Examination of the Iowa Medical Assistance Disproportionate Share Hospital Payments Program and the accompanying schedule identified as Schedule 1 for the Iowa Department of Human Services for the year ended June 30, 2010

Examination of the Iowa Medical Assistance Disproportionate Share Hospital Payments Program and the accompanying schedule identified as Schedule 1 for the Iowa Department of Human Services for the year ended June 30, 2010

Fiscal Year 2015 (Adjusted) State of Iowa Program and Budget, 2014

Budget in Brief from the Governor's Office

Audit report on the Iowa Water Pollution Control Works Financing Program and the Iowa Drinking Water Facilities Financing Program, joint programs of the Iowa Finance Authority and the Iowa Department of Natural Resources for the year ended June 30, 2013

Audit report on the Iowa Water Pollution Control Works Financing Program and the Iowa Drinking Water Facilities Financing Program, joint programs of the Iowa Finance Authority and the Iowa Department of Natural Resources for the year ended June 30, 2013

Pharmacokinetic and pharmacodynamic evaluation of valganciclovir in solid organ transplant patients

Goal: To validate oral vatgancictovir (VGC) in the prophylaxis of CMV infection in Lung (Lu) and Liver (L) recipients and in the treatment of CMV infection/disease in solid organ transplant recipients, using pharmacokinetic and pharmacodynamic studies in comparison with i/v gancicLovir (GCV). Methods: patients undergoing organ transpLantation donor or recipient CMV-seropositive receiving VGC prophylaxis for a period of 3 months (D+/R- Lung recipients, 6 months) were enroLLed. Heart (H), Lu, and L recipients received 900mg VGC q.d., adjusted to kidney (K) function. No K recipients received more than 450mg of VGC q.d. GCV trough (Ctrough) and peak (Cpeak = 3 hours after drug administration) LeveLs, and CMV DNA were measured at 7, 30, and 60 days post-transpLant (prophyLactic study). Patients who developed CMV infection/disease after stopping prophylaxis were treated with VGC (1800mg per day adjusted to K function and GCV blood LeveLs). GCV trough and peak LeveLs, and CMV DNA were measured weekly for the first 3 weeks and biweekly thereafter, until therapy cessation (therapeutic study). PLasma concentration of GCV is measured by HPLC. Results: In the first 8 prophyLaxed patients (6 K, and 1 L and 1 H transplant recipient) of 450mg VGC q.d., the average GCV concentration was 0.5±0.3 mg/t at trough, and 3.9±l.0mg/t 3 hours after administration. Inter-patient variability was substantiaL, especiaLLy for Ctrough (63% of total variance), which correlated with the patient's estimated gtomerutar filtration rate (r square = 42%). No CMV DNA was detected during VGC prophy- Laxis. Two patients (1 H and 1 L) were treated for Late CMV disease. Average GCV Cpeak were 8.9±2.3 mg/L and 4.6±0.5 rag/L, and GCV Ctrough were 2.0±0.9 mg/t and 1.6±0.2 mg/t respectively in each patient during induction phase. VGC treatment afforded a decrease in CMV DNA from 5.2 and 4.4 Log copies/10E6 cettutes at week 0, to 3.9 and 3.0 at week 1, and 3.3 and 2.1 at week 3, respectively.

Examination of the Iowa Medical Assistance Disproportionate Share Hospital Payments Program and the accompanying schedule identified as Schedule 1 for the Iowa Department of Human Services for the year ended June 30, 2011

Examination of the Iowa Medical Assistance Disproportionate Share Hospital Payments Program and the accompanying schedule identified as Schedule 1 for the Iowa Department of Human Services for the year ended June 30, 2011

Building a Better Future.... Together, We Can: Iowa's Program and Budget Fiscal Years 2016-2017, January 2015

Governor Terry E. Branstad's FY2016-17 budget report.

Audit report on the Iowa Water Pollution Control Works Financing Program and the Iowa Drinking Water Facilities Financing Program, joint programs of the Iowa Finance Authority and the Iowa Department of Natural Resources, for the year ended June 30, 2014

Audit report on the Iowa Water Pollution Control Works Financing Program and the Iowa Drinking Water Facilities Financing Program, joint programs of the Iowa Finance Authority and the Iowa Department of Natural Resources, for the year ended June 30, 2014

Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor α/γ ligand LT175.

The effects resulting from the introduction of an oxime group in place of the distal aromatic ring of the diphenyl moiety of LT175, previously reported as a PPARα/γ dual agonist, have been investigated. This modification allowed the identification of new bioisosteric ligands with fairly good activity on PPARα and fine-tuned moderate activity on PPARγ. For the most interesting compound (S)-3, docking studies in PPARα and PPARγ provided a molecular explanation for its different behavior as full and partial agonist of the two receptor isotypes, respectively. A further investigation of this compound was carried out performing gene expression studies on HepaRG cells. The results obtained allowed to hypothesize a possible mechanism through which this ligand could be useful in the treatment of metabolic disorders. The higher induction of the expression of some genes, compared to selective agonists, seems to confirm the importance of a dual PPARα/γ activity which probably involves a synergistic effect on both receptor subtypes.

Audit report on the Iowa Water Pollution Control Works Financing Program (Clean Water Program) and the Iowa Drinking Water Facilities Financing Program (Drinking Water Program), joint programs of the Iowa Finance Authority and the Iowa Department of Natural Resources, for the year ended June 30, 2005

Audit report on the Iowa Water Pollution Control Works Financing Program (Clean Water Program) and the Iowa Drinking Water Facilities Financing Program (Drinking Water Program), joint programs of the Iowa Finance Authority and the Iowa Department of Natural Resources, for the year ended June 30, 2005

Audit report on the Iowa Water Pollution Control Works Financing Program (Clean Water Program) and the Iowa Drinking Water Facilities Financing Program (Drinking Water Program), joint programs of the Iowa Finance Authority and the Iowa Department of Natural Resources, for the year ended June 30, 2004

Audit report on the Iowa Water Pollution Control Works Financing Program (Clean Water Program) and the Iowa Drinking Water Facilities Financing Program (Drinking Water Program), joint programs of the Iowa Finance Authority and the Iowa Department of Natural Resources, for the year ended June 30, 2004

Building a Better Future.... Together, We Can: Iowa's Program and Budget Fiscal Years 2016-2017, January 2015

Governor Terry E. Branstad's FY2016-17 budget in brief

Bayesian networks and the evaluation of scientific evidence in forensic science

Résumé Ce travail de thèse étudie des moyens de formalisation permettant d'assister l'expert forensique dans la gestion des facteurs influençant l'évaluation des indices scientifiques, tout en respectant des procédures d'inférence établies et acceptables. Selon une vue préconisée par une partie majoritaire de la littérature forensique et juridique - adoptée ici sans réserve comme point de départ - la conceptualisation d'une procédure évaluative est dite 'cohérente' lors qu'elle repose sur une implémentation systématique de la théorie des probabilités. Souvent, par contre, la mise en oeuvre du raisonnement probabiliste ne découle pas de manière automatique et peut se heurter à des problèmes de complexité, dus, par exemple, à des connaissances limitées du domaine en question ou encore au nombre important de facteurs pouvant entrer en ligne de compte. En vue de gérer ce genre de complications, le présent travail propose d'investiguer une formalisation de la théorie des probabilités au moyen d'un environment graphique, connu sous le nom de Réseaux bayesiens (Bayesian networks). L'hypothèse principale que cette recherche envisage d'examiner considère que les Réseaux bayesiens, en concert avec certains concepts accessoires (tels que des analyses qualitatives et de sensitivité), constituent une ressource clé dont dispose l'expert forensique pour approcher des problèmes d'inférence de manière cohérente, tant sur un plan conceptuel que pratique. De cette hypothèse de travail, des problèmes individuels ont été extraits, articulés et abordés dans une série de recherches distinctes, mais interconnectées, et dont les résultats - publiés dans des revues à comité de lecture - sont présentés sous forme d'annexes. D'un point de vue général, ce travail apporte trois catégories de résultats. Un premier groupe de résultats met en évidence, sur la base de nombreux exemples touchant à des domaines forensiques divers, l'adéquation en termes de compatibilité et complémentarité entre des modèles de Réseaux bayesiens et des procédures d'évaluation probabilistes existantes. Sur la base de ces indications, les deux autres catégories de résultats montrent, respectivement, que les Réseaux bayesiens permettent également d'aborder des domaines auparavant largement inexplorés d'un point de vue probabiliste et que la disponibilité de données numériques dites 'dures' n'est pas une condition indispensable pour permettre l'implémentation des approches proposées dans ce travail. Le présent ouvrage discute ces résultats par rapport à la littérature actuelle et conclut en proposant les Réseaux bayesiens comme moyen d'explorer des nouvelles voies de recherche, telles que l'étude de diverses formes de combinaison d'indices ainsi que l'analyse de la prise de décision. Pour ce dernier aspect, l'évaluation des probabilités constitue, dans la façon dont elle est préconisée dans ce travail, une étape préliminaire fondamentale de même qu'un moyen opérationnel.

Iowa Program and Budget Fiscal Year 2017

This document summarizes Governor Terry E. Branstad's Program and Budget Recommendations for the General Assembly