212 resultados para Zoé


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Inaug.-diss.--Heidelberg.

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Includes index.

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Mode of access: Internet.

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Mode of access: Internet.

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Mode of access: Internet.

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Tight junctions are directly involved in regulating the passage of ions and macromolecules (gate functions) in epithelial and endothelial cells. The modulation of these gate functions to transiently regulate the paracellular permeability of large solutes and ions could increase the delivery of pharmacological agents or gene transfer vectors. To reduce the inflammatory responses caused by tight junction-regulating agents, alternative strategies directly targeting specific tight junction proteins could prove to be less toxic to airway epithelia. The apical delivery of peptides corresponding to the first extracellular loop of occludin to transiently modulate apical paracellular flux has been demonstrated in intestinal epithelia. We hypothesized that apical application of these occludin peptides could similarly modulate tight junction permeability in airway epithelia. Thus, we investigated the effects of apically applied occludin peptide on the paracellular permeability of molecular tracers and viral vectors in well differentiated human airway epithelial cells. The effects of occludin peptide on cellular toxicity, tight junction protein expression and localization, and membrane integrity were also assessed. Our data showed that apically applied occludin peptide significantly reduced transepithelial resistance in airway epithelia and altered tight junction permeability in a concentration-dependent manner. These alterations enhanced the paracellular flux of dextrans as well as gene transfer vectors. The occludin peptide redistributed occludin but did not alter the expression or distribution of ZO-1, claudin-1, or claudin-4. These data suggest that specific targeting of occludin could be a better-suited alternative strategy for tight junction modulation in airway epithelial cells compared with current agents that modulate tight junctions.

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Dit boek is bestemd voor teamleden of begeleiders die het werken in een team zo effectief mogelijk willen maken. De auteur behandelt allerlei aspecten van het werken in teams. Aan de hand van voorbeelden maakt hij duidelijk welke factoren het effectief functioneren van een team kunnen verbeteren of tegenwerken. Het boek bevat ook richtlijnen om de dynamiek van een team te bevorderen. Dit boek is een vertaling van het boek Effective teamwork. Het is uitermate relevant voor veel beroepen in de openbare en particuliere sector: handel en bedrijfsleven, onderwijs, gezondheidszorg en maatschappelijke dienstverlening.

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Binnen veel organisaties staat de marketingafdeling onder druk. Resultaten moeten op korte termijn zichtbaar zijn en de afdeling krijgt intern soms een slechte pers. In dit boek worden de tien belangrijkste, meest actuele problemen van marketing, hun oorzaken én mogelijke oplossingen besproken. Marketing aan de top biedt zo een beknopte, maar sterk onderbouwde handreiking voor iedere marketeer en marketingmanager die zijn vak relevanter en waardevoller wil maken. Ook voor topmanagers en managers actief in functionele gebieden buiten de marketing biedt het boek inzicht in de rol die de marketingfunctie kan spelen om de organisatie als geheel succesvoller te maken.

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The goal of this dissertation is to explore the use of transgressive language in the works of Juan Goytisolo and Zoé Valdés. This study examines the socio-political and cultural contexts in which the narrative of both authors develops, as well as the textual devices employed by these writers for undermining the “official history” imposed by the dictatorial regimes in Francoist Spain and Castro's Cuba. Furthermore, this dissertation argues that the deconstructing strategies in Goytisolo and Valdés mark their literary trajectory. Their vindicatory standpoints seek an alternative discourse of national identity. ^ The function of language in demythifying and recodifying hegemonic discourse is examined in Goytisolo's trilogy Señas de identidad, Reivindicación del conde don Julián, and Juan sin tierra; and the novels of Zoé Valdés La nada cotidiana and Te di la vida entera. The parallelisms in the literary works of Goytisolo and Valdés are established by contrasting the authors' revisionist approach to history, the self-reflexivity of their novels, the sexual referent, and the use of irony and parody. The theoretical framework incorporates poststructuralist theorists such as Todorov, Foucault, Lacan, Barthes, Derrida, and Kristeva; the psychoanalytical theory of Freud; and the feminist theories of Cixous and Irigaray. The comparative approach of this study and the interplay of power, politics, aesthetic creation, and author's psychology provide an illuminating perspective that could be of interest to individuals from a variety of disciplines. ^

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E utrophication in continental aquatic ecosystems and the following deterioration of water quality are some of the greatest problems to be solved in this century. Due to their own peculiarities reservoirs from semi - arid regions constitute a great challenge to water management because of their greater vulnerability to eutrophication process. I dentification of biolo gical community components that may be used as bioindicators is important to allow an early detection of adverse changes, and also to provide subsidies for management and conservation actions. The aim of the present study is to evaluate the potential of zo oplankton community as bioindicator of the trophic state of two reservoirs belonging to the Piranhas - Açu basin, RN, Brazil: Boqueirão de Parelhas and Passagem das Traíras. Monthly sampling s of both systems were carried out in both systems during the period of January to December. Measurements were performed for temperature, pH, dissolved oxygen and water electrical conductivity besides water samples collection for nutrients, suspended solids, chlorophyll - a and zooplankton analyses. T axonomic composition of zooplankton , density and biomass were analysed. Trophic state index, ABC curves , W statistic and the Calanoida: Cyclopoida ratio were also obtained. The results evidenced that Boqueirão de Parelhas reservoir was a mesotrophic sy stem, and Passagem das Traíras r eservoir was eutrophic. In both reservoirs zooplankton community had low species richness, mostly constituted by tolerant species which have wide geographical distribution, as well the dominance of the rotifers Brachionus havanaensis , B. calyciflo rus and Keratella tropica ; of the calanoid copepods Notodiaptomus cearensis and N. iheringi ; cyclopoid copepod Thermocyclops decipiens, and of the cladocerans Ceriodaphnia cornuta and Diaphanosoma spinulosum . Among the biological indices the ABC curves fo r the zooplankton community indicated a moderate dis turbance in both reservoirs, th e Calanoida: Cyclopoida ration indicated not impacted environments , e xcept during the end of the study to the reservoir Passagem das Traíras . It was concluded that the indices used are good indicators of disturbance and alteration in the community, however they are not good indicators for monitoring the trophic state of the studied reservoirs due to the simultaneous occurrence of other factors selecting species, as the c oncentration of ions and high turbidity, which are part of the reservoir characteristics of semiarid.

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Acknowledgments We thank Nancy Barahona (IFOP), Rosemary Hurst (NIWA), Timothy Emery, FelipeBriceño and Jeremy Lyle (UTAS), Patricia Hobsbawn (ABARES), John Bower (HU), Mitsuo Sakai (TNFRI), Blue Ventures, SHOALS (Rodrigues), and the Fisheries Research and Training Unit (Rodrigues) for their assistance in sourcing time-series and providing catch and effort data, as well as Felipe Briceño and Eriko Hoshino (UTAS) for Spanish- and Japanese-to-English translation, respectively. This paper resulted from a workshop funded by The Environment Institute, University of Adelaide.

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We are grateful for the co-operation and assistance that we received from NHS staff in the co-ordinating centres and clinical sites. We thank the women who participated in TOMBOLA. The TOMBOLA trial was supported by the Medical Research Council (G9700808) and the NHS in England and Scotland. The TOMBOLA Group comprises the following: Grant-holders: University of Aberdeen and NHS Grampian, Aberdeen, Scotland: Maggie Cruickshank, Graeme Murray, David Parkin, Louise Smart, Eric Walker, Norman Waugh (Principal Investigator 2004–2008) University of Nottingham and Nottingham NHS, Nottingham, England: Mark Avis, Claire Chilvers, Katherine Fielding, Rob Hammond, David Jenkins, Jane Johnson, Keith Neal, Ian Russell, Rashmi Seth, Dave Whynes University of Dundee and NHS Tayside, Dundee, Tayside: Ian Duncan, Alistair Robertson (deceased) University of Ottawa, Ottawa, Canada: Julian Little (Principal Investigator 1999–2004) National Cancer Registry, Cork, Ireland: Linda Sharp Bangor University, Bangor, Wales: Ian Russell University of Hull, Hull, England: Leslie G Walker Staff in clinical sites and co-ordinating centres Grampian Breda Anthony, Sarah Bell, Adrienne Bowie, Katrina Brown (deceased), Joe Brown, Kheng Chew, Claire Cochran, Seonaidh Cotton, Jeannie Dean, Kate Dunn, Jane Edwards, David Evans, Julie Fenty, Al Finlayson, Marie Gallagher, Nicola Gray, Maureen Heddle, Alison Innes, Debbie Jobson, Mandy Keillor, Jayne MacGregor, Sheona Mackenzie, Amanda Mackie, Gladys McPherson, Ike Okorocha, Morag Reilly, Joan Rodgers, Alison Thornton, Rachel Yeats Tayside Lindyanne Alexander, Lindsey Buchanan, Susan Henderson, Tine Iterbeke, Susanneke Lucas, Gillian Manderson, Sheila Nicol, Gael Reid, Carol Robinson, Trish Sandilands Nottingham Marg Adrian, Ahmed Al-Sahab, Elaine Bentley, Hazel Brook, Claire Bushby, Rita Cannon, Brenda Cooper, Ruth Dowell, Mark Dunderdale, Dr Gabrawi, Li Guo, Lisa Heideman, Steve Jones, Salli Lawson, Zoë Philips, Christopher Platt, Shakuntala Prabhakaran, John Rippin, Rose Thompson, Elizabeth Williams, Claire Woolley Statistical analysis Seonaidh Cotton, Kirsten Harrild, John Norrie, Linda Sharp External Trial Steering Committee Nicholas Day (chair, 1999–2004), Theresa Marteau (chair 2004-), Mahesh Parmar, Julietta Patnick and Ciaran Woodman.

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La historia de la Actividad Física en general y de la Educación Física en particular son sin duda herederas de un cuerpo escindido, biologizado. La modernidad, montada sobre ese discurso dicotómico erige la razón como el nuevo Dios, y el cuerpo, siempre lo otro de sí, pasa a ser una maquinaria al servicio del cogito cartesiano. Considerar al cuerpo una construcción de la cultura, alejándose por completo del cuerpo físico que otrora fuera el centro de las preocupaciones, constituye un quiebre epistemológico radical que es preciso valorar. Efectivamente, limitar el análisis de la actividad física y las prácticas corporales de los hombres a una simple consideración orgánica, es reducirla a un nivel muy pobre de argumentación. Pero también, un enfoque culturalista que pretende deslindar toda consideración de la condición de animalidad del ser humano, su condición de ser vivo, constituye otra cara del reduccionismo. Como tampoco esencializar la cultura y no considerar las condiciones macroestructurales que la explican parece lo más plausible. En ese sentido, nos parece oportuno advertir que alentamos una postura antiesencialista que sostiene la no existencia de un sustrato primario, una esencia de lo social, sino que por el contrario asume el carácter contingente de toda identidad. De igual modo rechaza todo determinismo puesto que no concibe que exista una primacía de ninguna esfera, ya sea económica, cultural, o social, en la formación de las identidades; sino más bien entiende que todas ellas se interrelacionan e influencian mutuamente. Somos ese cuerpo que está, no solo atravesado por la razón, sino también por el poder y el deseo. Esa carne que somos es ese límite, ese punto ciego, esa piel que antecede toda reflexión y nos conecta con el mundo. En esta posibilidad de aunar la dimensión animal, humana y cósmica en una entidad indisoluble e integral, están quizás las huellas de nuevas (o viejas) sendas a ser transitadas