Le osservationi della lingua volgare di diversi huomini illustri : cioe del Bembo, del Gabrielo, del Fortunio, del Corso, dell' Acarisio, et di altri scrittori... ([Reprod.]) / [Francesco Sansovino]

Collection : Italian books before 1601 ; 192.6

Les actes de Sully passés au nom du roi de 1600 à 1610 : par devant Me Simon Fournyer, notaire au Châtelet de Paris, dont les minutes sont conservées en l'étude de Me Henri Motel, notaire à Paris / recueillis, publiés et annotés par M. F. de Mallevoüe

Collection : Collection de documents inédits sur l'histoire de France

Les actes de Sully passés au nom du roi de 1600 à 1610 : par devant Me Simon Fournyer, notaire au Châtelet de Paris, dont les minutes sont conservées en l'étude de Me Henri Motel, notaire à Paris / recueillis, publiés et annotés par M. F. de Mallevoüe

Collection : Collection de documents inédits sur l'histoire de France

A refutation of sundry reprehensions, cavils, and falses sleigthes, by M. Whitaker laboureth to deface the late english translation, and Catholike annotations of the New Testament, and the books of discovery of heretical corruptions ([Reprod.]) / by William Rainolds

Collection : French books before 1601 ; 210.3

Intraocular penetration of penciclovir after oral administration of famciclovir: a population pharmacokinetic model.

OBJECTIVES: We developed a population model that describes the ocular penetration and pharmacokinetics of penciclovir in human aqueous humour and plasma after oral administration of famciclovir. METHODS: Fifty-three patients undergoing cataract surgery received a single oral dose of 500 mg of famciclovir prior to surgery. Concentrations of penciclovir in both plasma and aqueous humour were measured by HPLC with fluorescence detection. Concentrations in plasma and aqueous humour were fitted using a two-compartment model (NONMEM software). Inter-individual and intra-individual variabilities were quantified and the influence of demographics and physiopathological and environmental variables on penciclovir pharmacokinetics was explored. RESULTS: Drug concentrations were fitted using a two-compartment, open model with first-order transfer rates between plasma and aqueous humour compartments. Among tested covariates, creatinine clearance, co-intake of angiotensin-converting enzyme inhibitors and body weight significantly influenced penciclovir pharmacokinetics. Plasma clearance was 22.8 ± 9.1 L/h and clearance from the aqueous humour was 8.2 × 10(-5) L/h. AUCs were 25.4 ± 10.2 and 6.6 ± 1.8 μg · h/mL in plasma and aqueous humour, respectively, yielding a penetration ratio of 0.28 ± 0.06. Simulated concentrations in the aqueous humour after administration of 500 mg of famciclovir three times daily were in the range of values required for 50% growth inhibition of non-resistant strains of the herpes zoster virus family. CONCLUSIONS: Plasma and aqueous penciclovir concentrations showed significant variability that could only be partially explained by renal function, body weight and comedication. Concentrations in the aqueous humour were much lower than in plasma, suggesting that factors in the blood-aqueous humour barrier might prevent its ocular penetration or that redistribution occurs in other ocular compartments.

I Relatório Nacional de Direitos Humanos 2004 - 2010

1. A ideia de que os seres humanos nascem livres e são iguais em dignidade, apesar de relativamente prosaica, tem uma poderosa força simbólica, com implicações concretas no campo de interacção e na forma como nos vemos a nós próprios e aos outros, enquanto indivíduos livres, com concepções próprias e formas particulares de realização pessoal, a quem devem ser garantidos espaços de autonomia e assegurado um mínimo existencial para as perseguir e concretizar, e que não podem ser nem beneficiados e nem discriminados injustificadamente, com base em categorias suspeitas de raça, religião, posição social, etc. Os direitos humanos consubstanciam-se, de facto, numa das mais poderosas forças ideológicas e institucionais que moldaram o ethos da modernidade e, gradualmente, se consolidaram e projectaram por grande parte do Mundo, particularmente no Ocidente. Com efeito, desde as revoluções liberais dos Séculos XVII e XVIII, com o surgimento do Estado liberal inglês e a democracia norte-americana, com o reconhecimento dessa categoria de direitos pela Declaração Francesa dos Direitos do Homem e do Cidadão de 1789 que, gradualmente, mas com hiatos importantes, os direitos humanos se têm afirmado como um dos pilares indissociáveis do Estado de Direito Democrático e, de certa forma, da própria comunidade internacional. Não obstante, foi curiosamente na sequência de um dos mais evidentes retrocessos que, aliás, não podem ser dissociados da própria modernidade, que eles se consolidam igualmente na esfera internacional, condição indispensável para a sua projecção além do número reduzido de países supramencionados. Destarte, o fim da II Guerra Mundial e as violações grosseiras aos direitos humanos promovidas principalmente pela Alemanha - mas também, embora sem qualquer equivalência, pela União das Repúblicas Socialistas Soviéticas e por outras potências vencedoras -, Declaração Universal dos Direitos Humanos de 19481 deixaram transparecer, de forma inequívoca, a necessidade de transformar princípios morais universais, decantados por filósofos e literatos, numa realidade positivada e palpável que pudesse conter a liberalidade de tratamento de Estados sobre indivíduos. Nasce, deste modo, a base do Direito Internacional dos Direitos Humanos, com a, posteriormente desenvolvida pelo conjunto de documentos que compõem a actual International Bill of Rights (Carta Internacional dos Direitos Humanos), designadamente os dois pactos de 1966 e convenções destinadas a lidar com situações ou categorias especiais de pessoas (discriminação racial, tortura, mulheres e crianças).

Factores Condicionantes da Eficácia Interna dos Estudantes da Escola Secundária Constantino Semedo

Reconhece-se hoje que o factor que exerce a maior influência sobre a competitividade de uma nação é factor educativo. Nesta perspectiva a valorização de recursos humanos através da educação, constitui um dos desafios para o futuro do país, sendo isto o principal trunfo de que Cabo Verde dispõe. É neste sentido que as grandes opções do plano salienta que é, no homem Cabo-Verdiano, portador de uma cultura rica, que deverá alicerçar-se o desenvolvimento do país1. No entanto todos têm a consciência dos resultados que a educação tem dado ás sociedades de nosso quotidiano, mas há necessidade de ver mais de perto o que acontece realmente nas nossas instituições educativas.

L'art de naviguer : contenant toutes les reigles, secrets, & enseignemens necessaires à la bonne navigation ([Reprod.]) / de M. Pierre de Medina ; traduict de Castillan en François, avec augmentation & illustration de plusieurs figures et annotations par Nicolas de Nicolai,...

Collection : French books before 1601 ; 69.4

Mechanisms of Symptomatic Spinal Cord Ischemia After TEVAR: Insights From the European Registry of Endovascular Aortic Repair Complications (EuREC).

Abstract Purpose: To test the hypothesis that simultaneous closure of at least 2 independent vascular territories supplying the spinal cord and/or prolonged hypotension may be associated with symptomatic spinal cord ischemia (SCI) after thoracic endovascular aortic repair (TEVAR). Methods: A pattern matching algorithm was used to develop a risk model for symptomatic SCI using a prospective 63-patient single-center cohort to test the positive predictive value (PPV) of prolonged intraoperative hypotension and/or simultaneous closure of at least 2 of 4 the vascular territories supplying the spinal cord (left subclavian, intercostal, lumbar, and hypogastric arteries). This risk model was then applied to data extracted from the multicenter European Registry on Endovascular Aortic Repair Complications (EuREC). Between 2002 and 2010, the 19 centers participating in EuREC reported 38 (1.7%) cases of symptomatic spinal cord ischemia among the 2235 patients in the database. Results: In the single-center cohort, direct correlations were seen between the occurrence of symptomatic SCI and both prolonged intraoperative hypotension (PPV 1.00, 95% CI 0.22 to 1.00, p = 0.04) and simultaneous closure of at least 2 independent spinal cord vascular territories (PPV 0.67, 95% CI 0.24 to 0.91, p = 0.005). Previous closure of a single vascular territory was not associated with an increased risk of symptomatic spinal cord ischemia (PPV 0.07, 95% CI 0.01 to 0.16, p = 0.56). The combination of prolonged hypotension and simultaneous closure of at least 2 territories exhibited the strongest association (PPV 0.75, 95% CI 0.38 to 0.75, p<0.0001). Applying the model to the entire EuREC cohort found an almost perfect agreement between the predicted and observed risk factors (kappa 0.77, 95% CI 0.65 to 0.90). Conclusion: Extensive coverage of intercostal arteries alone by a thoracic stent-graft is not associated with symptomatic SCI; however, simultaneous closure of at least 2 vascular territories supplying the spinal cord is highly relevant, especially in combination with prolonged intraoperative hypotension. As such, these results further emphasize the need to preserve the left subclavian artery during TEVAR.

Forecasting the effects of global warming on biodiversity

The demand for accurate forecasting of the effects of global warming on biodiversity is growing, but current methods for forecasting have limitations. in this article, we compare and discuss the different uses of four forecasting methods: (1) models that consider species individually, (2) niche-theory models that group species by habitat (more specifically, by environmental conditions under which a species can persist or does persist), (3) general circulation models and coupled ocean-atmosphere-biosphere models, and (4) specics-area curve models that consider all species or large aggregates of species. After outlining the different uses and limitations of these methods, we make eight primary suggestions for improving forecasts. We find that greater use of the fossil record and of modern genetic studies would improve forecasting methods. We note a Quaternary conundrum: While current empirical and theoretical ecological results suggest that many species could be at risk from global warming, during the recent ice ages surprisingly few species became extinct. The potential resolution of this conundrum gives insights into the requirements for more accurate and reliable forecasting. Our eight suggestions also point to constructive synergies in the solution to the different problems.

Plan I - Investigaciones de anchoveta

Presenta información referente a los hábitos alimenticios del recurso anchoveta con la finalidad de buscar la relación que existe entre las migraciones que realiza el recurso por exigencias alimenticias y la abundancia de determinado organismo del plancton, el cual constituye el alimento principal del recurso.