Comparative transcriptomics of extreme phenotypes of human HIV-1 infection and SIV infection in sooty mangabey and rhesus macaque

High levels of HIV-1 replication during the chronic phase of infection usually correlate with rapid progression to severe immunodeficiency. However, a minority of highly viremic individuals remains asymptomatic and maintains high CD4⁺ T cell counts. This tolerant profile is poorly understood and reminiscent of the widely studied nonprogressive disease model of SIV infection in natural hosts. Here, we identify transcriptome differences between rapid progressors (RPs) and viremic nonprogressors (VNPs) and highlight several genes relevant for the understanding of HIV-1-induced immunosuppression. RPs were characterized by a specific transcriptome profile of CD4⁺ and CD8⁺ T cells similar to that observed in pathogenic SIV-infected rhesus macaques. In contrast, VNPs exhibited lower expression of interferon-stimulated genes and shared a common gene regulation profile with nonpathogenic SIV-infected sooty mangabeys. A short list of genes associated with VNP, including CASP1, CD38, LAG3, TNFSF13B, SOCS1, and EEF1D, showed significant correlation with time to disease progression when evaluated in an independent set of CD4⁺ T cell expression data. This work characterizes 2 minimally studied clinical patterns of progression to AIDS, whose analysis may inform our understanding of HIV pathogenesis.

Effect of hydration status on cerebral blood flow and cerebrospinal fluid lactic acidosis in rabbits with experimental meningitis

The effects of hydration status on cerebral blood flow (CBF) and development of cerebrospinal fluid (CSF) lactic acidosis were evaluated in rabbits with experimental pneumococcal meningitis. As loss of cerebrovascular autoregulation has been previously demonstrated in this model, we reasoned that compromise of intravascular volume might severely affect cerebral perfusion. Furthermore, as acute exacerbation of the inflammatory response in the subarachnoid space has been observed after antibiotic therapy, animals were studied not only while meningitis evolved, but also 4-6 h after treatment with antibiotics to determine whether there would also be an effect on CBF. To produce different levels of hydration, animals were given either 50 ml/kg per 24 h of normal saline ("low fluid") or 150 ml/kg 24 h ("high fluid"). After 16 h of infection, rabbits that were given the lower fluid regimen had lower mean arterial blood pressure (MABP), lower CBF, and higher CSF lactate compared with animals that received the higher fluid regimen. In the first 4-6 h after antibiotic administration, low fluid rabbits had a significant decrease in MABP and CBF compared with, and a significantly greater increase in CSF lactate concentration than, high fluid rabbits. This study suggests that intravascular volume status may be a critical variable in determining CBF and therefore the degree of cerebral ischemia in meningitis.

Anna Popovitch,In the Shadow of Althusser: Culture and Politics in Late Twentieth-Century Argentina, Ann Arbor, umi Dissertation Publishing, 2011, 238 páginas

Fil: Starcenbaum, Marcelo. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación. Instituto de Investigaciones en Humanidades y Ciencias Sociales (UNLP-CONICET); Argentina.

Anna Popovitch,In the Shadow of Althusser: Culture and Politics in Late Twentieth-Century Argentina, Ann Arbor, umi Dissertation Publishing, 2011, 238 páginas

Fil: Starcenbaum, Marcelo. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación. Instituto de Investigaciones en Humanidades y Ciencias Sociales (UNLP-CONICET); Argentina.

Ann Barry Allen; Mrs. John Allen

On verso: This was said to be a picture of Ann Isabella Barry McCue Allen. She was born Jan. 22, 1797 daughter of Ihmus Barry (& brother of Andrew) & Ann Isabella Smith of New Kent, Md. The birthplace is given by John McCue at Staunton Va. She died there Nov. 28, 1876 at the home of her daughter Sarah Allen Waddell. Her first husband was Wm McCue M.D. born July 14, 1787 Augusta Co. Va. Died Nov. 7 1818 of flu. Her first husband was a man of prominence & education. She had two children Thomas W. McCue and John McCue

Class picture, 7th Grade - Ann Arbor Public School, June 14, 1884

Names of thirty-six individuals pictured are listed on verso

Ann Arbor Univ. Grounds

University of Michigan Diagonal

German American Day

German-American Day on Ann Arbor's west side. West Liberty from Main Street with open countryside beyond. John Haarer's Photograph Gallery is at the left. (Source: Old Ann Arbor Town by Hazel Proctor.)

Hospital, U. of M. Ann Arbor

When this image was taken this building was a hospital. Built 1840. Professors' Houses (East Residence) 1840-1868. University Hospital 1868-1891. Additions in 1877 and after in the form of two parallel wings built out from back of house and several additions onto them. Dental College 1891-1908. Building removed 1908. Replaced by new Chemistry Building 1910

Rev. Dr. Tappan's House at Ann Arbor. Michigan University.

[From Jasper Cropsey Sketch book, 1855-1856]