Graphics Processor Unit Based Parallelization of Optimized Baseline Wander Filtering Algorithms for Long-term Electrocardiography

Long-term electrocardiogram (ECG) often suffers from relevant noise. Baseline wander in particular is pronounced in ECG recordings using dry or esophageal electrodes, which are dedicated for prolonged registration. While analog high-pass filters introduce phase distortions, reliable offline filtering of the baseline wander implies a computational burden that has to be put in relation to the increase in signal-to-baseline ratio (SBR). Here we present a graphics processor unit (GPU) based parallelization method to speed up offline baseline wander filter algorithms, namely the wavelet, finite, and infinite impulse response, moving mean, and moving median filter. Individual filter parameters were optimized with respect to the SBR increase based on ECGs from the Physionet database superimposed to auto-regressive modeled, real baseline wander. A Monte-Carlo simulation showed that for low input SBR the moving median filter outperforms any other method but negatively affects ECG wave detection. In contrast, the infinite impulse response filter is preferred in case of high input SBR. However, the parallelized wavelet filter is processed 500 and 4 times faster than these two algorithms on the GPU, respectively, and offers superior baseline wander suppression in low SBR situations. Using a signal segment of 64 mega samples that is filtered as entire unit, wavelet filtering of a 7-day high-resolution ECG is computed within less than 3 seconds. Taking the high filtering speed into account, the GPU wavelet filter is the most efficient method to remove baseline wander present in long-term ECGs, with which computational burden can be strongly reduced.

Late-glacial and Holocene vegetation history and dynamics as shown by pollen and plant macrofossil analyses in annually laminated sediments from Soppensee, central Switzerland

The palynostratigraphy of two sediment cores from Soppensee, Central Switzerland (596 m asl) was correlated with nine regional pollen assemblage zones defined for the Swiss Plateau. This biostratigraphy shows that the sedimentary record of Soppensee includes the last 15 000 years, i.e. the entire Late-glacial and Holocene environmental history. The vegetation history of the Soppensee catchment was inferred by pollen and plant-macrofossil analyses on three different cores taken in the deepest part of the lake basin (27 m). On the basis of a high-resolution varve and calibrated radiocarbonchronology it was possible to estimate pollen accumulation rates, which together with the pollen percentage data, formed the basis for the interpretation of the past vegetation dynamics. The basal sediment dates back to the last glacial. After reforestation with juniper and birch at ca. 12 700 B.P., the vegetation changed at around 12 000 B.P. to a pine-birch woodland and at the onset of the Holocene to a mixed deciduous forest. At ca. 7000 B.P., fir expanded and dominated the vegetation with beech becoming predominant at ca. 50014C-years later until sometime during the Iron Age. Large-scale deforestation, especially during the Middle Ages, altered the vegetation cover drastically. During the Late-glacial period two distinct regressive phases in vegetation development are demonstrated, namely, the Aegelsee oscillation (equivalent to the Older Dryas biozone) and the Younger Dryas biozone. No unambiguous evidence for Holocene climatic change was detected at Soppensee. Human presence is indicated by early cereal pollen and distinct pulses of forest clearance as a result of human activity can be observed from the Neolithic period onwards.

A full pedigree based method for the statistical assessment of genetic anticipation

Genetic anticipation is defined as a decrease in age of onset or increase in severity as the disorder is transmitted through subsequent generations. Anticipation has been noted in the literature for over a century. Recently, anticipation in several diseases including Huntington's Disease, Myotonic Dystrophy and Fragile X Syndrome were shown to be caused by expansion of triplet repeats. Anticipation effects have also been observed in numerous mental disorders (e.g. Schizophrenia, Bipolar Disorder), cancers (Li-Fraumeni Syndrome, Leukemia) and other complex diseases. ^ Several statistical methods have been applied to determine whether anticipation is a true phenomenon in a particular disorder, including standard statistical tests and newly developed affected parent/affected child pair methods. These methods have been shown to be inappropriate for assessing anticipation for a variety of reasons, including familial correlation and low power. Therefore, we have developed family-based likelihood modeling approaches to model the underlying transmission of the disease gene and penetrance function and hence detect anticipation. These methods can be applied in extended families, thus improving the power to detect anticipation compared with existing methods based only upon parents and children. The first method we have proposed is based on the regressive logistic hazard model. This approach models anticipation by a generational covariate. The second method allows alleles to mutate as they are transmitted from parents to offspring and is appropriate for modeling the known triplet repeat diseases in which the disease alleles can become more deleterious as they are transmitted across generations. ^ To evaluate the new methods, we performed extensive simulation studies for data simulated under different conditions to evaluate the effectiveness of the algorithms to detect genetic anticipation. Results from analysis by the first method yielded empirical power greater than 87% based on the 5% type I error critical value identified in each simulation depending on the method of data generation and current age criteria. Analysis by the second method was not possible due to the current formulation of the software. The application of this method to Huntington's Disease and Li-Fraumeni Syndrome data sets revealed evidence for a generation effect in both cases. ^

Algunas consideraciones sobre el "argumento del tercer hombre" del Parménides

En el presente trabajo nos detendremos en el primer argumento regresivo o de la Grandeza (Pm. 132a-b) y concentraremos nuestra atención en los supuestos que allí aparecen para mostrar que, además de la autopredicación y la no identidad relevadas por Vlastos, también se encuentra implícita la separación entre dos ámbitos (Ideas y cosas sensibles) que son considerados ambos sujetos ontológicos. A continuación propondremos una lectura en paralelo con el pasaje de Timeo 51d-52a donde Platón argumenta en favor de las Ideas para mostrar un movimiento en la ontología tardía de alejamiento del presupuesto de la sustancialización de lo sensible para afirmar, más bien, a los particulares como cualidades en el espacio

Sulfur and iron speciations in bottom sediments from the southwest Caspian Sea

Speciations of sulfur (sulfide S, pyrite S, sulfate S) and of reactive iron (Fe3+, Fe2+, sulfide Fe) in bottom sediments have been studied in gravity cores and drill cores collected on the shelf of the southwest Caspian Sea. It has been shown that intensity of reduction processes, in particular sulfate reduction, as well as speciations of S and reactive Fe reflect the change of transgressive and regressive stages of the Caspian basin. Characteristic features for the investigated area are high sedimentation rate and high reactivity of organic matter entering bottom sediments.

Transformaciones habitacionales en la Región Metropolitana de Buenos Aires : El pasaje del neoliberalismo al neodesarrollismo urbano

La recuperación de la economía argentina luego de la crisis del 2001/02 implicó una importante mejora de múltiples indicadores sociales y económicos, dada entre otros factores, la orientación de políticas públicas tendiente a recuperar el tejido productivo y el empleo. En este contexto, el tándem construcción-obra pública se transformó en un tema central de la agenda y la expansión inmobiliaria fue bien recibida desde la mirada macroeconómica. Sin embargo, este proceso no estuvo exento de contradicciones, y se observan en la región metropolitana un conjunto de tendencias concurrentes producto de la hibridación entre el neoliberalismo urbano aún vigente y la difusión del neodesarrollismo urbano. De allí que la ampliación de acciones de desmercatilización estatal del consumo de bienes y servicios orientados a la reproducción social coexiste con la persistencia del proceso de desmercatilización social regresivo de la producción del espacio habitacional, junto a la intensa mercantilización del espacio construido asociada a la creciente financierización de los ladrillos

Transformaciones habitacionales en la Región Metropolitana de Buenos Aires : El pasaje del neoliberalismo al neodesarrollismo urbano

La recuperación de la economía argentina luego de la crisis del 2001/02 implicó una importante mejora de múltiples indicadores sociales y económicos, dada entre otros factores, la orientación de políticas públicas tendiente a recuperar el tejido productivo y el empleo. En este contexto, el tándem construcción-obra pública se transformó en un tema central de la agenda y la expansión inmobiliaria fue bien recibida desde la mirada macroeconómica. Sin embargo, este proceso no estuvo exento de contradicciones, y se observan en la región metropolitana un conjunto de tendencias concurrentes producto de la hibridación entre el neoliberalismo urbano aún vigente y la difusión del neodesarrollismo urbano. De allí que la ampliación de acciones de desmercatilización estatal del consumo de bienes y servicios orientados a la reproducción social coexiste con la persistencia del proceso de desmercatilización social regresivo de la producción del espacio habitacional, junto a la intensa mercantilización del espacio construido asociada a la creciente financierización de los ladrillos

Transformaciones habitacionales en la Región Metropolitana de Buenos Aires : El pasaje del neoliberalismo al neodesarrollismo urbano

La recuperación de la economía argentina luego de la crisis del 2001/02 implicó una importante mejora de múltiples indicadores sociales y económicos, dada entre otros factores, la orientación de políticas públicas tendiente a recuperar el tejido productivo y el empleo. En este contexto, el tándem construcción-obra pública se transformó en un tema central de la agenda y la expansión inmobiliaria fue bien recibida desde la mirada macroeconómica. Sin embargo, este proceso no estuvo exento de contradicciones, y se observan en la región metropolitana un conjunto de tendencias concurrentes producto de la hibridación entre el neoliberalismo urbano aún vigente y la difusión del neodesarrollismo urbano. De allí que la ampliación de acciones de desmercatilización estatal del consumo de bienes y servicios orientados a la reproducción social coexiste con la persistencia del proceso de desmercatilización social regresivo de la producción del espacio habitacional, junto a la intensa mercantilización del espacio construido asociada a la creciente financierización de los ladrillos

Sediment thickness and distribution of facies types in the Kara Sea

We studied the impact of the last glacial (late Weichselian) sea level cycle on sediment architecture in the inner Kara Sea using high-resolution acoustic sub-bottom profiling. The acoustic lines were ground-truthed with dated sediment cores. Furthermore we refined the location of the eastern LGM ice margin, by new sub bottom profiles. New model results of post-Last Glacial Maximum (LGM) isostatic rebound for this area allow a well-constrained interpretation of acoustic units in terms of sequence stratigraphy. The lowstand (or regressive) system tract sediments are absent but are represented by an unconformity atop of Pleistocene sediments on the shelf and by a major incised dendritic paleo-river network. The subsequent transgressive and highstand system tracts are best preserved in the incised channels and the recent estuaries while only minor sediment accumulation on the adjacent shelf areas is documented. The Kara Sea can be subdivided into three areas: estuaries (A), the shelf (B) and (C) deeper lying areas that accumulated a total of 114 * 10**10 t of Holocene sediments.

Algunas consideraciones sobre el "argumento del tercer hombre" del Parménides

En el presente trabajo nos detendremos en el primer argumento regresivo o de la Grandeza (Pm. 132a-b) y concentraremos nuestra atención en los supuestos que allí aparecen para mostrar que, además de la autopredicación y la no identidad relevadas por Vlastos, también se encuentra implícita la separación entre dos ámbitos (Ideas y cosas sensibles) que son considerados ambos sujetos ontológicos. A continuación propondremos una lectura en paralelo con el pasaje de Timeo 51d-52a donde Platón argumenta en favor de las Ideas para mostrar un movimiento en la ontología tardía de alejamiento del presupuesto de la sustancialización de lo sensible para afirmar, más bien, a los particulares como cualidades en el espacio

Transformaciones habitacionales en la Región Metropolitana de Buenos Aires : El pasaje del neoliberalismo al neodesarrollismo urbano

La recuperación de la economía argentina luego de la crisis del 2001/02 implicó una importante mejora de múltiples indicadores sociales y económicos, dada entre otros factores, la orientación de políticas públicas tendiente a recuperar el tejido productivo y el empleo. En este contexto, el tándem construcción-obra pública se transformó en un tema central de la agenda y la expansión inmobiliaria fue bien recibida desde la mirada macroeconómica. Sin embargo, este proceso no estuvo exento de contradicciones, y se observan en la región metropolitana un conjunto de tendencias concurrentes producto de la hibridación entre el neoliberalismo urbano aún vigente y la difusión del neodesarrollismo urbano. De allí que la ampliación de acciones de desmercatilización estatal del consumo de bienes y servicios orientados a la reproducción social coexiste con la persistencia del proceso de desmercatilización social regresivo de la producción del espacio habitacional, junto a la intensa mercantilización del espacio construido asociada a la creciente financierización de los ladrillos

Algunas consideraciones sobre el "argumento del tercer hombre" del Parménides

En el presente trabajo nos detendremos en el primer argumento regresivo o de la Grandeza (Pm. 132a-b) y concentraremos nuestra atención en los supuestos que allí aparecen para mostrar que, además de la autopredicación y la no identidad relevadas por Vlastos, también se encuentra implícita la separación entre dos ámbitos (Ideas y cosas sensibles) que son considerados ambos sujetos ontológicos. A continuación propondremos una lectura en paralelo con el pasaje de Timeo 51d-52a donde Platón argumenta en favor de las Ideas para mostrar un movimiento en la ontología tardía de alejamiento del presupuesto de la sustancialización de lo sensible para afirmar, más bien, a los particulares como cualidades en el espacio

Jurassic microfossils of DSDP Hole 79-547B

The first marine incursion of the incipient North Atlantic Ocean is recorded in the uppermost Triassic to Lower Jurassic sequence of DSDP Site 547 off central Morocco. A lithologic change from continental red beds below to slope breccias and hemipelagic carbonates above indicates that a carbonate ramp was probably established by Sinemurian time along the Moroccan continental margin and that subsidence in the adjacent basin was rapid in the early phases of continental rift. Foraminifers recovered from the Liassic (Sinemurian-Pliensbachian) basinal deposits are diverse and well preserved. The faunas are compositionally similar to contemporaneous neritic assemblages of Europe and the Grand Banks of Newfoundland. The Middle Jurassic in Hole 547B is characterized by regressive deposits that are poor in foraminifers. The major Late Jurassic "Atlantic" transgression is again represented by basinal deposits consisting of limestone breccias and pelagic carbonates. Foraminifers recovered from this interval are transitional between Late Jurassic assemblages reported from deep-sea deposits in the North Atlantic and typical Late Jurassic neritic assemblages of Europe. The Late Jurassic assemblages of Hole 547B are primarily dominated by nodosariids and spirillinids with moderate abundances of simple arenaceous forms. Nonreticulate epistominids occur very rarely in the Upper Jurassic of Hole 547B. It is tentatively suggested that these represent upper bathyal assemblages.

Distribution of the planktonic foraminifer genus Streptochilus in Neogene sediments

Study of four species of the biserial planktonic foraminifer Streptochitus from Deep Sea Drilling Project cores of the Eauripik Rise, western equatorial Pacific, and Ninety-east Ridge, Indian Ocean, shows that both the stratigraphic distribution of species and their frequency patterns (though not actual frequencies or abundances) are correlative in the two areas, supporting their use as stratigraphic and paleoecologic index fossils. Their distributional trends are linked to eustatic sea level changes and to changes in the mixing of surface waters; low frequencies and species turnovers occur during regressive phases when strong circulation of oxygenated waters could lead to the subsequent decline of their oxygen-minimum habitat. The species S. subglobigerum. S. latum. S. globigerum, and S. globulosum succeed one another at intervals averaging 2,5 my from late middle Miocene Zone N15 through Quaternary Zone N23. The new species, Streptochilus suhglobigerum, is described for what was formerly thought to be a stratiraphically lower, disjunct part of the range of S. globigerum. These four species most likely belong to a single phylogenetic lineage as evidenced by some transitional morphologies.

Siliceous components of Pliocene-Holocene sediments of the South Atlantic

The Pliocene-Holocene sediments recovered on ODP Leg 114 from Holes 699A, 701C, and 704B are the subject of a detailed investigation to interpret changes in the Oceanographic environment of the South Atlantic in the vicinity of the Polar Front Zone (PFZ). The cores sample sediments at shallow (Hole 704B, 2532 m), intermediate (Hole 699A, 3716 m), and basinal (Hole 701C, 4647 m) depths. Sites 699 and 704 come under the influence of the Antarctic Circumpolar Current (ACC) and Circumpolar Deep Water. It is possible that the upper reaches of Antarctic Bottom Water (AABW) may also affect Hole 699A. Site 701 is influenced by AABW. Closely spaced samples were analyzed for grain-size distribution, sand fraction components, biosiliceous microfossils, organic carbon, and water content. PFZ migrations are traced using changes in bulk sedimentaccumulation rates and the abundance of the diatoms Actiniscus ssp. and Genus et species indet. 1 Fenner (1991), as well as changes in sediment grain size and composition. Diatomaceous sediments of Gilbert age in Hole 699A indicate that the PFZ was positioned over this site, but during the Gauss it migrated north, bringing in less productive Antarctic Surface Water. All cores document a very gradual southerly movement of the PFZ throughout the Matuyama (with some sharp fluctuations of the northen PFZ border over Site 704 between 1.45 and 1.83 m.y.). This regressive shift culminated in the late Matuyama. The latest Matuyama to earliest Brunhes record in Hole 699A has been removed by a hiatus lasting from 1.0 to 0.6 m.y., which was probably caused by intensification of the deep-reaching ACC. The corresponding interval in Hole 704B, the shallowest core, contains evidence of winnowing. Sharp fluctuations of large amplitude and high frequency in the lithology of the sediments from Hole 704B in the eastern South Atlantic, starting at about 0.75 m.y. and characterizing the whole Brunhes Epoch, record the rapid movement of the northern border of the PFZ over the site. These reflect strong glacial/interglacial alternations in climate. To a lesser extent, lithologic fluctuations in Hole 701C reflect the same phenomenon, whereas in Hole 699A the lithology does not vary as dramatically.