El rol de la interdependencia asimétrica de Ucrania a Rusia en la calidad de la democracia ucraniana 2004 – 2010

El objetivo de este trabajo es explicar el rol de la Interdependencia Asimétrica de Rusia y Ucrania en la Calidad de la Democracia ucraniana 2004-2010; las democracias actuales se ven afectadas por actores externos dado el afianzamiento de relaciones económicas asimétricas. El estudio de caso será abordado desde el concepto de Calidad de la Democracia de Leonardo Morlino y el de Internacionalización de Robert Keohane y Helen Milner. La Revolución Naranja, las crisis del gas de 2006 - 2009 y las elecciones de 2010 serán los fenómenos explicados. Desde un enfoque neo-institucional, las relaciones de Interdependencia Asimétrica de Ucrania con Rusia, afectan la calidad de la democracia ucraniana configurándose en un actor más de la política doméstica.

The use of insect cells to identify potent and selective inhibitors of the replication of the Dengue and Chikungunya viruses and unravel their molecular mechanism of action

Dengue and Chikungunya viruses cause the most important arthropod-borne viral infections for humans. These viruses are predominant in tropical and subtropical regions. In addition, these viruses are predominant in tropical and subtropical regions. Dengue mortality rate is around 1.2 to 3.5% and deaths due to chikungunya fever are around 1 in 1000; however, half of chikungunya-infected patients evolve into a chronic state that can persist for months up to years. There are no antiviral drugs available for DENV and CHIKV treatment and prevention. Moreover, vector control strategies have failed so far. Thus, the development of potent inhibitors for a broad spectrum of RNA viruses is urgently needed. We established and characterized a new embryonic insect cell line from Culex quinquefasciatus mosquito. Also we established the flaviviruses and alphavirus replication, both in C6/36 and Lulo insect cell lines, as well as in Vero cell line. In addition we carried out a reference compound library and reference panel of assays and data for DENV, which provides a benchmark for further studies. During this study, a panel of 9 antiviral molecules, with proven in vitro anti-dengue virus activity and that act at different stages of the DENV life cycle, was selected. Finally, Favipiravir or T-705, was identified as inhibitor in vitro and in vivo of alphaviruses and the mutation K291R in nsP4, which is responsible of the polymerase activity, was found as the mode of action in CHIKV. Interestingly, lysine in motif F1 is also highly conserved in positive-stranded RNA viruses and this might explain the broad spectrum of T-705 antiviral activity.

СЛІДИ КОНФЛІКТУ – ПОЛІТИЧНІ В’ЯЗНІ У ПРОЗІ ЗОФІЇ НАЛКОВСЬКОЇ

The main aim of the article is highlighting subplots present in the prose works of Nałkowska which are devoted to Ukrainian and Belarusian political prisoners. The author maintains that the Polish colonizing activity along the so-called ‘Eastern Borderland’ requires a detailed and comprehensive study. The results of this analys is should then be compared against contemporary Ukrainian literature as well as the history of the national liberation and nationalist movements at the beginning of 20th century. The article explores three prose texts by Nałkowska, that is, “Węzły życia” (The Bonds of Life), “Niedobra miłość” (Bad Love) and “Ściany świata” (The Walls of the World). The subplots present in all three works can be analyzed in terms of inevident, yet indelible traces pertaining to ethnic conflicts between Poles, Ukrainians and Belarusians, as well as the Jewish pogroms. The themes that span the above- mentioned text can be outlined as follows: first of all, the radical metamorphosis of political attitudes on the part of the protagonists representing former Legionists; secondly, the heroines’ active work for the benefit of the prisoners, also the political ones. In spite of censorship and visibly more and more extreme politics of the authoritarian state towards ethnic minorities, Nałkowska remained one of the few writers who managed to deliver the arrested history of persecutions. Keywords: politics of colonization, national minority, traces of conflict, political prisoners

Naturaleza, paisaje y memoria: alturas y ciudades del Reino de Qutio en la experiencia viajera del siglo XVIII (Estudios)

A mediados del siglo XVIII las alturas de los Andes del Reino de Quito, al igual que sus centros urbanos, fueron visitadas por viajeros naturalistas y misioneros. Este artículo explora cómo algunos de esos viajeros percibieron, construyeron y recordaron desde dos puntos de vista distintos la naturaleza y el paisaje. Tras exponer las categorías y enfoques empleados, el artículo explora dos tipos de percepción y memoria de la naturaleza: el sobrenatural y el naturalista. Finalmente, se analiza el paisaje urbano en cuya construcción escrita se combinaron las antiguas ideas del orden colonial con la perspectiva de la prosperidad terrenal, correlato del interés por las ciencias aplicadas que animaba la exploración de las alturas nevadas y de los volcanes.

Building a left coast: the legacy of the California Popular Front and the challenge to Cold War liberalism in the post-world war two era

The Cold War in the late 1940s blunted attempts by the Truman administration to extend the scope of government in areas such as health care and civil rights. In California, the combined weakness of the Democratic Party in electoral politics and the importance of fellow travelers and communists in state liberal politics made the problem of how to advance the left at a time of heightened Cold War tensions particularly acute. Yet by the early 1960s a new generation of liberal politicians had gained political power in the Golden State and was constructing a greatly expanded welfare system as a way of cementing their hold on power. In this article I argue that the New Politics of the 1970s, shaped nationally by Vietnam and by the social upheavals of the 1960s over questions of race, gender, sexuality, and economic rights, possessed particular power in California because many activists drew on the longer-term experiences of a liberal politics receptive to earlier anti-Cold War struggles. A desire to use political involvement as a form of social networking had given California a strong Popular Front, and in some respects the power of new liberalism was an offspring of those earlier battles.

The sky is the limit? The determinants and constraints of European airports' commercial revenues

This study investigates the determinants of commercial and retail airport revenues as well as revenues from real estate operations. Cross-sectional OLS, 2SLS and robust regression models of European airports identify a number of significant drivers of airport revenues. Aviation revenues per passenger are mainly determined by the national income per capita in which the airport is located, the percentage of leisure travelers and the size of the airport proxied by total aviation revenues. Main drivers of commercial revenues per passenger include the total number of passengers passing through the airport, the ratio of commercial to total revenues, the national income, the share of domestic and leisure travelers and the total number of flights. These results are in line with previous findings of a negative influence of business travelers on commercial revenues per passenger. We also find that a high amount of retail space per passenger is generally associated with lower commercial revenues per square meter confirming decreasing marginal revenue effects. Real estate revenues per passenger are positively associated with national income per capita at airport location, share of intra-EU passengers and percent delayed flights. Overall, aviation and non-aviation revenues appear to be strongly interlinked, underlining the potential for a comprehensive airport management strategy above and beyond mere cost minimization of the aviation sector.

Do online hotel rating schemes influence booking behaviours?

Travelers’ hotel booking behaviors increasingly depend on peers' opinions and online ratings. This study investigates the effects of online hotel ratings on travelers' attitudes toward the hotel and booking intentions, using a 2 × 2 experimental research design. The results suggest that online rating lists are more useful and credible when published by well-known online travel communities (e.g., TripAdvisor). More favorable attitudes toward a hotel and higher booking intentions emerge when the hotel appears in best hotels lists. Finally, for the entries on best hotels lists, better attitudes and higher booking intentions result if the list is published on a well-known online travel community (Tripadvisor), whereas for entries on a worst hotel list, attitudes and booking intentions decrease even further if the list appears on TripAdvisor.

Time to act: the UK in NATO

Since 1989, NATO has expanded its strategic concept and geopolitical scope to the detriment of an efficient and well-defined military capability in Europe. The Ukrainian crisis has brought the attention back to Europe and to NATO’s deterrent value. As one of the Alliance’s leading members, Britain must act as a catalyst to ensure that NATO has the necessary military strength and political will to respond to the new security challenges.

Do online hotel rating schemes influence booking behaviors?

Travelers’ hotel booking behaviors increasingly depend on peers' opinions and online ratings. This study investigates the effects of online hotel ratings on travelers' attitudes toward the hotel and booking intentions, using a 2 × 2 experimental research design. The results suggest that online rating lists are more useful and credible when published by well-known online travel communities (e.g., TripAdvisor). More favorable attitudes toward a hotel and higher booking intentions emerge when the hotel appears in best hotels lists. Finally, for the entries on best hotels lists, better attitudes and higher booking intentions result if the list is published on a well-known online travel community (Tripadvisor), whereas for entries on a worst hotel list, attitudes and booking intentions decrease even further if the list appears on TripAdvisor.

Boosting systemic and secreted antibody responses in mice orally immunized with recombinant Bacillus subtilis strains following parenteral priming with a DNA vaccine encoding the enterotoxigenic Escherichia coli (ETEC) CFA/I fimbriae B subunit

Recombinant Bacillus subtilis strains, either spores or vegetative cells, may be employed as safe and low cost orally delivered live vaccine vehicles. In this study, we report the use of an orally delivered B. subtilis vaccine strain to boost systemic and secreted antibody responses in mice i.m. primed with a DNA vaccine encoding the structural subunit (CfaB) of the CFA/I fimbriae encoded by enterotoxigenic Escherichia coli (ETEC), an important etiological agent of diarrhea among travelers and children living in endemic regions. DBA/2 female mice submitted to the prime-boost immunization regimen developed synergic serum (IgG) and mucosal (IgA) antibody responses to the target CfaB antigen. Moreover, in contrast to mice immunized only with one vaccine formulation, sera harvested from prime-boosted vaccinated individuals inhibited adhesion of ETEC cells to human red blood cells. Additionally, vaccinated dams conferred full passive protection to suckling newborn mice challenged with a virulent ETEC strain. Taken together the present results further demonstrate the potential use of recombinant B. subtilis strains as an alternative live vaccine vehicle. (C) 2008 Elsevier Ltd. All rights reserved.

STABILITY FOR RETARDED FUNCTIONAL DIFFERENTIAL EQUATIONS

It is known that retarded functional differential equations can be regarded as Banach-space-valued generalized ordinary differential equations (GODEs). In this paper, some stability concepts for retarded functional differential equations are introduced and they are discussed using known stability results for GODEs. Then the equivalence of the different concepts of stabilities considered here are proved and converse Lyapunov theorems for a very wide class of retarded functional differential equations are obtained by means of the correspondence of this class of equations with GODEs.

SEMIPERFECT IPRI-RINGS AND RIGHT BEZOUT RINGS

We present a survey of some results on ipri-rings and right Bezout rings. All these rings are generalizations of principal ideal rings. From the general point of view, decomposition theorems are proved for semiperfect ipri-rings and right Bezout rings.

L'italiano in Svezia nel Seicento attraverso le testimonianze di viaggiatori italiani

Nell'articolo è illustrata la conoscenza della lingua italiana in Svezia nella prima età moderna, con particolare riguardo al Seicento. Gli studi pregressi su questo argomento mostrano che l'Italiano era in questo periodo una delle lingue di cultura più importanti in Svezia. Per verificare questi studi si sono utilizzate le notizie di prima mano contenute in alcuni testi odeporici (lettere, diari, relazioni ecc.) redatti da viaggiatori italiani recatisi in Svezia in questo secolo. Nei primi paragrafi del lavoro il lettore è introdotto alla comprensione dell'argomento grazie ad una esposizione contestualizzata sia della storia della Svezia sia di quella della lingua italiana tra Cinquecento e Seicento. Inoltre si offre anche una veloce introduzione ai contatti culturali tra l'Italia e la Svezia fino al Seicento. L'analisi dei testi odeporici seicenteschi conferma gli studi precedenti, basati su ricerche bibliografiche e d'archivio, dimostrando come l'Italiano, sebbene materia di studio accademico e di apprendimento privato, fosse in realtà conosciuto in Svezia solo da una piccola parte dei nobili, preferendosi ad esso il Francese, mentre il latino era conosciuto bene da tutti i rappresentanti del clero.

Ukrainas konstitutionella sicksackande : Regimförändring och partiutveckling under semipresidentialism

Ukraine has repeatedly shifted between the two sub-types of semi-presidentialism, i.e. between premier-presidentialism and president-parliamentarism. The aim of this article is to discuss to what extent theoretical arguments against premier-presidential and president-parliamentary systems are relevant for understanding the shifting directions of the Ukrainian regime. As a point of departure, I formulate three main claims from the literature: 1) “President-parliamentarism is less conducive to democratization than premier-presidentialism.”; 2) “Semi-presidentialism in both its variants have built-in incitements for intra-executive conflict between the president and the prime minister.”; 3) “Semi-presidentialism in general, and president-parliamentarism in particular, encourages presidentialization of political parties.” I conclude from the study’s empirical overview that the president-parliamentary system– the constitutional arrangement with the most dismal record of democratization – has been instrumental in strengthening presidential dominance and authoritarian tendencies. The premier-presidential period 2006–2010 was by no means smooth and stable, but the presidential dominance weakened and the survival of the government was firmly anchored in the parliament. During this period, there were also indications of a gradual strengthening of institutional capacity among the main political parties and the parliament began to emerge as a significant political arena.

Towards Presidential Rule in Ukraine : Hybrid Regime Dynamics under Semi-Presidentialism

This article sets out to analyse recent regime developments in Ukraine in relation to semi-presidentialism. The article asks: to what extent and in what ways theoretical arguments against semi-presidentialism (premier-presidential and president-parliamentary systems) are relevant for understanding the changing directions of the Ukrainian regime since the 1990s? The article also reviews the by now overwhelming evidence suggesting that President Yanukovych is turning Ukraine into a more authoritarian hybrid regime and raises the question to what extent the president-parliamentary system might serve this end. The article argues that both kinds of semi-presidentialism have, in different ways, exacerbated rather than mitigated institutional conflict and political stalemate. The return to the president-parliamentary system in 2010 – the constitutional arrangement with the most dismal record of democratisation – was a step in the wrong direction. The premier-presidential regime was by no means ideal, but it had at least two advantages. It weakened the presidential dominance and it explicitly anchored the survival of the government in parliament. The return to the 1996 constitution ties in well with the notion that President Viktor Yanukovych has embarked on an outright authoritarian path.