Clinical and pathological assessment of 82 patients with cardiovascular diseases undergoing autopsy at the Hospital das Clínicas of the Faculdade de Medicina de Botucatu from 1988 to 1993

OBJECTIVE: To evaluated the clinical diagnostic, efficiency for basic death causes in patients dying of circulatory disease and de relative frequency of those diseases. METHODS: Analysis of medical record data of 82 patients, ages from 16 to 84 years old (68 over 40 years old), whose died of circulatory disease and had undergone necropsy in the period from 1988 to 1993 years in the University Hospital of Medicine Faculty of Botucatu-UNESP, Br. RESULTS: The functional class of patients were III or IV, in 78%, and 81.7% needed urgent hospitalization. By the clinical judgment the death were by ischemic heart disease in 32 (21 acute myocardial infarction), Chagas'disease in 12, valvopathy in 11, cardiomyopathy in 7, heart failure with no specification of cardiopathy in 11 and other causes in 9. At the necropsy the death cause was ischemic heart disease in 34 patients, valvopathy in 10, Chagas'disease in 10, cardiomyopathy in 5, and heart failure with no specification of cardiopathy in 2.The concordance taxes were in thhe same order: 94,6%, 90,0%, 83.3%, 71.4% and 28.5%. CONCLUSION: There was a great efficiency of clinical diagnosis for death cause in a general university hospital. The ischemic heart disease were the main causes of death.

Caracterização histoquímica do colágeno e expressão de MMP-2, MMP-9 e TIMP-1 nas endometrites crônicas das éguas

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

MMP-2 and MMP-9 in lymph-node-positive bladder cancer

Matrix metalloproteinases (MMP), particularly MMP-2 and MMP-9, participate in tumour progression and metastasis in various cancers. Their significance in urothelial cancer of the bladder (UCB) is unclear. Expression analysis of MMP-2 and MMP-9 in tissue microarrays (TMA) constructed of corresponding samples from histopathological normal urothelium, tumour centre and invasion front of primary tumours and lymph-node (LN) metastases might help to elucidate their relevance in UCB.

Gelatinase B [matrix metalloproteinase (MMP)-9] and collagenases (MMP-8/-13) are upregulated in cerebrospinal fluid during aseptic and bacterial meningitis in children

We investigated the protein expression of gelatinases [matrix metalloproteinase (MMP)-2 and -9] and collagenases (MMP-8 and -13) in cerebrospinal fluid (CSF) from patients with bacterial (BM, n = 17) and aseptic (AM, n = 14) meningitis. In both, MMP-8 and -9 were increased in 100% of patients, whereas MMP-13 was detectable in 53% and 82% respectively. Three patients with clinical signs of meningitis, without CSF pleocytosis, scored positive for all three MMPs. MMP-8 appeared in two isoforms, granulocyte-type [polymorphonuclear cell (PMN)] and fibroblast/macrophage (F/M) MMP-8. Analysis of kinetic changes from serial lumbar punctures showed that these MMPs are independently regulated, and correlate only partly with CSF cytosis or levels of the endogenous inhibitor, tissue inhibitor of matrix metalloproteinase-1. In vitro, T cells, peripheral blood mononuclear cells (PBMCs) and granulocytes (PMN) release MMP-8 and -9, whereas MMP-13 could be found only in the former two cell types. Using models of exogenous (n-formyl-Met-Leu-Phe, T cell receptor cross-linking) and host-derived stimuli (interleukin-2), the kinetics and the release of the MMP-8, -9 and -13 showed strong variation between these immune cells and suggest release from preformed stocks. In addition, MMP-9 is also synthesized de novo in PBMCs and T cells. In conclusion, invading immune cells contribute only partially to MMPs in CSF during meningitis, and parenchymal cells are an equally relevant source. In this context, in patients with clinical signs of meningitis, but without CSF pleocytosis, MMPs seem to be a highly sensitive marker for intrathecal inflammation. The present data support the concept that broad-spectrum enzyme inhibition targeting gelatinases and collagenases is a potential strategy for adjunctive therapy in infectious meningitis.

Na 1 Nachlass Max Horkheimer, 76 - Korrespondenzen u.a. mit Hermann Igersheimer (p. II 9, 89-222c)

1 Brief und Beilage vom Institut für sozialwissenschaftliche Forschung Darmstadt an Max Horkheimer, 1949; 82 Briefe zwischen Hermann Igersheimer und Max Horkheimer, 1941-1950; 5 Briefe zwischen Harold E. Jones von der University of California und Max Horkheimer, 1947; 1 Brief von Morris Janowitz an Max Horkheimer, 1948; 2 Briefe vom Jewish Community Center an Max Horkheimer, 1948; 7 Briefe zwischen Robert P. St.John und Max Horkheimer, 1945; 2 Briefe zwischen Erich von Kahler und Max Horkheimer, 1945; 2 Briefe und Beilage zwischen Anselm Kahn und Max Horkheimer, 04.07.1945, 19.07.1945;

Na 1 Nachlass Max Horkheimer, 291 - Korrespondenzen u.a. mit Heinz Joachim Heydorn (p. V 82, 119-246)

3 Briefe zwischen Graf Lazy Henckel von Donnersmarck und Max Horkheimer, 1968; 2 Briefe zwischen Gräfin Nina Henckel von Donnersmarck und Max Horkheimer, 1968; 4 Briefe zwischen der Sängerin Carla Henius und Max Horkheimer, 1970-1971; 1 Brief an K. H. Hennings von Max Horkheimer, 1967; 4 Briefe zwischen Professor Wilhelm Hennis und Max Horkheimer, 1971; 1 Brief an Professor Dieter Henrich von Max Horkheimer, 1964; 2 Briefe zwischen Caroline Hergert und Max Horkheimer, 1970; 1 Brief von Professor Fred Herman an Max Horkheimer, 1959; 2 Briefe zwischen der Fachschülerin Dora Herrmann und Max Horkheimer, 1972; 2 Briefe zwischen Professor Franz Herrmann und Max Horkheimer, 1970; 6 Briefe zwischen Dr. phil. Gert-Julius Herrmann und Max Horkheimer, 1968; 2 Briefe zwischen Dipl. Kfm. Dr. Dr. Otto O. Herz und Max Horkheimer, 1969; 4 Briefe zwischen Professor und Museumsdirektor Erich Herzog und Max Horkheimer, 1970; 2 Briefe zwischen Hans Eberhard Hess und Max Horkheimer, 1970; 16 Briefe zwischen Professor Eugen Hess-Baer und Max Horkheimer, 1966-1971; 3 Briefe zwischen Karl Hess und Max Horkheimer, 1969-1971; 1 Drucksache von Pfarrer Walter Hess, 1971; 6 Briefe zwischen dem Bankier Walter Hesselbach und Max Horkheimer, 1971-1973; Drucksachen vom Hessischen Kreis, 1968; Briefe zwischen dem Hessischen Landesmuseum Darmstadt und Max Horkheimer, 1969; 25 Briefe zwischen Professor Heinz Joachim Heydorn und Max Horkheimer, 1965-1973; 2 Briefe zwischen Dr. Karl Heymann und Max Horkheimer, 1970; 1 Brief an den Hippokrates-Verlag von Max Horkheimer, 1971; 9 Briefe zwischen Walter Hirschmann und Max Horkheimer, 1969-1971;

Die unbedingte Zuverlässigkeit der Bibel auf geschichtlichem und naturwissenschaftlichem Gebiet : Vortrag auf der Herbstversammlung des Bibelbundes in Hannover am 9. Oktober 1927

von Heinrich Cornelius