661 resultados para Merlin, Buenaventura
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Mode of access: Internet.
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Mode of access: Internet.
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"Notice sur la vie et les ouvrages de Théophile Folengo et sur la poésie macaronique en général"
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"Réunion d'articles qui ont paru dans le journal ʻLa Presse'--Lorenz, Cat. de la libr. Francaise.
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Mode of access: Internet.
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Preface, "To the reader," signed: Thomas Heywood.
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Mode of access: Internet.
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Mode of access: Internet.
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Mode of access: Internet.
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Mode of access: Internet.
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Merlin has broad tumor-suppressor functions as its mutations have been identified in multiple benign tumors and malignant cancers. In all schwannomas, the majority of meningiomas and 1/3 of ependymomas Merlin loss is causative. In neurofibromatosis type 2, a dominantly inherited tumor disease because of the loss of Merlin, patients suffer from multiple nervous system tumors and die on average around age 40. Chemotherapy is not effective and tumor localization and multiplicity make surgery and radiosurgery challenging and morbidity is often considerable. Thus, a new therapeutic approach is needed for these tumors. Using a primary human in vitro model for Merlin-deficient tumors, we report that the Ras/Raf/mitogen-activated protein, extracellular signal-regulated kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) scaffold, kinase suppressor of Ras 1 (KSR1), has a vital role in promoting schwannomas development. We show that KSR1 overexpression is involved in many pathological phenotypes caused by Merlin loss, namely multipolar morphology, enhanced cell-matrix adhesion, focal adhesion and, most importantly, increased proliferation and survival. Our data demonstrate that KSR1 has a wider role than MEK1/2 in the development of schwannomas because adhesion is more dependent on KSR1 than MEK1/2. Immunoprecipitation analysis reveals that KSR1 is a novel binding partner of Merlin, which suppresses KSR1's function by inhibiting the binding between KSR1 and c-Raf. Our proteomic analysis also demonstrates that KSR1 interacts with several Merlin downstream effectors, including E3 ubiquitin ligase CRL4DCAF1. Further functional studies suggests that KSR1 and DCAF1 may co-operate to regulate schwannomas formation. Taken together, these findings suggest that KSR1 serves as a potential therapeutic target for Merlin-deficient tumors.
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General note: Title and date provided by Bettye Lane.
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Inscriptions: Verso: [stamped] Photograph by Freda Leinwand. [463 West Street, Studio 229G, New York, NY 10014].
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Tesis de Licenciatura en Historia
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Ledis Torres Copete, es la única mujer que participa en la contienda política por la alcaldía de Buenaventura. Diputada y concejal; su fuerte es el campo, sector donde goza de gran simpatía. El Archivo del Patrimonio Fotográfico y Fílmico del Valle del Cauca es responsabilidad de la Biblioteca Departamental del Valle Jorge Garcés Borrero, por convenio de cooperación suscrito con la Secretaría de Cultura Departamental, con el fin de aunar esfuerzos para la conservación, preservación y divulgación del Archivo entre la comunidad Vallecaucana, especialmente entre los estudiantes e investigadores que visitan la Biblioteca, propiciando su uso y consulta permanente. La universidad Icesi es un colaborador en el proceso de difusión, facilitando la tecnología que permite la consulta de las imágenes.