Protein restriction inhibits gastric cell proliferation during rat postnatal growth in parallel to ghrelin changes

Objective: Gastric development depends directly on the proliferation and differentiation of epithelial cells, and these processes are controlled by multiple elements, such as diet, hormones, and growth factors. Protein restriction affects gastrointestinal functions, but its effects on gastric growth are not fully understood. Methods: The present study evaluated cell proliferation in the gastric epithelia of rats subjected to protein restriction since gestation. Because ghrelin is increasingly expressed from the fetal to the weaning stages and might be part of growth regulation, its distribution in the stomach of rats was investigated at 14, 30, and 50 d old. Results: Although the protein restriction at 8% increased the intake of food and body weight, the body mass was lower (P < 0.05). The stomach and intestine were also smaller but increased proportionately throughout treatment. Cell proliferation was estimated through DNA synthesis and metaphase indices, and lower rates (P < 0.05) were detected at the different ages. The inhibition was concomitant with a larger number of ghrelin-immunolabeled cells at 30 and 50 d postnatally. Conclusion: Protein restriction impairs cell proliferation in the gastric epithelium, and a ghrelin upsurge under this condition is parallel to lower gastric and body growth rates. (C) 2012 Elsevier Inc. All rights reserved.

Entrevista radiofónica sobre la incorporación de las tesis de Acceda en Open Access Theses and Dissertations (OATD)

Entrevista realizada a María del Carmen Martín Marichal, directora de la Biblioteca Universitaria de la ULPGC, por la periodista Teresa Cárdenes en el programa de radio Teresa a las 8. La entrevista versa sobre la incorporación de las tesis de Acceda en Open Access Theses and Dissertations (OATD), también sobre los distintos servicios qu se ofrecen a los usuarios de la Biblioteca.

No association of the neuropeptide Y (Leu7Pro) and ghrelin gene (Arg51Gln, Leu72Met, Gln90Leu) single nucleotide polymorphisms with eating disorders

Genetic factors likely contribute to the biological vulnerability of eating disorders.

Towards optimal treatment with growth hormone in short children and adolescents: evidence and theses

Treatment with growth hormone (GH) has become standard practice for replacement in GH-deficient children or pharmacotherapy in a variety of disorders with short stature. However, even today, the reported adult heights achieved often remain below the normal range. In addition, the treatment is expensive and may be associated with long-term risks. Thus, a discussion of the factors relevant for achieving an optimal individual outcome in terms of growth, costs, and risks is required. In the present review, the heterogenous approaches of treatment with GH are discussed, considering the parameters available for an evaluation of the short- and long-term outcomes at different stages of treatment. This discourse introduces the potential of the newly emerging prediction algorithms in comparison to other more conventional approaches for the planning and evaluation of the response to GH. In rare disorders such as those with short stature, treatment decisions cannot easily be deduced from personal experience. An interactive approach utilizing the derived experience from large cohorts for the evaluation of the individual patient and the required decision-making may facilitate the use of GH. Such an approach should also lead to avoiding unnecessary long-term treatment in unresponsive individuals.

Reduction in total plasma ghrelin levels following catecholamine depletion: relation to bulimic and depressive symptoms

There is increasing preclinical and clinical evidence of the important role played by the gastric peptide hormone ghrelin in the pathogenesis of symptoms of depression and eating disorders. To investigate the role of ghrelin and its considered counterpart, peptide tyrosine tyrosine (PYY), in the development of bulimic and depressive symptoms induced by catecholamine depletion, we administered the tyrosine hydroxylase inhibitor alpha-methyl-paratyrosine (AMPT) in a randomized, double-blind, placebo-controlled crossover, single-site experimental trial to 29 healthy controls and 20 subjects with fully recovered bulimia nervosa (rBN). We found a decrease between peprandial and postprandial plasma ghrelin levels (p < 0.0001) and a postprandial rise in plasma PYY levels (p < 0.0001) in both conditions in the entire study population. Plasma ghrelin levels decreased in the entire study population after treatment with AMPT compared to placebo (p < 0.006). AMPT-induced changes in plasma ghrelin levels were negatively correlated with AMPT-induced depressive symptoms (p < 0.004). Plasma ghrelin and plasma PYY levels were also negatively correlated (p < 0.05). We did not observe a difference in ghrelin or PYY response to catecholamine depletion between rBN subjects and healthy controls, and there was no correlation between plasma ghrelin and PYY levels and bulimic symptoms induced by catecholamine depletion. These findings suggest a relationship between catecholamines and ghrelin with depressive symptoms.

Ms. lat. oct. 63 - Doctrina de lacte (Theses de natura viribusque lactis)

Vorbesitzer: Johann Hartmann Beyer

Ms. lat. oct. 30 - Theses variae medicae

Vorbesitzer: Johann Hartmann Beyer

Physico-mecanico-anatomicae theses

Fecha tomada del tít

Theses theologicae quas in petitione doctoratus concertationi

Tesis-Universitat de València

Theses ex logica metaphysica et ethica quas pro baccalaureatus gradu... D. Thoma Aquinate opitulante

El autor aparece en an. ms. después del "defendet"

Gregorius Morata et Melia... Propugnabit has theologicas theses ex Guillelmi Estii in lib. II. Sentent. comment. Desumtas... [Texto impreso]

Sign. : A2, B4

De linguis orientalibus [Texto impreso] : deque re antiquitatis litteraria theses atque exercitationes

Sign. : []3, A-B4, C1

Petri Morata et Melia Theses pro Philosophiae Cathedris quibus accedit ad calcem animadversio in appendicem ad dissert. de virib. corp. mot. in Valentina Universitate.. [Texto impreso]

Sign. : []2, A-B4, C2

D. Iosephus Elias de Valleio et Alcedo ... publico offerebat certamini has Publici Priuatique Iuris Ecclesiastici Theses ex veteri et noua Eccles [Texto impreso] ...]

Sign.: A-E4

D. Gregorius Morata et Meliá... propugnabit has theologicas theses ex Guillelmi Estü in lib. I. Sent. Comment. Desumtas... [Texto impreso]

Sign. : []2, *4