Audit report on the City of Van Horne, Iowa for the year ended June 30, 2007

Audit report on the City of Van Horne, Iowa for the year ended June 30, 2007

Audit report on the City of Van Meter, Iowa for the year ended June 30, 2008

Audit report on the City of Van Meter, Iowa for the year ended June 30, 2008

Long-term expansion of transplantable human fetal liver hematopoietic stem cells

Hematopoietic stem cells (HSCs), with their dual ability for self-renewal and multilineage differentiation, constitute an essential component of hematopoietic transplantations. Human fetal liver (FL) represents a promising alternative HSC source, and we previously reported simple culture conditions allowing long-term expansion of FL hematopoietic progenitors. In the present study, we used the nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mouse xenotransplantation assay to confirm that human FL is rich in NOD/SCID-repopulating cells (SRCs) and to show that these culture conditions repeatedly maintained short- and long-term SRCs from various FL samples for at least 28 days. Quantitative limited dilution analysis in NOD/SCID mice demonstrated for the first time that a 10- to over a 100-fold net expansion of FL SRCs could be achieved after 28 days of culture. The efficiency of this culture system may lead to an increase in the use of FL as a source of HSCs for transplantation in adult patients, as previously demonstrated with umbilical cord blood under different culture conditions.

Catalogue des dessins anciens du Moyen-Age et de la Renaissance (XVe et XVIe siècles), Oeuvres de J. Amman, B. Beham, P. Brueghel, H. Burgkmair, L. Cambiaso, J. Cousin, A. Durer, H. Goltzius, U. Graf, Lagneau, E. de Laune, F. Mazzuola, M. Ostendrofer, J. Palma, Le Primatice, B. Ramenghi, D. Robusti, J. Romain, T. Stimmer, P. Vénronèse, L. de Vinci, etc., etc. ; Dessins, pastels, aquarelles des XVIIe et XVIIIe siècle par N. Berchem, Brauwer, A. Guyp, Dumonstier, C. Dusart, A. Van Dyck, J.-H. Fragonard, Cl. Gellée, Van Goyen, J. Jordaens, J. Lievens, G. Metzu, I. Moucheron, R. Nanteuil, A. Van Ostade, A. Pajou, J.-B. Perronneau, P. Potter, N. Poussin, Rembrandt, P.-P. Rubens, J. Ruysdael, G.-B. Tiepolo, A. et W. Van de Velde, C. Visscher, A. Watteau, etc., etc., composant la collection de M. A. Beurdeley et dont la vente [6e vente] aux enchères publiques, après décès, aura lieu Galerie Georges Petit, 8, rue de Sèze, les mardi 8, mercredi 9 et jeudi 10 juin 1920 / Commissaires-priseurs, Me F. Lair-Dubreuil, Me Henri Baudoin ; experts M. Jules Féral, M. Marius Paulme ; [préface de Marcel Nicolle]

[Vente (Art). 1920-06-08 - 1920-06-10. Paris]

Sagopilone (ZK-EPO, ZK 219477) for recurrent glioblastoma. A phase II multicenter trial by the European Organisation for Research and Treatment of Cancer (EORTC) Brain Tumor Group.

Background: Sagopilone (ZK 219477), a lipophylic and synthetic analog of epothilone B, that crosses the blood-brain barrier has demonstrated preclinical activity in glioma models.Patients and methods: Patients with first recurrence/progression of glioblastoma were eligible for this early phase II and pharmacokinetic study exploring single-agent sagopilone (16 mg/m(2) over 3 h every 21 days). Primary end point was a composite of either tumor response or being alive and progression free at 6 months. Overall survival, toxicity and safety and pharmacokinetics were secondary end points.Results: Thirty-eight (evaluable 37) patients were included. Treatment was well tolerated, and neuropathy occurred in 46% patients [mild (grade 1) : 32%]. No objective responses were seen. The progression-free survival (PFS) rate at 6 months was 6.7% [95% confidence interval (CI) 1.3-18.7], the median PFS was just over 6 weeks, and the median overall survival was 7.6 months (95% CI 5.3-12.3), with a 1-year survival rate of 31.6% (95% CI 17.7-46.4). Maximum plasma concentrations were reached at the end of the 3-h infusion, with rapid declines within 30 min after termination.Conclusions: No evidence of relevant clinical antitumor activity against recurrent glioblastoma could be detected. Sagopilone was well tolerated, and moderate-to-severe peripheral neuropathy was observed in despite prolonged administration.

Vygotsky, Van Lier ja kielenoppiminen : sosiokulttuurinen viitekehys kielellisen tietoisuuden ja vieraan kielen oppimisen tutkimuksessa

Abstract

Response to the letter to the editor by Dr van den Berg

Letters to the editor