A practical treatise on rail-roads and carriages, shewing the principles of estimating their strength, proportions, expense, and annual produce, and the conditions which render them effective, economical, and durable; with the theory, effect, and expense of steam carriages, stationary engines, and gas machines. Illustrated by four engravings and numerous useful tables.

Mode of access: Internet.

The basis of durable peace,

"These papers were originally printed in the New York Times of November 20, 21, 22, 23, 24, 25, 27, 28, 30, and December 2, 4, 6, 9, 12, 15, and 18, 1916."--Publisher's note.

Durable complete clinical responses in a phase I/II trial using an autologous melanoma cell/dendritic cell vaccine

Advanced metastatic melanoma is incurable by standard treatments, but occasionally responds to immunotherapy. Recent trials using dendritic cells (DC) as a cellular adjuvant have concentrated on defined peptides as the source of antigens, and rely on foreign proteins as a source of help to generate a cell-mediated immune response. This approach limits patient accrual, because currently defined, non-mutated epitopes are restricted by a small number of human leucocyte antigens. It also fails to take advantage of mutated epitopes peculiar to the patient's own tumour, and of CD4(+) T lymphocytes as potential effectors of anti-tumour immunity. We therefore sought to determine whether a fully autologous DC vaccine is feasible, and of therapeutic benefit. Patients with American Joint Cancer Committee stage IV melanoma were treated with a fully autologous immunotherapy consisting of monocyte-derived DC, matured after culture with irradiated tumour cells. Of 19 patients enrolled into the trial, sufficient tumour was available to make treatments for 17. Of these, 12 received a complete priming phase of six cycles of either 0.9X10(6) or 5X10(6) DC/intradermal injection, at 2-weekly intervals. Where possible, treatment continued with the lower dose at 6-weekly intervals. The remaining five patients could not complete priming, due to progressive disease. Three of the 12 patients who completed priming have durable complete responses (average duration 3 5 months +), three had partial responses, and the remaining six had progressive disease (WHO criteria). Disease regression was not correlated with dose or with the development of delayed type hypersensitivity responses to intradermal challenge with irradiated, autologous tumour. However, plasma S-100B levels prior to the commencement of treatment correlated with objective clinical response (P = 0.05) and survival (log rank P < 0.001). The treatment had minimal side-effects and was well tolerated by all patients. Mature, monocyte-derived DC preparations exposed to appropriate tumour antigen sources can be reliably produced for patients with advanced metastatic melanoma, and in a subset of those patients with lower volume disease their repeated administration results in durable complete responses.

The application of expert systems techniques in the design of durable concrete

This thesis describes work done exploring the application of expert system techniques to the domain of designing durable concrete. The nature of concrete durability design is described and some problems from the domain are discussed. Some related work on expert systems in concrete durability are described. Various implementation languages are considered - PROLOG and OPS5, and rejected in favour of a shell - CRYSTAL3 (later CRYSTAL4). Criteria for useful expert system shells in the domain are discussed. CRYSTAL4 is evaluated in the light of these criteria. Modules in various sub-domains (mix-design, sulphate attack, steel-corrosion and alkali aggregate reaction) are developed and organised under a BLACKBOARD system (called DEX). Extensions to the CRYSTAL4 modules are considered for different knowledge representations. These include LOTUS123 spreadsheets implementing models incorporating some of the mathematical knowledge in the domain. Design databases are used to represent tabular design knowledge. Hypertext representations of the original building standards texts are proposed as a tool for providing a well structured and extensive justification/help facility. A standardised approach to module development is proposed using hypertext development as a structured basis for expert systems development. Some areas of deficient domain knowledge are highlighted particularly in the use of data from mathematical models and in gaps and inconsistencies in the original knowledge source Digests.

A technológiai fejlődés hatása a tartós eszközök gazdasági értékcsökkenésére (The effect of technological progress on economic depreciation of durable assets)

A cikk a tartós eszközök gazdasági értékcsökkenésének elméleti hátterét vizsgálja az eszközökben megtestesülő szolgálatok felemésztődése szempontjából. Ezt a felemésztődést az eszközök kimerülésén és elhasználódásán túl, a gazdasági környezetben megjelenő testet öltő és testet nem öltő technológiai fejlődés következtében fellépő avulás is befolyásolja, mely avulás hatását a cikk részletesen tárgyalja. A technológiai fejlődés következtében fellépő avulásnak igen fontos szerepe van az eszközökhöz, és azok használati módjához legjobban illeszkedő értékcsökkenési minta kirajzolásában, amely alapján meghatározott értékcsökkenés központi eleme a vállalkozások jövedelmének, valamint a vállalkozási output egységköltségének, ami az output árazásának fontos tényezője. Ezáltal az értékcsökkenés meghatározásánál figyelembe vett avulás hatással van a vállalkozás termék és tőkepiaci versenyképességére. ___________ The paper examines the theoretical background of durable asset’s economic depreciation, from the embodied services consumption point of view. This consumption is affected by the exhaustion and deterioration beyond obsolescence which is due to embodied and disembodied technological progress that appears in the economic environment. The effect of obsolescence on the economic depreciation is examined in this paper in detail. The obsolescence due to technological progress has an important role in determining the best fit depreciation pattern to the durable asset and its usage. The economic depreciation is a central component of the company’s income, as well as the unit cost of the company’s output, which is an important element of the output pricing process. Thereby the obsolescence recognised by determining economic depreciation influences the company’s competitiveness on the product and capital markets.

Essays on durable goods consumption and firm innovation

This dissertation comprises three individual chapters. Chapter Two examines how free riding across neighbors influenced the diffusion of color television sets in rural China. Chapter Three tests for asymmetric information between a firm’s management and other investors concerning its patent output. Chapter Four discusses how knowledge stocks influence a patenting firm’s later diversification. Chapter Two documents the existence of a type of network effects—free riding across neighbors—in the consumption of color television sets in rural China, which reduces the propensity of non-owners to purchase. I construct a model of the timing of the purchase of a durable good in the presence of free riding, and test its key implications using household survey data in rural China. Chapter Three tests for asymmetric information between a firm’s management and other investors about its patent output by examining insider trading patterns and stock price changes in R&D intensive firms. It demonstrates that management has considerable information about its patent output beyond what is known to investors. It also shows that the predictive power of insider trading patterns on patent output comes from purchases rather than sales. Chapter Four discusses two sequential channels through which knowledge stocks may influence a firm’s later diversification. One is that firms with more knowledge are more likely to enter a new industry. The other is that firms’ businesses have a better chance of surviving, conditional on being formed. By examining U.S. public patenting firms in manufacturing sectors for 1984-1996, I find that knowledge stocks predict the likelihood of new industry entry when controlling for firm size. However, this predictive power is weakened when diversification effects are included. On the other hand, a survival study of newly established segments shows that initial knowledge stocks have significant positive effects on segment survival, whereas diversification effects are insignificant.

La théorie sociale de la connaissance et la gestion du patrimoine documentaire à l’ère numérique

Les institutions de mémoire et de savoir (par exemple, les bibliothèques, les archives, les musées) font face à des défis importants dans leurs responsabilités d’assurer la pérennité du patrimoine documentaire à l’ère numérique. Citons la surabondance de l’information numérique, la possibilité de production, théoriquement illimitée, offerte aux individus comme aux groupes sociaux, les limites dans les capacités de stockage et de diffusion de l’information numérique qui sont à la disposition des institutions mandataires du patrimoine documentaire. De plus, il est apparu que les approches et les méthodes utilisées pour identifier, gérer, préserver et diffuser le patrimoine documentaire de la société canadienne dans un environnement analogique n’étaient transférables à un environnement numérique. Nous suggérons que la théorie sociale de la connaissance peut servir de base à une réflexion portant sur le développement d’une politique publique qui viserait à encadrer l’identification, la sélection, la gestion et la préservation du patrimoine documentaire d’une société à l'ère numérique. Nous définissons la problématique puis proposons des réponses à travers trois articles scientifiques. Les résultats indiquent que les connaissances et les pratiques professionnelles utilisées demeurent persistantes et limitent la formulation et l'application de nouveaux cadres théoriques, de politiques administratives et de techniques associés à l'identification et la sélection du patrimoine documentaire. Cette recherche propose un cadre conceptuel qui permet de développer des politiques publiques sur le patrimoine documentaire du Canada.

Le rapport des usagers aux produits de design dans une perspective de consommation durable

Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal.

La transmission du patrimoine seigneurial des familles du gouvernement de Montréal aux XVIIe et XVIIIe siècles

Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal.

L'espace périurbain de Gatineau face à son devenir horticole : quelques préoccupations pour un développement durable

Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal.

Le rapport des usagers aux produits de design dans une perspective de consommation durable

Un document accompagne le mémoire et est disponible pour consultation au Centre de conservation des bibliothèques de l'Université de Montréal (http://www.bib.umontreal.ca/conservation/).

La transmission du patrimoine seigneurial des familles du gouvernement de Montréal aux XVIIe et XVIIIe siècles

Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal.