Unique and shared techniques in cognitive-behavioural and short-term psychodynamic psychotherapy: a content analysis of randomised trials on depression

Randomised controlled trials (RCTs) of psychotherapeutic interventions assume that specific techniques are used in treatments, which are responsible for changes in the client's symptoms. This assumption also holds true for meta-analyses, where evidence for specific interventions and techniques is compiled. However, it has also been argued that different treatments share important techniques and that an upcoming consensus about useful treatment strategies is leading to a greater integration of treatments. This makes assumptions about the effectiveness of specific interventions ingredients questionable if the shared (common) techniques are more often used in interventions than are the unique techniques. This study investigated the unique or shared techniques in RCTs of cognitive-behavioural therapy (CBT) and short-term psychodynamic psychotherapy (STPP). Psychotherapeutic techniques were coded from 42 masked treatment descriptions of RCTs in the field of depression (1979-2010). CBT techniques were often used in studies identified as either CBT or STPP. However, STPP techniques were only used in STPP-identified studies. Empirical clustering of treatment descriptions did not confirm the original distinction of CBT versus STPP, but instead showed substantial heterogeneity within both approaches. Extraction of psychotherapeutic techniques from the treatment descriptions is feasible and could be used as a content-based approach to classify treatments in systematic reviews and meta-analyses.

Gas-phase Lifetimes of Nucleobase Analogues by Picosecond Pumpionization and Streak Techniques

The picosecond (ps) timescale is relevant for the investigation of many molecular dynamical processes such as fluorescence, nonradiative relaxation, intramolecular vibrational relaxation, molecular rotation and intermolecular energy transfer, to name a few. While investigations of ultrafast (femtosecond) processes of biological molecules, e.g. nucleobases and their analogues in the gas phase are available, there are few investigations on the ps time scale. We have constructed a ps pump-ionization setup and a ps streak camera fluorescence apparatus for the determination of lifetimes of supersonic jet-cooled and isolated molecules and clusters. The ps pump-ionization setup was used to determine the lifetimes of the nucleobase analogue 2-aminopurine (2AP) and of two 2AP˙(H2O)n water cluster isomers with n=1 and 2. Their lifetimes lie between 150 ps and 3 ns and are strongly cluster-size dependent. The ps streak camera setup was used to determine accurate fluorescence lifetimes of the uracil analogue 2-pyridone (2PY), its self-dimer (2PY)2, two isomers of its trimer (2PY)3 and its tetramer (2PY)4, which lie in the 7–12 ns range.

Sensitivity of the WRF model to PBL parametrisations and nesting techniques: evaluation of wind storms over complex terrain

Simulating surface wind over complex terrain is a challenge in regional climate modelling. Therefore, this study aims at identifying a set-up of the Weather Research and Forecasting Model (WRF) model that minimises system- atic errors of surface winds in hindcast simulations. Major factors of the model configuration are tested to find a suitable set-up: the horizontal resolution, the planetary boundary layer (PBL) parameterisation scheme and the way the WRF is nested to the driving data set. Hence, a number of sensitivity simulations at a spatial resolution of 2 km are carried out and compared to observations. Given the importance of wind storms, the analysis is based on case studies of 24 historical wind storms that caused great economic damage in Switzerland. Each of these events is downscaled using eight different model set-ups, but sharing the same driving data set. The results show that the lack of representation of the unresolved topography leads to a general overestimation of wind speed in WRF. However, this bias can be substantially reduced by using a PBL scheme that explicitly considers the effects of non-resolved topography, which also improves the spatial structure of wind speed over Switzerland. The wind direction, although generally well reproduced, is not very sensitive to the PBL scheme. Further sensitivity tests include four types of nesting methods: nesting only at the boundaries of the outermost domain, analysis nudging, spectral nudging, and the so-called re-forecast method, where the simulation is frequently restarted. These simulations show that restricting the freedom of the model to develop large-scale disturbances slightly increases the temporal agreement with the observations, at the same time that it further reduces the overestimation of wind speed, especially for maximum wind peaks. The model performance is also evaluated in the outermost domains, where the resolution is coarser. The results demonstrate the important role of horizontal resolution, where the step from 6 to 2 km significantly improves model performance. In summary, the combination of a grid size of 2 km, the non-local PBL scheme modified to explicitly account for non-resolved orography, as well as analysis or spectral nudging, is a superior combination when dynamical downscaling is aimed at reproducing real wind fields.

Fast Prediction of Femoral Biomechanics Using Supervised Machine Learning and Statistical Shape Modeling

Finite element (FE) analysis is an important computational tool in biomechanics. However, its adoption into clinical practice has been hampered by its computational complexity and required high technical competences for clinicians. In this paper we propose a supervised learning approach to predict the outcome of the FE analysis. We demonstrate our approach on clinical CT and X-ray femur images for FE predictions ( FEP), with features extracted, respectively, from a statistical shape model and from 2D-based morphometric and density information. Using leave-one-out experiments and sensitivity analysis, comprising a database of 89 clinical cases, our method is capable of predicting the distribution of stress values for a walking loading condition with an average correlation coefficient of 0.984 and 0.976, for CT and X-ray images, respectively. These findings suggest that supervised learning approaches have the potential to leverage the clinical integration of mechanical simulations for the treatment of musculoskeletal conditions.

The interweaving of popular generic modes and modernist techniques in Nostromo : A tale of the seaboard

Nostromo. A Tale of the Seaboard (1904), una de las novelas más experimentales del período modernista temprano, ha sido considerada la obra maestra de Joseph Conrad y su más grande lienzo. Un rasgo particular de la novela es que en ella coexisten la experimentación técnica del modernismo, la altamente difusa ficción del narrador y la situación de narración de historias y el paradigma narrativo de los subgéneros "degradados" de la novela de aventuras, el romance y el melodrama. Este estudio indaga las relaciones que se establecen entre dichos elementos, a todas luces anacrónicos o pertenecientes a espacios culturales diferentes, y se propone mostrar que estas discontinuidades no deben ser consideradas una falla sino índices de una tensión constitutiva de la novela.

The interweaving of popular generic modes and modernist techniques in Nostromo : A tale of the seaboard

Nostromo. A Tale of the Seaboard (1904), una de las novelas más experimentales del período modernista temprano, ha sido considerada la obra maestra de Joseph Conrad y su más grande lienzo. Un rasgo particular de la novela es que en ella coexisten la experimentación técnica del modernismo, la altamente difusa ficción del narrador y la situación de narración de historias y el paradigma narrativo de los subgéneros "degradados" de la novela de aventuras, el romance y el melodrama. Este estudio indaga las relaciones que se establecen entre dichos elementos, a todas luces anacrónicos o pertenecientes a espacios culturales diferentes, y se propone mostrar que estas discontinuidades no deben ser consideradas una falla sino índices de una tensión constitutiva de la novela.

The interweaving of popular generic modes and modernist techniques in Nostromo : A tale of the seaboard

Nostromo. A Tale of the Seaboard (1904), una de las novelas más experimentales del período modernista temprano, ha sido considerada la obra maestra de Joseph Conrad y su más grande lienzo. Un rasgo particular de la novela es que en ella coexisten la experimentación técnica del modernismo, la altamente difusa ficción del narrador y la situación de narración de historias y el paradigma narrativo de los subgéneros "degradados" de la novela de aventuras, el romance y el melodrama. Este estudio indaga las relaciones que se establecen entre dichos elementos, a todas luces anacrónicos o pertenecientes a espacios culturales diferentes, y se propone mostrar que estas discontinuidades no deben ser consideradas una falla sino índices de una tensión constitutiva de la novela.

Organic-walled dinoflagellate cysts analysis and statistical analysis of 116 surface sediment samples from the eastern Indian Ocean

Assemblages of organic-walled dinoflagellate cysts (dinocysts) from 116 marine surface samples have been analysed to assess the relationship between the spatial distribution of dinocysts and modern local environmental conditions [e.g. sea surface temperature (SST), sea surface salinity (SSS), productivity] in the eastern Indian Ocean. Results from the percentage analysis and statistical methods such as multivariate ordination analysis and end-member modelling, indicate the existence of three distinct environmental and oceanographic regions in the study area. Region 1 is located in western and eastern Indonesia and controlled by high SSTs and a low nutrient content of the surface waters. The Indonesian Throughflow (ITF) region (Region 2) is dominated by heterotrophic dinocyst species reflecting the region's high productivity. Region 3 is encompassing the area offshore north-west and west Australia which is characterised by the water masses of the Leeuwin Current, a saline and nutrient depleted southward current featuring energetic eddies.

The interweaving of popular generic modes and modernist techniques in Nostromo : A tale of the seaboard

Nostromo. A Tale of the Seaboard (1904), una de las novelas más experimentales del período modernista temprano, ha sido considerada la obra maestra de Joseph Conrad y su más grande lienzo. Un rasgo particular de la novela es que en ella coexisten la experimentación técnica del modernismo, la altamente difusa ficción del narrador y la situación de narración de historias y el paradigma narrativo de los subgéneros "degradados" de la novela de aventuras, el romance y el melodrama. Este estudio indaga las relaciones que se establecen entre dichos elementos, a todas luces anacrónicos o pertenecientes a espacios culturales diferentes, y se propone mostrar que estas discontinuidades no deben ser consideradas una falla sino índices de una tensión constitutiva de la novela.

Investigation of cell fate decision in Schizosaccharomyces pombe by ncRNA annotation and statistical analyses

Studies in the fission yeast Schizosaccharomyces pombe (S. pombe) have done much to inform the view of heterochromatin and its control by the RNA interference (RNAi) machinery. Using cDNA synthesised from poly(A)-enriched RNA samples, numerous novel ncRNA loci were discovered, and the 50 and 30 ends of many other genes were refined in previous studies. Although some of these transcripts may encode novel proteins the function of the majority is yet to be determined. The authors have used strand-specific deep sequencing of RNA, irrespective of poly(A) status, to reveal a highly structured antisense programme that modulates gene expression to dictate cell fate decisions during sexual differentiation. They show that an extensive and elaborate array of ncRNA production accompanies sexual differentiation in the fission yeast S. pombe. Experimental manipulation suggests that these transcripts specifically regulate the function of the target genes.