The role of CD4(+) and CD8(+) T cells on antibody production by murine Peyer's patch cells following mucosal presentation of Actinomyces viscosus

The aim of this study was to determine the role of CD4 and CD8 cells on specific antibody production by murine Peyer's patch (PP) cells after oral immunization with Actinomyces viscosus in mice. Female DBA/2 mice were orally immunized with three low doses of heat-killed A. viscosus. Sham-immunized mice served as a control group. Mice were depleted of CD4 or CD8 cells by intraperitoneal injection of anti-CD4 or anti-CD8 antibodies daily for 3 days before oral immunization. One week after the last oral immunization, PPs were removed and cell suspensions were cultured with A. viscosus. Specific antibody production in the culture supernatants was assessed by enzyme-linked immunosorbent assay. The results showed that oral immunization with A. viscosus induced a predominant specific immunoglobulin A (IgA) response by PP cells and, to a lesser extent, IgM antibodies. Depletion of CD4 but not CD8 cells suppressed the production of specific antibodies. These results suggest that oral immunization with low doses of A. viscosus may induce the production of specific antibodies by murine PP cells in a CD4-cell-dependent fashion.

Risks and benefits of selective (re)presentation of interviewees' talk:some insights from discourse analysis

Purpose: The purpose of this paper is to examine the quality of evidence collected during interview. Current UK national guidance on the interviewing of victims and witnesses recommends a phased approach, allowing the interviewee to deliver their free report before any questioning takes place, and stipulating that during this free report the interviewee should not be interrupted. Interviewers, therefore, often find it necessary during questioning to reactivate parts of the interviewee's free report for further elaboration. Design/methodology/approach: The first section of this paper draws on a collection of police interviews with women reporting rape, and discusses one method by which this is achieved - the indirect quotation of the interviewee by the interviewer - exploring the potential implications for the quality of evidence collected during this type of interview. The second section of the paper draws on the same data set and concerns itself with a particular method by which information provided by an interviewee has its meaning "fixed" by the interviewer. Findings: It is found that "formulating" is a recurrent practice arising from the need to clarify elements of the account for the benefit of what is termed the "overhearing audience" - in this context, the police scribe, CPS, and potentially the Court. Since the means by which this "fixing" is achieved necessarily involves the foregrounding of elements of the account deemed to be particularly salient at the expense of other elements which may be entirely deleted, formulations are rarely entirely neutral. Their production, therefore, has the potential to exert undue interviewer influence over the negotiated "final version" of interviewees' accounts. Originality/value: The paper highlights the fact that accurate re-presentations of interviewees' accounts are a crucial tool in ensuring smooth progression of interviews and that re-stated speech and formulation often have implications for the quality of evidence collected during significant witness interviews. © Emerald Group Publishing Limited.

Use of Knowledge Technologies for Presentation of Bulgarian Folklore Heritage Semantics

Preserving and presenting the Bulgarian folklore heritage is a long-term commitment of scholars and researchers working in many areas. This article presents ontological model of the Bulgarian folklore knowledge, exploring knowledge technologies for presenting the semantics of the phenomena of our traditional culture. This model is a step to the development of the digital library for the “Bulgarian Folklore Heritage” virtual exposition which is a part of the “Knowledge Technologies for Creation of Digital Presentation and Significant Repositories of Folklore Heritage” project.

Electronic Presentation of Bulgarian Educational Archives: an Ontology-Based Approach

The paper presents an ongoing effort aimed at building an electronic archive of documents issued by the Bulgarian Ministry of Education in the 40ies and 50ies of the 20th century. These funds are stored in the Archive of the Ministry of the People’s Education within the State Archival Fund of the General Department of Archives at the Council of Ministers of Bulgaria. Our basic concern is not the digitization process per se, but the subsequent organization of the archive in a clear and easily-searchable way which would allow various types of users to get access to the documents of interest to them. Here we present the variety of the documents which are stored in the archival collection, and suggestions on their electronic organization. We suggest using ontologies- based presentation of the archive. The basic benefit of this approach is the possibility to search the collection according to the stored content categories.

XML Presentation of Documents Used for Data Exchange in Management of Genetic Resources

In the global strategy for preservation genetic resources of farm animals the implementation of information technology is of great importance. In this regards platform independent information tools and approaches for data exchange are needed in order to obtain aggregate values for regions and countries of spreading a separate breed. The current paper presents a XML based solution for data exchange in management genetic resources of farm animals’ small populations. There are specific requirements to the exchanged documents that come from the goal of data analysis. Three main types of documents are distinguished and their XML formats are discussed. DTD and XML Schema for each type are suggested. Some examples of XML documents are given also.

Digital Preservation and Access to Cultural and Scientific Heritage: Presentation of the KT-DigiCult-BG Project

The fast development and wide application of digital methods, combined with broadened access to the Internet and falling computing costs, have created intense interest in electronic presentation and access to cultural and scientific heritage resources. Information technologies have offered cultural institutions new opportunities for the presentation of their holdings, which are now made accessible not only to the specialists, but also to the citizens and interested parties worldwide. The paper presents an overview of the Bulgarian experience in the field of digital preservation and access and on-going work on the project “Knowledge Transfer for the Digitisation of Scientific and Cultural Heritage to Bulgaria” (MTKD-CT-2004-509754) supported by the Marie Curie programme of the FP6 of the EC.

Ontological Presentation of East-Christian Iconographical Art Domain

In the recent years the East-Christian iconographical art works have been digitized providing a large volume of data. The need for effective classification, indexing and retrieval of iconography repositories was the motivation of the design and development of a systemized ontological structure for description of iconographical art objects. This paper presents the ontology of the East-Christian iconographical art, developed to provide content annotation in the Virtual encyclopedia of Bulgarian iconography multimedia digital library. The ontology’s main classes, relations, facts, rules, and problems appearing during the design and development are described. The paper also presents an application of the ontology for learning analysis on an iconography domain implemented during the SINUS project “Semantic Technologies for Web Services and Technology Enhanced Learning”.

Information Technologies for Presentation of Bulgarian-Indian Cooperation in a Virtual Museum

We investigate digitalization and security of the Bulgarian and Indian cultural artifacts in multimedia archive. In the paper we describe project implementation and methods for intellectual property protection that are result of bilateral cultural and scientific cooperation between research-workers in India and Bulgaria.

Development of New Solutions in the Field of Digitization and Digital Presentation of the National Folklore Heritage

This article briefly reviews the software developments for digital presentation and preservation of Bulgarian folklore treasure created within the project “Knowledge Technologies for Creation of Digital Presentation and Significant Repositories of Folklore Heritage” by teams of the Institute of Mathematics and Informatics.

Web-application for Presentation of Bulgarian Language Heritage: Bilingual Digital Corpora and Dictionaries

The paper describes three software packages - the main components of a software system for processing and web-presentation of Bulgarian language resources – parallel corpora and bilingual dictionaries. The author briefly presents current versions of the core components “Dictionary” and “Corpus” as well as the recently developed component “Connection” that links both “Dictionary” and “Corpus”. The components main functionalities are described as well. Some examples of the usage of the system’s web-applications are included.

Digitisation and Presentation of Historical Materials in a Virtual Exhibition ‘The Image of India in Bulgaria: from the late 19th to the late 20th Century’

The main contribution of this project is the study of collections of valuable documents related to the image of India in Bulgaria. Digital repositories of selected samples are constructed using modern information technologies. The results are presented in a virtual exhibition ‘The Image of India in Bulgaria: from the late 19th to the late 20th century’.

Augmented Reality as a Method for Expanded Presentation of Objects of Digitized Heritage

Augmented reality is the latest among information technologies in modern electronics industry. The essence is in the addition of advanced computer graphics in real and/or digitized images. This paper gives a brief analysis of the concept and the approaches to implementing augmented reality for an expanded presentation of a digitized object of national cultural and/or scientific heritage. ACM Computing Classification System (1998): H.5.1, H.5.3, I.3.7.

Medical Curriculum at Selected Colleges: Foundations and Integrated Presentation of Basic Medical Sciences Distribution over Pre-Clerkship Period

Overview and statistics on the medical curriculum at Arizona, Emory, FIU, Rochester, and Vermont.

Pro-Literacy: A Historical Evaluation and Presentation of Strategies That Have Influenced the Development of the Volunteer Based Adult Education

This paper will present a brief history and work of Pro-Literacy and identify the aspects that serve as a model for other volunteer organizations. Pro- Literacy is an adult literacy program that has been successful in sustaining growth and promoting literacy nationally.