Professori Juho Jännes 7/5 1957

Kirje 7.5.1957

Un projet multicentrique suisse pour améliorer la prévention et la récidive après un syndrome coronarien aigu [A Swiss multicentric project to improve the prevention of cardiovascular event recurrence after acute coronary syndromes].

Recurrence of cardiovascular events and mortality remain high after acute coronary syndromes. A Swiss multicentric study, "Inflammation and acute coronary syndromes (ACS)--Novel strategies for prevention and clinical managements", is currently underway with the support of the Swiss National Science Foundation. The study includes a clinical research subproject of which the aim is to assess the impact of the ELIPS program (multi-dimEnsionaL prevention Program after acute coronary Syndrome) on the recurrence of cardiovascular events after an ACS. The basic research sub-projects aim to investigate novel cardiovascular risk biomarkers and genetic determinants of recurrence and to study the role of stem cells after an ACS. Another sub-project will evaluate intracoronary imaging techniques and the efficacy of different types of stents.

Is atherosclerosis screening by noninvasive imaging effective in cardiovascular prevention? a systematic review

Texte intégral: http://www.springerlink.com/content/3q68180337551r47/fulltext.pdf

Epidemiology of uveitis in Switzerland.

During the period from January 1990 to December 1993, 558 new patients (250 female and 308 male, mean age 44 years; range 5-92) were seen at the Uveitis Clinic of the Hopital Jules Gonin. These 558 patients (740 eyes) were subdivided into anterior uveitis (343 patients-61%), intermediate uveitis (57 patients-10%), posterior uveitis (118 patients-21 %) and panuveitis (40 patients-7%). The incidence of uveitis for the referral area considered was calculated to be 17.5 per 100,000 inhabitants per year. A specific diagnosis was found in 386 cases (69%). The most frequently diagnosed entities were HLA-B27-associated acute anterior uveitis (89 cases-15.9%), uveitis associated with acute herpes zoster ophthalmicus (54 cases-9.7%), toxoplasmosis (53 cases-9.5%), sarcoidosis (33 cases-5.9%), typical pars planitis (31 cases-5.6%), Fuchs' heterochromic cyclitis (30 cases-5.4%), herpetic anterior uveitis (23 cases-4.1 %) and acute retinal necrosis (13 cases-2.3%). Incidence and distribution of most disease entities correspond to those of other European and American series.

Pitkäikäisyyden viimeaikainen kehitys

Perustuu III Gerontologian päivillä 30.1.1998 pidettyyn esitelmään

Etudes Coût-efficacité: ce que devraient retenir les médecins [Cost-effectiveness analyses: what doctors should know]

The resources of our heath care system are limited. Choices in the attribution of resources are necessary to ensure its stability. A cost-effectiveness analysis compares the effects of one health intervention to another, taking into account the costs (including the saved costs) and the saved life years, adjusted for the quality of life (cost-utility). Cost-effectiveness analyses should take the societal perspective and the studied intervention should be compared to a relevant intervention actually in use. Physicians, at the interface between patients and payers, are in an ideal position to interpret, or even perform cost-effectiveness analysis, and to promote the interventions that are most effective and that have a reasonable cost.

[Illustrations de Traité élémentaire de chimie, présenté dans un ordre nouveau et d'après les découvertes modernes, avec figures] / Paulze Lavoisier, grav. ; Antoine Laurent de Lavoiser, aut. du texte

Comprend : [Volume I. Bandeau au folio A : instruments de chimie, compas, sphère armillaires et globes terrestres, engins élévateurs.] [Cote : R 17237-17238/Microfilm R 132983 et 122179] ; [pl. dépl. 1 à la fin du volume II : instruments de chimie. Mortiers, passoirs, râpes etc...] [Cote : R 17237-17238/Microfilm R 132983 et 122179] ; [pl. dépl. II à la fin du volume II : instruments de chimie. Entonnoirs, fioles, bouteilles, terrines de grès, grand cuvier, chaudron...] [Cote : R 17237-17238/Microfilm R 132983 et 122179] ; [pl. dépl. III à la fin du volume II : instruments de chimie. Chauffeau, distillateurs, flacons, capsules de verre, cucurbite de verre ou de grès etc...] [Cote : R 17237-17238/Microfilm R 132983 et 122179] ; [pl. dépl. IV à la fin du volume II : instruments de chimie. Chauffeau, distillateurs, flacons, alambic, cornue de verre tubulée, ballons de verre blanc ou de cristal, appareil ou colonne au mercure, matras à cul-plat dit Enfer de Boyle etc...] [Cote : R 17237-17238/Microfilm R 132983 et 122179] ; [pl. dépl. VI à la fin du volume II : matériel de chimie. Cuve ou distillateur...] [Cote : R 17237-17238/Microfilm R 132983 et 122179] ; [pl. dépl. VII à la fin du volume II : matériel de chimie. Cuves, cornue tubulée, fourneau et bombonesetc...] [Cote : R 17237-17238/Microfilm R 132983 et 122179] ; [pl. dépl. VIII à la fin du volume II : matériel de chimie. Gazomètre.] [Cote : R 17237-17238/Microfilm R 132983 et 122179] ; [pl. dépl. IX à la fin du volume II Partie 1 : matériel de chimie. Distillateur. Cornues. Ballons. Serpentin. Lampe à esprit-de-vin à la Quinquet.] [Cote : R 17237-17238/Microfilm R 132983 et 122179] ; [pl. dépl. IX à la fin du volume II Partie 2 : matériel de chimie. Distillateur. Cornues. Ballons. Serpentin. Lampe à esprit-de-vin à la Quinquet.] [Cote : R 17237-17238/Microfilm R 132983 et 122179] ; [pl. dépl. X à la fin du volume II Partie 1 : matériel de chimie pour les fermentations vineuses et putrides. Distillateur. Cornues. Ballons. Grand matras, virole de cuivre etc...] [Cote : R 17237-17238/Microfilm R 132983 et 122179] ; [pl. dépl. X à la fin du volume II Partie 2 : matériel de chimie pour les fermentations vineuses et putrides. Distillateur. Cornues. Ballons. Grand matras, virole de cuivre etc...] [Cote : R 17237-17238/Microfilm R 132983 et 122179] ; [pl. dépl. XI à la fin du volume II Partie 1 : matériel de chimie. Distillateur. Serpentin. Tube déliquescent. Cornues. Gazomètre.] [Cote : R 17237-17238/Microfilm R 132983 et 122179] ; [pl. dépl. XI à la fin du volume II Partie 2 : matériel de chimie. Distillateur. Serpentin. Tube déliquescent. Cornues. Gazomètre.] [Cote : R 17237-17238/Microfilm R 132983 et 122179] ; [pl. dépl. XIII à la fin du volume II : matériel de chimie. Fourneaux de réverbère. Bain de sable sous une couverture de terre cuite. Soufflet. Cornues.] [Cote : R 17237-17238/Microfilm R 132983 et 122179]

dKDM5/LID regulates H3K4me3 dynamics at the transcription-start site (TSS) of actively transcribed developmental genes

H3K4me3 is a histone modification that accumulates at the transcription-start site (TSS) of active genes and is known to be important for transcription activation. The way in which H3K4me3 is regulated at TSS and the actual molecular basis of its contribution to transcription remain largely unanswered. To address these questions, we have analyzed the contribution of dKDM5/LID, the main H3K4me3 demethylase in Drosophila, to the regulation of the pattern of H3K4me3. ChIP-seq results show that, at developmental genes, dKDM5/LID localizes at TSS and regulates H3K4me3. dKDM5/LID target genes are highly transcribed and enriched in active RNApol II and H3K36me3, suggesting a positive contribution to transcription. Expression-profiling show that, though weakly, dKDM5/LID target genes are significantly downregulated upon dKDM5/LID depletion. Furthermore, dKDM5/LID depletion results in decreased RNApol II occupancy, particularly by the promoter-proximal Pol lloser5 form. Our results also show that ASH2, an evolutionarily conserved factor that locates at TSS and is required for H3K4me3, binds and positively regulates dKDM5/LID target genes. However, dKDM5/LID and ASH2 do not bind simultaneously and recognize different chromatin states, enriched in H3K4me3 and not, respectively. These results indicate that, at developmental genes, dKDM5/LID and ASH2 coordinately regulate H3K4me3 at TSS and that this dynamic regulation contributes to transcription.