Ms.Ff.F.Stoltze 3. 535 - Brief von Friedrich Stoltze an Unbekannt

Zu einem Zitat aus der Frankfurter Latern, Mumm von Schwarzenstein

Ms.Ff.F.Stoltze 3. 77 - Brief von Heinrich Dietz von Gesellschaft der Vogelfreunde an Friedrich Stoltze

Übersendung von "2 Paar blauer asiatischer Mövchen"

Na 1 Nachlass Max Horkheimer, 660 - Berichte über die Arbeit des Instituts für Sozialforschung u.a. (p. IX 66-IX 77)

"American Jewish Committee. Progress Report of the Scientific Department" (22.6.1945), a) als Typoskript vervielfältigt, 27 Blatt, b) Typoskript, 28 Blatt; "Über Geschichte und Tätigkeiten des Instituts für Sozialforschung", Interview Leo Löwenthal - David Berger gesendet am 29.10.1947 (?) von Radio Newsreel, USA, deutsche Übersetzung, als Typoskript vervielfältigt, mit handschriftlichen Korrekturen, 19 Blatt; "Papers Regarding the Institute of Social Research" (August 1948), Abschriften aus verschiedenen Berichten und Briefen, Typoskript, 14 Blatt; P. Hübner: "Soziologie im Kampf gegen das Vorurteil. HICOG fördert Institut für Sozialforschung an Frankfurts Universität", veröffentlicht in: Neue Zeitung, Frankfurt (1950), Typoskript mit handschriftlichen Korrekturen von Max Horkheimer, 3 Blatt; Theodor W. Adorno: "Plans of New Research Projects of the 'Institut für Sozialforschung'" (November 1950), Typoskript, 7 Blatt; "Memorandum über das Institut für Sozialforschung an der Universität Frankfurt/Main" (November 1950), a)-d) deutsche Fassung, 41 Blatt (mit Anlagen); e)-f) englische Fassung, 25 Blatt (mit Anlagen); "The Institute for Social Research, Oslo, Norway" (1950), Drucksache, 2 Blatt; "Report for UNESCO, Paris", Über das Institut für Sozialforschung (5.4. 1951), a) englische Fassung, Typoskript, 3 Blatt, b) deutscher Entwurf, Typoskript, 3 Blatt; Institut zur Förderung öffentlicher Angelegenheiten e.V., Frankfurt am Main: "3 Rundschreiben. Betreff: Clearingstelle zur Meinungsforschung (empirische Sozialforschung), Materialien zur Meinungsforschung, Institut für Sozialforschung an der Johann-Wolfgang Goethe-Universität in Frankfurt am Main" (16.4.1951), als Typoskript vervielfältigt, 4 Blatt; "Progress Report on the Institute of Social Research's Work at Frankfurt University" (10.2.1951), als Typoskript vervielfältigt, 2 Blatt; "Bericht über Geschichte und Tätigkeit des Instituts für Sozialforschung an der Johann Wolfgang Goethe-Universität, Frankfurt am Main" (1.7.1951), a) Typoskript, 3 Blatt, b) als Entwurf für ein Rundschreiben von Friedrich Pollock, Typoskript, 4 Blatt; Angaben über das Institut für Sozialforschung, Frankfurt, Antworten für einen Fragebogen (September 1951), Typoskript, 2 Blatt; "Memorandum über Arbeiten und die Organisation des Instituts" (Mai 1953), Typoskript, 4 Blatt;

Ms. lat. oct. 77 - Institutiones eclecticae de triplici philosophia: rationali, naturali et morali

Vorbesitzer: Philipp Konrad Loskandt

Genetic Predictors of Clinical Outcomes in Non-Small Cell Lung Cancer Patients

Lung cancer is the leading cause of cancer-related mortality in the US. Emerging evidence has shown that host genetic factors can interact with environmental exposures to influence patient susceptibility to the diseases as well as clinical outcomes, such as survival and recurrence. We aimed to identify genetic prognostic markers for non-small cell lung cancer (NSCLC), a major (85%) subtype of lung cancer, and also in other subgroups. With the fast evolution of genotyping technology, genetic association studies have went through candidate gene approach, to pathway-based approach, to the genome wide association study (GWAS). Even in the era of GWAS, pathway-based approach has its own advantages on studying cancer clinical outcomes: it is cost-effective, requiring a smaller sample size than GWAS easier to identify a validation population and explore gene-gene interactions. In the current study, we adopted pathway-based approach focusing on two critical pathways - miRNA and inflammation pathways. MicroRNAs (miRNA) post-transcriptionally regulate around 30% of human genes. Polymorphisms within miRNA processing pathways and binding sites may influence patients’ prognosis through altered gene regulation. Inflammation plays an important role in cancer initiation and progression, and also has shown to impact patients’ clinical outcomes. We first evaluated 240 single nucleotide polymorphisms (SNPs) in miRNA biogenesis genes and predicted binding sites in NSCLC patients to determine associations with clinical outcomes in early-stage (stage I and II) and late-stage (stage III and IV) lung cancer patients, respectively. First, in 535 early-stage patients, after correcting multiple comparisons, FZD4:rs713065 (hazard ratio [HR]:0.46, 95% confidence interval [CI]:0.32-0.65) showed a significant inverse association with survival in early stage surgery-only patients. SP1:rs17695156 (HR:2.22, 95% CI:1.44-3.41) and DROSHA:rs6886834 (HR:6.38, 95% CI:2.49-16.31) conferred increased risk of progression in the all patients and surgery-only populations, respectively. FAS:rs2234978 was significantly associated with improved survival in all patients (HR:0.59, 95% CI:0.44-0.77) and in the surgery plus chemotherapy populations (HR:0.19, 95% CI:0.07-0.46).. Functional genomics analysis demonstrated that this variant creates a miR-651 binding site resulting in altered miRNA regulation of FAS, providing biological plausibility for the observed association. We then analyzed these associations in 598 late-stage patients. After multiple comparison corrections, no SNPs remained significant in the late stage group, while the top SNP NAT1:rs15561 (HR=1.98, 96%CI=1.32-2.94) conferred a significantly increased risk of death in the chemotherapy subgroup. To test the hypothesis that genetic variants in the inflammation-related pathways may be associated with survival in NSCLC patients, we first conducted a three-stage study. In the discovery phase, we investigated a comprehensive panel of 11,930 inflammation-related SNPs in three independent lung cancer populations. A missense SNP (rs2071554) in HLA-DOB was significantly associated with poor survival in the discovery population (HR: 1.46, 95% CI: 1.02-2.09), internal validation population (HR: 1.51, 95% CI: 1.02-2.25), and external validation (HR: 1.52, 95% CI: 1.01-2.29) population. Rs2900420 in KLRK1 was significantly associated with a reduced risk for death in the discovery (HR: 0.76, 95% CI: 0.60-0.96) and internal validation (HR: 0.77, 95% CI: 0.61-0.99) populations, and the association reached borderline significance in the external validation population (HR: 0.80, 95% CI: 0.63-1.02). We also evaluated these inflammation-related SNPs in NSCLC patients in never smokers. Lung cancer in never smokers has been increasingly recognized as distinct disease from that in ever-smokers. A two-stage study was performed using a discovery population from MD Anderson (411 patients) and a validation population from Mayo Clinic (311 patients). Three SNPs (IL17RA:rs879576, BMP8A:rs698141, and STK:rs290229) that were significantly associated with survival were validated (pCD74:rs1056400 and CD38:rs10805347) were borderline significant (p=0.08) in the Mayo Clinic population. In the combined analysis, IL17RA:rs879576 resulted in a 40% reduction in the risk for death (p=4.1 × 10-5 [p=0.61, heterogeneity test]). We also validated a survival tree created in MD Anderson population in the Mayo Clinic population. In conclusion, our results provided strong evidence that genetic variations in specific pathways that examined (miRNA and inflammation pathways) influenced clinical outcomes in NSCLC patients, and with further functional studies, the novel loci have potential to be translated into clinical use.

Magnetic properties and chemical composition at DSDP Hole 77-538A

Magnetic properties of doleritic and some metamorphic basement rocks underlying Catoche Knoll are studied. Doleritic rocks show a high saturation magnetic moment (2-5 emu/g) compared to metamorphic rocks (0.1-1 emu/g). Magnetic minerals of rocks from this hole show a high stability when heated in vacuo up to 600°C at a fixed rate of heating. Curie temperatures are distributed close to 550°C. These properties differ markedly from those of common submarine basalts observed before. X-ray microprobe analysis techniques were used to determine internal structures of ferromagnetic minerals; in most of ferromagnetic minerals there exist two different types of magnetic phases (i.e., products of high-temperature and low-temperature oxidations). Interpretations on the coexisting, seemingly contradictory, phases can be made based upon present analyses.

Iridium contents and microprobe analyses of DSDP Leg 77 samples

Restudy of Deep Sea Drilling Project Sites 536 and 540 in the southeast Gulf of Mexico gives evidence for a giant wave at Cretaceous-Tertiary boundary time. Five units are recognized: (1) Cenomanian limestone underlies a hiatus in which the five highest Cretaceous stages are missing, possibly because of catastrophic K-T erosion. (2) Pebbly mudstone, 45 m thick, represents a submarine landslide possibly of K-T age. (3) Current-bedded sandstone, more than 2.5 m thick, contains anomalous iridium, tektite glass, and shocked quartz; it is interpreted as ejecta from a nearby impact crater, reworked on the deep-sea floor by the resulting tsunami. (4) A 50-cm interval of calcareous mudstone containing small Cretaceous planktic foraminifera and the Ir peak is interpreted as the silt-size fraction of the Cretaceous material suspended by the impact-generated wave. (5) Calcareous mudstone with basal Tertiary forams and the uppermost tail of the Ir anomaly overlies the disturbed interval, dating the impact and wave event as K-T boundary age. Like Beloc in Haiti and Mimbral in Mexico, Sites 536 and 540 are consistent with a large K-T age impact at the nearby Chicxulub crater.