Polybrominated diphenyl ether (PBDE) exposure in North Americans: Cause for concern?

Polybrominated diphenyl ethers (PBDEs) are brominated flame retardants (BFRs) that have been widely produced and used as flame retardants since the 1970’s in many consumer products such as carpet and drape linings, plastics used in electronics, computer and television casings and polyurethane foam used in chairs, sofas and mattresses. PBDEs are persistent organic pollutants (POPs), which, by definition, are toxic in nature, persistent in the environment and accumulative in living organisms. Animal studies have found PBDEs to cause health defects such as fetal malformations, delayed onset of puberty, decreased sperm count, behavioral changes, permanent learning and memory impairment, endocrine disruption, as well as cancer at high doses. Recent research involving humans reported that elevated breast milk PBDEs levels in their mothers are associated with cryptorchidism (absence of one or both testes from the scrotum) in newborn boys and adverse birth outcomes as well as elevated serum PBDE levels in mothers are associated with low sperm count in young men. There are three commonly manufactured PBDE commercial mixtures: Penta-, Octa-, and Deca-BDEs. Two of them (Octa- and Penta-BDEs) have been banned by the European Union and are being voluntarily phased out in the United States. However, Deca continues to be manufactured, used, and imported in the United States. This MPH thesis consists of a literature review of peer reviewed scientific articles concerned with PBDEs in the environment and in humans, as well as a discussion concerning different routes of exposure to PBDEs and their blood, milk and tissue levels as surrogates for body burdens in North Americans and in people from other countries. Results of this literature review shows PBDE levels in human blood, milk and tissues are higher in North Americans than people from other countries worldwide. To date, the highest level of PBDEs was found in a toddler’s blood in a California study. Despite the fact that PBDEs are associated with adverse health effects, and highest levels of PBDEs in North Americans, Deca-BDE is still manufactured, used and imported in the United States. There is an urgent need of new federal regulatory policy to ban completely the production, importation and use of all commercial mixtures of PBDEs.^

La homogeneidad varietal en viveros de olivo estudiada con marcadores moleculares

La difusión de variedades tradicionales de olivo (Olea europea L.) y la obtención de nuevas variantes fenotípicas han generado confusión en la correcta identificación y denominación de algunas de las aprox. 2 000 variedades conocidas a nivel mundial. En la Argentina, en los últimos años se ha triplicado la superficie implantada con olivo principalmente a partir de plantas de viveros locales e importadas. Con el fin de evaluar la homogeneidad genotípica del material comercializado en Mendoza, se probaron 7 marcadores RAPD altamente reproducibles en muestras de 5 viveros, correspondientes a 5 variedades de olivo. Los marcadores RAPD fueron previamente desarrollados para caracterizar las variedades del INTA Junín. Arbequina y Arauco fueron los materiales más homogéneos. En ambas variedades, todos los individuos compartieron el 100 % de los marcadores utilizados. Los lotes de muestras de Empeltre, Farga y Aloreña no fueron genotípicamente homogéneos, observándose 2-3 patrones diferentes por lote. Todas las variedades ensayadas -en alguna de sus muestras- tuvieron diferencias con su respectiva variedad del INTA Junín. Arbequina y Arauco también compartieron el 100 % de marcadores entre sí, no pudiéndose separar ambos grupos.

Strontium and oxygen isotope data for DSDP Hole 44-390A and ODP Leg 171 holes

Differences in regional responses to climate fluctuations are well documented on short time scales (e.g., El Niño-Southern Oscillation), but with the exception of latitudinal temperature gradients, regional patterns are seldom considered in discussions of ancient greenhouse climates. Contrary to the expectation of global warming or global cooling implicit in most treatments of climate evolution over millions of years, this paper shows that the North Atlantic warmed by as much as 6°C (1.5% decrease in d18O values of planktic foraminifera) during the Maastrichtian global cooling interval. We suggest that warming was the result of the importation of heat from the South Atlantic. Decreasing North Atlantic d18O values are also associated with increasing gradients in planktic d13C values, suggesting increasing surface-water stratification and a correlated strengthening of the North Atlantic Polar Front. If correct, this conclusion predicts arctic cooling during the late Maastrichtian. Beyond implications for the Maastrichtian, these data demonstrate that climate does not behave as if there is a simple global thermostat, even on geologic time scales.

Paleotemperature reconstructions from high Late Jurassic paleolatitudes

Oxygen and carbon isotopes have been determined from Late Jurassic (Oxfordian-Tithonian) belemnites and inoceramid bivalves from two Deep Sea Drilling Project (DSDP) sites located on the Falkland Plateau. Mean belemnite delta18O values, derived from well preserved skeletal material, were -1.29? from DSDP site 330 and -1.45? from DSDP site 511. Assuming a seawater SMOW value of -1.0?, mean palaeotemperatures calculated from the oxygen isotopic composition are 17.2°C and 17.9°C, respectively. The inoceramid bivalves yielded much lighter delta18O values (mean -3.58?). Petrographic and geochemical evidence points to the inoceramid bivalves being altered by diagenesis which accordingly accounts for the observed differences in isotopic values. "Vital effects" or the importation of belemnites or inocerarnids from another area, are considered not to account for the observed isotopic trends. The palaeotemperatures interpreted from the belemnites are significantly warmer than other recent estimates of Late Jurassic temperature (from oxygen isotope studies and climate model predictions) from similar southern palaeolatitudes. We suspect our apparent warmer temperatures are because of a combination of increased freshwater runoff depleting surface waters with respect to delta18O and related to the semi-enclosed nature of the depositional basin retaining warmth, relative to the open ocean of similar latitudes.

Cell-cell communication regulates the effects of protein aspartate phosphatases on the phosphorelay controlling development in Bacillus subtilis.

Rap phosphatases are a recently discovered family of protein aspartate phosphatases that dephosphorylate the Spo0F--P intermediate of the phosphorelay, thus preventing sporulation of Bacillus subtilis. They are regulators induced by physiological processes that are antithetical to sporulation. The RapA phosphatase is induced by the ComP-ComA two-component signal transduction system responsible for initiating competence. RapA phosphatase activity was found to be controlled by a small protein, PhrA, encoded on the same transcript as RapA. PhrA resembles secreted proteins and the evidence suggests that it is cleaved by signal peptidase I and a 19-residue C-terminal domain is secreted from the cell. The sporulation deficiency caused by the uncontrolled RapA activity of a phrA mutant can be complemented by synthetic peptides comprising the last six or more of the C-terminal residues of PhrA. Whether the peptide controls RapA activity directly or by regulating its synthesis remains to be determined. Complementation of the phrA mutant can also be obtained in mixed cultures with a wild-type strain, suggesting the peptide may serve as a means of communication between cells. Importation of the secreted peptide required the oligopeptide transport system. The sporulation deficiency of oligopeptide transport mutants can be suppressed by mutating the rapA and rapB genes or by introduction of a spo0F mutation Y13S that renders the protein insensitive to Rap phosphatases. The data indicate that the sporulation deficiency of oligopeptide transport mutants is due to their inability to import the peptides controlling Rap phosphatases.

Controle de cargas conteinerizadas utilizando elementos da cadeia logística segura e do programa brasileiro de Operador Econômico Autorizado (OEA).

O presente trabalho propõe um processo para auxiliar a tarefa de implantação de controles de Cadeia Logística Segura para a importação e exportação de cargas conteinerizadas, transportadas pelo modal rodoviário. Está em consonância com a legislação brasileira atual, no que se refere à Receita Federal do Brasil e demais Órgãos Anuentes. Além disso, inclui, também, as novas diretrizes do Programa Brasileiro de Operador Econômico Autorizado que teve seu início na primeira quinzena de Dezembro de 2014, bem como os aspectos principais do quadro SAFE, da Organização Mundial das Aduanas (OMA) e do programa americano Customs-Trade Partnership Against Terrorism (C-TPAT). O processo proposto no trabalho contempla a instrumentação dos controles e seus principais pontos de integração de dados, estágio em que grande parte dos operadores econômicos atuais se encontra. A proposta justifica-se pela complexidade dos processos de cadeias logísticas, sua importância para o comércio exterior e, portanto, para a economia do país, que exigem um aperfeiçoamento constante para atender à competitividade crescente dos mercados, controlar e gerenciar riscos e incertezas dos tempos da globalização. A metodologia do trabalho de pesquisa constou de estudos sobre o significado de cadeia logística segura, legislações e normatizações existentes, principais tecnologias utilizadas no Brasil e no mundo e suas estratégias de integração de sistemas, com enfoque em alguns projetos de gestão já existentes no país. O porto de Santos foi tomado como campo principal de pesquisa. O trabalho evidenciou a importância da presença de três características fundamentais em um processo de cadeia logística segura: ser instrumentado, integrado e inteligente. Considera-se que, a partir do processo proposto, será possível aumentar o grau de inteligência de uma cadeia logística, de forma a gerenciar e mitigar os potenciais riscos de forma mais racional.

Estudo da qualidade do mel de abelhas sem ferrão por análise por ativação neutrônica instrumental

O Brasil é um dos maiores produtores mundiais de mel, no qual sua produção é baseada principalmente na criação da espécie exótica Apis mellifera. A produção de mel da Apis mellifera é cerca de 10 vezes maior que das espécies de abelhas sem ferrão, contudo, o mel de abelhas nativas possui maior valor comercial. Embora pouco explorado, o mel de abelhas sem ferrão desperta interesse em indústrias de cosméticos e medicinas naturais. A sua produção se apresenta como uma ferramenta com grande potencial para agregar valor econômico aos ecossistemas brasileiros, em especial os florestais, de forma sustentável e com menor potencial de influências de contaminantes traços. A qualidade química do mel é um importante requisito comercial, principalmente o destinado à exportação. Como exemplo, a União Européia em 2006 decidiu suspender a importação do mel produzido no Brasil sob alegação de que o país não possuía equivalência ao bloco quanto as diretrizes para o controle de resíduos e qualidade do produto. Diante do potencial de produção comercial sustentável do mel de abelhas nativas brasileiras e a falta de conhecimento sobre possíveis resíduos encontrados em sua composição, em especial os elementos traços, como objetivo principal deste trabalho pretendeu-se caracterizar a composição de elementos químicos do mel de abelhas sem ferrão, comparar com o de Apis mellifera e verificar as possíveis variações causadas pelo ambiente. Este estudo investigou a composição química dos méis de abelhas sem ferrão de cinco estados brasileiros: Bahia, Minas Gerais, Rio Grande do Norte, Santa Catarina e São Paulo; compreendendo um total de 70 colméias de diferentes espécies: Melipona quadrifasciata, Melipona scutelaris, Melipona mandacaia, Melipona capixaba, Melipona rufiventris, Melipona compressipes, Melipona bicolor, Nannotrigona testaceicornis, Tetragona clavipes, Tetragonisca angustula e Scaptotrigona sp.. Pólen, a principal fonte de minerais para a colméia, e as próprias abelhas foram também coletadas para estudos de composição e correlação com os méis. A análise por ativação neutrônica instrumental permitiu a determinação de Br, Ca, Co, Cs, Fe, La, Na, Rb, Sc e Zn nos méis, Br, Ca, Co, Cs, Fe, K, La, Na, Rb, Sc, Se e Zn nas amostras de pólen e As, Br, Co, Cr, Cs, Fe, K, La, Na, Rb, Sb, Sc, Se e Zn em abelhas. Méis das abelhas da subtribo trigonina apresentaram maiores concentrações dos elementos alcalinos. Alta razão K/Na foram observadas nas amostras de mel e pólen. Pólen se apresentou como uma grande fonte de P e Se. Análises quimiométricas indicaram os méis e abelhas como bons indicadores de atividades antrópicas. Arsênio apareceu nas abelhas coletadas em áreas de maior atividade antrópica. Como resultado, este estudo tem demonstrado o potencial nutracêutico do mel e pólen meliponícola e o potencial das abelhas nativas como ferramentas de avaliação da qualidade ambiental. A proximidade a atividades antrópicas mostrou-se fator decisivo para concentrações mais elevadas de As mas abelhas

WTO law issues of emissions trading

Based on existing research in the interface of emissions trading schemes (ETSs) and WTO law, the paper looks more closely at the design elements of an ETS that are most vulnerable to a WTO challenge, including border adjustment on importation and exportation, recycling of revenues and cross-border linking. The analysis of WTO consistency of various ETS regulatory components reveals significant legal uncertainty. One explanation is that an ETS is not yet fully established as a regulatory tool. It does not have a fixed design and its design elements vary significantly with a scheme. Moreover, ETS-related issues have never been raised in WTO disputes. This makes it hard to predict with confidence the outcome of scrutiny of an ETS by a WTO adjudicative body. In this respect, the availability of environmental and/or health exceptions for justification of ETS-related measures is of great importance.

Summary of the U.S.-Canada free trade agreement.

Item 231-B-1

Probable economic effect redesignation of certain articles from certain countries as eligible for duty-free treatment under the U.S. generalized system of preferences : report to the President on investigation no. 332-284

Mode of access: Internet.

Laws relating to agriculture,

p. 464-536: Bureau of Animal Industry act and amendments; Meat importation act ... Infectious disease of livestock and poultry ... Bang's disease or tubercular cattle.

Our trade with Scandinavia, 1890-1900 /

"The statistics of importation and exportation given in the present bulletin are based on the official returns of trade published annually by the Bureau of Statistics, United States Treasury Department."--P. 7.

Acquisition and management of technology in Malaysian companies

This thesis is about the acquisition and diffusion of imported technology. Writers in the field of technology development in developing countries have always recognised that technical progress depends on the diffusion of imported technology and its applications to the provision of products and processes (Rosemberg, 1982). Despite the massive importation of technology by Malaysian companies, little effort has been made to study and understand the diffusion system in local companies. This study analyses: The problems associated with the acquisition of technology, highlighting the technology strategies adopted by the suppliers of technology; the diffusion pattern and key characteristics of the diffusion process; and major factors affecting the diffusion of technology. The policy implications are examined and the framework to manage the diffusion process within the enterprises is suggested. The findings indicated that the diffusion process is not one of passive acceptance but involves systematic efforts to acquire and diffuse the imported technology. A strong system of diffusion in companies had enabled a rapid diffusion of imported technology resulting in higher levels of technical capability. On the other hand, weakness in the company's diffusion system led to limited diffusion and slow technical progress. Characteristics of diffusion system are analysed and discussed extensively. The thesis attempts to develop the idea of `in-house system of diffusion' associated with the acquisition and development of imported technology. It argues for the development ofa stronger theoretical framework on the diffusion and development of technology particularly in countries like Malaysia which relies extensively on the importation of foreign technology.

Geographic provenancing of unprocessed cotton using elemental analysis and stable isotope ratios

Cotton is the most abundant natural fiber in the world. Many countries are involved in the growing, importation, exportation and production of this commodity. Paper documentation claiming geographic origin is the current method employed at U.S. ports for identifying cotton sources and enforcing tariffs. Because customs documentation can be easily falsified, it is necessary to develop a robust method for authenticating or refuting the source of the cotton commodities. This work presents, for the first time, a comprehensive approach to the chemical characterization of unprocessed cotton in order to provide an independent tool to establish geographic origin. Elemental and stable isotope ratio analysis of unprocessed cotton provides a means to increase the ability to distinguish cotton in addition to any physical and morphological examinations that could be, and are currently performed. Elemental analysis has been conducted using LA-ICP-MS, LA-ICP-OES and LIBS in order to offer a direct comparison of the analytical performance of each technique and determine the utility of each technique for this purpose. Multivariate predictive modeling approaches are used to determine the potential of elemental and stable isotopic information to aide in the geographic provenancing of unprocessed cotton of both domestic and foreign origin. These approaches assess the stability of the profiles to temporal and spatial variation to determine the feasibility of this application. This dissertation also evaluates plasma conditions and ablation processes so as to improve the quality of analytical measurements made using atomic emission spectroscopy techniques. These interactions, in LIBS particularly, are assessed to determine any potential simplification of the instrumental design and method development phases. This is accomplished through the analysis of several matrices representing different physical substrates to determine the potential of adopting universal LIBS parameters for 532 nm and 1064 nm LIBS for some important operating parameters. A novel approach to evaluate both ablation processes and plasma conditions using a single measurement was developed and utilized to determine the "useful ablation efficiency" for different materials. The work presented here demonstrates the potential for an a priori prediction of some probable laser parameters important in analytical LIBS measurement.

Restrição externa, dependência estrutural de commodities primárias e o investimento direto externo no Brasil

As the beginning of the discussion about the reprimarization process of the Brazilian exportations, or about a deindustrialization process of the country foreign sales, this study purpose that the discussion, actually, should be about the existence of the commodities structural dependence as a way to face the foreign restrictions. Therefore the intention is to show that, historically, the way that the Brazilian economy has crossed for its development depends of the foreign capital, mainly in its way of Foreign Direct Investment (FDI), and in the balance generated by the primary products, which make us try to understand the impact of this capital for the equilibrium of the Brazilian Payment Balance and also for the economy. These points were discussed not only based on the Brazilian classic writers as Francisco Oliveira, Caio Prado Jr. and Celso Furtado, but also using the newest studies which contributes to point the causes and consequences of the external capital dependence in the actual scenario. The conclusions acquired in the end of the study, indicates the fact that the Brazilian specialization in products of low aggregated value is not recent. Brazil is, historically, a competitive country in primary products. At the same time, the country importation always was a pressure factor of the National Payments Balance, being composed by products with more aggregated value. According to some authors, this characteristic of the Brazilian Economy will be surpassed with the economic opening process, which will attract external capital making possible the modernization of the Brazilian productive sector. Therefore, we can claim that the FDI, in the way it has been inserted in the country, does not offer the opportunity to get out of the commodities dependence, as generators of the payment balances, because the country international competitive standard didn t get any important changes, keeping itself out of the step related to the global standard which has been intensified in products with more aggregated value. The changes in the national insertion standard directed to more technological products is really important to surpass the historical scenario of commodities dependence, making the country less vulnerable to external crisis.