188 resultados para UDP-glucuronosyltransferase


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Il seguente lavoro di tesi si inserisce all'interno di un progetto accademico volto alla realizzazione di un sistema capace elaborare immagini utilizzando una rete FPGA, acquisite da un sensore. Ogni scrittura di un nuovo frame in memoria RAM genera un interrupt. L'obiettivo della tesi è creare un sistema client/server che permetta il trasferimento del flusso di frame dalla ZedBoard a un PC e la visualizzazione a video. Il progetto eseguito sulla ZedBoard è proposto in due versioni: la prima in assenza di sistema operativo (Standalone) e una seconda implementata su Linux. Il progetto eseguito sul PC è compatibile con Linux e Windows. La visualizzazione delle immagini è implementata utilizzando la libreria OpenCV.

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Il presente lavoro consiste nella realizzazione di un'interfaccia utente adibita all'assegnamento di missioni e al monitoraggio remoto di un rover agricolo autonomo. Sfruttando l'informatica per la sua implementazione, tale interfaccia trova invece applicazione nel campo dell'automazione e dell'agricoltura di precisione. L'utilizzatore ha perciò la facoltà di muovere il rover in campo aperto e di demandargli missioni specifiche, ricevendo allo stesso tempo un feedback continuo sul suo operato. L'applicativo software comunica quindi in maniera bidirezionale con il veicolo controllato ed è predisposto per sfruttare diversi canali di comunicazione (antenne seriali, pacchetti udp, socket tcp). La scrittura del codice è stata seguita da una serie di prove di comunicazione con il veicolo, effettuate indoor, e infine da alcuni test completi effettuati outdoor, con il rover in movimento.

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Erasure control coding has been exploited in communication networks with an aim to improve the end-to-end performance of data delivery across the network. To address the concerns over the strengths and constraints of erasure coding schemes in this application, we examine the performance limits of two erasure control coding strategies, forward erasure recovery and adaptive erasure recovery. Our investigation shows that the throughput of a network using an (n, k) forward erasure control code is capped by r =k/n when the packet loss rate p ≤ (te/n) and by k(l-p)/(n-te) when p > (t e/n), where te is the erasure control capability of the code. It also shows that the lower bound of the residual loss rate of such a network is (np-te)/(n-te) for (te/n) < p ≤ 1. Especially, if the code used is maximum distance separable, the Shannon capacity of the erasure channel, i.e. 1-p, can be achieved and the residual loss rate is lower bounded by (p+r-1)/r, for (1-r) < p ≤ 1. To address the requirements in real-time applications, we also investigate the service completion time of different schemes. It is revealed that the latency of the forward erasure recovery scheme is fractionally higher than that of the scheme without erasure control coding or retransmission mechanisms (using UDP), but much lower than that of the adaptive erasure scheme when the packet loss rate is high. Results on comparisons between the two erasure control schemes exhibit their advantages as well as disadvantages in the role of delivering end-to-end services. To show the impact of the bounds derived on the end-to-end performance of a TCP/IP network, a case study is provided to demonstrate how erasure control coding could be used to maximize the performance of practical systems. © 2010 IEEE.

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The difluoromethyl-allo-threonyl hydroxamate-based compound LPC-058 is a potent inhibitor of UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) in Gram-negative bacteria. A scalable synthesis of this compound is described. The key step in the synthetic sequence is a transition metal/base-catalyzed aldol reaction of methyl isocyanoacetate and difluoroacetone, giving rise to 4-(methoxycarbonyl)-5,5-disubstituted 2-oxazoline. A simple NMR-based determination of enantiomeric purity is also described.

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The first decades of the 19th century constituted a period of profound change for Chile, the principal results of which were to be seen in the consolidation of the process of independence from Spanish dominion in 1818. The consequences were not limited to a revolution of military and political nature; they also included a renovation of the cultural panorama -at least among the educated patriots who made an effort to distance themselves ideologically from the Monarchy-, with the implicit challenge of establishing a new order for Chile, based on legitimate and universally recognizable foundations. The inspirational framework for these efforts is usually associated with other revolutionary examples -France and the United States- that preceded the emancipation processes in Spanish America, as well as with the discourses of illustrated liberalism. As we will attempt to demonstrate in this study, a new reading of the texts written by the Creoles that lead the Chilean independence process may, nonetheless, also reveal the relevance of the classical tradition as a model for the configuration and legitimization of the first Republican projects that especially admired the ideals of Republicanism.

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The wide adaptation of Internet Protocol (IP) as de facto protocol for most communication networks has established a need for developing IP capable data link layer protocol solutions for Machine to machine (M2M) and Internet of Things (IoT) networks. However, the wireless networks used for M2M and IoT applications usually lack the resources commonly associated with modern wireless communication networks. The existing IP capable data link layer solutions for wireless IoT networks provide the necessary overhead minimising and frame optimising features, but are often built to be compatible only with IPv6 and specific radio platforms. The objective of this thesis is to design IPv4 compatible data link layer for Netcontrol Oy's narrow band half-duplex packet data radio system. Based on extensive literature research, system modelling and solution concept testing, this thesis proposes the usage of tunslip protocol as the basis for the system data link layer protocol development. In addition to the functionality of tunslip, this thesis discusses the additional network, routing, compression, security and collision avoidance changes required to be made to the radio platform in order for it to be IP compatible while still being able to maintain the point-to-multipoint and multi-hop network characteristics. The data link layer design consists of the radio application, dynamic Maximum Transmission Unit (MTU) optimisation daemon and the tunslip interface. The proposed design uses tunslip for creating an IP capable data link protocol interface. The radio application receives data from tunslip and compresses the packets and uses the IP addressing information for radio network addressing and routing before forwarding the message to radio network. The dynamic MTU size optimisation daemon controls the tunslip interface maximum MTU size according to the link quality assessment calculated from the radio network diagnostic data received from the radio application. For determining the usability of tunslip as the basis for data link layer protocol, testing of the tunslip interface is conducted with both IEEE 802.15.4 radios and packet data radios. The test cases measure the radio network usability for User Datagram Protocol (UDP) based applications without applying any header or content compression. The test results for the packet data radios reveal that the typical success rate for packet reception through a single-hop link is above 99% with a round-trip-delay of 0.315s for 63B packets.

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Purpose. To investigate the influence of diadenosine polyphosphates on the rate of corneal epithelial cell migration. Methods. Primary corneal epithelial cell cultures were obtained from New Zealand White rabbits. Immunocytochemical experiments were performed by fixing the cells with 4% paraformaldehyde (PFA) and incubated with cytokeratin 3 primary antibody, which was subsequently incubated with a secondary IgG mouse labeled with FITC, and the cells were observed under confocal microscopy. Migration studies were performed by taking confluent monolayers that were wounded with a pipette tip and challenged with different di- and mononucleotides with or without P2 antagonist (n = 8 each treatment). For concentration–response analysis, compounds were tested in doses ranging from 10−8 to 10−3 M (n = 8). The stability of the dinucleotides was assayed by HPLC, with an isocratic method (n = 4). Results. Cells under study were verified as corneal epithelial cells via the immunocytochemical analysis. Cell migration experiments showed that Ap4A, UTP, and ATP accelerated the rate of healing (5, 2.75, and 3 hours, respectively; P < 0.05; P < 0.001), whereas Ap3A, Ap5A, and UDP delayed it (6.5, 10, and 2 hours, respectively; P < 0.05). ADP did not modify the rate of migration. Antagonists demonstrated that Ap4A and Ap3A did activate different P2Y receptors mediating corneal wound-healing acceleration and delay. Concerning the possible degradation of the dinucleotides, it was almost impossible to detect any products resulting from their cleavage. Conclusions. Based on the pharmacological profile of all the compounds tested, the two main P2Y receptors that exist in these corneal cells are a P2Y2 receptor accelerating the rate of healing and a P2Y6 receptor that delays this process.

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El envejecimiento de la población es un fenómeno que no sólo está alterando las estructuras demográficas, sino que tiene y tendrá una amplia repercusión social, económica y cultural. La promoción del envejecimiento activo resulta un enfoque indispensable para afrontar esta situación, y es necesario abrir nuevas oportunidades a los mayores para seguir participando activamente en la sociedad. En este sentido, el voluntariado puede ser una forma de promover esa mayor participación social de los mayores. Con el objetivo de profundizar en el estudio del voluntariado realizado por mayores, se aborda el análisis de la relación entre, por un lado, la permanencia, e número de horas dedicadas al voluntariado y la intención de continuar en el futuro como voluntario en la organización, y, por otro lado, la satisfacción experimentada con los usuarios del servicio voluntario, con las actividades que realiza, con los compañeros voluntarios y con la asociación. Para llevar a cabo dicho análisis se utilizó la Encuesta de Satisfacción con el Voluntariado de la Unión Democrática de Pensionistas (UDP) 2011-2012 realizada por Simple Lógica Investigación, S.A. La muestra analizada estaba compuesta por 853 voluntarios mayores de 50 años pertenecientes a UDP. Los resultados muestran que aunque se encuentran relaciones significativas y positivas entre las horas dedicadas, la intención de continuar en el futuro y la mayoría de los tipos de satisfacción analizadas, sólo la satisfacción con la actividad desarrollada era un predictor significativo del tiempo dedicado al voluntariado, y únicamente la satisfacción con la asociación lo era de la intención de continuar en el futuro con el voluntariado. En los dos casos los porcentajes de varianza explicada son muy reducidos. Se analizan los resultados hallados a la luz de investigaciones previas y se derivan implicaciones prácticas de cara a la gestión de los voluntarios mayores en las entidades de acción social.