Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and east Asian ancestry. We tested the top BMD-associated markers for replication in 50,933 independent subjects and for association with risk of low-trauma fracture in 31,016 individuals with a history of fracture (cases) and 102,444 controls. We identified 56 loci (32 new) associated with BMD at genome-wide significance (P < 5 × 10−8). Several of these factors cluster within the RANK-RANKL-OPG, mesenchymal stem cell differentiation, endochondral ossification and Wnt signaling pathways. However, we also discovered loci that were localized to genes not known to have a role in bone biology. Fourteen BMD-associated loci were also associated with fracture risk (P < 5 × 10−4, Bonferroni corrected), of which six reached P < 5 × 10−8, including at 18p11.21 (FAM210A), 7q21.3 (SLC25A13), 11q13.2 (LRP5), 4q22.1 (MEPE), 2p16.2 (SPTBN1) and 10q21.1 (DKK1). These findings shed light on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility.

Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

The major histocompatibility complex (MHC) on chromosome 6 is associated with susceptibility to more common diseases than any other region of the human genome, including almost all disorders classified as autoimmune. In type 1 diabetes the major genetic susceptibility determinants have been mapped to the MHC class II genes HLA-DQB1 and HLA-DRB1 (refs 1–3), but these genes cannot completely explain the association between type 1 diabetes and the MHC region4, 5, 6, 7, 8, 9, 10, 11. Owing to the region's extreme gene density, the multiplicity of disease-associated alleles, strong associations between alleles, limited genotyping capability, and inadequate statistical approaches and sample sizes, which, and how many, loci within the MHC determine susceptibility remains unclear. Here, in several large type 1 diabetes data sets, we analyse a combined total of 1,729 polymorphisms, and apply statistical methods—recursive partitioning and regression...

Reproductive Biology and Spawning Periodicity of Endeavour Shrimps Metapenaeus endeavouri (Schmitt, 1926) and Metapenaeus ensis (de Haan, 1850) from a Central Queensland (Australia) Fishery

Metapenaeus endeavouri and M. ensis from coastal trawl fishing grounds off central Queensland, Australia, have marked seasonal reproductive cycles. Female M. endeavouri grew to a larger size than female M. ensis and occurred over a wider range of sites and depths. Although M. ensis was geographically restricted in distribution to only the shallowest sites it was highly abundant. Mating activity in these open thelycum species, indicated by the presence or absence of a spermatophore, was relatively low and highly seasonal compared with closed thelyeum shrimps. Seasonal variation in spermatophore insemination can be used as an independent technique to study spawning periodicity in open thelycum shrimps. Data strongly suggest an inshore movement of M. endeavouri to mature and spawn. This differs from most concepts of Penaeus species life cycles, but is consistent with the estuarine significance in the life cycle of Metapenaeus species. Monthly population fecundity indices suggest summer spawning for both species, which contrasts with the winter spawning of other shrimps from the same multispecies fishery.

Irish Folklore Commission 1935-1970 : history, ideology, methodology

Between 1935 and 1970 the state-funded Irish Folklore Commission (Coimisiún Béaloideasa Éireann) assembled one of the great folklore collections of the world under the direction of Séamus Ó Duilearga (James Hamilton Delargy). The aim of this study is to recount and assess the work and achievement of this commission. The cultural, linguistic, political and ideological factors that had a bearing on the establishment and making permanent of the Commission and that impinged on many aspects of its work are here elucidated. The genesis of the Commission is traced and the vision and mission of Séamus Ó Duilearga are outlined. The negotiations that preceded the setting up of the Commission in 1935 as well as protracted efforts from 1940 to 1970 to place it on a permanent foundation are recounted and examined at length. All the various collecting programmes and other activities of the Commission are described in detail and many aspects of its work are assessed. This study also deals with the working methods and conditions of employment of the Commission s field and Head Office staff as well as with Séamus Ó Duilearga s direction of the Commission. In executing this work extensive use has been made of primary sources in archives and libraries in Ireland, Sweden, Finland, Estonia, and North America. This is the first major study of this world-famous institute, which has been praised in passing in numerous publications, but here for the first time its work and achievement are detailed comprehensively and subjected to scholarly scrutiny. This study should be of interest not only to students of Irish oral tradition but to folklorists everywhere. The history of the Irish Folklore Commission is a part of a wider history, that of the history of folkloristics in Europe and North America in particular. Moreover, this work has relevance for many areas of the developing world today, where conditions are not dissimilar to those that pertained in Ireland in the 1930's when this great salvage operation was funded by the young, independent Irish state. It is also hoped that this work will be of practical assistance to scholars and the general public when utilising these collections, and that furthermore it will stimulate research into the assembling of other national collections of folklore as well as into the history of folkloristics in other countries, subjects which in recent years are beginning to attract more and more scholarly attention.

Liian huono kansalaiseksi? : Kansalaisihanne sterilisaatioasiakirjoissa v. 1935-1949

Tutkimuksessa tarkastellaan moderniin kansalaisuuteen sisältyneitä normeja ja ihanteita, joita analysoidaan vuoden 1935 sterilisaatiolain toteuttamisessa syntyneiden asiakirjojen kautta. Pyrkimyksenä on löytää asiakirjoihin implisiittisesti kirjatut hyvän elämän ja kansalaisuuden kriteerit. Työn laajemman kehyksen muodostaa suomalaisen modernisaation ja ns. uuden keskiluokan analyysi erityisesti lääketieteen ja huoltotoimen asiantuntijaviranomaisten avulla. Rotuhygienian tarkastelu avaa uuden väylän tutkia moderniin kansalaisuuteen liittyneitä määreitä. Rotuhygienia ja erityisesti sen käytäntöön soveltaminen sterilisaatiolain muodossa tarjoaa kansalaisuuden näkökulmalle konkreettisen ja fokusoidun tutkimuskohteen. Sterilisaatioasiakirjoissa kristallisoituu lääketieteellisin perustein tehty huonon kansalaisen määrittely. Tutkimus rakentuu kolmesta pääluvusta. Ensin käydään läpi vuoden 1935 sterilisaatiolain toteuttamista yleisesti aikaisemman tutkimuksen perusteella, minkä jälkeen tarkennetaan kuvaa otoksista saatujen tulosten avulla. Seuraavassa luvussa tarkastellaan hyvän elämän kriteerejä oikeanlaisen elämänkulun hahmottamisen avulla. Viimeinen pääluku keskittyy modernin kansalaisen muotokuvan rakentamiseen normeiksi määrittyvien fysionomisten ja seksuaalisten sekä luonne- ja älykkyysominaisuuksien palasilla. Normaali, terve kansalainen oli lapsesta asti sekä fyysisiltä että psyykkisiltä ominaisuuksiltaan normien mukaan kehittynyt. Hänessä ei ilmennyt diagnosoitavia häiriötiloja vaan hänen yksilöllinen elämänsä noudatti sisäsyntyistä "luonnollista" elämänkulkua. Fyysiseltä olemukseltaan ihannekansalainen oli sopusuhtainen, säännönmukainen ja mahdollisimman symmetrinen. Normaali kansalainen oli alistanut viettinsä rationaalin alle. Hän hallitsi tunteitaan ja elämäänsä järkevästi niitä itse tietoisesti ohjaillen. Seksuaaliviettinsä ihannekansalainen oli rajannut porvarillisen avioliiton alueelle, ja sielläkin sukupuolielämän tehtävänä oli reproduktio uusien kansalaisten tuottajana. Viettielämän hallitsemattomuus ja ylivalta suhteessa yksilön järjen tahtoon osoitti sisäsyntyistä rappiota, degeneraatiota, jolloin vajaan, epänormaalin yksilön elämä oli jäänyt lapsen tai lähes eläimen tasolle. Normaali kansalainen kulki jatkuvan yksilöllisen kehityksen polkua, jonka tarkoituksena oli saattaa atavistiset piirteet ja vietit järjen ja sivistyksen tuoman hallinnan alle.Ihannekansalaisen evolutionääriseen kehitykseen kuului valintojen tekeminen yhteneväisinä kansallisvaltion päämäärien kanssa. Hän kykeni elättämään itsensä ja perheensä mahdollisimman itsenäisesti muiden apuun turvautumatta. Hän eli kristillisten moraaliarvojen mukaisesti rehellisyydessä, säästäväisyydessä ja anteeksiannossa. Modernin ihannekansalaisen kasvatus alkoi kotona, jossa häntä oli hoidettu ja kasvatettu normien mukaisesti sekä oikeanlaisessa tunnesuhteessa äitiinsä. Indoktrinoiva kasvatus ja ohjaus ihannekansalaisuuteen jatkui koulussa. Tutkimukseni osoittaa kristilliseen opetukseen sisältyneiden arvojen ja moraalikäsitysten jatkumon objektiiviksi kutsutuissa moderneissa (luonnon-)tieteissä. Tieteen avulla perustellut käsitykset työnteosta, sukupuolimoraalista sekä auktoriteetin ylivallasta ovat verrattavissa luterilaisen opin sisältöihin. Avainsanat: Kansalainen, sterilisaatio, rotuhygienia, moderni keskiluokka, älykkyys

Tombstone for Fritz Gottschalk who died in an avalanche in 1935; Bothfeld Cemetery; Hannover.

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Tombstone for Fritz Gottschalk who died in an avalanche in 1935; Bothfeld Cemetery; Hannover.

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Lucien Levy-Bruehl, Albert Einstein, Franz Oppenheimer, Arthur Liebert and his son, Paul Tillich, unidentified woman and Mrs. Charles Blondel outside the Grand Hotel Curhaus during the Davoser Hochschulkurse; Davos, Switzerland Portraits Groups

The Davoser Hochschulkurse took place for the first time in 1928. Mainly university teachers from Germany, France, Switzerland (perhaps elsewhere) offered lectures to students recovering from tuberculosis at the health resort in the Swiss mountains. The lecturers were accommodated at the Grand Hotel Curhaus, where the lectures also took place.

Tombstone for Fritz Gottschalk who died in an avalanche in 1935; Bothfeld Cemetery; Hannover.

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Tombstone for Fritz Gottschalk who died in an avalanche in 1935; Bothfeld Cemetery; Hannover.

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Margarete Oppenheimer geb. Busch : 29. Mai 1883 - 8. August 1935.

Memorial book with the speeches by Leo Baeck and Hugo Jacobi.

Herman Bernstein 1897-1935

Correspondence, clippings, manuscripts, notes, reports, relating to Bernstein's journalistic, literary and diplomatic careers. Correspondence with well-known literary, political and communal, society personalities, 1908-1935. Includes Cyrus Adler, Viscount Allenby, Joseph Barondess, Bernard Baruch, Henri Bergson, Hayyim Nahman Bialik, Jacob Billikopf, Vladimir Bourtzeff, Louis Brandeis, Robert Cecil, Fyodor Chaliapin, Jacob de Haas, Albert Einstein, Henry Ford, Felix Frankfurter, Herbert Hoover, Vladimir Jabotinsky, Horace M. Kallen, Peretz Hirschbein, Peter Kropotkin, Herbert Lehman, Louis Lipsky, Judah L. Magnes, Louis Marshall, Henry Morgenthau, Max Nordau, Adolph Simon Ochs, David de Sola Pool, Bernard G. Richards, Theodore Roosevelt, Julius Rosenwald, Jacob Schiff, Harry Schneiderman, Maurice Schwartz, George Bernard Shaw, Sholem Aleichem, Nathan Straus, Henrietta Szold, Chaim Tchernowitz, Leo Tolstoy, Samuel Untermyer, Henry Van Dyke, Lillian Wald, Felix Warburg, Chaim Weizman n, Jefferson Williams, Stephen Wise, Israel Zangwill. Correspondence and other materials relating to Bernstein's post as U.S. ambassador to Albania. Materials pertaining to Bernstein's editorial work at *The Day*, *Jewish Tribune*, *New York Herald*, *Jewish Daily Bulletin*. Materials pertaining to Bernstein's involvement with the American Jewish Committee. Correspondence with organizations including American Jewish Congress, *American Hebrew*, HIAS, *Jewish Chronicle* (London), Jewish Community of New York, *Menorah Journal*, *New York American*, *New York Times*, ORT, U.S. Dept. of State, Yiddish Art Theater, Zionist Organization of America. Articles, clippings, correspondence and court materials relating to the Ford libel suit. Miscellaneous documents and reports relating to the Paris Peace Conference, the Jewish situation in Russia, 1917-1920, Russian revolutionary events of 1917. News dispatches from Russia, 1917-1920s. Translations by Bernstein of Russian wri Andre yev,

Lucien Wolf and David Mowshowitch papers, [ca. 1869-1959]

Correspondence, reports, minutes, manuscripts, and clippings relating to the activities of Wolf, Mowshowitch, and the Joint Foreign Committee, as well as to the political situation of Jews in various countries and to the Paris Peace Conference. Papers of Lucien Wolf include his diary, lectures on English-German relations and English-Russian relations; bibliography of Wolf's works on Jewish themes; clippings of Wolf's articles; congratulations on his seventieth birthday; article on his last interview with Chamberlain; and correspondence with parents, 1869-1882, A. Abrahams, 1914-1925, Chief Rabbi Dr. J.H. Hertz, 1892-1923, Clara Melchior, 1913-1929, Jacob Schiff, 1910, Maxim Vinawer, 1917, Mark Wischnitzer, 1926-1928, Lord Robert Cecil, 1916-1919, Lord Rothschild, 1906, Cyrus Adler, Count J. Bernstorff, Szymon Ashkenazy, Solomon Dingol, Louis Marshall, Claude G. Montefiore, Sir Edward Sassoon, Jacob Schiff, Lord William Selborne, Nakhum Sokolow, Oscar Straus, Chaim Weizmann, the American Jewish Congress, 1916-1923, Hilfsverein der Deutschen Juden, 1913, and Jewish Historical Society of England.

Philip Cowen papers undated, 1873-1935

Contains primarily correspondence and published material in English, German and Russian relating to anti-Semitism in Russia and Roumania, the Russian passport question, loans from Jewish bankers to the Russian government and immigration from Eastern Europe, especially Russia, to the United States. Includes also correspondence concerning Jewish welfare institutions and agricultural colonies in the United States and the National Farm School in Doylestown, Pa. Also contains correspondence relating to and drafts of articles for the American Hebrew, particularly the Emma Lazarus memorial number, and correspondence relating to the publication of the Jewish encyclopedia and to survey on anti-Semitism conducted in 1890, as well as information on the Jews in China and material relating to Count Arthur Cherep-Spiridovich.

Synagogue Council of America records 1935-1974

Contains the constitution, by-laws, correspondence, papers, and minutes of the Synagogue Council of America (1935-1958), an incomplete set of the minutes of the Plenum, (1949-1965), the minutes of the Executive Committee (1946-1969), Officers' (Summit) Meetings (1955-1967) and the minutes and reports of the Budget Committee (1946-1966), financial reports and statements for 1942-1965 and fundraising activities (1958-1968).