989 resultados para Isabel II, Reina de España-Poesías
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Mode of access: Internet.
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Memoria de Sefarad,
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Este proyecto de innovación educativa se presentó en el Congreso Internacional de Innovación en la Educación celebrado en Valladolid los dias 26, 27 y 28 de abril de 2005
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Este proyecto de innovación educativa se presentó en el Congreso Internacional de Innovación en la Educación celebrado en Valladolid los días 26, 27 y 28 de abril de 2005
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Material no publicado
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Tambi??n en biblioteca material no publicado R. 4702 y R.4703
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Digitalización Vitoria-Gasteiz Archivos y Bibliotecas Julio 1995 18-6
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Sign.: a8
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"Apêndices: I. A bibliotéca. II. O monetário. III. O testamento": p. [119]-167.
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Mode of access: Internet.
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Mode of access: Internet.
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BACKGROUND Fragile X syndrome (FXS) is an inherited neurodevelopmental condition characterised by behavioural, learning disabilities, physical and neurological symptoms. In addition, an important degree of comorbidity with autism is also present. Considered a rare disorder affecting both genders, it first becomes apparent during childhood with displays of language delay and behavioural symptoms.Main aim: To show whether the combination of 10 mg/kg/day of ascorbic acid (vitamin C) and 10 mg/kg/day of α-tocopherol (vitamin E) reduces FXS symptoms among male patients ages 6 to 18 years compared to placebo treatment, as measured on the standardized rating scales at baseline, and after 12 and 24 weeks of treatment.Secondary aims: To assess the safety of the treatment. To describe behavioural and cognitive changes revealed by the Developmental Behaviour Checklist Short Form (DBC-P24) and the Wechsler Intelligence Scale for Children-Revised. To describe metabolic changes revealed by blood analysis. To measure treatment impact at home and in an academic environment. METHODS/DESIGN A phase II randomized, double-blind pilot clinical trial. SCOPE male children and adolescents diagnosed with FXS, in accordance with a standardized molecular biology test, who met all the inclusion criteria and none of the exclusion criteria. INSTRUMENTATION clinical data, blood analysis, Wechsler Intelligence Scale for Children-Revised, Conners parent and teacher rating scale scores and the DBC-P24 results will be obtained at the baseline (t0). Follow up examinations will take place at 12 weeks (t1) and 24 weeks (t2) of treatment. DISCUSSION A limited number of clinical trials have been carried out on children with FXS, but more are necessary as current treatment possibilities are insufficient and often provoke side effects. In the present study, we sought to overcome possible methodological problems by conducting a phase II pilot study in order to calculate the relevant statistical parameters and determine the safety of the proposed treatment. The results will provide evidence to improve hyperactivity control and reduce behavioural and learning problems using ascorbic acid (vitamin C) and α-tocopherol (vitamin E). The study protocol was approved by the Regional Government Committee for Clinical Trials in Andalusia and the Spanish agency for drugs and health products. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT01329770 (29 March 2011).
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En este segundo artículo (véase Coüecianea Botánica, vol. I, n.' 9) se estudian grupos de particular interés; varios de ellos requieren trabajar con material vivo y son menos conocidos que el resto de las algas. Se da cuenta de especies que no fueron citadas anteriormente, de rectificaciones y de diversos datos sobre especies ya mencionadas en nuestra flora. Varias formas, posiblemente especies nuevas, que no han podido ser completamente estudiadas, son también tenidas en consideración. Numerosas nuevas citas de las especies menos raras se encontrarán en otro trabajo: sobre la vegetación, todavía no publicado.
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UANL