Avaliação dos efeitos promovidos pela sibutramina, associadas ou não à nicotina, nos tecidos reprodutivos de ratas albinas

Sibutramine is a drug recommended clinically for the treatment of obesity, but there are women that use the drug for maintenance of body weight. Many time this use occur associate to habit of tabagism, being the nicotine the main toxic compound in the cigarette. The goal of study was to evaluate the side effects promoted by sibutramine, associated or not to nicotine, in the reproductive tissue of adult female rats. Wistar animals (n = 30), were distributed in the groups: a) Control A (0.3 mL of distilled water; oral); b) Sibutramine (15 mg/kg of body weight; oral); c) Control B (0.3 mL of saline solution; intraperitoneal); d) Nicotine (4.0 mg/kg of body weight; intraperitoneal); e) sibutramine + nicotine. The treatments were conducted during 30 consecutive days (single dose, daily). Sibutramine, associated or not to nicotine, affected the folliculogenesis and luteogenesis. There were significant alterations (p<0.05) in the thickness of uterine layers, considerate each treatment. In conclusion, the administration isolated of sibutramine or nicotine promoted deleterious effects in the reproductive tissues of female rats and these effects were potential in the group that received both drugs.

Estudo da aplicabilidade do sistema pultrudado de fenólica/fibras de carbono em cabos condutores

Pós-graduação em Engenharia Mecânica - FEG

O ativismo judicial em investida ao Estado democrático

Pós-graduação em Direito - FCHS

Clareamento para dentes despolpados: revisão de literatura e considerações

The esthetics of the teeth is not a privilege of our days, because concerns in that effect have been reported since 1860. Faced with an endodontically treated tooth that presents any type of color change, professionals can use intracoronary bleaching, which is more conservative attempt to restore the normal color of teeth. Bleaching aims to remove pigments by oxidizing agents and for that, various techniques were developed. Among the risks of tooth whitening the external resorption is the most severe, which occurs when the whitening penetrates through the dentin tubules to the periodontal ligament and initiates an inflammatory response. To prevent external resorption is required to place an intracoronal bleaching barrier. It is important to know the time between the bleaching treatment for restoring procedure for getting a good sealing to prevent microleakage. This study aims to review the literature about the different types of bleaching agents and their risks.

Luteinizing Hormone Receptor (LHR): basic concepts in cattle and other mammals. a review

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Avaliação dos efeitos promovidos pela sibutramina, associada ou não à nicotina, nos tecidos reprodutivos de ratas albinas

Sibutramine is a drug recommended clinically for the treatment of obesity, but there are women that use the drug for maintenance of body weight. Many time this use occur associate to habit of tabagism, being the nicotine the main toxic compound in the cigarette. The goal of study was to evaluate the side effects promoted by sibutramine, associated or not to nicotine, in the reproductive tissue of adult female rats. Wistar animals (n =30), were distributed in the groups: a) Control A (0.3 mL of distilled water; oral); b) Sibutramine (15 mg/kg of body weight; oral); c) Control B (0.3 mL of saline solution; intraperitoneal); d) Nicotine (4.0 mg/kg of body weight; intraperitoneal); e) sibutramine + nicotine. The treatments were conducted during 30 consecutive days (single dose, daily). Sibutramine, associated or not to nicotine, affected the folliculogenesis and luteogenesis. There were significant alterations (p<0.05) in the thickness of uterine layers, considerate each treatment. In conclusion, the administration isolated of sibutramine or nicotine promoted deleterious effects in the reproductive tissues of female rats and these effects were potential in the group that received both drugs.

Desencantamento do mundo e ética na ação pedagógica: reflexões a partir de Max Weber

This article has a theoretical character and presents some of Weber's ideas, with emphasis on those that can supply elements to reflect on the current state of education, more particularly based on his understanding of modernity. Disenchantment of the world is the key concept in his sociology, and is taken as the basis for a reflection about the meaning that science and the teacher can have today. A classic author, Weber's interpretation of the modern world brings to our consideration a variety of themes that influence markedly the thinking and practice of contemporary culture by its concern with understanding human actions and values. By studying the Western process of rationalization, he initiates debates in science, in ethics and, correspondingly, in education, allowing us to expand our comprehension of the meaning, significance, and role of our actions towards knowledge and teaching. The main object of education is to offer students contents that stimulate the freedom of thought. For that, the teacher needs to adopt a non-partisan ethics in the classroom, presenting contents unbiased by her/his political opinions and, if failing to do so, having the honesty to explain what she/he is doing. It is therefore of the utmost importance that the teacher should keep a neutral position, so that in and out of the classroom the students may reflect and question what they see, experiment and decide upon. Only then the conduct of the teacher will be consistent with the process of rationalization of our culture.

Aspectos da linguagem e do espetáculo cinematográficos na narrativa literária brasileira do século XX

Pós-graduação em Letras - IBILCE

Effect of sequential medium with fibroblast growth factor-10 and follicle stimulating hormone on in vitro development of goat preantral follicles

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Oogenesis in Laetacara araguaiae (Ottoni and Costa, 2009) (Labriformes: Cichlidae)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Controle do crescimento e da seleção folicular por fatores locais e sistêmicos na espécie bovina

The regulation of ovarian activity is an integrated process involving extraovarian signals and intrafollicular factors. In such process, gonadotropins have an important role, but not always crucial. The initiation of primordial follicle growth and the early stages of folliculogenesis can occur without gonadotropins, however FSH may affect the rate of preantral follicle growth. On the other hand, the antral follicle development from 1 to 4 mm in diameter is completely gonadotropin-dependent in bovine, and the alternation of dependency from FSH to LH may be part of the mechanism involved in follicular selection. Locally produced growth factors, such as the IGF system, work in association with gonadotropins throughout the follicular growth and can influence follicular selection. Thus, the integration of these extraovarian signals and intrafollicular factors seems to determine whether a follicle will continue to develop or go atretic. This review focuses on the interaction between gonadotropins and intrafollicular factors in follicular development and selection in cattle.

Reconhecimento da perda de eficácia de protetor intra-auricular

Among the harmful health agents, it is given to the noise, one of the most present in urban and social environments. There are efficient measures to control the noise and the auricular Individual Protection Equipment (IPEa) is the most used. It has been observed the shortage in the comfortable and functional individual auditory protection products, related to durability, face to the efficiency right of the equipment. The main objective of this study was to recognize if there is effectiveness loss toward the used time on the Auditory Equipment, intra-auricular Individual Protection, of foam (3M), model 1110. It has been verified that the equipments suffer efficiency alteration according to the time of use, and the material consuming initiates reliable loss, mainly in audible frequencies going up to 100Hz, and from 16 days for sonorous pressure suffered started in 101dB 20Hz. For sonorous pressure suffered from 107dB to 20Hz, the reliable loss for the usage was of 8 days. The IPEas do not lose effectiveness on important attenuation by the daily use in frequencies from 1KHz until 20KHz. It has been concluded that there is effectiveness loss, according to the daily and frequent use of the IPEa studied.

Origami científico: a linguagem das dobraduras dentro do design contemporâneo

After crossing several generations and countries, broader functions are being incorporated to origami than simply making art objects: the fold initiates a series of new buildings within the design and creation. Under the new repre- sentations and performances that the art of paper folding keeps, this article aims to investigate how the origami is configured nowadays and how it behaves while contemporary language applied to projective processes of diverse natures. To better understand the actual origami, relations are used inside branch of math, conceptual and projectual. Relating theorists, artists, designers, etc., can point out the relevance of each of these areas in the configuration of cientific and projectual origami. The modularity, the collective, the conscious build, the contemporary and the inno- vation are relationships intrinsic to the praxis projectual that shape a landscape adjacent and subordinate to the main structure governing. It bets on the essence of origami as a tangible functionality for creative thinking.

Morfologia do útero e ovários de Artibeus planirostris (Phyllostomidae: Chiroptera) durante as fases do ciclo reprodutivo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Principais mecanismos envolvidos na maturação oocitária em bovinos: da oogenese a maturação in vitro

Despite the efforts made to improve the production of bovine embryos in vitro, their efficiency is still low, since only 30-40% of developed blastocysts are obtained from oocytes after in vitro maturation (IVM), fertilization and cultured embryos. Assisted reproductive technologies have a limiting impact due a lack of oocytes capable to fertilization.The comprehension of mechanism involved in oocyte maturation are crucial to establish a culture system that allows a larger number production of good quality embryos. The study of the early stages of oocyte and follicle development in vivo is important for a better understanding of the molecular pathways that regulate oogenesis, folliculogenesis and oocyte maturation. Thus the physiological biochemical and molecular mechanisms involved in maturation may contribute to the increased efficiency of in vitro embryo production. Therefore, the aim of this literature review is to understand the basic mechanisms that underlie oocyte maturation in cattle, since oocyte and follicle cells in vivo formation to its use in the in vitro environment.