The stress response to ionizing radiation involoves c-Abl-dependent phosphorylation of SHPTP1.

c-Abl is a nonreceptor tyrosine kinase that is activated by certain DNA-damaging agents. The present studies demonstrate that nuclear c-Abl binds constitutively to the protein tyrosine phosphatase SHPTP1. Treatment with ionizing radiation is associated with c-Abl-dependent tyrosine phosphorylation of SHPTP1. The results demonstrate that the SH3 domain of c-Abl interacts with a WPDHGVPSEP motif (residues 417-426) in the catalytic domain of SHPTP1 and that c-Abl phosphorylates C terminal Y536 and Y564 sites. The functional significance of the c-Abl-SHPTP1 interaction is supported by the demonstration that, like c-Abl, SHPTP1 regulates the induction of Jun kinase activity following DNA damage. These findings indicate that SHPTP1 is involved in the response to genotoxic stress through a c-Abl-dependent mechanism.

RADIANCE-A planning software for intra-operative radiation therapy

In the last decades accumulated clinical evidence has proven that intra-operative radiation therapy (IORT) is a very valuable technique. In spite of that, planning technology has not evolved since its conception, being outdated in comparison to current state of the art in other radiotherapy techniques and therefore slowing down the adoption of IORT. RADIANCE is an IORT planning system, CE and FDA certified, developed by a consortium of companies, hospitals and universities to overcome such technological backwardness. RADIANCE provides all basic radiotherapy planning tools which are specifically adapted to IORT. These include, but are not limited to image visualization, contouring, dose calculation algorithms-Pencil Beam (PB) and Monte Carlo (MC), DVH calculation and reporting. Other new tools, such as surgical simulation tools have been developed to deal with specific conditions of the technique. Planning with preoperative images (preplanning) has been evaluated and the validity of the system being proven in terms of documentation, treatment preparation, learning as well as improvement of surgeons/radiation oncologists (ROs) communication process. Preliminary studies on Navigation systems envisage benefits on how the specialist to accurately/safely apply the pre-plan into the treatment, updating the plan as needed. Improvements on the usability of this kind of systems and workflow are needed to make them more practical. Preliminary studies on Intraoperative imaging could provide an improved anatomy for the dose computation, comparing it with the previous pre-plan, although not all devices in the market provide good characteristics to do so. DICOM.RT standard, for radiotherapy information exchange, has been updated to cover IORT particularities and enabling the possibility of dose summation with external radiotherapy. The effect of this planning technology on the global risk of the IORT technique has been assessed and documented as part of a failure mode and effect analysis (FMEA). Having these technological innovations and their clinical evaluation (including risk analysis) we consider that RADIANCE is a very valuable tool to the specialist covering the demands from professional societies (AAPM, ICRU, EURATOM) for current radiotherapy procedures.

Manual of protective action guides and protective actions for nuclear incidents.

"EPA 520/1-75-001-A"--Cover.

Reactor safety conference, jointly sponsored by American Nuclear Society, Atomic Industrial Forum [and] United States Atomic Energy Commission, New York City, October 31, 1957.

Cover title.

Radiation detection : a literature search /

This bibliography contains 335 selected references on detection and measurement of radiation from isotopes when used in physical and biological research. These references were selected from scientific journals published during 1948-1957. A list of journals from which the references were selected and an author index are included.

Factors affecting the use of CaF2 : Mn thermoluminescent dosimeters for low-level environmental radiation monitoring /

Mode of access: Internet.

Nuclear instrumentation : a literature search /

"April 1960."

Nuclear instrumentation : a literature search /

"June 1961."

Long-time ecological effects of nuclear war /

"August 1959 [TIS Issuance Date]."

Elements of nuclear physics /

"To incorporate recent findings ... since the Italan text [Il nucleo atomico] was written, essential modifications have been introduced in the present edition."--Pref.

The nature of radioactive fallout and its effects on man : Hearings before the Special Subcommittee on Radiation of the Joint Committee on Atomic Energy, Congress of the United States, Eighty-fifth Congress, first session ...

Include bibliographies.

EPA assessment of fallout in the United States from atmospheric nuclear testing on September 26 and November 17, 1976 by the People's Republic of China /

Bibliography: p.66-67.

Air pathway exposure model validation study at the Monticello Nuclear Generating Plant /

Mode of access: Internet.

The ORINS human radiation counters : a preliminary report /

"July 1960."

Radiation measurements and the spectrum /

"From the Medical Division, Oak Ridge Institute of Nuclear Studies, Oak Ridge, Tennessee, under contract with the United States Atomic Energy Commission, and from the Medical School, Shinshu University, Matsumotoshi, Japan."--Page 1.