247 resultados para Carver


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http://lib.dr.iastate.edu/carver_narratives/1025/thumbnail.jpg

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http://lib.dr.iastate.edu/carver_narratives/1008/thumbnail.jpg

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http://lib.dr.iastate.edu/carver_narratives/1029/thumbnail.jpg

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There are many open issues that must be addressed before the replication process can be successfully formalized in empirical software engineering research. We define replication as the deliberate repetition of the same empirical study for the purpose of determining whether the results of the first experiment can be reproduced. This definition would appear at first glance to be good. However, it needs several clarifications that have not yet been forthcoming in software engineering: – What is the exact meaning of the same empirical study? Namely how similar should an experiment be to the baseline study for it to be considered a replication? What is the exact meaning of a result being reproduced? Namely how similar does a result have to be to the result of the baseline study for it to be considered reproduced? These and other methodological questions need to be researched and tailored for empirical software engineering.

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Context: The software engineering community is becoming more aware of the need for experimental replications. In spite of the importance of this topic, there is still much inconsistency in the terminology used to describe replications. Objective: Understand the perspectives of empirical researchers about various terms used to characterize replications and propose a consistent taxonomy of terms. Method: A survey followed by plenary discussion during the 2013 International Software Engineering Research Network meeting. Results: We propose a taxonomy which consolidates the disparate terminology. This taxonomy had a high level of agreement among workshop attendees. Conclusion: Consistent terminology is important for any field to progress. This work is the first step in that direction. Additional study and discussion is still necessary.

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Leaves of two barley (Hordeum vulgare L.) isolines, Alg-R, which has the dominant Mla1 allele conferring hypersensitive race-specific resistance to avirulent races of Blumeria graminis, and Alg-S, which has the recessive mla1 allele for susceptibility to attack, were inoculated with B. graminis f. sp. hordei. Total leaf and apoplastic antioxidants were measured 24 h after inoculation when maximum numbers of attacked cells showed hypersensitive death in Alg-R. Cytoplasmic contamination of the apoplastic extracts, judged by the marker enzyme glucose-6-phosphate dehydrogenase, was very low (less than 2%) even in inoculated plants. Dehydroascorbate, glutathione, superoxide dismutase, catalase, ascorbate peroxidase, glutathione reductase, monodehydroascorbate reductase, and dehydroascorbate reductase were present in the apoplast. Inoculation had no effect on the total foliar ascorbate pool size or the redox state. The glutathione content of Alg-S leaves and apoplast decreased, whereas that of Alg-R leaves and apoplast increased after pathogen attack, but the redox state was unchanged in both cases. Large increases in foliar catalase activity were observed in Alg-S but not in Alg-R leaves. Pathogen-induced increases in the apoplastic antioxidant enzyme activities were observed. We conclude that sustained oxidation does not occur and that differential strategies of antioxidant response in Alg-S and Alg-R may contribute to pathogen sensitivity.

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Microbes whose genomes are encoded by DNA and for which adequate information is available display similar genomic mutation rates (average 0.0034 mutations per chromosome replication, range 0.0025 to 0.0046). However, this value currently is based on only a few well characterized microbes reproducing within a narrow range of environmental conditions. In particular, no genomic mutation rate has been determined either for a microbe whose natural growth conditions may extensively damage DNA or for any member of the archaea, a prokaryotic lineage deeply diverged from both bacteria and eukaryotes. Both of these conditions are met by the extreme thermoacidophile Sulfolobus acidocaldarius. We determined the genomic mutation rate for this species when growing at pH 3.5 and 75°C based on the rate of forward mutation at the pyrE gene and the nucleotide changes identified in 101 independent mutants. The observed value of about 0.0018 extends the range of DNA-based microbes with rates close to the standard rate simultaneously to an archaeon and to an extremophile whose cytoplasmic pH and normal growth temperature greatly accelerate the spontaneous decomposition of DNA. The mutations include base pair substitutions (BPSs) and additions and deletions of various sizes, but the S. acidocaldarius spectrum differs from those of other DNA-based organisms in being relatively poor in BPSs. The paucity of BPSs cannot yet be explained by known properties of DNA replication or repair enzymes of Sulfolobus spp. It suggests, however, that molecular evolution per genome replication may proceed more slowly in S. acidocaldarius than in other DNA-based organisms examined to date.

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El objetivo de este estudio es analizar del afrontamiento al estrés, el afrontamiento del dolor y el apoyo social percibido, para establecer su relación con la incapacidad funcional y el dolor percibido, en pacientes diagnosticados de artritis reumatoide (AR), comparados con pacientes sin patología que limite su capacidad funcional (grupo comparación). Para ello, han sido evaluados un total de 230 pacientes, 110 pacientes con artritis reumatoide y 120 pacientes en el grupo de comparación, pertenecientes a hospitales de red de sanidad pública y privada de la Comunidad Autónoma de Madrid (España). El protocolo de evaluación ha consistido en el Cuestionario de afrontamiento al estrés COPE (Carver, Scheier y Weintraub, 1989), Cuestionario de afrontamiento al dolor CAD (Soriano y Monsalve, 2002), la Escala de apoyo social abreviada SSQ-6 (Sarason, Sarason, Shearin y Pierce, 1987), escala numérica de dolor (EN) y el Cuestionario de la evaluación de la salud de Stanford HAQ (Fries, Spitz, Kraines y Holman, 1980). También, se han recogido datos sociodemográficos y años de evolución de la enfermedad en el grupo de AR. El análisis estadístico se ha realizado mediante el programa SPSS v.22, y ha consistido en pruebas paramétricas, con contrastes de pruebas no paramétricas, de diferencias de medias, estudio de correlaciones y ecuaciones de regresión, tanto para las comparaciones entre ambos grupos, como para el estudio de los pacientes con AR...

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This layer is a georeferenced raster image of the historic paper map entitled: An accurate map of the country round Boston in New England. It was originally published by Archibald Hamilton in Town and country magazine (London), Jan. 16, 1776. Scale [ca. 1:362,500]. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Massachusetts State Plane Coordinate System, Mainland Zone (in Feet) (Fipszone 2001). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, or other information associated with the principal map. This map shows features such as roads, drainage, selected public buildings, town boundaries and more. Relief is shown by hachures. Includes ancillary map: A plan of Boston and Charlestown, from a drawing made in 1771, with index to points of interest. This layer is part of a selection of digitally scanned and georeferenced historic maps of Massachusetts from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates (1755-1922), scales, and purposes. The digitized selection includes maps of: the state, Massachusetts counties, town surveys, coastal features, real property, parks, cemeteries, railroads, roads, public works projects, etc.

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This layer is a digital raster graphic of the historic 15-minute USGS topographic map of the Middleborough, Massachusetts quadrangle. The survey date (ground condition) of the original paper map is 1885. A digital raster graphic (DRG) is a scanned image of a U.S. Geological Survey (USGS) standard series topographic map, including all map collar information. The image inside the map neatline is geo-referenced to the surface of the earth and fit to the Universal Transverse Mercator projection. The horizontal positional accuracy and datum of the DRG matches the accuracy and datum of the source map.

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This layer is a digital raster graphic of the historic 15-minute USGS topographic map of the Plymouth, Massachusetts quadrangle. The survey date (ground condition) of the original paper map is 1885-1886, the edition date is August, 1894 and this map has a reprint date of March 1898. A digital raster graphic (DRG) is a scanned image of a U.S. Geological Survey (USGS) standard series topographic map, including all map collar information. The image inside the map neatline is geo-referenced to the surface of the earth and fit to the Universal Transverse Mercator projection. The horizontal positional accuracy and datum of the DRG matches the accuracy and datum of the source map.

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Cover title.