Plan de negocio para una aplicación móvil orientada a la gestión de mascotas

En este documento se especifican aspectos importantes sobre un Modelo de Negocio que se llevará a cabo para justificar las expectativas de éxito de la empresa, pudiendo lograr con ello, financiación externa o socios capitalistas que quieran contribuir a alcanzar dicho éxito. En colaboración con la empresa Where Are Pets, formada por tres jóvenes emprendedores, entre los que me incluyo, se ha desarrollado este Modelo de Negocio para determinar la viabilidad económica y financiera del desarrollo de una aplicación móvil para la gestión de mascotas. Se han tratado puntos como las estrategias de marketing a seguir, el estudio de los clientes a los que la aplicación irá destinada y la estructura del capital necesario para llevar a cabo el proyecto, entre otros. Este Plan de Negocio está destinado a ser una herramienta de gran utilidad tanto para el emprendedor, como para socios, y para los posibles inversores. ABSTRACT This document lists important aspects of a Business Model to be carried out with the object of justify company’s success expectations, to achieve with this, external financing or financial partners who want to contribute to achieving this success. In collaboration with the company Where Are Pets, composed of three young entrepreneurs, myself included, we have developed this Business Model for determining the economic and financial viability of development of a mobile application for managing pets. Several points as marketing strategies, the study of potential customers and structure of the capital necessary to carry out the project, among others, have been treated. This Final Project is intended to be a useful for the entrepreneur, the partners or the potential investors.

TERT promoter mutations in pancreatic endocrine tumours are rare and mainly found in tumours from patients with hereditary syndromes

One of the hallmarks of cancer is its unlimited replicative potential that needs a compensatory mechanism for the consequential telomere erosion. Telomerase promoter (TERTp) mutations were recently reported as a novel mechanism for telomerase re-activation/expression in order to maintain telomere length. Pancreatic endocrine tumors (PETs) were so far recognized to rely mainly on the alternative lengthening of telomeres (ALT) mechanism. It was our objective to study if TERTp mutations were present in pancreatic endocrine tumors (PET) and could represent an alternative mechanism to ALT. TERTp mutations were detected in 7% of the cases studied and were mainly associated to patients harbouring hereditary syndromes. In vitro, using PET-derived cell lines and by luciferase reporter assay, these mutations confer a 2 to 4-fold increase in telomerase transcription activity. These novel alterations are able to recruit ETS transcription factor members, in particular GABP-α and ETV1, to the newly generated binding sites. We report for the first time TERTp mutations in PETs and PET-derived cell lines. Additionally, our data indicate that these mutations serve as an alternative mechanism and in an exclusive manner to ALT, in particular in patients with hereditary syndromes.

Doenças neurológicas

As convulsões são o problema neurológico mais comum nos animais de companhia. Convulsão é o quadro clínico gerado por descargas elétricas paroxísticas, descontroladas e transitórias nos neurónios do encéfalo, levando a alterações da consciência, atividade motora, funções viscerais, perceção sensorial, conduta e memória. A anamnese é muito importante para o diagnóstico, pois é o proprietário quem na maioria das vezes presencia o evento e, os dados obtidos podem auxiliar no plano de diagnóstico e terapêutico. É importante reconhecer, no entanto, que esta informação é coadjuvante ao exame neurológico. As convulsões podem ter causas extracranianas (ex: metabólicas e toxicas), intracranianas (ex: traumatismos, enfermidades infeciosas, malformações congénitas) e idiopáticas (epilepsia idiopática). É fundamental tentar identificar a causa das convulsões através da realização do exame clínico e neurológico, com atenção especial aos sistemas cardio-circulatório, respiratório, digestivo e urinário. Devem ser realizados exames complementares adequados (hemograma, urianálise, enzimas hepáticas, ureia, creatinina, glicemia, sorologias, reação em cadeia de polimerase, radiografias torácicas, ultrassonografia, tomografia computorizada e ressonância magnética quando disponíveis). O objetivo do tratamento antiepilético é controlar as convulsões sem efeitos adversos, no entanto, o clínico apenas pode tentar reduzir a frequência e severidade das convulsões a um nível que não comprometa substancialmente a qualidade de vida do animal e dos proprietários, evitando efeitos secundários.

Essays in miniature /

Our friends, the books.--Trials of a publisher.--The oppression of notes.--Conversation in novels.--A short defence of villains.--A by-way in fiction.--Comedy of the custom house.--Mr. Wilde's intentions.--Humors of gastronomy.--Children in fiction.--Three famous old maids.--The charm of the familiar.--Old World pets.--Battle of the babies.--The novel of incident.

Pet Theft Act of 1988 [microform] : hearing before the Subcommittee on Department Operations, Research, and Foreign Agriculture of the Committee on Agriculture, House of Representatives, One Hundredth Congress, second session, on S. 2353, September 28, 1988.

"Serial no. 100-109."

Finches;

Mode of access: Internet.

Wild pigeons and doves.

Mode of access: Internet.

Budgerigar guide; detailed breeding methods.

Mode of access: Internet.

The talking budgie (Australian shell parrakeet)

Mode of access: Internet.

España sagrada.

"Apéndices" de p. 390 a 484. De p. 390 a 479, texto en latín. Texto a dos col. Anteportada.

Letters from a cat : published by her mistress for the benefit of all cats and the amusement of little children /

Gilt illustration on title of cat with pen and ink inditing "Your Aff[ectionate] Pussy".

Pet hamsters.

Mode of access: Internet.

Soft-billed birds.

Mode of access: Internet.

Care of the aging dog.

Mode of access: Internet.

Pet alligators.

Includes bibliography.