Stanzas on the death of Oliver Cromwell : Astraea redux; Annus mirabilis; Absalom and Achitophel; Religio Laici; The hind and the panther /

Mode of access: Internet.

La barbarie buscando á la civilización.

Signed: Victor Proaño.

The rational hind,

Mode of access: Internet.

Qadim Tarikh-i Hind.

Mode of access: Internet.

José Aricó y la "crisis de civilización" : La búsqueda de una imbricación democrático-socialista para un desarrollo de la "dilatación de la subjetividad" (1979-1986)

Moviéndonos entre la sociología política y la historia intelectual, abordaremos en este trabajo aspectos de la obra del "gramsciano argentino" José María Aricó (1931-1991). Con una reconocida actividad político-intelectual desarrollada en su país durante tres décadas, el golpe militar de 1976 obliga a Aricó a marchar al exilio. Anclado en México, la temática de la transición a la democracia, acuciante en distintos países de América Latina y de Europa, lo hace desembocar en una serie de estudios sobre vínculos entre la tradición democrática y la socialista, sobre la noción de progreso y sobre el preocupante divorcio que entre cultura y política se viene profundizando desde los tiempos de la Segunda Guerra Mundial. Siempre con los escritos de Gramsci latiendo en el núcleo de sus preocupaciones, Aricó regresa a la Argentina en 1983. Considerando que ni el liberalismo, ni el marxismo-leninismo, ni el populismo, ni la socialdemocracia pueden ya contribuir al montaje de un "pensamiento fuerte" de expectativas emancipatorias, profundizando además en la temática de la "dilatación de la subjetividad" y en un manejo desprejuiciado de la obra del intelectual reaccionario alemán Carl Schmitt, Aricó ensaya un recorrido inédito, estimulado por la idea-fuerza de una "democracia social avanzada", capaz de dar respuestas ambiciosas a aquello que viene señalando como una crisis de civilización.

José Aricó y la "crisis de civilización" : La búsqueda de una imbricación democrático-socialista para un desarrollo de la "dilatación de la subjetividad" (1979-1986)

Moviéndonos entre la sociología política y la historia intelectual, abordaremos en este trabajo aspectos de la obra del "gramsciano argentino" José María Aricó (1931-1991). Con una reconocida actividad político-intelectual desarrollada en su país durante tres décadas, el golpe militar de 1976 obliga a Aricó a marchar al exilio. Anclado en México, la temática de la transición a la democracia, acuciante en distintos países de América Latina y de Europa, lo hace desembocar en una serie de estudios sobre vínculos entre la tradición democrática y la socialista, sobre la noción de progreso y sobre el preocupante divorcio que entre cultura y política se viene profundizando desde los tiempos de la Segunda Guerra Mundial. Siempre con los escritos de Gramsci latiendo en el núcleo de sus preocupaciones, Aricó regresa a la Argentina en 1983. Considerando que ni el liberalismo, ni el marxismo-leninismo, ni el populismo, ni la socialdemocracia pueden ya contribuir al montaje de un "pensamiento fuerte" de expectativas emancipatorias, profundizando además en la temática de la "dilatación de la subjetividad" y en un manejo desprejuiciado de la obra del intelectual reaccionario alemán Carl Schmitt, Aricó ensaya un recorrido inédito, estimulado por la idea-fuerza de una "democracia social avanzada", capaz de dar respuestas ambiciosas a aquello que viene señalando como una crisis de civilización.

José Aricó y la "crisis de civilización" : La búsqueda de una imbricación democrático-socialista para un desarrollo de la "dilatación de la subjetividad" (1979-1986)

Moviéndonos entre la sociología política y la historia intelectual, abordaremos en este trabajo aspectos de la obra del "gramsciano argentino" José María Aricó (1931-1991). Con una reconocida actividad político-intelectual desarrollada en su país durante tres décadas, el golpe militar de 1976 obliga a Aricó a marchar al exilio. Anclado en México, la temática de la transición a la democracia, acuciante en distintos países de América Latina y de Europa, lo hace desembocar en una serie de estudios sobre vínculos entre la tradición democrática y la socialista, sobre la noción de progreso y sobre el preocupante divorcio que entre cultura y política se viene profundizando desde los tiempos de la Segunda Guerra Mundial. Siempre con los escritos de Gramsci latiendo en el núcleo de sus preocupaciones, Aricó regresa a la Argentina en 1983. Considerando que ni el liberalismo, ni el marxismo-leninismo, ni el populismo, ni la socialdemocracia pueden ya contribuir al montaje de un "pensamiento fuerte" de expectativas emancipatorias, profundizando además en la temática de la "dilatación de la subjetividad" y en un manejo desprejuiciado de la obra del intelectual reaccionario alemán Carl Schmitt, Aricó ensaya un recorrido inédito, estimulado por la idea-fuerza de una "democracia social avanzada", capaz de dar respuestas ambiciosas a aquello que viene señalando como una crisis de civilización.

Gino Germani: Transición, modernizacion, civilización. Aportes para una revisión contemporáneaa

El presente trabajo se propone poner de relieve el marcado interés que demuestra Gino Germani por la explicación del fenómeno de la “modernidad” a partir de una revisión de algunos conceptos fundamentales presentes en ciertos pasajes de su obra. Por las características de la misma (fragmentaria, heterogénea, ecléctica) postular – y justificar – la existencia de una “teoría de la modernidad germaniana” implicaría una tarea de reconstrucción y análisis que excede por mucho el alcance del presente trabajo. Sin embargo, para llevar adelante nuestros objetivos, que de hecho son mucho menos ambiciosos, asumimos dicha existencia a modo de hipótesis de trabajo. Nuestra búsqueda parte de una lectura interesada por reconocer elementos teóricos (definiciones, mutaciones y/o transformaciones conceptuales) en una serie de textos claves. El trabajo se articulará en torno de tres movimientos teóricos que reconocemos en dicha selección: del concepto de “transición” al de “modernización” y de allí al de “civilización”. Hacia el final mencionaremos unas breves reflexiones y sugeriremos unas tareas pendientes que creemos las mismas habilitan en el marco de la/s “sociología/s latinoamericana/s”.

Gait analysis of the hind limb in Labrador Retrievers with and without cranial cruciate ligament disease

Cranial cruciate ligament (CCL) deficiency is the leading cause of lameness affecting the stifle joints of large breed dogs, especially Labrador Retrievers. Although CCL disease has been studied extensively, its exact pathogenesis and the primary cause leading to CCL rupture remain controversial. However, weakening secondary to repetitive microtrauma is currently believed to cause the majority of CCL instabilities diagnosed in dogs. Techniques of gait analysis have become the most productive tools to investigate normal and pathological gait in human and veterinary subjects. The inverse dynamics analysis approach models the limb as a series of connected linkages and integrates morphometric data to yield information about the net joint moment, patterns of muscle power and joint reaction forces. The results of these studies have greatly advanced our understanding of the pathogenesis of joint diseases in humans. A muscular imbalance between the hamstring and quadriceps muscles has been suggested as a cause for anterior cruciate ligament rupture in female athletes. Based on these findings, neuromuscular training programs leading to a relative risk reduction of up to 80% has been designed. In spite of the cost and morbidity associated with CCL disease and its management, very few studies have focused on the inverse dynamics gait analysis of this condition in dogs. The general goals of this research were (1) to further define gait mechanism in Labrador Retrievers with and without CCL-deficiency, (2) to identify individual dogs that are susceptible to CCL disease, and (3) to characterize their gait. The mass, location of the center of mass (COM), and mass moment of inertia of hind limb segments were calculated using a noninvasive method based on computerized tomography of normal and CCL-deficient Labrador Retrievers. Regression models were developed to determine predictive equations to estimate body segment parameters on the basis of simple morphometric measurements, providing a basis for nonterminal studies of inverse dynamics of the hind limbs in Labrador Retrievers. Kinematic, ground reaction forces (GRF) and morphometric data were combined in an inverse dynamics approach to compute hock, stifle and hip net moments, powers and joint reaction forces (JRF) while trotting in normal, CCL-deficient or sound contralateral limbs. Reductions in joint moment, power, and loads observed in CCL-deficient limbs were interpreted as modifications adopted to reduce or avoid painful mobilization of the injured stifle joint. Lameness resulting from CCL disease affected predominantly reaction forces during the braking phase and the extension during push-off. Kinetics also identified a greater joint moment and power of the contralateral limbs compared with normal, particularly of the stifle extensor muscles group, which may correlate with the lameness observed, but also with the predisposition of contralateral limbs to CCL deficiency in dogs. For the first time, surface EMG patterns of major hind limb muscles during trotting gait of healthy Labrador Retrievers were characterized and compared with kinetic and kinematic data of the stifle joint. The use of surface EMG highlighted the co-contraction patterns of the muscles around the stifle joint, which were documented during transition periods between flexion and extension of the joint, but also during the flexion observed in the weight bearing phase. Identification of possible differences in EMG activation characteristics between healthy patients and dogs with or predisposed to orthopedic and neurological disease may help understanding the neuromuscular abnormality and gait mechanics of such disorders in the future. Conformation parameters, obtained from femoral and tibial radiographs, hind limb CT images, and dual-energy X-ray absorptiometry, of hind limbs predisposed to CCL deficiency were compared with the conformation parameters from hind limbs at low risk. A combination of tibial plateau angle and femoral anteversion angle measured on radiographs was determined optimal for discriminating predisposed and non-predisposed limbs for CCL disease in Labrador Retrievers using a receiver operating characteristic curve analysis method. In the future, the tibial plateau angle (TPA) and femoral anteversion angle (FAA) may be used to screen dogs suspected of being susceptible to CCL disease. Last, kinematics and kinetics across the hock, stifle and hip joints in Labrador Retrievers presumed to be at low risk based on their radiographic TPA and FAA were compared to gait data from dogs presumed to be predisposed to CCL disease for overground and treadmill trotting gait. For overground trials, extensor moment at the hock and energy generated around the hock and stifle joints were increased in predisposed limbs compared to non predisposed limbs. For treadmill trials, dogs qualified as predisposed to CCL disease held their stifle at a greater degree of flexion, extended their hock less, and generated more energy around the stifle joints while trotting on a treadmill compared with dogs at low risk. This characterization of the gait mechanics of Labrador Retrievers at low risk or predisposed to CCL disease may help developing and monitoring preventive exercise programs to decrease gastrocnemius dominance and strengthened the hamstring muscle group.

Multi-body simulation of a canine hind limb: model development, experimental validation and calculation of ground reaction forces

Background: Among other causes the long-term result of hip prostheses in dogs is determined by aseptic loosening. A prevention of prosthesis complications can be achieved by an optimization of the tribological system which finally results in improved implant duration. In this context a computerized model for the calculation of hip joint loadings during different motions would be of benefit. In a first step in the development of such an inverse dynamic multi-body simulation (MBS-) model we here present the setup of a canine hind limb model applicable for the calculation of ground reaction forces. Methods: The anatomical geometries of the MBS-model have been established using computer tomography- (CT-) and magnetic resonance imaging- (MRI-) data. The CT-data were collected from the pelvis, femora, tibiae and pads of a mixed-breed adult dog. Geometric information about 22 muscles of the pelvic extremity of 4 mixed-breed adult dogs was determined using MRI. Kinematic and kinetic data obtained by motion analysis of a clinically healthy dog during a gait cycle (1 m/s) on an instrumented treadmill were used to drive the model in the multi-body simulation. Results and Discussion: As a result the vertical ground reaction forces (z-direction) calculated by the MBS-system show a maximum deviation of 1.75%BW for the left and 4.65%BW for the right hind limb from the treadmill measurements. The calculated peak ground reaction forces in z- and y-direction were found to be comparable to the treadmill measurements, whereas the curve characteristics of the forces in y-direction were not in complete alignment. Conclusion: In conclusion, it could be demonstrated that the developed MBS-model is suitable for simulating ground reaction forces of dogs during walking. In forthcoming investigations the model will be developed further for the calculation of forces and moments acting on the hip joint during different movements, which can be of help in context with the in silico development and testing of hip prostheses.

Lenguaje, discurso y civilización en Baquílides 11

Fil: González de Tobia, Ana María. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.

La isla y el exilio : Lenguaje y recuperación de la civilización en Odisea

Fil: Zecchin de Fasano, Graciela Cristina. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.

Peripheral P2x7 Receptor-induced Mechanical Hyperalgesia Is Mediated By Bradykinin.

P2X7 receptors play an important role in inflammatory hyperalgesia, but the mechanisms involved in their hyperalgesic role are not completely understood. In this study, we hypothesized that P2X7 receptor activation induces mechanical hyperalgesia via the inflammatory mediators bradykinin, sympathomimetic amines, prostaglandin E2 (PGE2), and pro-inflammatory cytokines and via neutrophil migration in rats. We found that 2'(3')-O-(4-benzoylbenzoyl)adenosine 5'-triphosphate triethylammonium salt (BzATP), the most potent P2X7 receptor agonist available, induced a dose-dependent mechanical hyperalgesia that was blocked by the P2X7 receptor-selective antagonist A-438079 but unaffected by the P2X1,3,2/3 receptor antagonist TNP-ATP. These findings confirm that, although BzATP also acts at both P2X1 and P2X3 receptors, BzATP-induced hyperalgesia was mediated only by P2X7 receptor activation. Co-administration of selective antagonists of bradykinin B1 (Des-Arg(8)-Leu(9)-BK (DALBK)) or B2 receptors (bradyzide), β1 (atenolol) or β2 adrenoceptors (ICI 118,551), or local pre-treatment with the cyclooxygenase inhibitor indomethacin or the nonspecific selectin inhibitor fucoidan each significantly reduced BzATP-induced mechanical hyperalgesia in the rat hind paw. BzATP also induced the release of the pro-inflammatory cytokines tumor necrosis factor α (TNF-α), interleukin (IL)-1β, IL-6 and cytokine-induced neutrophil chemoattractant-1 (CINC-1), an effect that was significantly reduced by A-438079. Co-administration of DALBK or bradyzide with BzATP significantly reduced BzATP-induced IL-1β and CINC-1 release. These results indicate that peripheral P2X7 receptor activation induces mechanical hyperalgesia via inflammatory mediators, especially bradykinin, which may contribute to pro-inflammatory cytokine release. These pro-inflammatory cytokines in turn may mediate the contributions of PGE2, sympathomimetic amines and neutrophil migration to the mechanical hyperalgesia induced by local P2X7 receptor activation.

Inflammatory Sensitization Of Nociceptors Depends On Activation Of Nmda Receptors In Drg Satellite Cells.

The present study evaluated the role of N-methyl-D-aspartate receptors (NMDARs) expressed in the dorsal root ganglia (DRG) in the inflammatory sensitization of peripheral nociceptor terminals to mechanical stimulation. Injection of NMDA into the fifth lumbar (L5)-DRG induced hyperalgesia in the rat hind paw with a profile similar to that of intraplantar injection of prostaglandin E2 (PGE2), which was significantly attenuated by injection of the NMDAR antagonist D(-)-2-amino-5-phosphonopentanoic acid (D-AP-5) in the L5-DRG. Moreover, blockade of DRG AMPA receptors by the antagonist 6,7-dinitroquinoxaline-2,3-dione had no effect in the PGE2-induced hyperalgesia in the paw, showing specific involvement of NMDARs in this modulatory effect and suggesting that activation of NMDAR in the DRG plays an important role in the peripheral inflammatory hyperalgesia. In following experiments we observed attenuation of PGE2-induced hyperalgesia in the paw by the knockdown of NMDAR subunits NR1, NR2B, NR2D, and NR3A with antisense-oligodeoxynucleotide treatment in the DRG. Also, in vitro experiments showed that the NMDA-induced sensitization of cultured DRG neurons depends on satellite cell activation and on those same NMDAR subunits, suggesting their importance for the PGE2-induced hyperalgesia. In addition, fluorescent calcium imaging experiments in cultures of DRG cells showed induction of calcium transients by glutamate or NMDA only in satellite cells, but not in neurons. Together, the present results suggest that the mechanical inflammatory nociceptor sensitization is dependent on glutamate release at the DRG and subsequent NMDAR activation in satellite glial cells, supporting the idea that the peripheral hyperalgesia is an event modulated by a glutamatergic system in the DRG.