アブドッラー国王統治下のサウジ権力構造の変化 -- 2015年1月のサルマーン国王即位後の動きを含めて

The Basic Law of Governance in Saudi Arabia stipulates that the king of Saudi Arabia has absolute power in the government of Saudi Arabia. However, after King Abdullah's accession to the throne in 2005, his political powers were limited because of the presence of the so-called Sudeiri Seven, the powerful royal group that consists of the seven sons of King Abdel-Aziz's purported favorite wife, Sheikha Hussa bin Ahmad Sudeiri. The death of the crown prince Sultan in 2011 followed by the death of the next crown prince Naif in 2012, both members of the Sudeiri Seven, weakened the power of the Sudeiri Seven. As a result, King Abdullah's power had increased greatly compared to that of the Sudeiri Seven. Also, the sons of King Abdullah, who occupied prominent governmental posts, were acquiring strong influence in the regime. The death of King Abdullah in January 2015 and Salman's accession to the throne caused changes to the ruling regime in Saudi Arabia. King Salman appointed Prince Muqrin as crown prince and deputy premier, and Prince Muhammad b. Naif as deputy crown prince. King Salman also appointed his son Muhammad b. Salman as defence minister and head of the royal court. Finally, King Salman issued a royal order on January 29 to reshuffle his cabinet and dismiss the governors of the Riyadh and Makka.

Regulation of Sticholysin II-Induced Pore Formation by Lipid Bilayer Composition, Phase State, and Interfacial Properties

Sticholysin II (StnII) is a pore-forming toxin that uses sphingomyelin (SM) as the recognition molecule in targeting membranes.After StnII monomers bind to SM, several toxin monomers act in concert to oligomerize into a functional pore. The regulation of StnII binding to SM, and the subsequent pore-formation process, is not fully understood. In this study, we examined how the biophysical properties of bilayers, originating from variations in the SM structure, from the presence of sterol species, or from the presence of increasingly polyunsaturated glycerophospholipids,affected StnII-induced pore formation. StnII-induced pore formation, as determined from calcein permeabilization, was fastest in the pure unsaturated SM bilayers. In 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC)/saturated SM bilayers (4:1 molar ratio), pore formation became slower as the chain length of the saturated SMs increased from 14 up to 24 carbons. In the POPC/palmitoyl-SM (16:0-SM) 4:1 bilayers, SM could not support pore formation by StnII if dimyristoyl-PC was included at 1:1 stoichiometry with 16:0-SM, suggesting that free clusters of SM were required for toxin binding and/or pore formation. Cholesterol and other sterols facilitated StnII-induced pore formation markedly, but the efficiency did not appear to correlate with the sterol structure. Benzyl alcohol was more efficient than sterols in enhancing the pore-formation process, suggesting that the effect on pore formation originated from alcohol-induced alteration of the hydrogen-bonding network in the SM-containing bilayers. Finally, we observed that pore formation by StnII was enhanced in the PC/16:0-SM 4:1 bilayers, in which the PC was increasingly unsaturated. We conclude that the physical state of bilayer lipids greatly affected pore formation by StnII. Phase boundaries were not required for pore formation, although SM in a gel state attenuated pore formation.

Electroencephalogram based Causality Graph Analysis in Behavior Tasks of Parkinson’s Disease Patients

Electroencephalographic (EEG) signals of the human brains represent electrical activities for a number of channels recorded over a the scalp. The main purpose of this thesis is to investigate the interactions and causality of different parts of a brain using EEG signals recorded during a performance subjects of verbal fluency tasks. Subjects who have Parkinson's Disease (PD) have difficulties with mental tasks, such as switching between one behavior task and another. The behavior tasks include phonemic fluency, semantic fluency, category semantic fluency and reading fluency. This method uses verbal generation skills, activating different Broca's areas of the Brodmann's areas (BA44 and BA45). Advanced signal processing techniques are used in order to determine the activated frequency bands in the granger causality for verbal fluency tasks. The graph learning technique for channel strength is used to characterize the complex graph of Granger causality. Also, the support vector machine (SVM) method is used for training a classifier between two subjects with PD and two healthy controls. Neural data from the study was recorded at the Colorado Neurological Institute (CNI). The study reveals significant difference between PD subjects and healthy controls in terms of brain connectivities in the Broca's Area BA44 and BA45 corresponding to EEG electrodes. The results in this thesis also demonstrate the possibility to classify based on the flow of information and causality in the brain of verbal fluency tasks. These methods have the potential to be applied in the future to identify pathological information flow and causality of neurological diseases.

Hülasat ül-ecvibe

[Çeşmizade Mehmet Halis].

Semerat ül-fuad fi 'l-mebde ve 'l-me'ad

li-şarih il-Mesnevi Abdullah Efendi.

Commonplace book : manuscript, 1820-1841

Written in several hands, some in red and black. Texts nos. 1, 2, 3, 7, 8, 9 are in the hand of Abdullah bin Abdulkadir.

Kitāb al-Taʻarruf li-madhhab ahl al-taṣawwuf : manuscript, 1605

Title from f. 2v.

Risâle-yi şârih-i Fusûs Abdî Efendi : manuscript, undated

Cream laid paper with watermarks. 19.9 x 14.3 cm ( x cm.)

În risâle-yi diger der beyân-ı ehl-i cem' ve erbâb-ı tercih : manuscript, undated

Cream laid paper with watermarks. 19.9 x 14.3 cm ( x cm.)

Risâle-yi sırr-ı nokta : manuscript, undated

Cream laid paper with watermarks. 19.9 x 14.3 cm ( x cm.)