Polimorfismos dos genes ADA e CNTNAP2 em indivíduos com Transtornos do Espectro do Autismo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Uso do método de Monte Carlo para simulação e detecção do espectro de raios-X gerado com feixes de elétrons em alvo de Molibdênio, utilizando o Geant4

The huge demand for procedures involving ionizing radiation promotes the need for safe methods of experimentation considering the danger of their biological e ects with consequent risk to humans. Brazilian's legislation prohibits experiments involving this type of radiation in humans through Decree 453 of Ministry of Health with determines that such procedures comply with the principles of justi cation, optimization and dose limitation. In this line, concurrently with the advancement of available computer processing power, computing simulations have become relevant in those situations where experimental procedures are too cost or impractical. The Monte Carlo method, created along the Manhattan Project duringWorldWar II, is a powerful strategy to simulations in computational physics. In medical physics, this technique has been extensively used with applications in diagnostics and cancer treatment. The objective of this work is to simulate the production and detection of X-rays for the energy range of diagnostic radiology, for molybdenum target, using the Geant4 toolkit. X-ray tubes with this kind of target material are used in diagnostic radiology, speci cally in mammography, one of the most used techniques for screening of breast cancer in women. During the simulations, we used di erent models for bremsstrahlung available in physical models for low energy, in situations already covered by the literature in earlier versions of Geant4. Our results show that although the physical situations seems qualitatively adequate, quantitative comparisons to available analytical data shows aws in the code of Geant4 Low Energy source

Avaliação de métodos de triagem e de detecção fenotípica de ß-lactamase de espectro ampliado (ESBL)

The catalytic function of extended-spectrum β-lactamases can result in high degrees of bacterial resistance to β-lactamic antimicrobials and in the emergence of ESBL among the members of Enterobacteriaceae family, especially Klebsiella pneumoniae and Escherichia coli. This occurs due to the dissemination and emergence of new variants of these enzymes caused by the high utilization of antibiotics like broad-spectrum cephalosporins. The ESBL are β-lactamases capable of conferring bacterial resistance to the penicillins, 1st, 2nd and 3rd generation cephalosporins, and aztreonam (but not cephamycins and carbapenems) through the hydrolysis of these antibiotics. In view of this phenomenon, the exact screening and detection of the producers of ESBL are essential for the appropriate selection of the antimicrobial therapy. The purposes of this study were to evaluate the best antimicrobial for the selection of ESBL producers and to determine the best method for the detection of such microorganisms. We evaluated 200 sequential bacterial samples including the species Klebsiella pneumoniae (56.5%), Escherichia coli (34%), Proteus mirabilis (8.5%) and Klebsiella oxytoca (1%), previously characterized as ESBL producers between February and September 2008 in the Laboratory of Microbiology, Botucatu Medical School - UNESP, Botucatu, São Paulo State, Brazil. To select the ESBL-producer bacteria, we used the disks recommended by CLSI 2008, aztreonam (ATM), cefpodoxime (CPD), ceftriaxone (CRO), cefotaxime (CTX) and ceftazidime (CAZ), besides cefepime (FEP). ESBL production was confirmed by three methods: double disk screening, ESBL Etest®, and Vitek® automated system. The disks employed in the double disk screening were: penicillin associated with β-lactamase inhibitor, amoxicillin-clavulanic acid, and two β-lactamic antibiotics, ceftazidime and cefotaxime...(Complete abstract click electronic access below)

Caracterização da contribuição da albumina para a formação do espectro de ressonância magnética nuclear (RMN) do plasma sanguíneo

The plasma represents a average of the information referring biochemists to the physiology of the organism as a whole, therefore it indirectly or directly interacts with all tissues of the body. In such a way the plasma can be considered as a metabolic “soup”. Using the Nuclear Magnetic Resonance Spectroscopy sanguineous plasma spectra had been generated and using deconvolution techniques it was possible to know the contribution of the albumin for the formation of the spectra of the sanguineous plasma

Análise de genes envolvidos na neurotransmissão, formação e manutenção sináptica em indivíduos com transtornos do espectro do Autismo

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Investigação de mutações nos genes sinápticos SHANK2 e SHANK3 em Transtornos do Espectro do Autismo

Pós-graduação em Genética - IBILCE

Ensino de operantes verbais e requisitos para ensino por tentativas discretas em crianças com transtorno do espectro autista (TEA)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Práticas pedagógicas inclusivas na educação infantil: atividades lúdicas envolvendo crianças com Transtorno do Espectro Autista (TEA)

Pós-graduação em Docência para a Educação Básica - FC

Espectro de gotas e potencial de deriva de caldas contendo o herbicida 2,4-d amina em misturas em tanque

Pós-graduação em Agronomia (Energia na Agricultura) - FCA

Espectro de gotas gerado por diferentes adjuvantes e pontas de pulverização

The application technology shows many parameters related to the quality of the application, one is the droplet spectrum, which is influenced by the spray nozzles and the adjuvant used. Therefore, the objective of this work was estimate the behavior of the droplet spectrum generated with different nozzles and different adjuvants. The experiment was installed containing four solutions from different type adjuvant dilution, as vegetal oil, mineral oil, surfactant and drift reduction, which were applied with two nozzle, one pre-orifice flat fan (DG 8003 VS) and other of air induction flat fan (AI 8003 VS), totaling 8 treatments with 3 repetitions. The experiment was realized in ideal weather conditions for spraying. The treatments averages were compared using Confidence Interval at 95% probability and the correlations between variables were analyzed using Pearson at 5% of probability. The analysis of droplet spectrum showed different behavior for each adjuvant and nozzle. The surfactant treatment showed VMD superior for all treatments when sprayed with AI nozzles. For the %vol.<100 µm the lowest value found was for the AI nozzle in combination with the surfactant. The significant correlations found for the nozzles AI and DG were negative between VMD and %vol.<100 µm. It can be concluded that the values of DMV and %vol.<100 µm showed that the nozzle with pre-orifice have droplet spectrum more prone to drift. The surfactant showed to be the best drift reduction technique when combined with the AI nozzle.

Influência de adjuvantes no espectro de gotas de ponta com indução de ar

This study aimed to verify the influence of adjuvants on the droplet spectrum of an air induction nozzle. The experiment used nine spray solutions, one including only water and eight containing adjuvants: Nimbus® (mineral oil), Óleo vegetal Nortox (vegetal oil), Li-700® (a mixture of lecithin and propionic acid), Agral® (nonyl phenoxy poly ethanol), In-Tec® (nonyl phenol ethoxylate), Antideriva (nonyl phenol ethoxylate), Silwet® L-77 Ag (copolymer polyester and silicon) and TA 35 (sodium lauryl ether sulfate). A flat fan air induction nozzle Hypro® Guardian Air 110 03 was used for the droplet spectrum evaluation. The study was conducted at the Laboratory for Particle Size Analysis (Lapar), at FCAV/UNESP, Jaboticabal/SP - Brazil. The determination of the droplet spectrum characteristics (Volume Median Diameter/VMD, percentage of droplets smaller than 100 micrometers and span) was carried out by a particle size analyzer by laser diffraction Mastersizer S (Malvern Instruments). For statistical analysis the mean values were compared using Confidence Interval at 95% (CI 95%). The results showed that for the Hypro® GA air induction nozzle the oil based adjuvants (Óleo Vegetal Nortox e Nimbus®) increased the VMD. The percentage of droplets smaller than 100 micrometers was lower for the Agral®, Antideriva, In-Tec® e TA 35, in comparison with the Óleo Vegetal Nortox and Li-700®. The span was higher for the oil based adjuvants (Óleo Vegetal Nortox e Nimbus®) and lower for the TA 35 (sodium lauryl ether sulfate), showing that the TA 35 adjuvant has a potential to improve the quality of the droplet spectrum of the Hypro® GA 11003 nozzle.

Processo educacional de crianças com Transtorno do Espectro Autista na Educação Infantil: interconexões entre contextos

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Comportamento, fluência verbal e ritmos circadianos em indivíduos com o Transtorno do Espectro do Autismo (TEA) antes e após o uso de melatonina

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Índice de resistência múltipla aos antimicrobianos, concentração inibitória e beta-lactamases de espectro estendido em linhagens de Proteus mirabilis e Proteus vulgaris isoladas de diferentes afecções em animais domésticos

Pós-graduação em Medicina Veterinária - FMVZ