993 resultados para ADAM, TAPI, CDC42


Relevância:

20.00% 20.00%

Publicador:

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Digitalisat der Ausg. Wilne, 1921

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Vorbesitzer: Abraham Merzbacher

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Welsch (Projektbearbeiter): Organisierung des Abwehrkampfes gegen den nach Ungarn eingedrungenen Jellačić. Der ungarische Vizekönig Erzherzog Stephan erklärt sich bereit, die Nachfolge des zum Feind übergelaufenen Oberkommandierenden der ungarischen Armee, Graf Adam Teleky, zu übernehmen

Relevância:

20.00% 20.00%

Publicador:

Resumo:

The three canonical Rho GTPases RhoA, Rac1 and Cdc42 co-ordinate cytoskeletal dynamics. Recent studies indicate that all three Rho GTPases are activated at the leading edge of motile fibroblasts, where their activity fluctuates at subminute time and micrometer length scales. Here, we use a microfluidic chip to acutely manipulate fibroblast edge dynamics by applying pulses of platelet-derived growth factor (PDGF) or the Rho kinase inhibitor Y-27632 (which lowers contractility). This induces acute and robust membrane protrusion and retraction events, that exhibit stereotyped cytoskeletal dynamics, allowing us to fairly compare specific morphodynamic states across experiments. Using a novel Cdc42, as well as previously described, second generation RhoA and Rac1 biosensors, we observe distinct spatio-temporal signaling programs that involve all three Rho GTPases, during protrusion/retraction edge dynamics. Our results suggest that Rac1, Cdc42 and RhoA regulate different cytoskeletal and adhesion processes to fine tune the highly plastic edge protrusion/retraction dynamics that power cell motility.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Lesser Ury

Relevância:

20.00% 20.00%

Publicador:

Resumo:

G. Kutna

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Jan van Eyck

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Michelangelo Buonarroti

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Jan Brueghel

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Jan Gossaert

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Raffaello Sanzio