Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 419 - Aufstellung der Klassikerlektüre mit dem Titel: "Index scriptorum quae perlegi, Graecorum"

veröffentlicht in: Schopenhauer, Arthur : Arthur Schopenhauers sämtliche Werke - München : Piper - Bd. 16 : Der Briefwechsel Arthur Schopenhauers ; 3, Nr.6, S 98-101;

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 54 - Kritische Anmerkungen des preußischen Kreisgerichtsdirektors Drassado an Schopenhauers "Preisschrift über die Freiheit des Willens"

u.a.: Rezeption "Vierfache Wurzel des Satzes vom zureichenden Grunde"; Rezeption von Kants "Kritik der reinen Vernunft; Freier Wille; Bibelzitate; Hinweis auf Parerga; Kreisgerichtsdirektor; Georg Wilhelm Friedrich Hegel; Immanuel Kant;

Ms.Ff.F.Stoltze 3. 54 - Brief von Franz Fabricius an Friedrich Stoltze

Dank für ein Gedicht

Ms. germ. fol. 54 - Volkstum und Staatsvolkstum als Frucht und Aufgabe der Volksentwicklung

Vorbesitzer: Friedrich Schaefer; Wöhler-Realgymnasium Frankfurt am Main

Ms.Ff.F.Stoltze 3. 419 - Brief von Friedrich Stoltze an Alice Stoltze

Königstein: Kur, Leopold Sonnemann, Georg Pingler

Fragm. lat. VII 54 - Quaestionen zur Physik des Aristoteles

Trägerbände: Inc. qu. 1198; Inc. qu. 1240; Vorbesitzer: Dominikanerkloster Frankfurt am Main

Inc. hebr. 54 - Talmud Bavli : Masekhet Nida

Vorbesitzer: Abraham Merzbacher;

54 Rollenbilder, Bayreuth, 1891, mit Durchstreichungen

Signatur des Originals: S 36/F12189

Ms. lat. oct. 54 - Responsionale secundum usum ecclesiae S. Bartholomaei Francfordensis

Vorbesitzer: Jakob Butsch; Bertold Diller; Johannes Adam Mohr

Adagio et polonaise pour la clarinette : avec accompagnement d'orchestre ou de pianoforte ; op. 54

composé par Iwan Müller

Fragm. lat. I 16 - Psalterium (Ps 45,8 - 48,8; 48,11 - 18; 54,13 - 55,9; 62,3 - 63,11)

Trägerband: Ms. Barth. 129; Vorbesitzer: Bartholomaeusstift Frankfurt am Main

Genetic variants within the Wnt/ B-catenin signaling pathway as indicators of bladder cancer clinical outcomes

The genetic factors that influence bladder cancer clinical outcomes are largely unknown. In this clinical outcomes study, I assessed genetic variations in the Wnt/β-catenin stem-cell pathway genes for association with recurrence and progression. A total of 230 SNPS in 40 genes from the Wnt/β-catenin pathway were genotyped in 419 histologically confirmed non-muscle invasive bladder cancer cases. Several significant associations were observed in the clinical outcomes analysis. Under the dominant model WNT8B: rs4919464 (HR: 1.55, 95% CI: 1.17-2.06, P=2.2x10-3) and WNT8B: rs3793771 (HR: 1.54, 95% CI: 1.09-1.62, P=4.6x10-3 ) were statistically significantly associated with an increase risk of recurrence while two other variants, APC2: rs11668593 (HR: 2.50, 95% CI: 1.43-4.35, P=1.2x10-3) and LRP5 : rs312778 (HR: 1.81, 95% CI: 1.23-2.65, P=2.7x10-3), were significantly associated with recurrence risk under the recessive model of inheritance. Four SNPs in the recessive model were associated with an increased risk of progression (AXIN2: rs1544427, LRP5: rs312778, AXIN1: rs370681, AXIN1: rs2301522). LRP5: rs312778 had the most significant increased risk of progression with a 2.68 (95% CI: 1.52-4.72, P=6.4x10-4)-fold increased risk. Stratification analysis based on treatment regimen (transurethral resection (TUR) and Bacillus Calmette-Guérin (BCG)) was also performed. Individuals with at least one variant in AXIN2: rs2007085 were found to have a 2.09 (95% CI: 1.24-3.52, P=5.4x10-3) -fold increased risk of recurrence in those that received TUR only, and no statistically significant effect was seen in those that received BCG. Individuals who received TUR with at least one variant in LEF1: rs10516550 were found to have a 2.26 (95% CI: 1.22-4.18, P=9.7x10-3)-fold increase risk of recurrence and no statistically significant effect was found in individuals who received BCG. Also, the recessive model of LRP6: rs2302684 in TUR only treatment was shown to have a 1.95 (95%CI: 1.18-3.21, P=8.8x10 -3)-fold increased risk of recurrence, and a suggested protective effect associated with a (HR: 0.83, 95% CI: 0.51-1.37, P=0.468) decreased risk of recurrence. Together, these findings implicate the Wnt/β-catenin stem-cell pathway as playing a role in bladder cancer clinical outcomes and have important implications for personalization of future treatment regimens. ^

Physical oceanography from the TRACTOR project

Primary Objectives - Describe and quantify the present strength and variability of the circulation and oceanic processes of the Nordic Seas regions using primarily observations of the long term spread of a tracer purposefully released into the Greenland Sea Gyre in 1996. - Improve our understanding of ocean processes critical to the thermaholine circulation in the Nordic Seas regions so as to be able to predict how this region may respond to climate change. - Assess the role of mixing and ageing of water masses on the carbon transport and the role of the thermohaline circulation in carbon storage using water transports and mixing coefficients derived from the tracer distribution. Specific Objectives Perform annual hydrographic, chemical and SF6 tracer surveys into the Nordic regions in order to: - Measure lateral and diapycnal mixing rates in the Greenland Sea Gyre and in the surrounding regions. - Document the depth and rates of convective mixing in the Greenland Sea using the SF6 and the water masses characteristics. - Measure the transit time and transport of water from the Greenland Sea to surrounding seas and outflows. Document processes of water mass transformation and entrainment occurring to water emanating from the central Greenland Sea. - Measure diapycnal mixing rates in the bottom and margins of the Greenland Sea basin using the SF6 signal observed there. Quantify the potential role of bottom boundary-layer mixing in the ventilation of the Greenland Sea Deep Water in absence of deep convection. Monitor the variability of the entrainment of water from the Greenland Sea using time series auto-sampler moorings at strategic positions i.e., sill of the Denmark Strait, Labrador Sea, Jan Mayen fracture zone and Fram Strait. Relate the observed variability of the tracer signal in the outflows to convection events in the Greenland Sea and local wind stress events. Obtain a better description of deepwater overflow and entrainment processes in the Denmark Strait and Faeroe Bank Channel overflows and use these to improve modelling of deepwater overflows. Monitor the tracer invasion into the North Atlantic using opportunistic SF6 measurements from other cruises: we anticipate that a number of oceanographic cruises will take place in the north-east Atlantic and the Labrador Sea. It should be possible to get samples from some cruises for SF6 measurements. Use process models to describe the spread of the tracer to achieve better parameterisation for three-dimensional models. One reason that these are so resistant to prediction is that our best ocean models are as yet some distance from being good enough, to predict climate and climate change.