Identification of mechanisms controlling the transcriptional activity of nuclear factor kappa B (NF-κB) p65/RelA

Dissertação para a obtenção do grau de doutor em Biologia pelo Instituto de Tecnologia Química e Biológica. Universidade Nova de Lisboa.

Study of nuclear reactions relevant for astrophysics by Micro-AMS

Dissertação para obtenção do Grau de Doutor em Física

Structural change in the ruhr region: problems, potentials and developments

Due to the decline of the heavy industries in the Ruhr region, the area has to reinvent itself. The orientation towards service industries proves to be a difficult task for the district and its population. This paper examines the challenges, problems and potentials of the Ruhr region against the backdrop of its economical history out of a sociological perspective. Thereby the economical situation and its outcome towards the population stand in the foreground of the paper.

Ressonância magnética nuclear com recurso a um transreceptor rádio controlado por software

Dissertação para obtenção do Grau de Mestre em Engenharia Electrotécnica e de Computadores

Irão Nuclear

O Irão é desde 1979 uma potência a ter em consideração. A sua história reflecte a força da nação e a razão pela qual é fortemente reprimido pelos seus pares. A presente dissertação pretende abordar a capacidade nuclear e mais concretamente o seu desenvolvimento pela República Islâmica do Irão, assim como todas as medidas de controlo a esta capacidade, procurando despertar a questão de quem deve ou tem capacidade de determinar a detenção e desenvolvimento de energia nuclear. Vivemos hoje, num mundo multipolar com novos arranjos à estrutura internacional outrora conhecida, verificando-se necessárias novas incursões por estas matérias de forma que as mesmas possam evoluir tanto teórica como praticamente a similar ritmo.

Measurements of the nuclear modification factor for jets in Pb+Pb collisions at sNN =2.76TeV with the ATLAS detector

Measurements of inclusive jet production are performed in pp and Pb+Pb collisions at sNN−−−√=2.76 TeV with the ATLAS detector at the LHC, corresponding to integrated luminosities of 4.0 pb−1 and 0.14 nb−1 , respectively. The jets are identified with the anti-kt algorithm with R=0.4, and the spectra are measured over the kinematic range of jet transverse momentum 32nuclear modification factor, RAA, is evaluated and jets are found to be suppressed by approximately a factor of two in central collisions compared to pp collisions. The RAA shows a slight increase with pT and no significant variation with rapidity.

A possible contribution to improving the therapeutic potentials of Babor's Typology of Alcohol Dependent Patients

ABSTRACT Objective The objective of this study was to replicate Babor's Typology and to explore clinical features related to personality traits that may underlie this classification, in order to improve its therapeutic possibilities. Methods Observational prospective study on a group of 273 male alcoholics. After a replication of Babor's variables, Cluster Analysis, Chi-Square – applied on clinical variables related to a Lappda Tipology – and Kappa tests were performed. Results The study identified two distinct clusters that held similar features to those described for the Type A/Type B classification. Besides presenting a lower socio-economic situation, Cluster 2 patients were associated with higher vulnerability and severe clinical features and also differed from Cluster 1 in their response to treatment. These replicated clusters retained connections and also differences in relation to the variables derived from the Lappda Typology. Conclusion Considering that each of the two replicated clusters seem to be associated to different personality traits – according to their correlations to the affective, cognitive and behavioral dimensions brought forward by the Lappda Typology – it is acceptable that this study may contribute to the development of more comprehensive and effective therapeutic strategies specifically tailored to target more specific personality traits of these subgroups of alcoholic patients.

Ressonância nuclear magnética no diagnóstico de pseudoaneurisma de ventrículo esquerdo. Antigo problema, nova opção

Paciente feminina, 67 anos, internada por infarto agudo do miocárdio de parede lateral, com edema agudo de pulmão e evolução para choque cardiogênico nas primeiras horas. Ecocardiograma transesofágico e ressonância nuclear magnética confirmaram o diagnóstico de pseudoaneurisma de ventrículo esquerdo. A paciente foi submetida a tratamento cirúrgico com sucesso.

Analysis of the Prevalence of Ventricular Late Potentials in the Late Phase of Myocardial Infarction Based on the Site of Infarction

OBJECTIVE: The initial site of myocardial infarction (MI) may influence the prevalence of ventricular late potentials (VLP), high-frequency signals, due to the time course of ventricular activation. The prevalence of VLP in a period of more than 2 years after acute MI was assessed focusing on the initially injured wall . METHODS: The prevalence of VLP in a late phase after MI (median of 924 days) in anterior/antero-septal and inferior/infero-dorsal wall lesion was analyzed using signal-averaged electrocardiogram in time domain. The diagnostic performance of the filters employed for analysis on was tested at high-pass cut-off frequencies of 25 Hz, 40 Hz and 80 Hz. RESULTS: The duration of the ventricular activation and its terminal portion were larger in inferior than anterior infarction, at high-pass cut-off frequencies of 40 Hz and 80 Hz. In patients with ventricular tachycardia, these differences were more remarked. The prevalence of ventricular late potentials was three times greater in inferior than anterior infarction. CONCLUSION: Late after myocardial infarction, the prevalence and the duration of ventricular late potentials are greater in lesions of inferior/infero-dorsal than anterior/antero-septal wall confirming their temporal process, reflecting their high-frequency content.

Genetic diversity and population structure in Vicia faba L. landraces and wild related species assessed by nuclear SSRs

Research Article

Estudio básico y aplicado de polímeros elastómeros mediante la Técnica de Resonancia Magnética Nuclear (RMN)

Los polímeros son materiales que poseen una variedad muy grande de aplicaciones. Por esta razón, el estudio de sus propiedades físicas y químicas resulta de gran interés. Un polímero es una macromolécula cuyo peso molecular puede llegar a varios millones de umas. Mediante la selección de el o los monómeros y de su secuenciamiento en el proceso de polimerización (microestructura del polímero), se puede lograr que el material tenga propiedades predeterminadas. Es posible, entonces, encontrar o desarrollar polímeros para las más variadas aplicaciones: elásticos, rígidos, resistentes a la temperatura, conductores, aisladores, inertes, etc. (...) La Resonancia Magnética Nuclear (RMN) de alta resolución es una de las técnicas más poderosas para la caracterización de los polímeros, brindando información sobre la microestructura y la dinámica de estas macromoléculas, tanto cuando se encuentran en estado sólido como cuando están disueltas en soluciones líquidas. El entendimiento de la microestructura de un polímero es de interés porque ella está íntimamente relacionada con las propiedades macroscópicas del material. Por otra parte, la microestructura de un polímero depende del proceso de polimerización utilizado y en consecuencia, es posible obtener información sobre los mecanismos de reacción química que ocurren durante su síntesis, dentro de los reactores de polimerización. NMR permite, también, obtener información detallada sobre la dinámica de los polímeros. La gran longitud de los polímeros hace que su dinámica molecular sea sumamente compleja. Sin embargo, mediante el empleo de secuencias de pulsos particulares y mediciones de los tiempos de relajación característicos de los espines nucleares, se obtiene información sobre la dinámica de la macromolécula, de los segmentos que la componen y de los grupos colgantes que pueda poseer. Objetivos Generales y Específicos El trabajo a realizar en el período correspondiente al subsidio solicitado, es la continuación de las investigaciones comenzadas en septiembre de 1995. Se avanzará en el entendimiento de los elastómeros que se están estudiando actualmente. El estudio abarca los elastómeros sin tratamientos térmicos y con tratamientos térmicos (vulcanizados).