Inhibition of function in Xenopus oocytes of the inwardly rectifying G-protein-activated atrial K channel (GIRK1) by overexpression of a membrane-attached form of the C-terminal tail.

Coexpression in Xenopus oocytes of the inwardly rectifying guanine nucleotide binding (G)-protein-gated K channel GIRK1 with a myristoylated modification of the (putative) cytosolic C-terminal tail [GIRK1 aa 183-501 fused in-frame to aa 1-15 of p60src and denoted src+ (183-501)] leads to a high degree of inhibition of the inward G-protein-gated K+ current. The nonmyristoylated segment, src- (183-501), is not active. Although some interference with assembly is not precluded, the evidence indicates that the main mechanism of inhibition is interference with functional activation of the channel by G proteins. In part, the tail functions as a blocking particle similar to a "Shaker ball"; it may also function by competing for the available supply of free G beta gamma liberated by hormone activation of a seven-helix receptor. The non-G-protein-gated weak inward rectifier ROMK1 is less effectively inhibited, and a Shaker K channel was not inhibited. Immunological assays show the presence of a high concentration of src+ (183-501) in the plasma membrane and the absence of any membrane forms for the nonmyristoylated segment.

The functional significance of the hypocercal tail and lateral fin fold of Anaspid ostracoderms / James A. Hopson --.

v.33:no.5(1974)

The brown-tail moth, Euproctis chrysorrhcea (L.). A report on the life history and habits of the imported brown-tail moth, together with a description of the remedies best suited for destroying it. By Charles H. Fernald ... and Archie H. Kirkland ... Pub. under the direction of the State board of agriculture by authority of the legislature.

1903

The brown-tail moth, Euproctis chrysorrhcea (L.). A report on the life history and habits of the imported brown-tail moth, together with a description of the remedies best suited for destroying it. By Charles H. Fernald ... and Archie H. Kirkland ... Pub. under the direction of the State board of agriculture by authority of the legislature.

1903

Switching Axial Progenitors from Producing Trunk to Tail Tissues in Vertebrate Embryos

The vertebrate body is made by progressive addition of new tissue from progenitors at the posterior embryonic end. Axial extension involves different mechanisms that produce internal organs in the trunk but not in the tail. We show that Gdf11 signaling is a major coordinator of the trunk-to-tail transition. Without Gdf11 signaling, the switch from trunk to tail is significantly delayed, and its premature activation brings the hindlimbs and cloaca next to the forelimbs, leaving extremely short trunks. Gdf11 activity includes activation of Isl1 to promote formation of the hindlimbs and cloaca-associated mesoderm as the most posterior derivatives of lateral mesoderm progenitors. Gdf11 also coordinates reallocation of bipotent neuromesodermal progenitors from the anterior primitive streak to the tail bud, in part by reducing the retinoic acid available to the progenitors. Our findings provide a perspective to understand the evolution of the vertebrate body plan.

An SDF approach to hedge funds’ tail risk: evidence from Brazilian funds

The main purpose of this paper is to propose a methodology to obtain a hedge fund tail risk measure. Our measure builds on the methodologies proposed by Almeida and Garcia (2015) and Almeida, Ardison, Garcia, and Vicente (2016), which rely in solving dual minimization problems of Cressie Read discrepancy functions in spaces of probability measures. Due to the recently documented robustness of the Hellinger estimator (Kitamura et al., 2013), we adopt within the Cressie Read family, this specific discrepancy as loss function. From this choice, we derive a minimum Hellinger risk-neutral measure that correctly prices an observed panel of hedge fund returns. The estimated risk-neutral measure is used to construct our tail risk measure by pricing synthetic out-of-the-money put options on hedge fund returns of ten specific categories. We provide a detailed description of our methodology, extract the aggregate Tail risk hedge fund factor for Brazilian funds, and as a by product, a set of individual Tail risk factors for each specific hedge fund category.

Traité des maladies du gros bétail,

Mode of access: Internet.

Carte ankologique de l'île de Gotland, indiquant les bassins, les lignes de partage des eaux et les courbes de niveau, outre un plan général de dessèchement de 22,000 hectares, avec 12 cartes de détail de districts différents de drainage, dressé, dans les années 1872-77,

Mode of access: Internet.

Cahier, contenant six differentes parties de plans de villes, avec le moyen de varier les places qui se trouvent dans les centres, de plus de quarante manières différentes : suivi d'un imprimé qui contient le détail de la forme générale et particulière de chaque objet, ainsi que le moyen de réunir ces differentes parties pour en faire des villes, de telles formes et grandeurs que l'on juge à propos /

The plates in the Getty Research Institute copy are hand-colored.

Hydrology of the White Tail Butte area, northern Campbell County, Wyoming /

Shipping list no.: 87-323-P.

L'alimentation et l'élevage rationnels du bétail. Opinions du professeur A. Mallèvre,

"Les pages ... ont été déjà publiées dans les Annales de la science agronomique, sous le titre de Notes prises au cours de zootechnie de A. Mallèvre."--Verso of t.-p.

De la péripneumonie épizootique du gros bétail; rapport général des travaux de la Commission Scientifique instituée près le Ministère de l'Agriculture, du Commerce et des Travaux Publics.

Mode of access: Internet.

In the tail of the peacock /

"With 48 illustrations from photographs and a photogravure portrait."