design problems, like solar concentrator, illumination system, ultra-compact camera, etc., that require maximum energy transfer efficiency, or ultra-compact optical structure. These problems do not have simple solutions from classical imaging design methods, because not only paraxial rays, but also non-paraxial rays should be well considered in the design process. Non-imaging optics is a newly developed optical discipline, which does not aim to form images, but to maximize energy transfer efficiency. One important concept developed from non-imaging optics is the “edge-ray principle”, which states that the energy flow contained in a bundle of rays will be transferred to the target, if all its edge rays are transferred to the target. Based on that concept, many CPC solar concentrators have been developed with efficiency close to the thermodynamic limit. When more than one bundle of edge-rays needs to be considered in the design, one way to obtain solutions is to use SMS method. SMS stands for Simultaneous Multiple Surface, which means several optical surfaces are constructed simultaneously. The SMS method was developed as a design method in Non-imaging optics during the 90s. The method can be considered as an extension to the Cartesian Oval calculation. In the traditional Cartesian Oval calculation, one optical surface is built to transform an input wave-front to an out-put wave-front. The SMS method however, is dedicated to solve more than 1 wave-fronts transformation problem. In the beginning, only 2 input wave-fronts and 2 output wave-fronts transformation problem was considered in the SMS design process for rotational optical systems or free-form optical systems. Usually “SMS 2D” method stands for the SMS procedure developed for rotational optical system, and “SMS 3D” method for the procedure for free-form optical system. Although the SMS method was originally employed in non-imaging optical system designs, it has been found during this thesis that with the improved capability to design more surfaces and control more input and output wave-fronts, the SMS method can also be applied to imaging system designs and possesses great advantage over traditional design methods. In this thesis, one of the main goals to achieve is to further develop the existing SMS-2D method to design with more surfaces and improve the stability of the SMS-2D and SMS-3D algorithms, so that further optimization process can be combined with SMS algorithms. The benefits of SMS plus optimization strategy over traditional optimization strategy will be explained in details for both rotational and free-form imaging optical system designs. Another main goal is to develop novel design concepts and methods suitable for challenging non-imaging applications, e.g. solar concentrator and solar tracker. This thesis comprises 9 chapters and can be grouped into two parts: the first part (chapter 2-5) contains research works in the imaging field, and the second part (chapter 6-8) contains works in the non-imaging field. In the first chapter, an introduction to basic imaging and non-imaging design concepts and theories is given. Chapter 2 presents a basic SMS-2D imaging design procedure using meridian rays. In this chapter, we will set the imaging design problem from the SMS point of view, and try to solve the problem numerically. The stability of this SMS-2D design procedure will also be discussed. The design concepts and procedures developed in this chapter lay the path for further improvement. Chapter 3 presents two improved SMS 3 surfaces’ design procedures using meridian rays (SMS-3M) and skew rays (SMS-1M2S) respectively. The major improvement has been made to the central segments selections, so that the whole SMS procedures become more stable compared to procedures described in Chapter 2. Since these two algorithms represent two types of phase space sampling, their image forming capabilities are compared in a simple objective design. Chapter 4 deals with an ultra-compact SWIR camera design with the SMS-3M method. The difficulties in this wide band camera design is how to maintain high image quality meanwhile reduce the overall system length. This interesting camera design provides a playground for the classical design method and SMS design methods. We will show designs and optical performance from both classical design method and the SMS design method. Tolerance study is also given as the end of the chapter. Chapter 5 develops a two-stage SMS-3D based optimization strategy for a 2 freeform mirrors imaging system. In the first optimization phase, the SMS-3D method is integrated into the optimization process to construct the two mirrors in an accurate way, drastically reducing the unknown parameters to only few system configuration parameters. In the second optimization phase, previous optimized mirrors are parameterized into Qbfs type polynomials and set up in code V. Code V optimization results demonstrates the effectiveness of this design strategy in this 2-mirror system design. Chapter 6 shows an etendue-squeezing condenser optics, which were prepared for the 2010 IODC illumination contest. This interesting design employs many non-imaging techniques such as the SMS method, etendue-squeezing tessellation, and groove surface design. This device has theoretical efficiency limit as high as 91.9%. Chapter 7 presents a freeform mirror-type solar concentrator with uniform irradiance on the solar cell. Traditional parabolic mirror concentrator has many drawbacks like hot-pot irradiance on the center of the cell, insufficient use of active cell area due to its rotational irradiance pattern and small acceptance angle. In order to conquer these limitations, a novel irradiance homogenization concept is developed, which lead to a free-form mirror design. Simulation results show that the free-form mirror reflector has rectangular irradiance pattern, uniform irradiance distribution and large acceptance angle, which confirm the viability of the design concept. Chapter 8 presents a novel beam-steering array optics design strategy. The goal of the design is to track large angle parallel rays by only moving optical arrays laterally, and convert it to small angle parallel output rays. The design concept is developed as an extended SMS method. Potential applications of this beam-steering device are: skylights to provide steerable natural illumination, building integrated CPV systems, and steerable LED illumination. Conclusion and future lines of work are given in Chapter 9. Resumen La óptica de formación de imagen clásica se ha ido desarrollando durante siglos, dando lugar tanto a la teoría de óptica paraxial y los métodos de diseño prácticos como a técnicas de optimización multiparamétricas. Aunque estos métodos de diseño óptico para formación de imagen puede aportar soluciones elegantes a muchos problemas convencionales, siguen apareciendo nuevos problemas de diseño óptico, concentradores solares, sistemas de iluminación, cámaras ultracompactas, etc. que requieren máxima transferencia de energía o dimensiones ultracompactas. Este tipo de problemas no se pueden resolver fácilmente con métodos clásicos de diseño porque durante el proceso de diseño no solamente se deben considerar los rayos paraxiales sino también los rayos no paraxiales. La óptica anidólica o no formadora de imagen es una disciplina que ha evolucionado en gran medida recientemente. Su objetivo no es formar imagen, es maximazar la eficiencia de transferencia de energía. Un concepto importante de la óptica anidólica son los “rayos marginales”, que se pueden utilizar para el diseño de sistemas ya que si todos los rayos marginales llegan a nuestra área del receptor, todos los rayos interiores también llegarán al receptor. Haciendo uso de este principio, se han diseñado muchos concentradores solares que funcionan cerca del límite teórico que marca la termodinámica. Cuando consideramos más de un haz de rayos marginales en nuestro diseño, una posible solución es usar el método SMS (Simultaneous Multiple Surface), el cuál diseña simultáneamente varias superficies ópticas. El SMS nació como un método de diseño para óptica anidólica durante los años 90. El método puede ser considerado como una extensión del cálculo del óvalo cartesiano. En el método del óvalo cartesiano convencional, se calcula una superficie para transformar un frente de onda entrante a otro frente de onda saliente. El método SMS permite transformar varios frentes de onda de entrada en frentes de onda de salida. Inicialmente, sólo era posible transformar dos frentes de onda con dos superficies con simetría de rotación y sin simetría de rotación, pero esta limitación ha sido superada recientemente. Nos referimos a “SMS 2D” como el método orientado a construir superficies con simetría de rotación y llamamos “SMS 3D” al método para construir superficies sin simetría de rotación o free-form. Aunque el método originalmente fue aplicado en el diseño de sistemas anidólicos, se ha observado que gracias a su capacidad para diseñar más superficies y controlar más frentes de onda de entrada y de salida, el SMS también es posible aplicarlo a sistemas de formación de imagen proporcionando una gran ventaja sobre los métodos de diseño tradicionales. Uno de los principales objetivos de la presente tesis es extender el método SMS-2D para permitir el diseño de sistemas con mayor número de superficies y mejorar la estabilidad de los algoritmos del SMS-2D y SMS-3D, haciendo posible combinar la optimización con los algoritmos. Los beneficios de combinar SMS y optimización comparado con el proceso de optimización tradicional se explican en detalle para sistemas con simetría de rotación y sin simetría de rotación. Otro objetivo importante de la tesis es el desarrollo de nuevos conceptos de diseño y nuevos métodos en el área de la concentración solar fotovoltaica. La tesis está estructurada en 9 capítulos que están agrupados en dos partes: la primera de ellas (capítulos 2-5) se centra en la óptica formadora de imagen mientras que en la segunda parte (capítulos 6-8) se presenta el trabajo del área de la óptica anidólica. El primer capítulo consta de una breve introducción de los conceptos básicos de la óptica anidólica y la óptica en formación de imagen. El capítulo 2 describe un proceso de diseño SMS-2D sencillo basado en los rayos meridianos. En este capítulo se presenta el problema de diseñar un sistema formador de imagen desde el punto de vista del SMS y se intenta obtener una solución de manera numérica. La estabilidad de este proceso se analiza con detalle. Los conceptos de diseño y los algoritmos desarrollados en este capítulo sientan la base sobre la cual se realizarán mejoras. El capítulo 3 presenta dos procedimientos para el diseño de un sistema con 3 superficies SMS, el primero basado en rayos meridianos (SMS-3M) y el segundo basado en rayos oblicuos (SMS-1M2S). La mejora más destacable recae en la selección de los segmentos centrales, que hacen más estable todo el proceso de diseño comparado con el presentado en el capítulo 2. Estos dos algoritmos representan dos tipos de muestreo del espacio de fases, su capacidad para formar imagen se compara diseñando un objetivo simple con cada uno de ellos. En el capítulo 4 se presenta un diseño ultra-compacto de una cámara SWIR diseñada usando el método SMS-3M. La dificultad del diseño de esta cámara de espectro ancho radica en mantener una alta calidad de imagen y al mismo tiempo reducir drásticamente sus dimensiones. Esta cámara es muy interesante para comparar el método de diseño clásico y el método de SMS. En este capítulo se presentan ambos diseños y se analizan sus características ópticas. En el capítulo 5 se describe la estrategia de optimización basada en el método SMS-3D. El método SMS-3D calcula las superficies ópticas de manera precisa, dejando sólo unos pocos parámetros libres para decidir la configuración del sistema. Modificando el valor de estos parámetros se genera cada vez mediante SMS-3D un sistema completo diferente. La optimización se lleva a cabo variando los mencionados parámetros y analizando el sistema generado. Los resultados muestran que esta estrategia de diseño es muy eficaz y eficiente para un sistema formado por dos espejos. En el capítulo 6 se describe un sistema de compresión de la Etendue, que fue presentado en el concurso de iluminación del IODC en 2010. Este interesante diseño hace uso de técnicas propias de la óptica anidólica, como el método SMS, el teselado de las lentes y el diseño mediante grooves. Este dispositivo tiene un límite teórica en la eficiencia del 91.9%. El capítulo 7 presenta un concentrador solar basado en un espejo free-form con irradiancia uniforme sobre la célula. Los concentradores parabólicos tienen numerosas desventajas como los puntos calientes en la zona central de la célula, uso no eficiente del área de la célula al ser ésta cuadrada y además tienen ángulos de aceptancia de reducido. Para poder superar estas limitaciones se propone un novedoso concepto de homogeneización de la irrandancia que se materializa en un diseño con espejo free-form. El análisis mediante simulación demuestra que la irradiancia es homogénea en una región rectangular y con mayor ángulo de aceptancia, lo que confirma la viabilidad del concepto de diseño. En el capítulo 8 se presenta un novedoso concepto para el diseño de sistemas afocales dinámicos. El objetivo del diseño es realizar un sistema cuyo haz de rayos de entrada pueda llegar con ángulos entre ±45º mientras que el haz de rayos a la salida sea siempre perpendicular al sistema, variando únicamente la posición de los elementos ópticos lateralmente. Las aplicaciones potenciales de este dispositivo son varias: tragaluces que proporcionan iluminación natural, sistemas de concentración fotovoltaica integrados en los edificios o iluminación direccionable con LEDs. Finalmente, el último capítulo contiene las conclusiones y las líneas de investigación futura.

Remarks on methods for the computation of boundary-element integrals by co-ordinate transformation

It is well known that the evaluation of the influence matrices in the boundary-element method requires the computation of singular integrals. Quadrature formulae exist which are especially tailored to the specific nature of the singularity, i.e. log(*- x0)9 Ijx- JC0), etc. Clearly the nodes and weights of these formulae vary with the location Xo of the singular point. A drawback of this approach is that a given problem usually includes different types of singularities, and therefore a general-purpose code would have to include many alternative formulae to cater for all possible cases. Recently, several authors1"3 have suggested a type independent alternative technique based on the combination of standard Gaussian rules with non-linear co-ordinate transformations. The transformation approach is particularly appealing in connection with the p.adaptive version, where the location of the collocation points varies at each step of the refinement process. The purpose of this paper is to analyse the technique in eference 3. We show that this technique is asymptotically correct as the number of Gauss points increases. However, the method possesses a 'hidden' source of error that is analysed and can easily be removed.

A bi-cubic transformation for the numerical evaluation of the Cauchy principal value integrals in boundary methods

The numerical strategies employed in the evaluation of singular integrals existing in the Cauchy principal value (CPV) sense are, undoubtedly, one of the key aspects which remarkably affect the performance and accuracy of the boundary element method (BEM). Thus, a new procedure, based upon a bi-cubic co-ordinate transformation and oriented towards the numerical evaluation of both the CPV integrals and some others which contain different types of singularity is developed. Both the ideas and some details involved in the proposed formulae are presented, obtaining rather simple and-attractive expressions for the numerical quadrature which are also easily embodied into existing BEM codes. Some illustrative examples which assess the stability and accuracy of the new formulae are included.

Efficient sampling from truncated bivariate Gaussians via Box-Muller transformation

Many practical simulation tasks demand procedures to draw samples efficiently from multivariate truncated Gaussian distributions. In this work, we introduce a novel rejection approach, based on the Box-Muller transformation, to generate samples from a truncated bivariate Gaussian density with an arbitrary support. Furthermore, for an important class of support regions the new method allows us to achieve exact sampling, thus becoming the most efficient approach possible. RESUMEN. Método específico para generar muestras de manera eficiente de Gaussianas bidimensionales truncadas con cualquier zona de truncamiento basado en la transformación de Box-Muller.

Gear dynamics monitoring using discrete wavelet transformation and multi-layer perceptron neural networks

This paper presents a multi-stage algorithm for the dynamic condition monitoring of a gear. The algorithm provides information referred to the gear status (fault or normal condition) and estimates the mesh stiffness per shaft revolution in case that any abnormality is detected. In the first stage, the analysis of coefficients generated through discrete wavelet transformation (DWT) is proposed as a fault detection and localization tool. The second stage consists in establishing the mesh stiffness reduction associated with local failures by applying a supervised learning mode and coupled with analytical models. To do this, a multi-layer perceptron neural network has been configured using as input features statistical parameters sensitive to torsional stiffness decrease and derived from wavelet transforms of the response signal. The proposed method is applied to the gear condition monitoring and results show that it can update the mesh dynamic properties of the gear on line.

Robust Image Registration with Global Intensity Transformation

This paper presents a registration method for images with global illumination variations. The method is based on a joint iterative optimization (geometric and photometric) of the L1 norm of the intensity error. Two strategies are compared to directly find the appropriate intensity transformation within each iteration: histogram specification and the solution obtained by analyzing the necessary optimality conditions. Such strategies reduce the search space of the joint optimization to that of the geometric transformation between the images.

Teoría y práctica de la restauración de la Mezquita-Catedral de Córdoba durante el siglo XX

La Mezquita-Catedral de Córdoba es un edificio vivo. Un edificio que ha sido transformado sucesivamente por hombres de razas, culturas y religiones distintas durante sus más de 1.200 años de vida y que, a pesar de ello, no ha dejado de estar en uso ni uno solo de esos días de esa larga vida. De esta forma, el edificio se muestra ante el visitante como un complejo objeto arquitectónico, resultado de una continua transformación. La capacidad de la transformación de los edificios es algo inherente a su propia condición arquitectónica, no es un hecho exclusivo de la Mezquita-Catedral. Sin embargo, en este edificio esa transformación se produce con una gran intensidad y sin pérdida de su autenticidad. Tradicionalmente, los edificios se han adaptado a los nuevos requerimientos de cada época en un proceso que ha buscado en el propio edificio las leyes o principios que habían de regir la intervención. De esta forma, tanto las sucesivas ampliaciones de la Mezquita de Abd al-Rahman I como las siguientes intervenciones cristianas debieron asumir lo preexistente como material de trabajo. Así, los arquitectos del califa al-Hakam II dialogaron con sus antecesores complejizando el espacio que recibieron, así como los Hernán Ruiz consiguieron un nuevo organismo resultante de la introducción de su arquitectura luminosa en la trama hispanomusulmana. El siglo XIX confirmó el deseo por descubrir las huellas de un pasado esplendoroso que la intervención barroca había silenciado bajo un tratamiento homogéneo del espacio. La recuperación de esas huellas supuso, hace exactamente dos siglos, el inicio de la última gran etapa en la transformación del edificio, la de la restauración. La fábrica es considerada como objeto a conservar y los esfuerzos desde ese momento se centraron en la recuperación de la arquitectura omeya latente. De este modo, la práctica de la restauración como disciplina se encontró absolutamente influenciada por la Arqueología como única fuente de conocimiento. Las intervenciones buscaban lo original como modo de recuperar espacial y formalmente aquel pasado, concentrándose en los lugares del edificio considerados como esenciales. La declaración del edificio como monumento nacional en 1882 propició que el Estado se hiciera cargo de su mantenimiento y conservación, sustituyendo en esa tarea a los Obispos y Cabildos del siglo XIX, que tuvieron un entendimiento muy avanzado para su época. La llegada del arquitecto Velázquez Bosco en las últimas décadas del siglo XIX supuso un cambio trascendental en la historia del edificio, puesto que recibió un edificio con importantes deterioros y consiguió poner las bases del edificio que hoy contemplamos. El empeño por la recuperación material y espacial devolvió a la Mezquita-Catedral buena parte de su imagen original, reproduciendo con exactitud los modelos hallados en las exploraciones arqueológicas. La llegada de Antonio Flórez tras la muerte de Velázquez Bosco supuso la traslación al edificio del debate disciplinar que se desarrolló en las dos primeras décadas del siglo XX. Flórez procuró un nuevo entendimiento de la intervención, considerando la conservación como actuación prioritaria. En 1926 el Estado reformó la manera en que se atendía al patrimonio con la creación de un sistema de zonas y unos arquitectos a cargo de ellas. La existencia de un nuevo marco legislativo apuntaló esa nueva visión conservativa, avalada por la Carta de Atenas de 1931. Este modelo restauración científica huía de la intervención en estilo y valoraba la necesidad de intervenir de la manera más escueta posible y con un lenguaje diferenciado, basándose en los datos que ofrecía la Arqueología. Por tanto, se continuaba con la valoración del edificio como documento histórico, buscando en este caso una imagen diferenciada de la intervención frente a la actitud mimética de Velázquez. Resulta destacable la manera en la que el historiador Manuel Gómez-Moreno influyó en varias generaciones de arquitectos, arqueólogos e historiadores, tanto en el entendimiento científico de la restauración como en la propia estructura administrativa. La labor desarrollada en el edificio por José Mª Rodríguez Cano primero y Félix Hernández a continuación estuvo influida de manera teórica por el método de Gómez-Moreno, aunque en muchos aspectos su labor no representó una gran diferencia con lo hecho por Velázquez Bosco. La búsqueda de lo original volvió a ser recurrente, pero la carga económica del mantenimiento de un edificio tan extenso conllevó la no realización de muchos de los proyectos más ambiciosos. Esta obsesiva búsqueda de la imagen original del edificio tuvo su última y anacrónica etapa con la intervención de la Dirección General de Arquitectura en los 70. Sin embargo, el agotamiento del modelo científico ya había propiciado un nuevo escenario a nivel europeo, que cristalizó en la Carta de Venecia de 1964 y en una nueva definición del objeto a preservar, más allá del valor como documento histórico. Esta nueva posición teórica tuvo su traslación al modelo restaurador español en el último cuarto de siglo XX, coincidiendo con la Transición. El arquitecto Dionisio Hernández Gil defendió una interpretación distinta a la de los arqueólogos y de los historiadores, que había prevalecido durante todo el siglo. En opinión de Hernández Gil, los problemas de intervención debían enfocarse fundamentalmente como problemas de Arquitectura, abandonando la idea de que solamente podían ser resueltos por especialistas. Esta convicción teórica fue defendida desde la nueva Administración y deparó la utilización de unos criterios de intervención particularizados, provenientes del análisis multifocal de cada situación y no sólo desde el valor de los edificios como documentos históricos. Y este cambio tuvo su traslación a la Mezquita-Catedral con la práctica de Gabriel Ruiz Cabrero y Gabriel Rebollo. En consecuencia con esa nueva perspectiva, aceptaron el edificio que recibieron, sustituyendo la búsqueda de aquella página original por la aceptación de cada una de las páginas de su historia y el respeto a las técnicas constructivas del pasado. La búsqueda de soluciones específicas desde el propio objeto arquitectónico significó la renovada atención a la potente estructura formal-constructiva como origen de toda reflexión. Considerar la Mezquita-Catedral en primer lugar como Arquitectura implicaba la atención a todo tipo de factores además de los históricos, como medio para preservar su autenticidad. Esta tesis pretende demostrar que la práctica de la restauración realizada en la Mezquita-Catedral a lo largo del siglo XX ha evolucionado desde la búsqueda de lo original hasta la búsqueda de lo auténtico, como reflejo de una visión basada en lo arqueológico frente a una renovada visión arquitectónica más completa, que incluye a la anterior. La consideración de la intervención en este edificio como otra página más de su historia y no como la última, significa la reedición de un mecanismo recurrente en la vida del edificio y un nuevo impulso en ese proceso de continua transformación. ABSTRACT The Mosque-Cathedral of Cordoba is a living building. A building transformed by men of different races, cultures and religions during more than 1.200 years old and that, nevertheless, it has continued to be in use all days in that long life. Thus, the building shows to the visitor as a complex architectural object, the result of continuous transformation. This transformation capacity of the buildings is inherent in their own architectural condition, it’s not an exclusive fact of the Mosque-Cathedral. However, in this building that transformation happens with a great intensity, without losing their authenticity. Traditionally, buildings have been adapted to the new requirements of times in a process that looked for laws or principles in order to guide the intervention. Thus, both the successive enlargements of the Mosque of Abd al-Rahman and Christian interventions must assume the preexistence as a working material. So, the architects of the caliph al-Hakam II spoke to their predecessors, complexing the receiving space, as well as Hernan Ruiz got a new organism as result the introduction of his luminous architecture into hispanic-muslim weft. The nineteenth century confirmed the desire to discover the traces of a glorious past that Baroque intervention had silenced, under a uniform space treatment. Exactly two centuries ago, the recovery of these traces meant the start of the last major phase in the transformation of the building: the restoration. The building was considered subject to conserve and since then, efforts focused on the recovery of latent Umayyad architecture. Thus, the practice of restoration as a discipline was absolutely influenced by Archaeology as the only source of knowledge. Interventions were seeking the original as the way to recover that past in a space and formal way, concentrating on essential sites of the building. The statement as a national monument in 1882 prompted the State take charge of its maintenance and preservation, replacing to the nineteenth century Bishops and Cabildos, which had a very advanced understanding for that time. The arrival of the architect Velazquez Bosco in the last decades of the nineteenth century involved a momentous change in the history of the building, since he received a building with significant damage and he achieved the foundations of the building that we can see today. Efforts to a material and space recover returned the Mosque-Cathedral to its original image, accurately reproducing the models found in archaeological explorations. The arrival of Antonio Florez after Velazquez’s death involved the translation of discipline debate, which was developed in the first two decades of the twentieth century. Florez tried a new understanding of the intervention, considering conservation as a priority action. In 1926, the State reformed the way in which heritage was attended, creating a zones system with a few architects in charge of them. The existence of a new legislative framework, underpinned this new conservative vision, supported by the Athens Charter of 1931. This scientific restoration model fleeing from intervention in style and it appreciated the need to intervene in the most concise way, with a distinct language based on the data offered by Archaeology. Therefore, it continued with the appraisement of the building as a historical document, seeking in this case a differentiated image of intervention, against Velazquez mimetic attitude. It is remarkable the way in which the historian Manuel Gomez-Moreno influenced several generations of architects, archaeologists and historians, both in the scientific understanding of the restoration and the administrative structure. The work of Jose Maria Rodriguez Cano first and then Felix Hernandez was theoretically influenced by the Gomez-Moreno’s method, although in many respects their work did not represent a great difference to Velazquez Bosco. The search of the original returned to recur, but the economic charge of maintaining such a large building led to the non-realization of many of the most ambitious projects. This obsessive search for the original image of the building had its last and anachronistic stage with the intervention of the Department of Architecture at 70’s. However, the exhaustion of the scientific model had already led to a new scenario at European level, which crystallized in the Venice Charter of 1964 and a new definition of the object to be preserved beyond the value as a historical document. This new theoretical position had its translation to Spanish restaurateur model in the last quarter of the twentieth century, coinciding with the Transition. The architect Dionisio Hernandez Gil defended a different interpretation from archaeologists and historians, that had prevailed throughout the century. According to Hernandez Gil, the problems of intervention should focus primarily as architectural issues, abandoning the idea that they could only be determined by specialist. This theoretical conviction was defended from the new administration and led to the use of particularized criteria, from a multifocal analysis of each situation. And this change had its translation to the Mosque with the practice of Gabriel Ruiz Cabrero and Gabriel Rebollo. Consistent with this new perspective, they accepted the receiving building, replacing the search on original page for acceptance of all historical pages and respecting the constructive techniques of the past. The search for specific solutions from the architectural object meant the renewed attention to the powerful formal-constructive structure as the origin of all thought. Consider the Mosque-Cathedral as Architecture, involved the attention to all kinds of factors in addition to the historical, as a means to preserve its authenticity. This thesis aims to demonstrate that the practice of restoration in the Mosque-Cathedral throughout the twentieth century has evolved from the search of the original to the search for the authentic, reflecting a vision based on the archaeological against a renewed more complete architectural vision, including the above. Consideration of intervention in this building as another page in its history and not the last one, means the reissue of an own mechanism and a new impetus in that continuous transformation process.

Instruments for analysing urban conflicts in the Global South: The case of urban transformation processes in Dakar

Physical and social transformation processes that take place in urban contexts with strong spatial growth and hardly any economic development frequently have significant adverse impacts for the affected people, which tend to be made invisible. This paper presents an analytical framework to explore different ways to approach urban transformation processes (supply side), their impacts on the set of needs of the community (demand side) and their consequences on the urban environment as a whole (context). The proposed method has been used to assess three actions related to the physical and social transformation of the largest self-made settlement in the city of Dakar, Senegal, during the 2005–2012 period. Research findings show how exogenous interests are privileged over the common good when the affected citizens are not effectively involved in decision-making processes.

Epigallocathechin-3 Gallate Selectively Inhibits the PDGF-BB–induced Intracellular Signaling Transduction Pathway in Vascular Smooth Muscle Cells and Inhibits Transformation of sis-transfected NIH 3T3 Fibroblasts and Human Glioblastoma Cells (A172)

Enhanced activity of receptor tyrosine kinases such as the PDGF β-receptor and EGF receptor has been implicated as a contributing factor in the development of malignant and nonmalignant proliferative diseases such as cancer and atherosclerosis. Several epidemiological studies suggest that green tea may prevent the development of cancer and atherosclerosis. One of the major constituents of green tea is the polyphenol epigallocathechin-3 gallate (EGCG). In an attempt to offer a possible explanation for the anti-cancer and anti-atherosclerotic activity of EGCG, we examined the effect of EGCG on the PDGF-BB–, EGF-, angiotensin II-, and FCS-induced activation of the 44 kDa and 42 kDa mitogen-activated protein (MAP) kinase isoforms (p44mapk/p42mapk) in cultured vascular smooth muscle cells (VSMCs) from rat aorta. VSMCs were treated with EGCG (1–100 μM) for 24 h and stimulated with the above mentioned agonists for different time periods. Stimulation of the p44mapk/p42mapk was detected by the enhanced Western blotting method using phospho-specific MAP kinase antibodies that recognized the Tyr204-phosphorylated (active) isoforms. Treatment of VSMCs with 10 and 50 μM EGCG resulted in an 80% and a complete inhibition of the PDGF-BB–induced activation of MAP kinase isoforms, respectively. In striking contrast, EGCG (1–100 μM) did not influence MAP kinase activation by EGF, angiotensin II, and FCS. Similarly, the maximal effect of PDGF-BB on the c-fos and egr-1 mRNA expression as well as on intracellular free Ca2+ concentration was completely inhibited in EGCG-treated VSMCs, whereas the effect of EGF was not affected. Quantification of the immunoprecipitated tyrosine-phosphorylated PDGF-Rβ, phosphatidylinositol 3′-kinase, and phospholipase C-γ1 by the enhanced Western blotting method revealed that EGCG treatment effectively inhibits tyrosine phosphorylation of these kinases in VSMCs. Furthermore, we show that spheroid formation of human glioblastoma cells (A172) and colony formation of sis-transfected NIH 3T3 cells in semisolid agar are completely inhibited by 20–50 μM EGCG. Our findings demonstrate that EGCG is a selective inhibitor of the tyrosine phosphorylation of PDGF-Rβ and its downstream signaling pathway. The present findings may partly explain the anti-cancer and anti-atherosclerotic activity of green tea.

Thermodynamic parameters for the helix-coil transition of oligopeptides: molecular dynamics simulation with the peptide growth method.

The helix-coil transition equilibrium of polypeptides in aqueous solution was studied by molecular dynamics simulation. The peptide growth simulation method was introduced to generate dynamic models of polypeptide chains in a statistical (random) coil or an alpha-helical conformation. The key element of this method is to build up a polypeptide chain during the course of a molecular transformation simulation, successively adding whole amino acid residues to the chain in a predefined conformation state (e.g., alpha-helical or statistical coil). Thus, oligopeptides of the same length and composition, but having different conformations, can be incrementally grown from a common precursor, and their relative conformational free energies can be calculated as the difference between the free energies for growing the individual peptides. This affords a straightforward calculation of the Zimm-Bragg sigma and s parameters for helix initiation and helix growth. The calculated sigma and s parameters for the polyalanine alpha-helix are in reasonable agreement with the experimental measurements. The peptide growth simulation method is an effective way to study quantitatively the thermodynamics of local protein folding.

The transform likelihood ratio method for rare event simulation with heavy tails

We present a novel method, called the transform likelihood ratio (TLR) method, for estimation of rare event probabilities with heavy-tailed distributions. Via a simple transformation ( change of variables) technique the TLR method reduces the original rare event probability estimation with heavy tail distributions to an equivalent one with light tail distributions. Once this transformation has been established we estimate the rare event probability via importance sampling, using the classical exponential change of measure or the standard likelihood ratio change of measure. In the latter case the importance sampling distribution is chosen from the same parametric family as the transformed distribution. We estimate the optimal parameter vector of the importance sampling distribution using the cross-entropy method. We prove the polynomial complexity of the TLR method for certain heavy-tailed models and demonstrate numerically its high efficiency for various heavy-tailed models previously thought to be intractable. We also show that the TLR method can be viewed as a universal tool in the sense that not only it provides a unified view for heavy-tailed simulation but also can be efficiently used in simulation with light-tailed distributions. We present extensive simulation results which support the efficiency of the TLR method.