Discurso sobre las ventajas prácticas de la escuela vitalista respecto de la orgánica y anatómica leído en la solemne investidura del grado de Doctor en medicina por el Licenciado D. Francisco de P. Medina y Gutierrez.

Tesis doctoral Univ. Central, 1864.

Discurso leído en la Universidad Central por el ... D. Enrique Medina y Pulido en el acto de recibir la investidura de Doctor en la Facultad de Jurisprudencia.

Tesis de la Universidad Central (Madrid), Facultad de Jurisprudencia, leída el 17-06-1857.

Obras en prossa y verso de Salvador Jacinto Polo de Medina ... /

Mode of access: Internet.

La vida que hizo el siervo de Dios Fr. Iuan de Vallejo de la Orden de nuestra Señora de la Merced ... ; y sus exercicios y sentencias espirituales ... /

Mode of access: Internet.

Juicio analítico sobre el discurso canónico-legal que dió a luz...Pedro González Vallejo /

Indice.

[¿Cuál es la educacion fisica y moral de la muger, mas conforme a los grandes destinos la ha confiado la providencia?] : Discurso pronunciado ante el claustro de la Universidad Central por el Licenciado don Miguel Mayoral y Medina, en el acto solemne de recibir la investidura de doctor en la Facultad de Medicina y Cirugía.

Tesis Universidad Central, 1859.

[Cuál es la educación física y moral de la mujer más conforme á los altos destinos que le ha confiado la providencia] : discurso leído en la Universidad Central por el Licenciado Miguel Medina y Pulido, en el acto de recibir la investidura de Doctor en la Facultad de Medicina.

Mode of access: Internet.

Medina Azzahrá : leyenda histórica árabe ... [y otras obras]

Mode of access: Internet.

Epítome de las publicaciones de d. José Toribio Medina,

Issued also as a contribution to "Homenaje de la Sociedad chilena de historia y geografía a don José Toribio Medina," published in the Revista chilena de historia y geografía, Santiago de Chile, 1924, t. 47, p. [333]-402, and also separately, each with title: Catálogo de las publicaciones de don José Toribio Medina (1873-1914)

Historia de la ciudad de Medina Sidonia /

Originally published: Cádiz : Imprenta y Litografía de la Revista Médica, 1875.

Corrected opinion of Harold R. Medina, United States circuit judge in United States of America, plaintiff v. Henry S. Morgan, Harold Stanley, et al., doing business as Morgan Stanley & Co., et al., defendants. Filed, February 4, 1954. [Civil action no. 43.-757.]

Mode of access: Internet.

Visualization of molecular fingerprints

A visualization plot of a data set of molecular data is a useful tool for gaining insight into a set of molecules. In chemoinformatics, most visualization plots are of molecular descriptors, and the statistical model most often used to produce a visualization is principal component analysis (PCA). This paper takes PCA, together with four other statistical models (NeuroScale, GTM, LTM, and LTM-LIN), and evaluates their ability to produce clustering in visualizations not of molecular descriptors but of molecular fingerprints. Two different tasks are addressed: understanding structural information (particularly combinatorial libraries) and relating structure to activity. The quality of the visualizations is compared both subjectively (by visual inspection) and objectively (with global distance comparisons and local k-nearest-neighbor predictors). On the data sets used to evaluate clustering by structure, LTM is found to perform significantly better than the other models. In particular, the clusters in LTM visualization space are consistent with the relationships between the core scaffolds that define the combinatorial sublibraries. On the data sets used to evaluate clustering by activity, LTM again gives the best performance but by a smaller margin. The results of this paper demonstrate the value of using both a nonlinear projection map and a Bernoulli noise model for modeling binary data.

Increased diversity of libraries from libraries: chemoinformatic analysis of bis-diazacyclic libraries

Combinatorial libraries continue to play a key role in drug discovery. To increase structural diversity, several experimental methods have been developed. However, limited efforts have been performed so far to quantify the diversity of the broadly used diversity-oriented synthetic (DOS) libraries. Herein we report a comprehensive characterization of 15 bis-diazacyclic combinatorial libraries obtained through libraries from libraries, which is a DOS approach. Using MACCS keys, radial and different pharmacophoric fingerprints as well as six molecular properties, it was demonstrated the increased structural and property diversity of the libraries from libraries over the individual libraries. Comparison of the libraries to existing drugs, NCI Diversity and the Molecular Libraries Small Molecule Repository revealed the structural uniqueness of the combinatorial libraries (mean similarity < 0.5 for any fingerprint representation). In particular, bis-cyclic thiourea libraries were the most structurally dissimilar to drugs retaining drug-like character in property space. This study represents the first comprehensive quantification of the diversity of libraries from libraries providing a solid quantitative approach to compare and contrast the diversity of DOS libraries with existing drugs or any other compound collection.

Data compilation on the biological response to ocean acidification: environmental and experimental context of data sets and related literature

The exponential growth of studies on the biological response to ocean acidification over the last few decades has generated a large amount of data. To facilitate data comparison, a data compilation hosted at the data publisher PANGAEA was initiated in 2008 and is updated on a regular basis (doi:10.1594/PANGAEA.149999). By January 2015, a total of 581 data sets (over 4 000 000 data points) from 539 papers had been archived. Here we present the developments of this data compilation five years since its first description by Nisumaa et al. (2010). Most of study sites from which data archived are still in the Northern Hemisphere and the number of archived data from studies from the Southern Hemisphere and polar oceans are still relatively low. Data from 60 studies that investigated the response of a mix of organisms or natural communities were all added after 2010, indicating a welcomed shift from the study of individual organisms to communities and ecosystems. The initial imbalance of considerably more data archived on calcification and primary production than on other processes has improved. There is also a clear tendency towards more data archived from multifactorial studies after 2010. For easier and more effective access to ocean acidification data, the ocean acidification community is strongly encouraged to contribute to the data archiving effort, and help develop standard vocabularies describing the variables and define best practices for archiving ocean acidification data.