636 resultados para bipolar seesaw
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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In this work we show that we can generate neutrino masses through the type II seesaw mechanism working at TeV scale in the context of a 331 model. (C) 2001 Published by Elsevier B.V. B.V.
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In this work we show that in a version of the 3-3-1 model proposed by Duong and Ma, in which the introduction of a scalar sextet is avoided by adding a singlet heavy charged lepton, the tau lepton gains mass through a seesawlike mechanism. We also show how to generate neutrino masses at the one-loop level, and give the respective Maki-Nakagawa-Sakata mixing matrices for a set of the parameters. We also consider the effect of adding a singlet right-handed neutrino.
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Some years ago it was shown by Ma that in the context of the electroweak standard model there are, at the tree level, only three ways to generate small neutrino masses by the seesaw mechanism via one effective dimension-five operator. Here we extend this approach to 3-3-1 chiral models showing that in this case there are several dimension-five operators and we also consider their tree level realization.
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Investigation of Wnt signalling cascade in the peripheral blood mononuclear cell of bipolar patients
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Although the bipolar disorder (BD) occurs almost with the same frequency in both genders, the phenomenology and the outcome of the illness differ between them. Nevertheless, there is evidence that women with BD show, more than men, delayed beginning, especially in their fifth decade, more rapid cycling outcome, more depressive episodes, more dysphoric mania, more mixed states and more BD type II. Even so, the findings are not always consistent. Although the risk of comorbidities in BD includes, for both the sorts, excessive alcoholic consumption and drugs, bipolar men would have greater probability of being alcohol dependent, of not seeking treatment and of committing suicide. Suggested hypotheses to explain such differences vary from those centered in cultural or psychological aspects to those that focus on the steroids hormones, and other hormones such as cortisol, thyroid hormones and even on the cerebral anatomy. The reproductive cycle (menstrual cycle, pregnancy and menopause) influences on the BD phenomenology and its relevance to the therapeutical options in the treatment of the BD in women are presented in the last part of this review. Further investigations must to be done in order to clarify this controversy. However, up to now the data indicate that estrogen therapy is not to be primarily indicated to prevent depression, Alzheimer disease or cognition impairment.
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Pós-graduação em Cirurgia Veterinária - FCAV
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To quantify the effects of methylmercury (MeHg) on amacrine and on ON-bipolar cells in the retina, experiments were performed in MeHg-exposed groups of adult trahiras (Hoplias malabaricus) at two dose levels (2 and 6 µg/g, ip). The retinas of test and control groups were processed by mouse anti-parvalbumin and rabbit anti-aprotein kinase C (aPKC) immunocytochemistry. Morphology and soma location in the inner nuclear layer were used to identify immunoreactive parvalbumin (PV-IR) and aPKC (aPKC-IR) in wholemount preparations. Cell density, topography and isodensity maps were estimated using confocal images. PV-IR was detected in amacrine cells in the inner nuclear layer and in displaced amacrine cells from the ganglion cell layer, and aPKC-IR was detected in ON-bipolar cells. The MeHg-treated group (6 µg/g) showed significant reduction of the ON-bipolar aPKC-IR cell density (mean density = 1306 ± 393 cells/mm2) compared to control (1886 ± 892 cells/mm2; P < 0.001). The mean densities found for amacrine PV-IR cells in MeHg-treated retinas were 1040 ± 56 cells/mm2 (2 µg/g) and 845 ± 82 cells/mm2 (6 µg/g), also lower than control (1312 ± 31 cells/mm2; P < 0.05), differently from the data observed in displaced PV-IR amacrine cells. These results show that MeHg changed the PV-IR amacrine cell density in a dose-dependent way, and reduced the density of aKC-IR bipolar cells at the dose of 6 µg/g. Further studies are needed to identify the physiological impact of these findings on visual function.
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An infinite hierarchy of solvable systems of purely differential nonlinear equations is introduced within the framework of asymptotic modules. Eacy system consists of (2+1)-dimensional evolution equations for two complex functions and of quite strong differential constraints. It may be interpreted formally as an integro-differential equation in (1+1) dimensions. © 1988.