Computer aided geometric design of form-rolls for NC manufacture

Conventional methods of form-roll design and manufacture for Cold Roll-Forming of thin-walled metal sections have been entirely manual, time consuming and prone to errors, resulting in inefficiency and high production costs. With the use of computers, lead time can be significantly improved, particularly for those aspects involving routine but tedious human decisions and actions. This thesis describes the development of computer aided tools for producing form-roll designs for NC manufacture in the CAD/CAM environment. The work was undertaken to modernise the existing activity of a company manufacturing thin-walled sections. The investigated areas of the activity, including the design and drafting of the finished section, the flower patterns, the 10 to 1 templates, and the rolls complete with pinch-difference surfaces, side-rolls and extension-contours, have been successfully computerised by software development . Data generated by the developed software can be further processed for roll manufacturing using NC lathes. The software has been specially designed for portability to facilitate its implementation on different computers. The Opening-Radii method of forming was introduced as a subsitute to the conventional method for better forming. Most of the essential aspects in roll design have been successfully incorporated in the software. With computerisation, extensive standardisation in existing roll design practices and the use of more reliable and scientifically-based methods have been achieved. Satisfactory and beneficial results have also been obtained by the company in using the software through a terminal linked to the University by a GPO line. Both lead time and productivity in roll design and manufacture have been significantly improved. It is therefore concluded that computerisation in the design of form-rolls for automation by software development is viable. The work also demonstrated the promising nature of the CAD/CAM approach.

N-terminal His7-modification of glucagon-like peptide-1(7-36) amide generates dipeptidyl peptidase IV-stable analogues with potent antihyperglycaemic activity

Glucagon-like peptide-1(7-36)amide (GLP-1) possesses several unique and beneficial effects for the potential treatment of type 2 diabetes. However, the rapid inactivation of GLP-1 by dipeptidyl peptidase IV (DPP IV) results in a short half-life in vivo (less than 2 min) hindering therapeutic development. In the present study, a novel His7-modified analogue of GLP-1, N-pyroglutamyl-GLP-1 as well as N-acetyl-GLP-1 were synthesised and tested for DPP IV stability and biological activity. Incubation of GLP-1 with either DPP IV or human plasma resulted in rapid degradation of native GLP-1 to GLP-1(9-36)amide, while N-acetyl-GLP-1 and N-pyroglutamyl-GLP-1 were completely resistant to degradation. N-acetyl-GLP-1 and N-pyroglutamyl-GLP-1 bound to the GLP-1 receptor but had reduced affinities (IC50 values 32.9 and 6.7 nM, respectively) compared with native GLP-1 (IC50-37 nM). Similarly, both analogues stimulated cAMP production with EC50 values of 16.3 and 27 nM respectively compared with GLP-1 (EC50 4.7 nM). However, N-acetyl-GLP-1 and N-pyroglutamyl-GLP-1 exhibited potent insulinotropic activity in vitro at 5.6 mM glucose (P< 0.05 to P< 0.001) similar to native GLP-1. Both analogues (25 nM/kg body weight) lowered plasma glucose and increased plasma insulin levels when administered in conjunction with glucose (18 nM/kg body weight) to adult obese diabetic (ob/ob) mice. N-pyroglutamyl-GLP-1 was substantially better at lowering plasma glucose compared with the native peptide, while N-acetyl-GLP-1 was significantly more potent at stimulating insulin secretion. These studies indicate that N-terminal modification of GLP-1 results in DPP IV-resistant and biologically potent forms of GLP-1. The particularly powerful antihyperglycaemic action of N-pyroglutamyl-GLP-1 shows potential for the treatment of type 2 diabetes. © 2004 Society for Endocrinology.

Clinical utility of implantable neurostimulation devices as adjunctive treatment of uncontrolled seizures

About one third of patients with epilepsy are refractory to medical treatment. For these patients, alternative treatment options include implantable neurostimulation devices such as vagus nerve stimulation (VNS), deep brain stimulation (DBS), and responsive neurostimulation systems (RNS). We conducted a systematic literature review to assess the available evidence on the clinical efficacy of these devices in patients with refractory epilepsy across their lifespan. VNS has the largest evidence base, and numerous randomized controlled trials and open-label studies support its use in the treatment of refractory epilepsy. It was approved by the US Food and Drug Administration in 1997 for treatment of partial seizures, but has also shown significant benefit in the treatment of generalized seizures. Results in adult populations have been more encouraging than in pediatric populations, where more studies are required. VNS is considered a safe and well-tolerated treatment, and serious side effects are rare. DBS is a well-established treatment for several movement disorders, and has a small evidence base for treatment of refractory epilepsy. Stimulation of the anterior nucleus of the thalamus has shown the most encouraging results, where significant decreases in seizure frequency were reported. Other potential targets include the centromedian thalamic nucleus, hippocampus, cerebellum, and basal ganglia structures. Preliminary results on RNS, new-generation implantable neurostimulation devices which stimulate brain structures only when epileptic activity is detected, are encouraging. Overall, implantable neurostimulation devices appear to be a safe and beneficial treatment option for patients in whom medical treatment has failed to adequately control their epilepsy. Further large-scale randomized controlled trials are required to provide a sufficient evidence base for the inclusion of DBS and RNS in clinical guidelines.

A cidadania no contexto do estado constitucional democrático de direito brasileiro

The citizenship is a fundamental category to the democratic progress and the development and concretization of human rights, in addition to being one of the essential foundations of democratic contextualized in the rule of law of the Federative Republic of Brazil. That’s exactly why the discussion about its concept and content is a paramount requirement to the understanding and interpretation-application-concretization of the Federal Constitution of 1988, as well as its democracy, since there is no democracy without citizenship. That is why the general objective of the research is to determine the characteristics of the citizenship, relating it to the Law, as well as to discuss (critically) its inclusion in the list of fundamental rights and delimitate the scope of protection and the limits of this right, in the context of Brazilian law post-1988 Constitution. The specific objectives are: a) to analyze the concept of citizenship, its extent and scope, contextualizing it historically; b) to examine the evolution of the legal and regulatory treatment of the citizenship in Brazilian constitutions, focusing on the 1988 Constitution; c) assess whether citizenship can be considered a fundamental right; d) to investigate which implications, theoretical and practical, of assignment fundamentality character to the right to citizenship. This research identifies and deconstructs current conceptual confusions, such as the lack of distinction between citizenship and nationality; citizenship and electoral capacity; citizenship and person. It also helps to identify and oppose the generalizations, as well as the excessively abstract associations which tend to purely metaphysical understandings, fluid and empty of any content. The main virtue, however, is the proposed of understanding of the citizenship as a fundamental right and the examination of the relationship between citizenship and human dignity. In this context, citizenship appears as a corollary of human dignity and it goes beyond. This (human dignity) requires equality, non-arbitraries, non-excessive, disproportionate or unreasonable impositions affecting their freedom rights, and, yet, doesn’t affect a minimum core of possibilities of have to a decent life, in conditions of freedom and self-conformation involved in the necessary consideration of the individual as a subject. All of this requires a decision-making process, molded by the citizenship, which reaches the entire development process of possible state interventions, to ensure the person as a subject, the right holder and the objective point of reference of the juridical relations. Thus, the citizenship represents a substantial and beneficial addition to the human dignity, since the emancipated citizen is a person, formally and materially, qualified, to be able to build their own and collectively organized history, to participate effectively in the making processes decision juridical and social

Crescimento inicial e morfologia foliar em plantas de Mimosa caesalpiniaefolia Benth. Em função do manejo microbiano, sob estresse salino

The sabiá (Mimosa caesalpiniaefolia Benth.) is an endemic species of the Caatinga biome, considered tolerant to salt and water stress. The process of salinization of soil and groundwater and surface water is one of the most important problems of environmental degradation, with its harmful effects being more pronounced in the areas of arid and semiarid regions, and rapidly growing in many parts of the globe, causing problems of the major crop yield. Organic conditioners as barnyard manure, and rice hulls can contribute to reducing the PST, possibly due to the release of CO2 and the production of organic acids during the decomposition of organic matter, and act as sources of calcium and magnesium and inhibit the availability sodium. The intimate association of mycorrhizae and beneficial to plants results in increased uptake of water and nutrients by plants, especially phosphorus, due to their low mobility in soil. The objective of this study was to evaluate the initial growth of thrush seedlings under inoculation with mycorrhizal fungi and fertilized with manure corral and irrigated with water of different salinity levels. The experiment was conducted in greenhouse conditions of vegetation on the premises of the Agricultural School of Jundiaí - UFRN, Campus Macaíba. The adopted statistical design was randomized composed of twelve treatments - three substrates (sterile soil, manure and FMA), four salinity levels (0.2, 1.5, 3.0 and 4.5 dS m-1 ) and five repetitions, totaling sixty experimental units. The results indicate that inoculation with mycorrhizal fungi own contributions to the growth of plants, especially in roots and shoots, which suggests that its application is beneficial in establishing thrush plants in natural conditions, with poor soil in P. Levels salinity caused no effects with statistical significance in plant development, indicating Sabia resistance to it.

Experimental Study on Key Generation for Physical Layer Security in Wireless Communications

This paper presents a thorough experimental study on key generation principles, i.e. temporal variation, channel reciprocity, and spatial decorrelation, via a testbed constructed by using wireless open-access research platform (WARP). It is the first comprehensive study through (i) carrying out a number of experiments in different multipath environments, including an anechoic chamber, a reverberation chamber and an indoor office environment, which represents little, rich, and moderate multipath, respectively; (ii) considering static, object moving, and mobile scenarios in these environments, which represents different levels of channel dynamicity; (iii) studying two most popular channel parameters, i.e., channel state information and received signal strength. Through results collected from over a hundred tests, this paper offers insights to the design of a secure and efficient key generation system. We show that multipath is essential and beneficial for key generation as it increases the channel randomness. We also find that the movement of users/objects can help introduce temporal variation/randomness and help users reach an agreement on the keys. This paper complements existing research by experiments constructed by a new hardware platform.

Knowledge Exchange Institutional Repository Workshop

The workshop took place on 16-17 January in Utrecht, with Seventy experts from eight European countries in attendance. The workshop was structured in six sessions: usage statistics research paper metadata exchanging information author identification Open Archives Initiative eTheses Following the workshop, the discussion groups were asked to continue their collaboration and to produce a report for circulation to all participants. The results can be downloaded below. The recommendations contained in the reports above have been reviewed by the Knowledge Exchange partner organisations and formed the basis for new proposals and the next steps in Knowledge Exchange work with institutional repositories. Institutional Repository Workshop - Next steps During April and May 2007 Knowledge Exchange had expert reviewers from the partner organisations go though the workshop strand reports and make their recommendations about the best way to move forward, to set priorities, and find possibilities for furthering the institutional repository cause. The KE partner representatives reviewed the reviews and consulted with their partner organisation management to get an indication of support and funding for the latest ideas and proposals, as follows: Pragmatic interoperability During a review meeting at JISC offices in London on 31 May, the expert reviewers and the KE partner representatives agreed that ‘pragmatic interoperability' is the primary area of interest. It was also agreed that the most relevant and beneficial choice for a Knowledge Exchange approach would be to aim for CRIS-OAR interoperability as a step towards integrated services. Within this context, interlinked joint projects could be undertaken by the partner organisations regarding the areas that most interested them. Interlinked projects The proposed Knowledge Exchange activities involve interlinked joint projects on metadata, persistent author identifiers, and eTheses which are intended to connect to and build on projects such as ISPI, Jisc NAMES and the Digital Author Identifier (DAI) developed by SURF. It is important to stress that the projects are not intended to overlap, but rather to supplement the DRIVER 2 (EU project) approaches. Focus on CRIS and OAR It is believed that the focus on practical interoperability between Current Research Information Systems and Open Access Repository systems will be of genuine benefit to research scientists, research administrators and librarian communities in the Knowledge Exchange countries; accommodating the specific needs of each group. Timing June 2007: Write the draft proposal by KE Working Group members July 2007: Final proposal to be sent to partner organisations by KE Group August 2007: Decision by Knowledge Exchange partner organisations.

Distribuição espaço-temporal e dieta de Lontra longicaudis (Carnivora: mustelidae) em região costeira do sul do RS

A lontra-neotropical (Lontra longicaudis) é um carnívoro semi-aquático, com adaptações morfológicas para viver nos mais diversos habitats aquáticos, como rios, lagos, mangues e estuários. Além disso, também é encontrada em ambientes marinhos, onde se alimenta, ou apenas transita. São carnívoros que se alimentam principalmente de peixes e crustáceos. O objetivo desde trabalho foi verificar a utilização de ambientes de influência do mar, por L. longicaudis, no litoral sul do RS. A área de estudo foi a Praia do Cassino, onde foram percorridos seis cursos d’água (sangradouros), por cerca de 1 km em cada, à procura de fezes de lontras, entre dezembro de 2009 e novembro de 2010. As fezes foram analisadas para determinar a distribuição espaço-temporal e a dieta das lontras. Foram encontradas 75 fezes de lontras, sendo a maior quantidade no inverno e outono, diminuindo na primavera e verão. As maiores quantidades de fezes foram encontradas nos sangradouros R7 e R9, por estes serem mais extensos e profundos. As menores quantidades de fezes nos sangradouros R4, R8 e R10 se deve ao fato de estes serem menores e menos profundos. Os peixes foram as principais presas das lontras, seguidos pelos crustáceos, anfíbios, moluscos, insetos, aves e mamíferos. Os peixes foram mais predados na maior parte das estações, exceto no outono, quando os crustáceos predominaram. No inverno, os anfíbios predominaram sobre os crustáceos, sendo o segundo grupo mais predado. Os peixes mais consumidos foram Perciformes e Siluriformes. Foi verificado que as lontras utilizam os sangradouros da Praia do Cassino, mesmo estes não possuindo vegetação e substrato mais favoráveis à espécie. A maior utilização dos ambientes durante o inverno provavelmente se deve ao fato de neste período os sangradouros estarem mais profundos. A dieta das lontras variou ao longo do ano, possivelmente conforme a disponibilidade das presas.

Pesquisa de proteínas citotóxicas e nematicidas em isolados Bacillus thuringiensis dos Açores

Dissertação de Mestrado, Ciências Biomédicas, 25 de Maio de 2016, Universidade dos Açores.

INCORPORATING STIMULATING QUICK-WRITE PROMPTS WITHIN A SECONDARY SCIENCE CLASSROOM: A CASE STUDY IN LESOTHO

The use of intriguing open-ended quick-write prompts within the Basotho science classroom could potentially provide a way for secondary teachers in Lesotho to have a time-efficient alternative to stimulate student thinking and increase critical thinking or application of scientific principles. Writing can be used as a powerful means to improve the achievement of students across many subject areas, including the sciences (Moore, 1993; Rivard, 1994; Rillero, Zambo, Cleland, and Ryan, 1996; Greenstein, 2013). This study focuses on the use of a non-traditional nor extensively studied writing method that could potentially support learning in science. A quasi-experimental research design, with a control and experimental group, was applied. The study was conducted at two schools, with one experimental classroom in one school and a second control group classroom in the second school for a period of 4 weeks. 51 Form B (US Grade 9 equivalent) students participated as the experimental group and 43 Form B students as the control group. In an effort to assess learning achievement, a 1 hour (35 mark) pre-test evaluation was made by and given to students by Basotho teachers at the beginning of this study to have an idea of student’s previous knowledge. Topics covered were Static Electricity, Current Electricity, Electromagnetic Waves, and Chemistry of Water. After the experimental trial period, an almost completely identical post-test evaluation was given to students in the same fashion to observe and compare gains in achievement. Test data was analyzed using an inferential statistics procedure that compared means and gains in knowledge made by the experimental and control groups. Difference between the gains of mean pre-test and post-test scores were statistically significant within each group, but were not statistically significant when the control and experimental groups were compared. Therefore, there was no clear practical effect. Qualitative data from teachers’ journals and students’ written feedback provides insight on the assessments, incorporation of the teaching method, and the development of participating students. Both mid and post-study student feedback shows that students had an overall positive and beneficial experience participating in this activity. Assessments and teacher journals showed areas of strength and weaknesses in student learning and on differences in teaching styles. They also helped support some feedback claims made by students. Areas of further research and improvement of the incorporation of this teaching method in the Basotho secondary science classroom are explored.

Projeto de intervenção em adolescentes com ansiedade em contexto de ambulatório

A adolescência é uma fase de transição, pautada de inúmeras alterações físicas, mentais e sociais. Diversos fatores influenciam a construção da identidade, podendo provocar reações de ansiedades. Estas podem transtornar o percurso do jovem, impedindo-o de tomar decisões eficazes, adequadas e benéficas. É importante saber identificar sintomas e controlá-los nos momentos em que podem ser prejudiciais. Para promover um desenvolvimento salutar, dotar os adolescentes de instrumentos que os ajudem a gerir a ansiedade, pode ser uma resposta. Este relatório descreve um percurso em ensino clínico, numa unidade de pedopsiquiatria, onde foram implementadas intervenções de enfermagem a adolescentes que apresentaram sinais e/ou sintomas de ansiedade. Visou trabalhar atitudes como, assertividade, autoconhecimento e capacidade de reflexão, e fornecer ferramentas como, técnicas de relaxamento e atividade física, demonstrando que é possível controlar a ansiedade e consequentemente apresentar comportamentos mais adequados e vantajosos; ABSTRACT: INTERVENTION PROJECT IN ADOLESCENTS WITH ANXIETY IN OUTPATIENT CONTEXT Adolescence is a transitional stage, guided with several physical, mental and social changes. The construction of identity is influenced by several factors which can cause anxiety reactions. These can cause disorders on their path, preventing it from taking effective, appropriate and beneficial decisions. It is important to identify symptoms and control them at moments that can be harmful. The answer may be, promote a healthy development by providing to adolescents tools to help them manage anxiety. This report describes a path in a clinical training, in a child and adolescent’s psychiatry unit, where nursing interventions were implemented to adolescents who present signs and/or symptoms of anxiety. It aimed to work attitudes such as assertiveness, self-awareness and reflection, and provide them tools as relaxation techniques and physical activity, showing that it is possible to control anxiety and consequently, obtain a more appropriate and beneficial behavior.

Injurious insects and diseases of plants with remedial measures for the same /

"New series" vol. II, no. 1.

Considerations relating to the laying any additional duty on sugar from the British plantations; wherein is shewn, that such duty will be injurious to the commerce and navigation of this kingdom, ruinous to our sugar colonies, beneficial to those of France, and insufficient for the purposes intended.

Earlier eds. issued under titles: Considerations against laying any new duty upon sugar and Considerations relating to a new duty upon sugar.

First [-ninth] annual report on the noxious, beneficial and other insects, of the state of Missouri : made to the State board of agriculture, pursuant to an appropriation for this purpose from the Legislature of the state /

Detached: General index and supplement to the nine reports of the insects of Missouri.

Notes on the injurious scale insects and mealy bugs of Egypt;

Mode of access: Internet.