Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and Pentostam.

Successful treatment in allergic, autoimmune, and infectious diseases often requires altering the nature of a detrimental immune response mediated by a particular CD4+ T helper (Th) cell subset. While several factors contribute to the development of CD4+ Th1 and Th2 cells, the requirements for switching an established response are not understood. Here we use infection with Leishmania major as a model to investigate those requirements. We report that treatment with interleukin 12 (IL-12), in combination with the antimony-based leishmanicidal drug Pentostam, induces healing in L. major-infected mice and that healing is associated with a switch from a Th2 to a Th1 response. The data suggest that decreasing antigen levels may be required for IL-12 to inhibit a Th2 response and enhance a Th1 response. These observations are important for treatment of nonhealing forms of human leishmaniasis and also demonstrate that in a chronic infectious disease an inappropriate Th2 response can be switched to an effective Th1 response.

Abolishing Oil Indexation in Gas Contracts: Is it the cure-all? CEPS Commentaries, 3 March 2014

Recently, the EU energy debate has been dominated by the discussion on energy prices and the competitiveness of the European industry. According to the latest estimates of the International Energy Agency, gas prices in the US are one-quarter of those in Europe. Moreover, prices of imported gas vary across the EU member states. Some EU policy-makers hope that the completion of the internal energy market and the transition to hub-based pricing will solve these discrepancies. Julian Wieczorkiewicz asks in this Commentary whether the abolition of oil-indexation will constitute a cure-all for the above-mentioned problems.

ISDS and TTIP – A miracle cure for a systemic challenge? EPC Policy Brief, 14 July 2014

The European Commission decided to carry out a public consultation, which closed on 13 July, on the possible inclusion of investor-to-state dispute settlement (ISDS) provisions in the Transatlantic Trade and Investment Partnership (TTIP). This decision came in a context of polarised public debate around this procedural mechanism which enables investors to bring a case against a country that hosts their investments. Even though the main question is whether or not to include ISDS in TTIP, the Commission eyes the public consultation as a way to correct the inconsistencies of the mechanism by modernising it. However, the inclusion of ISDS in TTIP will not be a miracle cure because ISDS is a complex multilayered systemic challenge which requires a multilateral solution. In this Policy Brief, Romain Pardo explores which challenges are posed by ISDS and the extent at which TTIP’s contribution can tackle these challenges.

The medical genius ; a guide to the cure /

Mode of access: Internet.

The book of the fly; a nature study of the house-fly and its kin, the fly plague and a cure.

Mode of access: Internet.

Ralston gardens of life : a study of health and the best way of living, including the natural cure of disease and the perfecting of the faculties : also private walks and talks with the author and a complete presentation of diets in health and disease and foods of the Ralstonites /

Includes index.

Home cure for stammerers,

Mode of access: Internet.

Sea-sickness: cause, prevention, and cure. Voyaging for health, with an appendix on ship-surgeons. A concise practical treatise

Mode of access: Internet.

Chickens and how to raise them. All about chickens, how to hatch, house, feed and fatten them, and cure their diseases.

Mode of access: Internet.

The economic crisis; a study of cause and cure,

Mode of access: Internet.

A plea for ragged schools, or, Prevention better than cure : Supplement to "A plea for ragged schools."

"Constitution and rules of the Association for the Establishment of Ragged Industrial Schools for Destitute Children in Edinburgh": p. 12-13.

The natural method of cureing the diseases of the body and the disorders of the mind, depending on the body : in three parts, Part I. General reflections ... Part II. The means and method for preserving life and faculties ..., Part III. Reflections on the nature and cure of particular chronical distempers /

Mode of access: Internet.

Observations on the superior efficacy on the red peruvian bark in the cure of fevers ... /

Mode of access: Internet.